LOCUS       NM_001170600            6555 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus myosin heavy chain 11 (Myh11), mRNA.
ACCESSION   NM_001170600 XM_001053536
VERSION     NM_001170600.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6555)
  AUTHORS   Yokoyama,U., Arakawa,N., Ishiwata,R., Yasuda,S., Minami,T.,
            Goda,M., Uchida,K., Suzuki,S., Matsumoto,M., Koizumi,N., Taguri,M.,
            Hirano,H., Yoshimura,K., Ogino,H., Masuda,M. and Ishikawa,Y.
  TITLE     Proteomic analysis of aortic smooth muscle cell secretions reveals
            an association of myosin heavy chain 11 with abdominal aortic
            aneurysm
  JOURNAL   Am J Physiol Heart Circ Physiol 315 (4), H1012-H1018 (2018)
   PUBMED   30004237
REFERENCE   2  (bases 1 to 6555)
  AUTHORS   LaHaye,S., Corsmeier,D., Basu,M., Bowman,J.L., Fitzgerald-Butt,S.,
            Zender,G., Bosse,K., McBride,K.L., White,P. and Garg,V.
  TITLE     Utilization of Whole Exome Sequencing to Identify Causative
            Mutations in Familial Congenital Heart Disease
  JOURNAL   Circ Cardiovasc Genet 9 (4), 320-329 (2016)
   PUBMED   27418595
REFERENCE   3  (bases 1 to 6555)
  AUTHORS   Revenu,C., Ubelmann,F., Hurbain,I., El-Marjou,F., Dingli,F.,
            Loew,D., Delacour,D., Gilet,J., Brot-Laroche,E., Rivero,F.,
            Louvard,D. and Robine,S.
  TITLE     A new role for the architecture of microvillar actin bundles in
            apical retention of membrane proteins
  JOURNAL   Mol Biol Cell 23 (2), 324-336 (2012)
   PUBMED   22114352
REFERENCE   4  (bases 1 to 6555)
  AUTHORS   Martin,A.F., Bhatti,S., Pyne-Geithman,G.J., Farjah,M., Manaves,V.,
            Walker,L., Franks,R., Strauch,A.R. and Paul,R.J.
  TITLE     Expression and function of COOH-terminal myosin heavy chain
            isoforms in mouse smooth muscle
  JOURNAL   Am J Physiol Cell Physiol 293 (1), C238-C245 (2007)
   PUBMED   17392380
  REMARK    GeneRIF: Suggest in vivo function for COOH-terminal isoforms of
            smooth muscle myosin heavy chains and that isoform ratio it tightly
            regulated.
REFERENCE   5  (bases 1 to 6555)
  AUTHORS   Zhu,L., Vranckx,R., Khau Van Kien,P., Lalande,A., Boisset,N.,
            Mathieu,F., Wegman,M., Glancy,L., Gasc,J.M., Brunotte,F.,
            Bruneval,P., Wolf,J.E., Michel,J.B. and Jeunemaitre,X.
  TITLE     Mutations in myosin heavy chain 11 cause a syndrome associating
            thoracic aortic aneurysm/aortic dissection and patent ductus
            arteriosus
  JOURNAL   Nat Genet 38 (3), 343-349 (2006)
   PUBMED   16444274
REFERENCE   6  (bases 1 to 6555)
  AUTHORS   Yam,J.W., Chan,K.W., Li,N. and Hsiao,W.L.
  TITLE     Molecular cloning and functional analysis of the promoter region of
            rat nonmuscle myosin heavy chain-B gene
  JOURNAL   Biochem Biophys Res Commun 276 (3), 1203-1209 (2000)
   PUBMED   11027611
REFERENCE   7  (bases 1 to 6555)
  AUTHORS   Morano,I., Chai,G.X., Baltas,L.G., Lamounier-Zepter,V., Lutsch,G.,
            Kott,M., Haase,H. and Bader,M.
  TITLE     Smooth-muscle contraction without smooth-muscle myosin
  JOURNAL   Nat Cell Biol 2 (6), 371-375 (2000)
   PUBMED   10854329
REFERENCE   8  (bases 1 to 6555)
  AUTHORS   Suzuki,T., Kim,H.S., Kurabayashi,M., Hamada,H., Fujii,H.,
            Aikawa,M., Watanabe,M., Watanabe,N., Sakomura,Y., Yazaki,Y. and
            Nagai,R.
  TITLE     Preferential differentiation of P19 mouse embryonal carcinoma cells
            into smooth muscle cells. Use of retinoic acid and antisense
            against the central nervous system-specific POU transcription
            factor Brn-2
  JOURNAL   Circ Res 78 (3), 395-404 (1996)
   PUBMED   8593698
REFERENCE   9  (bases 1 to 6555)
  AUTHORS   White,S., Martin,A.F. and Periasamy,M.
  TITLE     Identification of a novel smooth muscle myosin heavy chain cDNA:
            isoform diversity in the S1 head region
  JOURNAL   Am J Physiol 264 (5 Pt 1), C1252-C1258 (1993)
   PUBMED   7684561
REFERENCE   10 (bases 1 to 6555)
  AUTHORS   Babij,P. and Periasamy,M.
  TITLE     Myosin heavy chain isoform diversity in smooth muscle is produced
            by differential RNA processing
  JOURNAL   J Mol Biol 210 (3), 673-679 (1989)
   PUBMED   2614841
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            [WARNING] On May 1, 2024 this sequence was replaced by
            NM_001170600.2.
            
            On Dec 26, 2009 this sequence version replaced XM_001053536.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.891978.1,
                                           SRR26360194.416668.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               JAXUCZ010000010.1  1250916-1251047
            133-493             JAXUCZ010000010.1  1263194-1263554
            494-650             JAXUCZ010000010.1  1270177-1270333
            651-678             JAXUCZ010000010.1  1278726-1278753
            679-781             JAXUCZ010000010.1  1283165-1283267
            782-874             JAXUCZ010000010.1  1286941-1287033
            875-938             JAXUCZ010000010.1  1288092-1288155
            939-1037            JAXUCZ010000010.1  1288534-1288632
            1038-1181           JAXUCZ010000010.1  1292210-1292353
            1182-1277           JAXUCZ010000010.1  1295273-1295368
            1278-1396           JAXUCZ010000010.1  1297209-1297327
            1397-1549           JAXUCZ010000010.1  1297981-1298133
            1550-1723           JAXUCZ010000010.1  1298878-1299051
            1724-1897           JAXUCZ010000010.1  1300780-1300953
            1898-2012           JAXUCZ010000010.1  1302956-1303070
            2013-2206           JAXUCZ010000010.1  1306007-1306200
            2207-2328           JAXUCZ010000010.1  1308565-1308686
            2329-2398           JAXUCZ010000010.1  1308778-1308847
            2399-2559           JAXUCZ010000010.1  1309007-1309167
            2560-2668           JAXUCZ010000010.1  1317772-1317880
            2669-2800           JAXUCZ010000010.1  1319560-1319691
            2801-3007           JAXUCZ010000010.1  1319778-1319984
            3008-3145           JAXUCZ010000010.1  1320884-1321021
            3146-3269           JAXUCZ010000010.1  1321588-1321711
            3270-3441           JAXUCZ010000010.1  1323822-1323993
            3442-3654           JAXUCZ010000010.1  1326733-1326945
            3655-3799           JAXUCZ010000010.1  1328265-1328409
            3800-4006           JAXUCZ010000010.1  1329848-1330054
            4007-4111           JAXUCZ010000010.1  1331377-1331481
            4112-4264           JAXUCZ010000010.1  1331572-1331724
            4265-4513           JAXUCZ010000010.1  1331925-1332173
            4514-4726           JAXUCZ010000010.1  1334908-1335120
            4727-4939           JAXUCZ010000010.1  1335330-1335542
            4940-5101           JAXUCZ010000010.1  1335763-1335924
            5102-5230           JAXUCZ010000010.1  1336297-1336425
            5231-5319           JAXUCZ010000010.1  1336648-1336736
            5320-5443           JAXUCZ010000010.1  1337616-1337739
            5444-5652           JAXUCZ010000010.1  1338527-1338735
            5653-5761           JAXUCZ010000010.1  1339177-1339285
            5762-5934           JAXUCZ010000010.1  1339386-1339558
            5935-6555           JAXUCZ010000010.1  1345061-1345681
FEATURES             Location/Qualifiers
     source          1..6555
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q11"
     gene            1..6555
                     /gene="Myh11"
                     /note="myosin heavy chain 11"
                     /db_xref="GeneID:24582"
                     /db_xref="RGD:3136"
     exon            1..132
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            133..493
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..6067
                     /gene="Myh11"
                     /note="myosin, heavy polypeptide 11, smooth muscle; SMMHC;
                     myosin heavy chain 21; smooth muscle myosin heavy chain;
                     myosin, heavy chain 11, smooth muscle"
                     /codon_start=1
                     /product="myosin-11"
                     /protein_id="NP_001164071.1"
                     /db_xref="GeneID:24582"
                     /db_xref="RGD:3136"
                     /translation="MAQKGQLSDDEKFLFVDKNFINSPMAQADWVAKKLVWVPSEKQG
                     FEAASIKEEKGDEVVVELVENGKKVTVGKDDIQKMNPPKFSKVEDMAELTCLNEASVL
                     HNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIADT
                     AYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDSSITGELEKQL
                     LQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQAR
                     DERTFHIFYYLIAGAKEKMRNDLLLESFNSYTFLSNGFVPIPAAQDDEMFQETLEAMS
                     IMGFSEEEQLAILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLVGINVTDF
                     TRAILTPRIKVGRDVVQKAQTKEQADFAIEALAKATYERLFRWILSRVNKALDKTHRQ
                     GASFLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNF
                     IDFGLDLQPCIELIERPNNPPGVLALLDEECWFPKATDKSFVEKLCSEQGNHPKFQKP
                     KQLKDKTEFSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKDVDR
                     IVGLDQMAKMTESSLPSASKTKKGMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPN
                     HEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILAANAIPKGF
                     MDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCR
                     GYLARKAFTKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQA
                     KEEEMQKIKERQQKAESELKELEQRHTQLAEEKTLLQEQLQAETELYAEAEEMRVRLA
                     AKKQELEEILHEMEARLEEEEDRSQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE
                     KVTAEAKIKKLEDDILVMDDQNNKLSKERKLLEERVSDLTTNLAEEEEKAKNLTKLKS
                     KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK
                     EEELQAALARLDEEITQKNNALKKIRELEGHVSDLQEDLDSERAARNKAEKQKRDLGE
                     ELEALKTELEDTLDSTATQQELRAKREQEVTMLKKALDEETRSHEAQVQEMRQKHTQA
                     VEELTEQLEQFKRAKANLDKSKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEGQLQ
                     ELQSKCSDGERARTELSDKVHKLQNEVESVTGMLNEAEGKAIKLAKEVASLGSQLQDT
                     QELLQEETRQKLNVSTKLRQLEDERNSLQDQLDEEMEAKQNLERHVSTLNIQLSDSKK
                     KLQDLASTIEVMEEGKKRLQKEMEGLGQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL
                     DNQRQLVSNLEKKQKKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE
                     ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMRTQLEELE
                     DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK
                     QRALAAAAKKKLEGDLKDLELQADSAVKGREEAIKQLRKLQAQMKDFQRELDDARASR
                     DEIFATSKENEKKAKSLEAELMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNT
                     LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATLQAEQLSNELVTERSAAQKNE
                     SARQQLERQNKELRSKLQEVEGAVKAKLKSTVAALEAKIVQLEEQIEQEAREKQAATK
                     LLKQKDKKLKEVLLQVEDERKMVEQYKEQAEKGNTKVKQLKRQLEEAEEESQRINANR
                     RKLQRELDEATESNEAMGREVNALKSKLRRGNEASFVPSRRAGGRRVIENTDGSEEEM
                     DARDSDFNGTKASE"
     exon            494..650
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            651..678
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            679..781
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            782..874
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            875..938
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1037
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1181
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1277
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1396
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1549
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1723
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1897
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2012
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2206
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2328
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2398
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2559
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2668
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..2800
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..3007
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            3008..3145
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            3146..3269
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            3270..3441
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            3442..3654
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            3655..3799
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            3800..4006
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            4007..4111
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            4112..4264
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            4265..4513
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            4514..4726
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            4727..4939
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            4940..5101
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            5102..5230
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            5231..5319
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            5320..5443
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            5444..5652
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            5653..5761
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            5762..5934
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
     exon            5935..6555
                     /gene="Myh11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtagcgctg actctataaa gccagatgtc cgaagcatac agagagattt ggaccatccc
       61 agcctgggat cagtgtcaga tccgagctct ccatccggtg ttctcctgct agtccacccc
      121 agtagcagat ctgggaccac caagcacaat ggcacagaaa gggcagctca gtgatgatga
      181 gaagttcctc tttgtggata aaaacttcat aaacagccca atggcccagg ccgactgggt
      241 agccaagaag ctagtatggg tcccttcaga gaagcagggc ttcgaagcag ccagcatcaa
      301 ggaggagaag ggcgatgagg tggttgtaga gctggtggaa aacggaaaga aggtcacagt
      361 gggcaaagat gacatccaaa aaatgaaccc gcccaagttc tccaaggtgg aagacatggc
      421 cgagctgaca tgcctcaatg aggcttctgt gctgcacaac ctgagggagc ggtacttctc
      481 aggcctcatc tacacctact cgggcctctt ctgtgtggtg gtcaacccct acaagcacct
      541 acccatctac tcagaaaaga ttgtggacat gtacaagggc aagaagaggc atgagatgcc
      601 gcctcacatc tatgccattg ctgatacggc ctacagaagc atgctacaag atcgtgaaga
      661 ccagtccatt ctgtgcacag gtgagtctgg agctggaaag acagagaaca caaagaaagt
      721 catacagtat ttggctgtgg tggcatcctc ccacaaaggc aagaaagaca gcagcatcac
      781 gggggagctg gaaaagcagc ttctacaggc aaacccaatc ctggaggctt tcggcaatgc
      841 aaaaactgtc aagaatgaca actcctcccg ctttggcaag ttcattcgca tcaactttga
      901 tgtcactggt tacattgtgg gtgccaatat cgaaacatat cttctggaaa agtctcgggc
      961 tattcgacag gctagggacg agagaacgtt ccacatcttc tactatctga tcgctggagc
     1021 caaggagaag atgagaaatg acctactttt ggagagcttc aacagctaca catttttatc
     1081 caatggcttt gtgcccatcc cagctgcaca agatgatgag atgttccagg agacactaga
     1141 ggccatgtcc atcatgggct tcagtgaaga ggaacagcta gccatcttga aggtagtatc
     1201 atccgtcctt cagcttggaa acattgtctt caagaaggag cgaaacacag accaggcatc
     1261 catgcctgat aacacagctg ctcagaaagt ttgccacctt gtggggatta atgtgacaga
     1321 tttcaccaga gccatcctga ccccacgtat aaaagttgga cgggatgtgg tgcagaaagc
     1381 tcagaccaaa gaacaggctg actttgccat tgaggcctta gccaaggcca cctatgagcg
     1441 ccttttccga tggattctca gccgtgtgaa caaagccttg gataagaccc atcgtcaggg
     1501 ggcctccttc ctgggcattc tggatattgc tgggtttgaa atctttgagg taaactcctt
     1561 cgagcagctg tgcatcaact acaccaatga gaagttgcag cagctgttca atcacaccat
     1621 gttcatcctg gagcaggaag agtaccaacg agagggcatc gagtggaact tcatcgactt
     1681 tggcctggac ctacagcctt gtattgaact gattgagcgg ccgaacaacc ctcctggtgt
     1741 gctggccctg ctggatgaag aatgctggtt ccccaaagct acggacaagt cttttgtgga
     1801 gaagctgtgc tcagagcagg gcaatcaccc caaatttcag aagcccaagc agctaaagga
     1861 caaaacagag ttctccatca tccactatgc tgggaaggtg gactataatg caagtgcgtg
     1921 gctgaccaag aacatggacc cgctaaatga taatgtgacc tcactcctca atgcctcctc
     1981 ggacaagttt gtggccgacc tgtggaagga tgtggaccgc attgtggggt tggaccagat
     2041 ggccaagatg actgagagct cactgcccag tgcctccaag accaaaaagg gcatgttccg
     2101 caccgtgggc cagctctaca aagagcagct ggggaagctg atgaccacac tgcgcaacac
     2161 cacgcctaac tttgtgcgct gcatcatccc caaccatgaa aagaggtctg gcaagctgga
     2221 tgcatttcta gttctggagc agctgcggtg caatggtgtg ttggaaggca tccgcatctg
     2281 ccgtcagggc ttccccaaca ggattgtctt ccaagagttc cggcaacgct acgagatcct
     2341 ggcagcgaac gccatcccca aaggcttcat ggacggaaag caagcctgca ttctcatgat
     2401 caaagccctt gaacttgacc ccaatctgta caggattggg cagagcaaaa tcttctttcg
     2461 tacgggagtc ctggcccacc tagaggaaga acgagacctg aagattactg atgtcatcat
     2521 ggctttccag gcaatgtgtc gtggctacct ggccagaaaa gccttcacca agaggcagca
     2581 acagttaaca gccatgaagg tgatccagag gaactgcgct gcctacctta agctccgcaa
     2641 ctggcaatgg tggaggctct tcactaaagt aaagccgctg ctccaggtga cgcggcagga
     2701 ggaggagatg caggccaagg aggaggagat gcagaagatc aaggagcggc agcagaaggc
     2761 agagtctgag ctgaaggagc tggagcaaag acacactcag ctggctgagg agaagaccct
     2821 gctgcaggag cagttgcagg cagagacaga gctgtatgct gaggctgaag agatgcgggt
     2881 ccgcttggca gcgaagaagc aggagctaga ggagatcctc catgagatgg aggcccgctt
     2941 ggaggaggag gaggaccgga gccaacaact gcaggctgag aggaagaaga tggctcagca
     3001 gatgctggac ctggaggagc aactggagga ggaagaagct gccagacaga aactacagct
     3061 agagaaggtc acagctgagg ccaagatcaa gaaactggag gatgacatct tggttatgga
     3121 tgaccagaac aataagcttt ccaaagaaag aaaactcctt gaagagaggg tcagcgactt
     3181 gacaaccaac ctagcagaag aggaagaaaa ggctaaaaac ctcacaaaac taaagagcaa
     3241 gcatgagtcc atgatctcag agctagaggt gaggctgaag aaagaggaga agagccggca
     3301 ggagctggag aaactcaaga ggaaactgga gggtgatgcc agtgacttcc acgagcagat
     3361 cgctgacctg caggcccaga ttgcagagct caagatgcag ctggcaaaga aagaggaaga
     3421 gctacaggca gctctagcca ggctcgatga agagatcacc cagaaaaaca atgccctaaa
     3481 gaagattcga gagctggagg gccatgtctc agacctacag gaggacctgg actcagagcg
     3541 agctgctagg aacaaggctg agaaacagaa gcgagacctg ggggaggaac tggaggcgct
     3601 caagacagag ctggaagata cactggacag cacagctacc cagcaggagc tcagagccaa
     3661 gagggaacag gaagtgacaa tgctgaagaa ggccctggat gaagagacgc gatcccatga
     3721 ggcccaggtc caggagatga ggcagaagca cacacaggca gtggaggaac tcacagagca
     3781 gctggaacag ttcaaaaggg ccaaggcaaa cctggataaa agcaagcaga cgctggagaa
     3841 ggagaacgca gacctggctg gggagctgcg tgtcctgggc caggcaaagc aggaggtaga
     3901 gcacaagaag aagaagctgg aggggcagct gcaggagctg cagtccaagt gcagtgatgg
     3961 ggagcgtgcc cggactgagc tcagtgacaa ggtccacaaa ctacagaatg aagtggagag
     4021 tgtcacaggc atgctcaatg aggcagaagg caaggccatt aaactggcca aggaagtggc
     4081 ttcccttgga tctcaacttc aggacaccca agagctgctt caagaagaaa cccggcagaa
     4141 gctcaatgtg tccaccaagc tgcgccagtt ggaagatgag aggaacagcc tgcaggacca
     4201 gctggatgag gagatggaag ctaagcaaaa ccttgagcgc catgtctcca ccttgaacat
     4261 tcagctctca gactctaaga agaagctgca ggaccttgca agcactattg aggtcatgga
     4321 ggaggggaag aagaggttgc agaaagagat ggagggtctc ggccagcagt atgaggagaa
     4381 ggccgctgcc tatgacaaac tggagaaaac taagaacagg cttcagcagg agctagatga
     4441 cttggtcgtg gacttggaca accagcggca actggtatcc aatctggaaa agaagcagaa
     4501 gaaattcgat cagttgttag ctgaggaaaa gaacatctcc tccaagtatg cggatgagag
     4561 agaccgagct gaagcagagg ccagggaaaa ggaaacgaag gctttgtctc tggcccgggc
     4621 cctggaggaa gccctggaag ccaaagagga actggaaagg accaacaaga tgctcaaggc
     4681 cgagatggaa gacctggtca gctccaagga tgacgtgggc aagaatgtgc acgagctgga
     4741 gaagtccaaa cgagccctgg agacccagat ggaagagatg agaactcagc tagaggagct
     4801 ggaggacgag ctgcaggcca ctgaagacgc caagctgcgg ctggaggtca acatgcaggc
     4861 cctcaagggc cagtttgaac gagatctcca ggctcgggat gagcagaatg aggagaagag
     4921 gaggcagcta cagcggcagc tgcatgagta tgagacagaa ctggaagatg aacggaagca
     4981 aagggctctg gcggcagcag ccaagaagaa gctggaaggg gatctgaaag acctggaact
     5041 ccaggctgac tcagccgtca aagggaggga ggaagccatc aagcagcttc gaaaactgca
     5101 ggctcagatg aaggacttcc aaagagagct ggatgatgcc cgtgcctcca gagatgagat
     5161 ctttgccacc tcaaaagaga atgagaagaa agccaagagt ctggaggcag agctcatgca
     5221 gctccaggag gacctggcag cagctgagag agctcgcaag caagctgacc tggagaagga
     5281 ggagctggct gaggagctgg ctagcagctt atcaggaagg aatacactgc aggatgagaa
     5341 gcgccgcctg gaggcaagga tcgcccagct ggaggaggag ctggaggaag agcagggcaa
     5401 catggaggcc atgagtgaca gagtccgcaa ggccacattg caggctgagc aactgagcaa
     5461 tgagctggtc actgagcgca gtgcagctca gaagaatgag agtgcacggc aacagctgga
     5521 gcgccagaac aaggaactcc gaagcaagtt gcaggaggta gaaggtgctg tcaaagccaa
     5581 gcttaagtcc actgttgcgg cactagaggc caagattgtg cagctggagg agcagattga
     5641 acaagaggcc agagaaaaac aggcagccac caagttgctg aagcaaaagg acaagaagct
     5701 aaaggaggtc ctactgcagg tggaggatga gcgcaagatg gtggagcagt acaaggagca
     5761 ggcagagaaa ggaaacacca aggtcaagca gctcaagagg cagctggaag aggccgagga
     5821 ggaatcccag cgcatcaatg ccaaccgcag gaagctgcag cgggagctgg atgaggccac
     5881 tgagagcaat gaggccatgg gccgtgaggt gaatgccctc aagagcaaac tcaggagagg
     5941 aaacgaggct tcatttgttc cttccagaag ggctggaggc cgtagagtta ttgaaaacac
     6001 agatggttct gaagaagaaa tggatgctcg ggactcagac ttcaatggaa ccaaagccag
     6061 tgaataaatt cagttggaca ctatgtcagg gaaaacaaaa taccaaatga cagcaaagcc
     6121 cagcaggctg attagcattt gtctccattc gttctcaagt catagacatt accccacctc
     6181 tcaccaggag tcaaccacag ccctgcacaa aggatgtgaa tttaagtttt taaatgtgct
     6241 accagagaaa atccagatag atgcaggtcg ggagctgcag tcgccagtgc ctttgtttac
     6301 atgaaatgga acgttacgtg aatgggtgcc ccagcccgca acccgctccc aaccatcaac
     6361 tgcctgacct tccagtttgg gaggaaaacc tgtttgaaaa ttcccctccc tttcctgcct
     6421 gcacacctca gacacacagt tcactaagac caagtgactt tttcagtcat ctgaattaag
     6481 gaagagcaga gcgagcgcac cgccttattt gcacccacgg acactttcac gaataaaagg
     6541 ttttaagtca cgaga
//
