LOCUS       NM_198130               2158 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus MYD88, innate immune signal transduction adaptor
            (Myd88), mRNA.
ACCESSION   NM_198130 XM_236690
VERSION     NM_198130.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2158)
  AUTHORS   Gao,Z., Guo,C., Xiang,S., Zhang,H., Wang,Y. and Xu,H.
  TITLE     Suppression of MALAT1 promotes human synovial mesenchymal stem
            cells enhance chondrogenic differentiation and prevent
            osteoarthritis of the knee in a rat model via regulating
            miR-212-5p/MyD88 axis
  JOURNAL   Cell Tissue Res 395 (3), 251-260 (2024)
   PUBMED   38291253
  REMARK    GeneRIF: Suppression of MALAT1 promotes human synovial mesenchymal
            stem cells enhance chondrogenic differentiation and prevent
            osteoarthritis of the knee in a rat model via regulating
            miR-212-5p/MyD88 axis.
REFERENCE   2  (bases 1 to 2158)
  AUTHORS   Wen,R., Zhang,T.N., Zhang,T., Tong,Y.J., Song,W.L., Liu,Y.P.,
            Yang,N. and Liu,C.F.
  TITLE     A novel long noncoding RNA-lncRNA-AABR07066529.3 alleviates
            inflammation, apoptosis, and pyroptosis by inhibiting MyD88 in
            lipopolysaccharide-induced myocardial depression
  JOURNAL   FASEB J 37 (8), e23063 (2023)
   PUBMED   37401890
  REMARK    GeneRIF: A novel long noncoding RNA-lncRNA-AABR07066529.3
            alleviates inflammation, apoptosis, and pyroptosis by inhibiting
            MyD88 in lipopolysaccharide-induced myocardial depression.
REFERENCE   3  (bases 1 to 2158)
  AUTHORS   Chai,H., Lei,Z., Liu,Y., Gong,J., Cao,Z., Huang,Z., Yang,H. and
            Wu,Z.
  TITLE     miR-505-5p alleviates acute rejection of liver transplantation by
            inhibiting Myd88 and inducing M2 polarizationof Kupffer cells
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 54 (8), 1148-1158 (2022)
   PUBMED   35959879
  REMARK    GeneRIF: miR-505-5p alleviates acute rejection of liver
            transplantation by inhibiting Myd88 and inducing M2 polarizationof
            Kupffer cells.
REFERENCE   4  (bases 1 to 2158)
  AUTHORS   El-Shamarka,M.E., Eliwa,H.A. and Ahmed,M.A.E.
  TITLE     Inhibition of boldenone-induced aggression in rats by curcumin:
            Targeting TLR4/MyD88/TRAF-6/NF-kappaB pathway
  JOURNAL   J Biochem Mol Toxicol 36 (1), e22936 (2022)
   PUBMED   34719837
  REMARK    GeneRIF: Inhibition of boldenone-induced aggression in rats by
            curcumin: Targeting TLR4/MyD88/TRAF-6/NF-kappaB pathway.
REFERENCE   5  (bases 1 to 2158)
  AUTHORS   Wang,Y.F., Wang,Y., Zhang,Y., Guo,X., He,X., Zhang,J.L. and
            Rong,P.J.
  TITLE     [Effect of transcutaneous auricular vagus nerve stimulation on the
            expression of TLR4MyD88IL-18 protein in the prefrontal cortex of
            depression rats]
  JOURNAL   Zhen Ci Yan Jiu 46 (7), 580-585 (2021)
   PUBMED   34369678
  REMARK    GeneRIF: [Effect of transcutaneous auricular vagus nerve
            stimulation on the expression of TLR4MyD88IL-18 protein in the
            prefrontal cortex of depression rats].
REFERENCE   6  (bases 1 to 2158)
  AUTHORS   Mamidipudi,V., Li,X. and Wooten,M.W.
  TITLE     Identification of interleukin 1 receptor-associated kinase as a
            conserved component in the p75-neurotrophin receptor activation of
            nuclear factor-kappa B
  JOURNAL   J Biol Chem 277 (31), 28010-28018 (2002)
   PUBMED   12034707
REFERENCE   7  (bases 1 to 2158)
  AUTHORS   Fitzgerald,K.A., Palsson-McDermott,E.M., Bowie,A.G.,
            Jefferies,C.A., Mansell,A.S., Brady,G., Brint,E., Dunne,A.,
            Gray,P., Harte,M.T., McMurray,D., Smith,D.E., Sims,J.E., Bird,T.A.
            and O'Neill,L.A.
  TITLE     Mal (MyD88-adapter-like) is required for Toll-like receptor-4
            signal transduction
  JOURNAL   Nature 413 (6851), 78-83 (2001)
   PUBMED   11544529
REFERENCE   8  (bases 1 to 2158)
  AUTHORS   Takeuchi,O., Hoshino,K. and Akira,S.
  TITLE     Cutting edge: TLR2-deficient and MyD88-deficient mice are highly
            susceptible to Staphylococcus aureus infection
  JOURNAL   J Immunol 165 (10), 5392-5396 (2000)
   PUBMED   11067888
REFERENCE   9  (bases 1 to 2158)
  AUTHORS   Burns,K., Clatworthy,J., Martin,L., Martinon,F., Plumpton,C.,
            Maschera,B., Lewis,A., Ray,K., Tschopp,J. and Volpe,F.
  TITLE     Tollip, a new component of the IL-1RI pathway, links IRAK to the
            IL-1 receptor
  JOURNAL   Nat Cell Biol 2 (6), 346-351 (2000)
   PUBMED   10854325
REFERENCE   10 (bases 1 to 2158)
  AUTHORS   Takeuchi,O., Takeda,K., Hoshino,K., Adachi,O., Ogawa,T. and
            Akira,S.
  TITLE     Cellular responses to bacterial cell wall components are mediated
            through MyD88-dependent signaling cascades
  JOURNAL   Int Immunol 12 (1), 113-117 (2000)
   PUBMED   10607756
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 27, 2020 this sequence version replaced NM_198130.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY191270.1, BC097266.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840107,
                                           SAMN12840111 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-410               JAXUCZ010000008.1  127955821-127956230 c
            411-545             JAXUCZ010000008.1  127954991-127955125 c
            546-726             JAXUCZ010000008.1  127954419-127954599 c
            727-818             JAXUCZ010000008.1  127954159-127954250 c
            819-994             JAXUCZ010000008.1  127953729-127953904 c
            995-2158            JAXUCZ010000008.1  127952161-127953324 c
FEATURES             Location/Qualifiers
     source          1..2158
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2158
                     /gene="Myd88"
                     /note="MYD88, innate immune signal transduction adaptor"
                     /db_xref="GeneID:301059"
                     /db_xref="RGD:735043"
     exon            1..410
                     /gene="Myd88"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..973
                     /gene="Myd88"
                     /note="myeloid differentiation primary response gene 88;
                     myeloid differentiation primary response 88"
                     /codon_start=1
                     /product="myeloid differentiation primary response protein
                     MyD88"
                     /protein_id="NP_937763.2"
                     /db_xref="GeneID:301059"
                     /db_xref="RGD:735043"
                     /translation="MSAGGPRVGSVSVDSYLFSLPLVALNVGVRRRLSLFLNPRTTAA
                     ADWTSLAEEMGFEYLEIREFETRPDPTRSLLDAWQGRSGSSVGRLLELLALLDREDIL
                     YELKDRIEEDCQKYIRNQQKQESEKPLQVARVESSVPQTKELGGITTLDDPLGQTPEL
                     FDAFICYCPSDIEFVQEMIRQLEQTDYRLKLCVSDRDVLPGTCVWSIASELIEKRCRR
                     MVVVVSDDYLQSKECDFQTKFALSLSPGVQQKRLIPIKYKAMKKDFPSILRFITICDY
                     TNPCTKSWFWTRLAKALSLP"
     exon            411..545
                     /gene="Myd88"
                     /inference="alignment:Splign:2.1.0"
     exon            546..726
                     /gene="Myd88"
                     /inference="alignment:Splign:2.1.0"
     exon            727..818
                     /gene="Myd88"
                     /inference="alignment:Splign:2.1.0"
     exon            819..994
                     /gene="Myd88"
                     /inference="alignment:Splign:2.1.0"
     exon            995..2158
                     /gene="Myd88"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggttggca ggagccttaa gggaagtagg aagctcaaca agcgagcgca ccgtacagaa
       61 ccggggccca gggttgcttg ccatgtctgc gggaggcccc cgcgtgggat ccgtgtccgt
      121 ggactcctac ttgttctctc taccgttggt cgcgctcaac gtgggagtga ggcgccgcct
      181 ctcgctgttc ttgaacccgc ggacaaccgc ggcggccgac tggacctcgc tggcggagga
      241 gatgggtttc gagtacttgg agatccgcga gtttgagacg cgccccgatc ccactcgcag
      301 tttgttggat gcctggcagg ggcgctctgg ctcgtcggtc ggcaggctgc tagagttgct
      361 agccttgtta gaccgtgagg atatactgta tgaactgaag gaccgcatcg aggaggactg
      421 ccagaaatac atacgcaacc agcagaaaca ggagtctgag aagcccttgc aggtggccag
      481 agtggagagc agtgtcccac agacaaagga actgggaggc atcaccaccc tcgatgaccc
      541 cctggggcaa acgccggagc ttttcgacgc cttcatctgc tactgcccca gtgatattga
      601 gtttgtgcag gagatgatcc ggcaactaga acagacagac tatcggctta aattgtgtgt
      661 gtccgaccgc gatgtcctgc ctggcacctg cgtgtggtcc atcgccagcg agctcattga
      721 gaaaaggtgt cgtcgcatgg tggtggttgt ttctgacgat tacctgcaaa gtaaggaatg
      781 tgacttccag accaagtttg ctctcagcct gtctccaggt gtccaacaga agcgactgat
      841 ccctatcaag tacaaagcaa tgaagaagga ctttcctagt atcctacggt tcatcactat
      901 ctgcgactat accaaccctt gcaccaagtc ctggttctgg acccgtcttg ccaaggctct
      961 gtccctgccc tgaagatggc cccgggagcc ctagggcaga gaggaagatg agctgacttg
     1021 gagccggatt ctccaacgct gtcctgtctg catctttggc tcccctcagg ctcagtccat
     1081 gttcagtggt gactggcctg agcaaccagg acagcctttt actcccaccc acccatgcct
     1141 gggcacacat ctcagttttg ccttgcttga ggtggcatcc tgtctcccct gacatgccta
     1201 tcacttacga gctgggccac caggaccaca aggacaatgt catcagggaa gcttcctccc
     1261 tggctcgcca accccgaagg ctttctacca accttctgta cgatgattac ttgctttgtt
     1321 aacaagcagc agacacacaa aaacattccg cccccagtgg ctggaggcat gtggccccat
     1381 atagtcttgt ttgtgcttcc gggaacacac aggcatctgc atatgtgtgt ttcctttggg
     1441 acagctccta agaatagctg agaggaagag ttctaccatc aagggggcct ggcggtctcc
     1501 ctggacaaaa atgaagtgcc tttgcatgag gtagtggcac gtgcctataa ctccagcatt
     1561 tgggcggtag tccagggtta tcactgacta cacaccaagt ttaaggtcag cctgggctac
     1621 atgagagcct attcccccac atcctccccc acccccacaa aagatgatgg cactgttaat
     1681 ttctcctctc ttttctccaa tcattgaaag caaagtctag aaaggcccct aatgtgatag
     1741 catttgggcc tttagcaaac tgaagattta aaaaaaaaag gagaagcagt ttggcttcac
     1801 cccacaaacc agctgcagga tcagctgttt tctccccagc agtgcggttt gcaaattcct
     1861 ctcaagttct ctaacacaga gacaatgtca tggtccctct cagggcacac accccagggt
     1921 cctgagtcct aaagaaaatg ggtctcccct cagtgtctgg aggaggaatg gaggcctctt
     1981 tgcacgagct cgtggggcat ttcaatgctt gatgttgagc atttgaaagc agccttggga
     2041 aagtgtctcc tgtacctgtt ttataggttt tctgaggatg tcaatagaga ggctcctatt
     2101 tgtggtttgt acttctgtat gtgaaattta taataaaaag tattctattt tgagaaag
//
