LOCUS       NM_001013096            2610 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Rattus norvegicus MYCN proto-oncogene, bHLH transcription factor
            (Mycn), mRNA.
ACCESSION   NM_001013096 XM_234025
VERSION     NM_001013096.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2610)
  AUTHORS   Yang,D.W., Kang,J.H., Kim,M.S. and Kim,S.H.
  TITLE     Regulatory role of N-myc downregulated genes in amelogenesis in
            rats
  JOURNAL   J Mol Histol 55 (2), 149-157 (2024)
   PUBMED   38407765
  REMARK    GeneRIF: Regulatory role of N-myc downregulated genes in
            amelogenesis in rats.
            Review article
REFERENCE   2  (bases 1 to 2610)
  AUTHORS   Jiang,X., Yang,J., Li,H., Qu,Y., Xu,W., Yu,H. and Tong,Y.
  TITLE     Huwe1 is a novel mediator of protection of neural progenitor L2.3
            cells against oxygen-glucose deprivation injury
  JOURNAL   Mol Med Rep 18 (5), 4595-4602 (2018)
   PUBMED   30221657
  REMARK    GeneRIF: the effects of Huwe1 on Notch1 signaling were completely
            abolished by knockdown of NMyc, indicating that Huwe1 may require
            NMyc to suppress the activation of the Notch1 signaling in L2.3
            cells.
REFERENCE   3  (bases 1 to 2610)
  AUTHORS   Richards,M.W., Burgess,S.G., Poon,E., Carstensen,A., Eilers,M.,
            Chesler,L. and Bayliss,R.
  TITLE     Structural basis of N-Myc binding by Aurora-A and its
            destabilization by kinase inhibitors
  JOURNAL   Proc Natl Acad Sci U S A 113 (48), 13726-13731 (2016)
   PUBMED   27837025
REFERENCE   4  (bases 1 to 2610)
  AUTHORS   Suenaga,Y., Islam,S.M., Alagu,J., Kaneko,Y., Kato,M., Tanaka,Y.,
            Kawana,H., Hossain,S., Matsumoto,D., Yamamoto,M., Shoji,W.,
            Itami,M., Shibata,T., Nakamura,Y., Ohira,M., Haraguchi,S.,
            Takatori,A. and Nakagawara,A.
  TITLE     NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved
            protein that inhibits GSK3beta resulting in the stabilization of
            MYCN in human neuroblastomas
  JOURNAL   PLoS Genet 10 (1), e1003996 (2014)
   PUBMED   24391509
REFERENCE   5  (bases 1 to 2610)
  AUTHORS   Kumps,C., Fieuw,A., Mestdagh,P., Menten,B., Lefever,S., Pattyn,F.,
            De Brouwer,S., Sante,T., Schulte,J.H., Schramm,A., Van Roy,N., Van
            Maerken,T., Noguera,R., Combaret,V., Devalck,C., Westermann,F.,
            Laureys,G., Eggert,A., Vandesompele,J., De Preter,K. and
            Speleman,F.
  TITLE     Focal DNA copy number changes in neuroblastoma target MYCN
            regulated genes
  JOURNAL   PLoS One 8 (1), e52321 (2013)
   PUBMED   23308108
REFERENCE   6  (bases 1 to 2610)
  AUTHORS   Beierle,E.A., Trujillo,A., Nagaram,A., Kurenova,E.V., Finch,R.,
            Ma,X., Vella,J., Cance,W.G. and Golubovskaya,V.M.
  TITLE     N-MYC regulates focal adhesion kinase expression in human
            neuroblastoma
  JOURNAL   J Biol Chem 282 (17), 12503-12516 (2007)
   PUBMED   17327229
REFERENCE   7  (bases 1 to 2610)
  AUTHORS   Okubo,T., Knoepfler,P.S., Eisenman,R.N. and Hogan,B.L.
  TITLE     Nmyc plays an essential role during lung development as a
            dosage-sensitive regulator of progenitor cell proliferation and
            differentiation
  JOURNAL   Development 132 (6), 1363-1374 (2005)
   PUBMED   15716345
REFERENCE   8  (bases 1 to 2610)
  AUTHORS   Ciani,E., Severi,S., Contestabile,A., Bartesaghi,R. and
            Contestabile,A.
  TITLE     Nitric oxide negatively regulates proliferation and promotes
            neuronal differentiation through N-Myc downregulation
  JOURNAL   J Cell Sci 117 (Pt 20), 4727-4737 (2004)
   PUBMED   15331636
  REMARK    GeneRIF: Data show that nitric oxide negatively regulates
            proliferation and promotes neuronal differentiation through N-Myc
            downregulation.
REFERENCE   9  (bases 1 to 2610)
  AUTHORS   Bannasch,D., Weis,I. and Schwab,M.
  TITLE     Nmi protein interacts with regions that differ between MycN and Myc
            and is localized in the cytoplasm of neuroblastoma cells in
            contrast to nuclear MycN
  JOURNAL   Oncogene 18 (48), 6810-6817 (1999)
   PUBMED   10597290
REFERENCE   10 (bases 1 to 2610)
  AUTHORS   Sugiyama,A., Miyagi,Y., Shirasawa,Y. and Kuchino,Y.
  TITLE     Different usage of two polyadenylylation signals in transcription
            of the N-myc gene in rat tumor cells
  JOURNAL   Oncogene 6 (11), 2027-2032 (1991)
   PUBMED   1719466
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001013096.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.34589.1,
                                           SRR26643298.34815.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               JAXUCZ010000006.1  41452304-41452508   c
            206-1079            JAXUCZ010000006.1  41450268-41451141   c
            1080-2610           JAXUCZ010000006.1  41446684-41448214   c
FEATURES             Location/Qualifiers
     source          1..2610
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q15"
     gene            1..2610
                     /gene="Mycn"
                     /gene_synonym="N-myc; Nmuc1; Nmyc"
                     /note="MYCN proto-oncogene, bHLH transcription factor"
                     /db_xref="GeneID:298894"
                     /db_xref="RGD:1584995"
     exon            1..205
                     /gene="Mycn"
                     /gene_synonym="N-myc; Nmuc1; Nmyc"
                     /inference="alignment:Splign:2.1.0"
     exon            206..1079
                     /gene="Mycn"
                     /gene_synonym="N-myc; Nmuc1; Nmyc"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..1684
                     /gene="Mycn"
                     /gene_synonym="N-myc; Nmuc1; Nmyc"
                     /note="v-myc myelocytomatosis viral related oncogene,
                     neuroblastoma derived; Avian myelocytomatosis viral
                     (v-myc) related oncogene, neuroblastoma derived (Nmyc);
                     v-myc avian myelocytomatosis viral oncogene neuroblastoma
                     derived homolog"
                     /codon_start=1
                     /product="N-myc proto-oncogene protein"
                     /protein_id="NP_001013114.2"
                     /db_xref="GeneID:298894"
                     /db_xref="RGD:1584995"
                     /translation="MPSCTASTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTP
                     PGEDIWKKFELLPTPPLSPSRAFPEHSPEPSNWATEMLLPEADLWGNPAEEDAFGLGG
                     LGGLTPNPVILQDCMWSGFSAREKLERAVNEKLQHGHGPPGASSSCPAPGVGASSSGG
                     RALGGSASAGRTGATLPTDLSHPAAECVDPAVVFPFPVNKRESASVPAAPTSAPATSA
                     VVTSVSVPAVAPVAAPARAGGRPANSGEHKALSTSGEDTLSDSDDEDDEEEDEEEEID
                     VVTVEKRRSSSNNKAVTTFTITVRPKTSALGLGRAQPGELILKRCVPIHQQHNYAAPS
                     PYVESEDAPPQKKIKSEASPRPLKSVVPPKAKSLSPRNSDSEDSERRRNHNILERQRR
                     NDLRSSFLTLRDHVPELVKNEKAAKVVILKKATEYVHALQANEHQLLLEKEKLQARQQ
                     QLLKKIEHARTC"
     exon            1080..2610
                     /gene="Mycn"
                     /gene_synonym="N-myc; Nmuc1; Nmyc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccagtgaca gtcatctgtc tggacgcgct gggtggatgc ggggggctcc tgggaactgg
       61 gttggagccg aacgagcgct agccaggcgt aagcgcgcac acactgcagc gtcccgagga
      121 cgacccccct cccaccgccg ccccctcagc ccacccggag acccctgcac cgagtcgcct
      181 ccggatcccc ggcagtctgc gggagagttg gaggttggag cgactctgct ccccacggga
      241 aggaagcaca cccccatatt aaaaagagcg gagatattaa aagagaggcg aacccatgcc
      301 cagctgcacc gcgtccacca tgccggggat gatctgcaag aacccagacc tcgagtttga
      361 ctccctgcag ccctgcttct acccggacga agatgacttc tacttcggcg gtcccgactc
      421 gaccccacca ggggaggaca tctggaagaa gtttgagctg ctgcccacgc ccccgttgtc
      481 gcccagccgc gccttcccag agcacagccc ggagccctca aattgggcca cggagatgct
      541 gctgccggag gccgacctgt ggggcaaccc ggccgaggag gatgcgtttg gtctgggggg
      601 actgggtggc ctcactccta atccggtcat ccttcaggac tgcatgtgga gcggcttctc
      661 tgcccgcgag aagctggagc gcgcagtgaa cgagaagctg cagcacggcc acgggccccc
      721 gggagccagc tcatcctgtc cggctccggg agtgggtgcc agtagctccg ggggccgtgc
      781 ccttggtggg tcggcgagtg ctggtcgcac cggggccacc ctgcctaccg acctttccca
      841 cccggctgcg gagtgtgtgg atcccgccgt ggtcttcccc ttcccggtga acaagcgaga
      901 gtcggcttcg gtgcccgctg ccccgaccag tgccccggcg accagcgctg tggtcactag
      961 tgtgtctgtc ccggctgtag ccccggtggc tgctcctgct cgtgcaggcg gtcgtcctgc
     1021 caacagtggc gagcacaagg ccctcagcac ctctggagag gataccttga gcgactcaga
     1081 tgatgaagac gatgaggagg aagatgaaga ggaggagatc gatgtggtca cggtagagaa
     1141 gagacgctcc tcctctaaca acaaggcagt caccactttc accatcactg tacgccccaa
     1201 gacctcggct ctgggcctgg ggcgagcaca acctggcgag ctgatcctca agcgctgtgt
     1261 ccccatccat cagcaacaca actatgccgc accctcaccc tatgtggaga gcgaggatgc
     1321 gccaccacag aagaagatca agagcgaggc ttctccacgc cccctcaaaa gtgtcgttcc
     1381 accaaaggct aagagcttga gcccccgaaa ctcagactcg gaggacagcg agcgccgccg
     1441 aaaccacaac atcctggagc gccagcgccg caacgacctg cgctccagct tcctgacgct
     1501 cagggaccat gtgcccgagc tggtgaagaa cgagaaggcc gccaaggtgg tcatcttaaa
     1561 aaaggccacc gagtacgtcc acgccctaca ggccaacgag caccagctcc tgctggaaaa
     1621 ggagaaactg caggcgaggc agcagcagtt gctaaagaag atcgaacacg ctcggacttg
     1681 ctaaaatgct aaaacgtttc tcacacggac agtcactgcc actttgcaca ttttgatttt
     1741 ttttttttaa acaaacattg tgttgacatt aagaatgttg gtttactttc aaatcggtcc
     1801 cctgtcgagt ttggatctgg gtagggggca ggacgcgggg ttctgccatg accttggaat
     1861 aaaaaaaaaa actgagttta tgggatgctg ggtggcttgt tttcctcctc catatgacct
     1921 ggtgacagcc gtggaagttc gggacactta ggagcttcag gaggctgtga agtcaccgtg
     1981 ttccggtcca agtttccaaa cagagtcatt ccttcttttt acaatggtgc ttaagttcca
     2041 gcaaatgcca cagaaggggg gttgccattt gatgcccctg ggaacgcttg tgtaaatacc
     2101 attgatacac ccgccttttg tatacgtcct gggtaatgag aggtggctct cgggccagta
     2161 ttagactgga agttcacacc taagtactgt aagaatacct caatgtttga ggagcatgtt
     2221 ttgtatacaa atacattgtt aatctgttat gtactgtact aattcctaca cggcctgtat
     2281 actttagtat gatgctgata cataactaaa tttgatactt atattttcgt atgaaaatga
     2341 gttgtggaag ttttgagtag atattacttt atcacttttt gaactaagaa acttttgtaa
     2401 agaaatttta ctatatatat atattccttt tttttttcct agcctgtttc tcttccttgt
     2461 tactgtattt gttcatgttt ggtgcataga actgggtaaa aatggcaaag ttctgtgttt
     2521 aattttcttc aaaatgtgta tatatttagt gctgcacctt agagcacttt gaaatacctc
     2581 atgtttatga aaataaatag caattaaatg
//
