LOCUS       NM_001135158            6031 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus myosin heavy chain 1 (Myh1), mRNA.
ACCESSION   NM_001135158 XM_001077982 XM_001078018
VERSION     NM_001135158.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6031)
  AUTHORS   Sharlo,K.A., Paramonova,I.I., Lvova,I.D., Mochalova,E.P.,
            Kalashnikov,V.E., Vilchinskaya,N.A., Tyganov,S.A.,
            Konstantinova,T.S., Shevchenko,T.F., Kalamkarov,G.R. and
            Shenkman,B.S.
  TITLE     Plantar Mechanical Stimulation Maintains Slow Myosin Expression in
            Disused Rat Soleus Muscle via NO-Dependent Signaling
  JOURNAL   Int J Mol Sci 22 (3), 1372 (2021)
   PUBMED   33573052
  REMARK    GeneRIF: Plantar Mechanical Stimulation Maintains Slow Myosin
            Expression in Disused Rat Soleus Muscle via NO-Dependent Signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6031)
  AUTHORS   Damatto,R.L., Martinez,P.F., Lima,A.R., Cezar,M.D., Campos,D.H.,
            Oliveira Junior,S.A., Guizoni,D.M., Bonomo,C., Nakatani,B.T., Dal
            Pai Silva,M., Carvalho,R.F., Okoshi,K. and Okoshi,M.P.
  TITLE     Heart failure-induced skeletal myopathy in spontaneously
            hypertensive rats
  JOURNAL   Int J Cardiol 167 (3), 698-703 (2013)
   PUBMED   22464481
  REMARK    GeneRIF: The relative amount of type I MyHC isoform is increased in
            spontaneously hypertensive rats (SHR) compared to the Wistar-Kyoto
            strain.
REFERENCE   3  (bases 1 to 6031)
  AUTHORS   Cosper,P.F., Harvey,P.A. and Leinwand,L.A.
  TITLE     Interferon-gamma causes cardiac myocyte atrophy via selective
            degradation of myosin heavy chain in a model of chronic myocarditis
  JOURNAL   Am J Pathol 181 (6), 2038-2046 (2012)
   PUBMED   23058369
  REMARK    GeneRIF: IFN-gamma increased both proteasome and immunoproteasome
            activity in cardiac myocytes and their inhibition blocked myosin
            heavy chain loss and myocyte atrophy.
REFERENCE   4  (bases 1 to 6031)
  AUTHORS   Pandorf,C.E., Haddad,F., Wright,C., Bodell,P.W. and Baldwin,K.M.
  TITLE     Differential epigenetic modifications of histones at the myosin
            heavy chain genes in fast and slow skeletal muscle fibers and in
            response to muscle unloading
  JOURNAL   Am J Physiol Cell Physiol 297 (1), C6-C16 (2009)
   PUBMED   19369448
  REMARK    GeneRIF: Differential epigenetic modifications of histones at the
            myosin heavy chain genes in fast and slow skeletal muscle fibers
            and in response to muscle unloading.
REFERENCE   5  (bases 1 to 6031)
  AUTHORS   Racz,G., Szabo,A., Ver,A. and Zador,E.
  TITLE     The slow sarco/endoplasmic reticulum Ca2+ -ATPase declines
            independently of slow myosin in soleus muscle of diabetic rats
  JOURNAL   Acta Biochim Pol 56 (3), 487-493 (2009)
   PUBMED   19738937
  REMARK    GeneRIF: MyHC1 levels were not different on immunoblots of the
            soleus of streptozocin-treated and control rats.
REFERENCE   6  (bases 1 to 6031)
  AUTHORS   Villace,P., Marion,R.M. and Ortin,J.
  TITLE     The composition of Staufen-containing RNA granules from human cells
            indicates their role in the regulated transport and translation of
            messenger RNAs
  JOURNAL   Nucleic Acids Res 32 (8), 2411-2420 (2004)
   PUBMED   15121898
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6031)
  AUTHORS   Zhang,J.Q., Elzey,B., Williams,G., Lu,S., Law,D.J. and Horowits,R.
  TITLE     Ultrastructural and biochemical localization of N-RAP at the
            interface between myofibrils and intercalated disks in the mouse
            heart
  JOURNAL   Biochemistry 40 (49), 14898-14906 (2001)
   PUBMED   11732910
REFERENCE   8  (bases 1 to 6031)
  AUTHORS   Shoemaker,S.D., Ryan,A.F. and Lieber,R.L.
  TITLE     Transcript-specific mRNA trafficking based on the distribution of
            coexpressed myosin isoforms
  JOURNAL   Cells Tissues Organs 165 (1), 10-15 (1999)
   PUBMED   10460968
REFERENCE   9  (bases 1 to 6031)
  AUTHORS   DeNardi,C., Ausoni,S., Moretti,P., Gorza,L., Velleca,M.,
            Buckingham,M. and Schiaffino,S.
  TITLE     Type 2X-myosin heavy chain is coded by a muscle fiber type-specific
            and developmentally regulated gene
  JOURNAL   J Cell Biol 123 (4), 823-835 (1993)
   PUBMED   8227143
REFERENCE   10 (bases 1 to 6031)
  AUTHORS   Ogata,I., Saez,C.G., Greenwel,P., Ponce Mde,L., Geerts,A.,
            Leinwand,L.A. and Rojkind,M.
  TITLE     Rat liver fat-storing cell lines express sarcomeric myosin heavy
            chain mRNA and protein
  JOURNAL   Cell Motil Cytoskeleton 26 (2), 125-132 (1993)
   PUBMED   8287498
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Sep 25, 2008 this sequence version replaced
            XM_001078018.1, XM_001077982.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.26433.1,
                                           SRR26643295.38504.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                JAXUCZ010000010.1  52384912-52384933
            23-55               JAXUCZ010000010.1  52385183-52385215
            56-299              JAXUCZ010000010.1  52386589-52386832
            300-443             JAXUCZ010000010.1  52386943-52387086
            444-600             JAXUCZ010000010.1  52387202-52387358
            601-628             JAXUCZ010000010.1  52388311-52388338
            629-743             JAXUCZ010000010.1  52389096-52389210
            744-836             JAXUCZ010000010.1  52389309-52389401
            837-900             JAXUCZ010000010.1  52389515-52389578
            901-999             JAXUCZ010000010.1  52390249-52390347
            1000-1079           JAXUCZ010000010.1  52390435-52390514
            1080-1103           JAXUCZ010000010.1  52390515-52390538
            1104-1242           JAXUCZ010000010.1  52390656-52390794
            1243-1361           JAXUCZ010000010.1  52391008-52391126
            1362-1511           JAXUCZ010000010.1  52391215-52391364
            1512-1682           JAXUCZ010000010.1  52392160-52392330
            1683-1995           JAXUCZ010000010.1  52393755-52394067
            1996-2072           JAXUCZ010000010.1  52394183-52394259
            2073-2160           JAXUCZ010000010.1  52395345-52395432
            2161-2278           JAXUCZ010000010.1  52395517-52395634
            2279-2402           JAXUCZ010000010.1  52395860-52395983
            2403-2539           JAXUCZ010000010.1  52396071-52396207
            2540-2795           JAXUCZ010000010.1  52396298-52396553
            2796-3038           JAXUCZ010000010.1  52398006-52398248
            3039-3215           JAXUCZ010000010.1  52398360-52398536
            3216-3361           JAXUCZ010000010.1  52399298-52399443
            3362-3452           JAXUCZ010000010.1  52399523-52399613
            3453-3842           JAXUCZ010000010.1  52399701-52400090
            3843-3969           JAXUCZ010000010.1  52400623-52400749
            3970-4088           JAXUCZ010000010.1  52401579-52401697
            4089-4285           JAXUCZ010000010.1  52401865-52402061
            4286-4469           JAXUCZ010000010.1  52403272-52403455
            4470-4635           JAXUCZ010000010.1  52403724-52403889
            4636-4760           JAXUCZ010000010.1  52403978-52404102
            4761-5069           JAXUCZ010000010.1  52404525-52404833
            5070-5273           JAXUCZ010000010.1  52404918-52405121
            5274-5399           JAXUCZ010000010.1  52405425-52405550
            5400-5570           JAXUCZ010000010.1  52405640-52405810
            5571-5675           JAXUCZ010000010.1  52406298-52406402
            5676-5771           JAXUCZ010000010.1  52406522-52406617
            5772-6031           JAXUCZ010000010.1  52408439-52408698
FEATURES             Location/Qualifiers
     source          1..6031
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..6031
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /note="myosin heavy chain 1"
                     /db_xref="GeneID:287408"
                     /db_xref="RGD:735061"
     exon            1..22
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            23..55
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            56..299
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..5924
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /note="type 2X myosin heavy chain; myosin, heavy chain 1,
                     skeletal muscle, adult"
                     /codon_start=1
                     /product="myosin, heavy polypeptide 1, skeletal muscle,
                     adult"
                     /protein_id="NP_001128630.1"
                     /db_xref="GeneID:287408"
                     /db_xref="RGD:735061"
                     /translation="MSSDAEMAVFGEAAPYLRKSEKERIEAQNKPFDAKSSVFVVDAK
                     ESFVKATVQSREGGKVTAKTEGGATVTVKDDQVFPMNPPKYDKIEDMAMMTHLHEPAV
                     LYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRQEAPPHIFSISD
                     NAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKEEAPSGKMQGT
                     LEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRV
                     TFQLKAERSYHIFYQIMSNKKPDLIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMA
                     TDSAIDILGFTSDERVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQN
                     LNSADLLKALCYPRVKVGNEYVTKGQTVQQVYNAVGALAKAVYEKMFLWMVTRINQQL
                     DTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEG
                     IEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNF
                     QKPKPAKGKVEAHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSMKTLAYLF
                     SGAAAAAEAESGGGGGKKGAKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIP
                     NETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEG
                     QFIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQLITRTQAM
                     CRGYLARVEYQKMVERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAETEKEM
                     ANMKEEFEKTKENLAKAEAKRKELEEKMVALMQEKNDLQLQVQSEADSLADAEERCDQ
                     LIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE
                     KEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA
                     KIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDVENDKQQLDEKLK
                     KKEFEMSNLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDL
                     SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHA
                     DSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMEVISKSKGNLEKMCRTLEDQ
                     VSELKTKEEEQQRLINELTAQRGRLQTESGEYSRQLDEKDSLVSQLSRGKQAFTQQIE
                     ELKRQLEEEVKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQW
                     RTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLM
                     IDVERTNAACAALDKKQRNFDKILAEWKQKYEETHAELEASQKESRSLSTELFKIKNA
                     YEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQIEQEKSELQAALE
                     EAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEEIDQLKRNHIRVVESMQSTLDA
                     EIRSRNDAIRIKKKMEGDLNEMEIQLNHSNRMAAEALRNYRNTQGILKDTQLHLDDAL
                     RGQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQ
                     NTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSA
                     HLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNVE
                     AIKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQSKVKAYKRQAEEAEEQSNVNL
                     AKFRKIQHELEEAEERADIAESQVNKLRVKSREVHTKIISEE"
     exon            300..443
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            444..600
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            601..628
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            629..743
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            744..836
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            837..900
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            901..999
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1103
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1242
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1361
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1511
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1682
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1995
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2072
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2160
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2278
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2402
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2539
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..2795
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..3038
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            3039..3215
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            3216..3361
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3452
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            3453..3842
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            3843..3969
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            3970..4088
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            4089..4285
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            4286..4469
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            4470..4635
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            4636..4760
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            4761..5069
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            5070..5273
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            5274..5399
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            5400..5570
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            5571..5675
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            5676..5771
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
     exon            5772..6031
                     /gene="Myh1"
                     /gene_synonym="MYHC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctttcctca taaagcttca agttcagacc cacggtcgaa gttgcatccc taaaggcaga
       61 ctctcccact gggctgcccc caatagcccg cagccatgag ttccgacgcc gagatggccg
      121 ttttcgggga ggctgctcct tacctccgga agtctgaaaa ggagcgaatc gaggctcaga
      181 acaagccttt tgatgccaag tcatccgtgt ttgtggtgga tgctaaggag tcttttgtaa
      241 aagcaacggt gcagagcagg gaagggggga aggtgacagc caagaccgaa ggtggcgcta
      301 ctgtaacagt aaaagatgat caagtcttcc ccatgaaccc tcccaagtac gacaagatcg
      361 aggacatggc catgatgacc cacctccacg agcctgctgt gctgtacaac ctcaaagagc
      421 gttacgcagc ctggatgatc tacacctact cgggcctgtt ctgtgtcact gtcaacccct
      481 acaagtggct gccagtgtat aatgcagagg tggtggcagc ttaccgaggc aaaaagcgcc
      541 aggaggcccc gccccacatc ttctctatct ctgacaacgc ctaccagttc atgttgacag
      601 atcgggagaa ccagtctatt ttgatcaccg gagaatctgg ggctgggaag actgtgaaca
      661 cgaagcgtgt catccagtac tttgcaacaa ttgcagtcac tggggagaag aagaaggagg
      721 aagcaccttc tggcaaaatg caggggaccc tggaggatca aatcatcagt gccaatcctc
      781 tgctggaagc cttcgggaat gccaagaccg tgaggaatga caactcctct cgctttggta
      841 aattcatcag gatccacttt ggtaccacag ggaagctggc ttctgctgat attgaaacat
      901 atcttctgga gaagtctaga gtcaccttcc agctaaaagc tgagagaagc taccatattt
      961 tttaccagat catgtctaac aagaagccag atctaattga aatgctcctg atcaccacca
     1021 acccatacga ctacgccttt gtcagtcagg gggagatcac agtgcccagc attgatgacc
     1081 aagaagagtt gatggccaca gatagtgcca ttgatattct gggcttcact tctgatgaaa
     1141 gagtctccat ctataagctc acgggggctg tgatgcatta tgggaacatg aagttcaagc
     1201 agaagcaacg tgaggagcag gctgagccgg atggcacgga agtggctgac aaggctgcct
     1261 atctccaaaa tctgaactct gctgacctgc tcaaagccct gtgttacccc agggtcaagg
     1321 tcggcaatga gtatgtcacc aaaggccaga ctgtgcagca ggtgtacaac gctgtgggtg
     1381 ccctggccaa agctgtctac gagaagatgt tcctttggat ggtcacccgc atcaaccagc
     1441 agctggacac caagcagccc aggcagtact tcatcggggt cttggacatc gctggctttg
     1501 agatctttga tttcaacagc ctggagcagc tgtgcatcaa cttcaccaac gagaaactgc
     1561 aacagttttt caaccaccac atgttcgtgc tggagcagga ggagtacaag aaggaaggca
     1621 tcgagtggga gttcatcgac ttcgggatgg acctggcggc ctgcatcgag ctcatcgaga
     1681 agccaatggg catcttctcc atcctggaag aggagtgcat gttccccaaa gcgacagaca
     1741 cctccttcaa gaacaagctg tatgaacagc atcttggaaa gtccaacaac ttccagaagc
     1801 ccaaacccgc caaaggcaag gttgaggccc acttctctct ggtgcactat gccggcaccg
     1861 ttgactacaa catcgctggc tggctggaca agaacaagga ccccctgaat gagaccgtgg
     1921 tggggctgta ccagaagtct tcaatgaaaa ctctggctta cctcttctct ggggcagcag
     1981 ctgctgctga agcagagtct ggtggcggtg gtggaaagaa aggggcaaag aagaagggtt
     2041 cttccttcca gactgtgtca gctctcttca gggagaacct gaataagctg atgaccaatc
     2101 tgaggagcac tcacccccac tttgtccggt gcatcatccc caatgagact aagacgcctg
     2161 gtgccatgga gcacgaactg gtcctgcacc agctgaggtg taacggggta ctggaaggca
     2221 tccgcatctg caggaagggg ttccccagca ggatcctcta cgcagacttc aagcagagat
     2281 acaaggtgtt aaatgcaagt gccatccccg agggacaatt catcgatagc aagaaggctt
     2341 ctgagaagct ccttggctcc atcgacattg accacactca gtataagttt ggtcacacca
     2401 aggtcttttt caaagctggt cttctggggc tcctagagga gatgagagat gacaagttgg
     2461 cccagctgat tacccggacg caggccatgt gccgagggta cttggcaaga gtggagtacc
     2521 agaagatggt ggagcgaaga gagtccatct tctgcatcca gtacaacgtc cgagccttca
     2581 tgaatgtgaa acactggccc tggatgaagc tgtatttcaa gatcaaacct ctcttgaaga
     2641 gtgccgagac agagaaggag atggccaaca tgaaggaaga gtttgaaaaa actaaagaaa
     2701 accttgcaaa ggcagaggcc aaaaggaaag agctagaaga aaagatggtg gctctgatgc
     2761 aggagaaaaa tgacctgcag ctccaagttc agtctgaagc agacagcttg gctgatgctg
     2821 aggaaagatg cgaccagctg atcaaaacca aaatccagct ggaggccaaa atcaaagagg
     2881 tgactgagag agcagaggat gaggaagaga tcaacgccga gctcaccgcc aagaagagga
     2941 agctggagga cgagtgctca gagctgaaga aagacatcga tgaccttgag ctgacactgg
     3001 ccaaggttga gaaggagaag cacgccacgg agaacaaggt gaaaaacctc acagaggaga
     3061 tggcgggcct ggacgaaacc atcgccaagc tgaccaagga gaagaaggcc ttgcaggagg
     3121 cccaccagca gaccctggat gacctgcagg cagaggagga caaagtcaac accctgacca
     3181 aagccaaaat caagctggaa cagcaagtgg atgaccttga aggctctctg gaacaagaaa
     3241 agaaaatccg gatggatctt gaaagagcca agaggaaact cgagggggac ctaaaactgg
     3301 cccaagagtc cacaatggac gtagaaaatg acaaacagca gctcgatgag aaactcaaaa
     3361 agaaagagtt tgaaatgagc aacctgcaga gcaagatcga ggatgaacag gccctcggca
     3421 tgcagctgca gaagaagatc aaggagttgc aggctcgcat tgaggagctg gaggaggaaa
     3481 tcgaggcaga gcgggcctcc agggccaaag cagagaagca gcgctctgac ctctcccggg
     3541 aactggagga gatcagcgag cggctggaag aagccggcgg ggccacttca gcccagatcg
     3601 agatgaacaa gaagagagag gccgagttcc agaaaatgcg cagggacctg gaggaggcca
     3661 ccctgcagca cgaagccaca gcagccaccc tgaggaagaa gcacgcggac agcgtggctg
     3721 agctcgggga gcagatcgac aacctgcagc gggtgaagca gaagctggag aaggagaaga
     3781 gcgagatgaa gatggagatc gacgacctcg ctagcaacat ggaggtcatt tccaaatcca
     3841 agggaaacct tgagaagatg tgccgcactc tggaggacca ggtgagcgag ctgaagacca
     3901 aggaggagga gcagcagcgg ctcatcaacg agctgaccgc gcagaggggg cgtctgcaga
     3961 cagagtcagg tgaatattca cgccagctgg atgaaaagga ttcattagtt tctcagctct
     4021 ccaggggcaa acaggcattc actcaacaga ttgaggagct gaagaggcag cttgaagagg
     4081 aagtaaaggc caagagtgcc ctggctcatg ctcttcagtc ctcccgccat gactgtgacc
     4141 ttctgcggga acagtatgaa gaagaacagg aagccaaggc tgaactgcag agggccatgt
     4201 ccaaggccaa cagtgaagtg gcccagtgga ggacgaaata tgagacggat gccatccagc
     4261 gcacggaaga actggaggag gccaagaaga agctggctca gcgtctgcag gatgctgagg
     4321 agcacgtaga agccgtgaac gccaagtgtg cttccctgga gaagacgaag cagaggctgc
     4381 agaatgaggt ggaggacctc atgattgatg tggagaggac caacgctgcc tgtgccgccc
     4441 tggacaagaa gcagagaaac ttcgacaaga tcctggcaga atggaaacag aagtatgagg
     4501 aaacgcatgc tgaacttgaa gcctcccaga aggagtcccg ctctctcagc acagagttgt
     4561 tcaagattaa gaatgcttat gaggaatctt tagaccaact tgaaaccttg aaaagggaaa
     4621 ataagaattt gcaacaggag atctctgacc tcactgaaca gattgcagaa ggagggaaac
     4681 gtatccatga actggaaaaa ataaagaagc aaattgagca agaaaaatcc gagctccagg
     4741 ctgctttaga ggaagcagag gcatctctgg agcacgagga gggaaagatc ctgcgcatcc
     4801 agctggagct gaaccaagtc aagtctgaga tcgacaggaa gattgctgag aaggatgagg
     4861 aaattgacca gctgaagaga aaccacattc gagtcgtgga gtccatgcag agcacgctgg
     4921 atgccgagat caggagcagg aatgacgcca tcaggatcaa gaagaagatg gagggagacc
     4981 tcaatgagat ggaaatccag ctgaaccact ccaaccgcat ggctgctgag gccctgagaa
     5041 actacaggaa cacccaaggc atcctcaagg acacccagtt gcacctggat gacgctctcc
     5101 ggggccagga ggacctgaag gagcagctgg ccatggtgga gcgcagagcc aacctgctgc
     5161 aggctgagat cgaggagctg cgggccactc tggagcagac tgagaggagc aggaagattg
     5221 cagagcagga actgctggac gccagtgagc gcgtgcagct cctccacacc cagaacacca
     5281 gcctcatcaa caccaagaag aagctggaga cagacatttc ccagatccag ggagagatgg
     5341 aggacatcgt ccaggaagcc cgcaatgcag aagagaaggc caagaaagcc atcactgacg
     5401 ccgccatgat ggcggaggag ctgaagaagg agcaggacac cagcgcccat ctggagcgga
     5461 tgaagaagaa cctggagcag acggtgaagg acctgcagca ccgtctggac gaggctgagc
     5521 agctggcgct gaagggcggc aagaagcaga tccagaaact ggaggccagg gtccgtgaac
     5581 ttgaaggaga agttgaaaac gaacagaagc gcaatgttga agctatcaag ggtctgcgca
     5641 aacatgagag aagagtgaaa gaactcactt accaaactga ggaagaccgc aagaacgttc
     5701 tcaggctcca ggaccttgtg gacaaactgc aatcaaaggt caaagcatac aagagacaag
     5761 ccgaggaagc ggaggaacaa tccaacgtca acctggccaa gttccgcaag atccagcacg
     5821 agctggagga agccgaggag cgggctgaca tcgccgagtc ccaggtcaac aagctgcggg
     5881 tgaagagccg cgaggttcac accaaaatca taagcgaaga gtgatcgatc caaagcagga
     5941 aagtgaccaa agagatgagc aaaatgtgaa gatctttgtc actccatttt gtacttacga
     6001 ctttgggaga taaaaaattt atctgccaag a
//
