LOCUS       NM_013172               1271 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus myogenic factor 6 (Myf6), mRNA.
ACCESSION   NM_013172
VERSION     NM_013172.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1271)
  AUTHORS   Moretti,I., Ciciliot,S., Dyar,K.A., Abraham,R., Murgia,M.,
            Agatea,L., Akimoto,T., Bicciato,S., Forcato,M., Pierre,P.,
            Uhlenhaut,N.H., Rigby,P.W., Carvajal,J.J., Blaauw,B., Calabria,E.
            and Schiaffino,S.
  TITLE     MRF4 negatively regulates adult skeletal muscle growth by
            repressing MEF2 activity
  JOURNAL   Nat Commun 7, 12397 (2016)
   PUBMED   27484840
  REMARK    GeneRIF: MRF4 acts by stabilizing a repressor complex that controls
            MEF2 activity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1271)
  AUTHORS   Bowlin,K.M., Embree,L.J., Garry,M.G., Garry,D.J. and Shi,X.
  TITLE     Kbtbd5 is regulated by MyoD and restricted to the myogenic lineage
  JOURNAL   Differentiation 86 (4-5), 184-191 (2013)
   PUBMED   24361185
REFERENCE   3  (bases 1 to 1271)
  AUTHORS   Damatto,R.L., Martinez,P.F., Lima,A.R., Cezar,M.D., Campos,D.H.,
            Oliveira Junior,S.A., Guizoni,D.M., Bonomo,C., Nakatani,B.T., Dal
            Pai Silva,M., Carvalho,R.F., Okoshi,K. and Okoshi,M.P.
  TITLE     Heart failure-induced skeletal myopathy in spontaneously
            hypertensive rats
  JOURNAL   Int J Cardiol 167 (3), 698-703 (2013)
   PUBMED   22464481
  REMARK    GeneRIF: Decreased myostatin expression combined with significant
            muscle atrophy is observed in spontaneously hypertensive rats (SHR)
            with heart failure; MRF4 levels positively correlate with type I
            MyHC isoform.
REFERENCE   4  (bases 1 to 1271)
  AUTHORS   Rajan,S., Chu Pham Dang,H., Djambazian,H., Zuzan,H., Fedyshyn,Y.,
            Ketela,T., Moffat,J., Hudson,T.J. and Sladek,R.
  TITLE     Analysis of early C2C12 myogenesis identifies stably and
            differentially expressed transcriptional regulators whose
            knock-down inhibits myoblast differentiation
  JOURNAL   Physiol Genomics 44 (2), 183-197 (2012)
   PUBMED   22147266
REFERENCE   5  (bases 1 to 1271)
  AUTHORS   Sambasivan,R., Gayraud-Morel,B., Dumas,G., Cimper,C., Paisant,S.,
            Kelly,R.G. and Tajbakhsh,S.
  TITLE     Distinct regulatory cascades govern extraocular and pharyngeal arch
            muscle progenitor cell fates
  JOURNAL   Dev Cell 16 (6), 810-821 (2009)
   PUBMED   19531352
  REMARK    Erratum:[Dev Cell. 2009 Jul;17(1):150. Kelly, Robert [corrected to
            Kelly, Robert G]]
REFERENCE   6  (bases 1 to 1271)
  AUTHORS   Patapoutian,A., Yoon,J.K., Miner,J.H., Wang,S., Stark,K. and
            Wold,B.
  TITLE     Disruption of the mouse MRF4 gene identifies multiple waves of
            myogenesis in the myotome
  JOURNAL   Development 121 (10), 3347-3358 (1995)
   PUBMED   7588068
REFERENCE   7  (bases 1 to 1271)
  AUTHORS   Zhang,W., Behringer,R.R. and Olson,E.N.
  TITLE     Inactivation of the myogenic bHLH gene MRF4 results in
            up-regulation of myogenin and rib anomalies
  JOURNAL   Genes Dev 9 (11), 1388-1399 (1995)
   PUBMED   7797078
REFERENCE   8  (bases 1 to 1271)
  AUTHORS   Braun,T. and Arnold,H.H.
  TITLE     Inactivation of Myf-6 and Myf-5 genes in mice leads to alterations
            in skeletal muscle development
  JOURNAL   EMBO J 14 (6), 1176-1186 (1995)
   PUBMED   7720708
REFERENCE   9  (bases 1 to 1271)
  AUTHORS   Hinterberger,T.J., Mays,J.L. and Konieczny,S.F.
  TITLE     Structure and myofiber-specific expression of the rat muscle
            regulatory gene MRF4
  JOURNAL   Gene 117 (2), 201-207 (1992)
   PUBMED   1639267
REFERENCE   10 (bases 1 to 1271)
  AUTHORS   Rhodes,S.J. and Konieczny,S.F.
  TITLE     Identification of MRF4: a new member of the muscle regulatory
            factor gene family
  JOURNAL   Genes Dev 3 (12B), 2050-2061 (1989)
   PUBMED   2560751
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M27151.1.
            
            On Apr 28, 2015 this sequence version replaced NM_013172.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M27151.1, CR755776.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1271
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q21"
     gene            1..1271
                     /gene="Myf6"
                     /gene_synonym="MRF4AA"
                     /note="myogenic factor 6"
                     /db_xref="GeneID:25714"
                     /db_xref="RGD:3134"
     exon            1..563
                     /gene="Myf6"
                     /gene_synonym="MRF4AA"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..773
                     /gene="Myf6"
                     /gene_synonym="MRF4AA"
                     /note="myf-6; muscle-specific regulatory factor 4;
                     Myogenic factor 6 (herculin)"
                     /codon_start=1
                     /product="myogenic factor 6"
                     /protein_id="NP_037304.1"
                     /db_xref="GeneID:25714"
                     /db_xref="RGD:3134"
                     /translation="MMMDLFETGSYFFYLDGENVTLQPLEVAEGSPLYPGSDGTLSPC
                     QDQMPQEAGSDSSGEEHVLAPPGLQPPHCPGQCLIWACKTCKRKSAPTDRRKAATLRE
                     RRRLKKINEAFEALKRRTVANPNQRLPKVEILRSAINYIERLQDLLHRLDQQEKMQEL
                     GVDPYSYKPKQEILEGADFLRTCSPQWPSVSDHSRGLVITAKEGGASVDASASSSLQR
                     LSSIVDSISSEERKLPSVEEVVEK"
     exon            564..654
                     /gene="Myf6"
                     /gene_synonym="MRF4AA"
                     /inference="alignment:Splign:2.1.0"
     exon            655..1271
                     /gene="Myf6"
                     /gene_synonym="MRF4AA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccatcacc cagttcagat cagtcagagg ccaaggagga gaacatgatg atggaccttt
       61 ttgaaactgg ctcctatttc ttctacttag atggagaaaa tgtgactctt cagccattag
      121 aagtggcaga gggctctcct ttgtacccag ggagtgatgg taccctatcc ccttgccagg
      181 accaaatgcc ccaggaagcc gggagcgaca gcagtggaga ggaacacgtt ctggctcccc
      241 caggccttca gccaccccac tgcccaggtc agtgtctgat ctgggcttgc aagacttgca
      301 agagaaaatc tgcccccaca gatcgtcgga aagcagctac cctgcgcgaa aggaggaggc
      361 ttaagaaaat caacgaagcc tttgaggcct tgaagcgtag aactgtggcc aaccccaacc
      421 agaggctgcc caaggtggag attctgagaa gtgccatcaa ctacattgag cgtctgcagg
      481 acctgctgca ccggctggat cagcaagaga aaatgcagga gctgggggtg gacccttaca
      541 gctacaaacc caagcaagaa attcttgagg gtgcggattt cctgcgcacc tgcagcccgc
      601 agtggccaag tgtttcggat cattccaggg gcctggtgat aactgctaag gaaggaggag
      661 caagcgtcga tgcttcagcc tccagcagtc ttcagcgcct ttcttccatc gtggacagta
      721 tttcctcaga ggaacgcaaa ctccccagcg tggaggaggt ggtggagaag taactcagtc
      781 agcatttgga acattcttcg ctcagcagga agagcccctt tccgcctaat catttagatt
      841 agggctcaca gaccccagaa tttatgaaag gcaagagact tagtgttaaa aaagaaacct
      901 ctccccacct caagtgaaaa tccttcggct tggggctttt attataacta ttattgtatc
      961 tgaaccgcta gtggcttagc tctagaaccc taattttgtt tttagtttgg ttggtttttt
     1021 ataacatatt aacttttgct atgatcacgt gaccctttcc tgtcagttgc aaacgaagtt
     1081 cattcctgtc taaatcaaag tgggaacgtt taatcctaag agtatttaat gtacttttgt
     1141 aaatagtctt agtactttcg tttttatgta aacctaaagg acatatttta aatgtggaat
     1201 taagcattgt atataaaatg tgtgagagtc tgatattgta atattaaaat attaatacgt
     1261 ttctacacgt a
//
