LOCUS       NM_031520               7632 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus myosin heavy chain 10 (Myh10), mRNA.
ACCESSION   NM_031520
VERSION     NM_031520.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7632)
  AUTHORS   Bergeron,A., Brezai,A., Shukr,R., Villeneuve,L., Allen,B.G.,
            Qureshi,W.M.S., Hentges,K.E. and Calderone,A.
  TITLE     Filamentous nestin and nonmuscle myosin IIB are associated with a
            migratory phenotype in neonatal rat cardiomyocytes
  JOURNAL   J Cell Physiol 236 (2), 1281-1294 (2021)
   PUBMED   32654195
  REMARK    GeneRIF: Filamentous nestin and nonmuscle myosin IIB are associated
            with a migratory phenotype in neonatal rat cardiomyocytes.
REFERENCE   2  (bases 1 to 7632)
  AUTHORS   Young,E.J., Blouin,A.M., Briggs,S.B., Daws,S.E., Lin,L.,
            Cameron,M.D., Rumbaugh,G. and Miller,C.A.
  TITLE     Nonmuscle myosin IIB as a therapeutic target for the prevention of
            relapse to methamphetamine use
  JOURNAL   Mol Psychiatry 21 (5), 615-623 (2016)
   PUBMED   26239291
  REMARK    GeneRIF: Study suggests that NMIIB remains constitutively active in
            support of methamphetamine associations, continuing to drive actin
            polymerization, such that memories associated with methamphetamine
            can be selectively targeted without the need for retrieval days to
            weeks after learning
REFERENCE   3  (bases 1 to 7632)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   4  (bases 1 to 7632)
  AUTHORS   Yagi,H., Nagano,T., Xie,M.J., Ikeda,H., Kuroda,K., Komada,M.,
            Iguchi,T., Tariqur,R.M., Morikubo,S., Noguchi,K., Murase,K.,
            Okabe,M. and Sato,M.
  TITLE     Filamin A-interacting protein (FILIP) is a region-specific
            modulator of myosin 2b and controls spine morphology and NMDA
            receptor accumulation
  JOURNAL   Sci Rep 4, 6353 (2014)
   PUBMED   25220605
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7632)
  AUTHORS   Shutova,M.S., Spessott,W.A., Giraudo,C.G. and Svitkina,T.
  TITLE     Endogenous species of mammalian nonmuscle myosin IIA and IIB
            include activated monomers and heteropolymers
  JOURNAL   Curr Biol 24 (17), 1958-1968 (2014)
   PUBMED   25131674
REFERENCE   6  (bases 1 to 7632)
  AUTHORS   Simerly,C., Nowak,G., de Lanerolle,P. and Schatten,G.
  TITLE     Differential expression and functions of cortical myosin IIA and
            IIB isotypes during meiotic maturation, fertilization, and mitosis
            in mouse oocytes and embryos
  JOURNAL   Mol Biol Cell 9 (9), 2509-2525 (1998)
   PUBMED   9725909
REFERENCE   7  (bases 1 to 7632)
  AUTHORS   Tullio,A.N., Accili,D., Ferrans,V.J., Yu,Z.X., Takeda,K.,
            Grinberg,A., Westphal,H., Preston,Y.A. and Adelstein,R.S.
  TITLE     Nonmuscle myosin II-B is required for normal development of the
            mouse heart
  JOURNAL   Proc Natl Acad Sci U S A 94 (23), 12407-12412 (1997)
   PUBMED   9356462
REFERENCE   8  (bases 1 to 7632)
  AUTHORS   Itoh,K. and Adelstein,R.S.
  TITLE     Neuronal cell expression of inserted isoforms of vertebrate
            nonmuscle myosin heavy chain II-B
  JOURNAL   J Biol Chem 270 (24), 14533-14540 (1995)
   PUBMED   7782316
REFERENCE   9  (bases 1 to 7632)
  AUTHORS   Maupin,P., Phillips,C.L., Adelstein,R.S. and Pollard,T.D.
  TITLE     Differential localization of myosin-II isozymes in human cultured
            cells and blood cells
  JOURNAL   J Cell Sci 107 (Pt 11), 3077-3090 (1994)
   PUBMED   7699007
REFERENCE   10 (bases 1 to 7632)
  AUTHORS   Murakami,N., Trenkner,E. and Elzinga,M.
  TITLE     Changes in expression of nonmuscle myosin heavy chain isoforms
            during muscle and nonmuscle tissue development
  JOURNAL   Dev Biol 157 (1), 19-27 (1993)
   PUBMED   8482409
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031520.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF139055.1, SRR26643287.24581.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               JAXUCZ010000010.1  53893264-53893420
            158-533             JAXUCZ010000010.1  53900799-53901174
            534-690             JAXUCZ010000010.1  53922066-53922222
            691-718             JAXUCZ010000010.1  53935928-53935955
            719-821             JAXUCZ010000010.1  53949357-53949459
            822-914             JAXUCZ010000010.1  53955763-53955855
            915-978             JAXUCZ010000010.1  53966838-53966901
            979-1077            JAXUCZ010000010.1  53967670-53967768
            1078-1221           JAXUCZ010000010.1  53969685-53969828
            1222-1317           JAXUCZ010000010.1  53970008-53970103
            1318-1436           JAXUCZ010000010.1  53971385-53971503
            1437-1589           JAXUCZ010000010.1  53972163-53972315
            1590-1763           JAXUCZ010000010.1  53976758-53976931
            1764-1937           JAXUCZ010000010.1  53979030-53979203
            1938-2052           JAXUCZ010000010.1  53979969-53980083
            2053-2246           JAXUCZ010000010.1  53991351-53991544
            2247-2368           JAXUCZ010000010.1  53991630-53991751
            2369-2438           JAXUCZ010000010.1  53993228-53993297
            2439-2599           JAXUCZ010000010.1  53993509-53993669
            2600-2708           JAXUCZ010000010.1  53993974-53994082
            2709-2840           JAXUCZ010000010.1  53994172-53994303
            2841-3047           JAXUCZ010000010.1  53996510-53996716
            3048-3185           JAXUCZ010000010.1  53999061-53999198
            3186-3309           JAXUCZ010000010.1  53999600-53999723
            3310-3481           JAXUCZ010000010.1  54000892-54001063
            3482-3694           JAXUCZ010000010.1  54002006-54002218
            3695-3839           JAXUCZ010000010.1  54005845-54005989
            3840-4046           JAXUCZ010000010.1  54006804-54007010
            4047-4151           JAXUCZ010000010.1  54009328-54009432
            4152-4304           JAXUCZ010000010.1  54010050-54010202
            4305-4553           JAXUCZ010000010.1  54010572-54010820
            4554-4766           JAXUCZ010000010.1  54011284-54011496
            4767-4979           JAXUCZ010000010.1  54012832-54013044
            4980-5141           JAXUCZ010000010.1  54013820-54013981
            5142-5270           JAXUCZ010000010.1  54016517-54016645
            5271-5359           JAXUCZ010000010.1  54017910-54017998
            5360-5483           JAXUCZ010000010.1  54018665-54018788
            5484-5692           JAXUCZ010000010.1  54018865-54019073
            5693-5801           JAXUCZ010000010.1  54020053-54020161
            5802-5974           JAXUCZ010000010.1  54021608-54021780
            5975-7632           JAXUCZ010000010.1  54022375-54024032
FEATURES             Location/Qualifiers
     source          1..7632
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..7632
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /note="myosin heavy chain 10"
                     /db_xref="GeneID:79433"
                     /db_xref="RGD:71000"
     exon            1..157
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            158..533
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..6119
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /note="nonmuscle myosin heavy chain-B; cellular myosin
                     heavy chain, type B; myosin heavy chain, nonmuscle type B;
                     nonmuscle myosin heavy chain IIB; NMMHC-IIB; NMMHC II-b;
                     non-muscle myosin heavy chain B; non-muscle myosin heavy
                     chain IIb; myosin heavy chain, non-muscle IIb; MCH-B(B2);
                     myosin, heavy polypeptide 10, non-muscle; myosin, heavy
                     chain 10, non-muscle"
                     /codon_start=1
                     /product="myosin-10"
                     /protein_id="NP_113708.2"
                     /db_xref="GeneID:79433"
                     /db_xref="RGD:71000"
                     /translation="MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHG
                     FEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDMAELTCLNEASVL
                     HNLKDRYYSGLIYTYSGLFCVVINPYKNLPIYSENIIEMYRGKKRHEMPPHIYAISES
                     AYRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRKDHNIPGELERQL
                     LQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAVRQAK
                     DERTFHIFYQLLSGAGEHLKSDLLLEGFNNYRFLSNGYIPIPGQQDKDNFQETMEAMH
                     IMGFSHEEILSMLKVVSSVLQFGNISFKKERNTDQASMPENTVAQKLCHLLGMNVMEF
                     TRAILTPRIKVGRDYVQKAQTKEQADFAVEALAKATYERLFRWLVHRINKALDRTKRQ
                     GASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNF
                     IDFGLDLQPCIDLIERPANPPGVLALLDEECWFPKATDKTFVEKLVQEQGSHSKFQKP
                     RQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKDVDR
                     IVGLDQVTGMTETAFGSAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPN
                     HEKRAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIPKGF
                     MDGKQACERMIRALELDPNLYRIGQSKIFFRAGVLAHLEEERDLKITDIIIFFQAVCR
                     GYLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQA
                     KDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLA
                     AKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLE
                     KVTAEAKIKKMEEEVLLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRN
                     KQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQVDELKVQLTKK
                     EEELQGALARGDDETLHKNNALKVARELQAQIAELQEDFESEKASRNKAEKQKRDLSE
                     ELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEDETKNHEAQIQDMRQRHATA
                     LEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQ
                     ELHAKVSEGDRLRVELAEKANKLQNELDNVSTLLEEAEKKGMKFAKDAAGLESQLQDT
                     QELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKK
                     KVDDDLGTIEGLEEAKKKLLKDVEALSQRLEEKVLAYDKLEKTKNRLQQELDDLTVDL
                     DHQRQIVSNLEKKQKKFDQLLAEEKGISARYAEERDRAEAEAREKETKALSLARALEE
                     ALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELE
                     DELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLLKQVRELEAELEDERK
                     QRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASR
                     DEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEIANSASGKSA
                     LLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNTELAAERSAAQKSD
                     NARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANK
                     LVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASR
                     RKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHIEGASLELSDD
                     DTESKTSDVNETQPPQSE"
     exon            534..690
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            691..718
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            719..821
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            822..914
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            915..978
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1077
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1221
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1317
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1436
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1589
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1763
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1937
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2052
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2246
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2368
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2438
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2599
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2708
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            2709..2840
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..3047
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            3048..3185
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            3186..3309
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..3481
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            3482..3694
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            3695..3839
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            3840..4046
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            4047..4151
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            4152..4304
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            4305..4553
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            4554..4766
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            4767..4979
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            4980..5141
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            5142..5270
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            5271..5359
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            5360..5483
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            5484..5692
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            5693..5801
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            5802..5974
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
     exon            5975..7632
                     /gene="Myh10"
                     /gene_synonym="MCH-B; NMMHC-B; SMemb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgtggagct ggcccaatga gggtgggagt gggtggggca ggcgcgagcg gcagtgctaa
       61 aggagcccgg cggaggcagc ggtgggtttg gaactgagac gctggatctt tggtcgctgc
      121 tggggacgtg tgccggcgcc accatcttcg gctgaagagg caataacttt tgggtccttc
      181 tgtttacaat ggcccagaga actggactgg aggatcccga gaggtatctc tttgtggaca
      241 gggctgtcat ctacaaccct gccactcaag ctgactggac agctaaaaag ctggtgtgga
      301 ttccatctga acgccatggt tttgaggcag ctagtattaa agaagaacgg ggcgatgagg
      361 ttatggtgga gctggcagag aacgggaaga aagcgatggt caacaaagat gacattcaga
      421 agatgaaccc gccgaagttc tccaaggtgg aggacatggc agagctcacg tgcttgaacg
      481 aagcctctgt tttacacaat ctgaaggatc gctactattc aggactcatc tatacttact
      541 ctggactctt ctgtgtggtg ataaatccct acaagaacct tccgatttac tctgagaata
      601 ttattgagat gtacagaggg aagaagcgcc atgagatgcc gccacacatc tacgccatat
      661 cagagtctgc ctacagatgc atgcttcaag atcgtgagga ccagtcgatt ctttgcacgg
      721 gtgaatcagg tgccgggaag acagaaaata caaagaaagt cattcagtac cttgcccacg
      781 ttgcttcttc acacaaagga agaaaggacc acaatattcc tggggaactt gaacggcagc
      841 ttttacaagc aaatccaatt ctggaatcat ttggaaatgc gaagactgtg aaaaatgata
      901 actcatctcg ctttggcaag tttatccgga tcaactttga tgtaaccggc tatattgttg
      961 gggccaacat tgaaacatac cttctggaaa agtcccgtgc tgttcgtcaa gctaaagatg
     1021 aacgcacgtt tcatatcttt tatcagttgc tctctggagc aggggaacac ctgaagtccg
     1081 acttactcct ggaaggcttt aataactaca gattcctctc caacggctac atccctattc
     1141 ctggacagca agacaaggat aactttcagg agaccatgga agccatgcac ataatgggct
     1201 tctctcacga agagatcctc tcaatgctta aagtcgtgtc ttcagtgctg cagtttggaa
     1261 acatctcttt caaaaaggag aggaacactg accaagcttc catgcccgag aacacagttg
     1321 cacagaaact ctgccacctg cttgggatga atgtgatgga gttcactcgg gctatcctca
     1381 cgcccaggat caaagttggc cgagattatg tacagaaagc ccagaccaaa gagcaggcag
     1441 attttgcagt ggaagcattg gcaaaggcta cctatgagcg gttgtttcgc tggctcgttc
     1501 accgcatcaa taaggcgctg gataggacca aacgccaggg agcgtctttc attgggatcc
     1561 tggatattgc tggttttgaa atttttgagc tgaactcctt tgaacaacta tgcatcaact
     1621 acaccaatga gaagctgcag cagctgttca accacaccat gttcatcctg gagcaggagg
     1681 agtaccagcg agagggcatc gagtggaact tcatcgactt tggtctcgac ttgcagccct
     1741 gcatcgacct gatagagaga cctgccaatc cccctggtgt gctggccctc ctggatgaag
     1801 aatgctggtt ccccaaagcc acagacaaaa cgtttgttga gaagctggtt caggagcaag
     1861 gttcccactc caagtttcag aaaccacggc aactgaaaga caaagccgac ttctgcatca
     1921 tccactatgc agggaaggtg gactataagg cggatgagtg gctgatgaag aacatggacc
     1981 ccctgaatga caacgtggcc accctcctgc accagtcatc agacagattt gtcgccgagc
     2041 tttggaagga tgtggaccga attgtaggtc tggatcaagt cactggcatg actgagacag
     2101 cttttggctc tgcatataaa accaagaagg gcatgttccg caccgtcggg cagctctaca
     2161 aagagtctct caccaagctc atggcaaccc tccgaaacac caaccccaac ttcgtacgct
     2221 gcatcattcc aaatcacgag aagcgggctg gaaaactgga tccacatctc gtgctggatc
     2281 agctccgctg taacggtgtc ctggaaggaa tcaggatctg tcgccaggga ttccccaacc
     2341 ggatagtttt ccaggagttc agacagagat atgagatcct aactcccaac gctattccca
     2401 aaggcttcat ggatggcaaa caggcctgtg agcgaatgat ccgagcttta gaactggacc
     2461 caaacctgta tagaattgga cagagcaaga tatttttccg agctggagtt ctggcgcact
     2521 tagaggaaga aagagattta aaaatcactg atataatcat ctttttccaa gctgtatgca
     2581 gaggctacct agccagaaag gcctttgcca agaaacagca gcagctaagt gccttaaagg
     2641 tcttgcagcg gaactgtgcg gcgtacctga agctgcgaca ctggcagtgg tggcgcgtct
     2701 tcacaaaggt gaagcctctc ctccaagtga cccgccagga ggaggagctc caggctaaag
     2761 atgaggagct gctgaaggtg aaagagaagc agacaaaagt ggaaggggaa cttgaggaga
     2821 tggaacggaa gcaccagcag ctgctggaag agaagaatat cctggcagaa cagctgcagg
     2881 ccgagactga gctctttgct gaagcagagg agatgagagc aagactcgct gccaagaagc
     2941 aggaactgga ggagatcctc catgacctgg agtccagggt ggaggaggag gaagagcgaa
     3001 accagatcct gcagaacgag aagaagaaga tgcaagcgca cattcaggat ctagaagagc
     3061 aactggatga ggaggagggg gcgcggcaaa agctgcagct ggagaaggtg accgcggagg
     3121 ctaaaatcaa gaagatggaa gaggaggttc tgcttctcga ggaccagaat tccaaattta
     3181 tcaaagaaaa gaaactcatg gaagatcgaa ttgctgagtg ttcctctcag ctggctgaag
     3241 aggaagaaaa ggcaaaaaac ttagccaaaa tcaggaataa gcaagaagtg atgatctcgg
     3301 atttagaaga acgcttgaag aaggaggaga aaacacggca ggaactggaa aaggccaaac
     3361 ggaaactgga cggtgaaaca actgatctgc aggaccagat cgccgagttg caagcacagg
     3421 tcgatgagct caaagtccag ttgaccaaga aggaggagga gcttcagggg gcgctggcca
     3481 gaggagatga tgagacgctg cacaagaata atgcgcttaa agttgcgcgg gagctgcagg
     3541 cccaaatcgc cgagctccag gaagactttg agtctgaaaa ggcttcaagg aacaaggctg
     3601 agaaacaaaa acgggacctg agtgaggagc tggaagctct aaagacagaa ctggaggaca
     3661 ccctagacac cacagcagct cagcaggaac tccgcacaaa gcgggagcag gaagtagctg
     3721 agctgaagaa ggctcttgag gatgaaacta agaaccacga agctcagatc caggacatga
     3781 gacagaggca cgccacggca ctggaggaac tctctgagca actggaacag gctaagaggt
     3841 tcaaagccaa tctggagaag aacaaacagg gcctggagac ggacaacaag gagctggcgt
     3901 gtgaggtgaa ggtgctgcag caagtcaagg ctgagtcaga gcacaagagg aagaagctcg
     3961 atgcccaggt ccaggagctc cacgccaagg tgtcagaagg tgacaggctc agggtagaac
     4021 tggccgagaa agcaaacaag ctacagaatg agctggataa tgtctcaacc ctgctggaag
     4081 aagccgagaa gaaaggaatg aagttcgcta aggacgccgc aggtctcgag tctcagctac
     4141 aggacacaca ggagctcctt caggaggaga cgcggcagaa actgaacctg agcagtcgga
     4201 tccggcagct ggaggaggag aagaacagcc ttcaggagca gcaggaggag gaagaggagg
     4261 ccaggaagaa cttggaaaag caggtgttgg ccctgcagtc ccagctggct gacaccaaga
     4321 agaaagtgga cgatgacctg gggacaattg agggtttgga agaagccaag aagaaactgc
     4381 ttaaggacgt ggaggcactg agtcagcgac tggaggaaaa ggtcctagca tatgacaagc
     4441 tggagaagac caagaaccgg ctgcaacagg agctggatga cctgacggtg gacctggacc
     4501 accagcgcca gatcgtctcc aacttggaga agaaacagaa gaagtttgac cagctgttgg
     4561 cagaagagaa gggcatctct gctcgctatg cagaagaacg ggaccgggct gaagctgagg
     4621 ccagagagaa agaaaccaag gcgctctccc tggcgcgggc cctggaggag gccttggagg
     4681 ccaaggagga attcgagagg cagaataagc agcttcgggc agacatggaa gacctcatga
     4741 gctcgaaaga tgatgtgggg aagaacgtcc acgagctgga gaagtccaag cgggccctgg
     4801 agcagcaggt ggaggagatg aggacccagc tggaggagct ggaggacgag ttgcaggcca
     4861 ctgaggacgc caaactccgc ctggaagtca acatgcaggc catgaaggcc cagtttgaga
     4921 gggacctgca aaccagagat gagcagaatg aagagaagaa gcggctgctg ctcaagcagg
     4981 tacgggagct cgaggcagag ctggaggatg agcggaagca gcgggcactt gctgtggctt
     5041 caaagaagaa gatggagata gacctgaagg acctggaggc tcagatcgag gccgccaaca
     5101 aggcccggga tgaagtgatc aagcagcttc gcaagcttca ggcacagatg aaggattacc
     5161 agcgtgaact agaagaagct cgagcatcta gagatgagat ttttgctcaa tccaaagaaa
     5221 gtgaaaagaa actgaagagt ctagaagcag aaatcctcca gttgcaagag gagctggcct
     5281 catctgagcg agcccgcaga cacgcagagc aggagcgaga tgagctggct gacgagattg
     5341 ccaacagcgc ctctgggaag tccgctctgc tggatgagaa gcggcgcctg gaagcccgga
     5401 tcgcgcagct ggaggaggag ctagaagagg agcagagtaa catggagctg ctcaatgacc
     5461 gcttccgcaa gaccacgctc caggtggaca ccctgaacac agagttggca gcggagcgca
     5521 gcgctgccca gaagagcgac aatgcccgcc agcagctgga gcgacaaaac aaggagctga
     5581 aggccaagct gcaggagctg gagggggcgg tcaagtccaa gttcaaagcc accatctcag
     5641 ccctggaagc caagattggg cagctggagg aacagctgga gcaggaagcc aaggaacgcg
     5701 cagctgccaa caaactagtc cgtcggacag agaagaaact gaaagagatc ttcatgcagg
     5761 tcgaagacga gcgccggcat gcggatcagt ataaggagca gatggagaaa gccaatgcca
     5821 ggatgaagca gcttaaacgc cagctggaag aagctgagga ggaggctaca cgtgccaatg
     5881 catctcggcg taaactccaa agggaactgg atgatgccac cgaggccaat gagggcctga
     5941 gccgtgaggt cagcactctc aagaaccggc ttaggcgggg cggcccaatc agcttttctt
     6001 caagccgatc tggccggcgc cagctacaca ttgagggggc atcgctagag ctgtcagatg
     6061 acgacacaga aagcaagacc agtgatgtca atgagacaca gccaccccag tcggaataga
     6121 cacaggcagt cagaggtgat gctgaggaca ggccggaacc caacccagca ctggtctgct
     6181 tgagccctgc actcgggagc ggcaagcccc aggttcctta aggaaatcaa ctgtgtctta
     6241 aggctttgcg gcctgcgcag actgaatcct gcttcagact aggtacaatt gcccctttta
     6301 tatatacacc tccacaagac atgcgtatta aacagattgt ctcatcgttg catctatttt
     6361 ccatatattc atcaagagac cattttatga tgcattaaga agaaagaacc tttttgaaac
     6421 aaactccaga ccctttgttg ccagtggctg ggcctggggt tgccccgggg acgttgctca
     6481 gttgctctgc atgctctgtc ctgccgacag gtaccttagt tctgtgttca tgtggccctg
     6541 acccttccac cacacccggt cttagagcat tgtgaaccca acctgcactt gtctctcatt
     6601 tcctctgaat agtgatcgct gtctcggtga gcaaactgtg agaagggctt tggcggctta
     6661 ggaggggtgg gtttgggttg ggaagcagca tccatttggg gtgaccctgc ccctcaaatt
     6721 tatggtgtcc ccactgtctc atgtgaatag ccccagagtt ctatgcacag agaggacagt
     6781 ggcctcaaca tataaggtgc cccaggtggc agccatcaca gtgacttcca ggtggtctct
     6841 gagtgtctgg cttgatgatg ccctccctcc tcaattcagg agtgagcctc tgtgaccctt
     6901 ggggtgctca cagaaggcct ctccaaccag tcaggccctc ttgcaaattc agccactgct
     6961 ttgagcccaa aatgggaata ttagttttgt gtcggaggtg tgttccaagt ttgtcaatga
     7021 ggccacagag cctcgagaac agatgccatc tgcctgaatg ttgacgccag tgggcgtgtg
     7081 ccctccattt cccttccctc ctttggacag tgttacaatg aacacttagc attctggttt
     7141 tggttggtag ttgagcagac tgacgttaca gaaagtgcct tagacactgc agcactaaga
     7201 caatgttaaa tgtattattt gcctctaaca actcagtgta ttaggttttg tctgtgcttt
     7261 atatcatgta cctctgtagt gaagtagaaa cattcagtga cagcagcaaa tcagtgttaa
     7321 tgacaagccc cgacccgtgg caatgtgctc gaaaacacag accttttggg ttaaaagctt
     7381 taacatctgt gaggaagaat tggtcacatg ggtttggaat ctttgatttc ccctgtatga
     7441 attgtactgg ctgttgacca ccagacacct gactgcaaat atcttttctt gtactcccat
     7501 atttctagac aatgattttt gtaagacaat aaatttattc attatagata tttgcgcctg
     7561 ctctgtttac ttggaggaaa aagcacccgt tgagaacaaa cagacctcaa taaacaagaa
     7621 taatcatgtg aa
//
