LOCUS       NP_001099525            4749 aa            linear   ROD 14-JAN-2025
DEFINITION  E3 ubiquitin-protein ligase MYCBP2 [Rattus norvegicus].
ACCESSION   NP_001099525 XP_001076799 XP_214245
VERSION     NP_001099525.2
DBSOURCE    REFSEQ: accession NM_001106055.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 4749)
  AUTHORS   AlAbdi,L., Desbois,M., Rusnac,D.V., Sulaiman,R.A., Rosenfeld,J.A.,
            Lalani,S., Murdock,D.R., Burrage,L.C., Billie Au,P.Y., Towner,S.,
            Wilson,W.G., Wong,L., Brunet,T., Strobl-Wildemann,G., Burton,J.E.,
            Hoganson,G., McWalter,K., Begtrup,A., Zarate,Y.A.,
            Christensen,E.L., Opperman,K.J., Giles,A.C., Helaby,R., Kania,A.,
            Zheng,N., Grill,B. and Alkuraya,F.S.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     Loss-of-function variants in MYCBP2 cause neurobehavioural
            phenotypes and corpus callosum defects
  JOURNAL   Brain 146 (4), 1373-1387 (2023)
   PUBMED   36200388
REFERENCE   2  (residues 1 to 4749)
  AUTHORS   Wang,G., Miao,C., Mo,L., Kahlert,U.D., Wu,J., Ou,M., Huang,R.,
            Feng,R., Pang,W. and Shi,W.
  TITLE     MYCBP2 expression correlated with inflammatory cell infiltration
            and prognosis immunotherapy in thyroid cancer patients
  JOURNAL   Front Immunol 13, 1048503 (2022)
   PUBMED   36582246
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 4749)
  AUTHORS   Liang,J., Zhou,W., Sakre,N., DeVecchio,J., Ferrandon,S., Ting,A.H.,
            Bao,S., Bissett,I., Church,J. and Kalady,M.F.
  TITLE     Epigenetically regulated miR-1247 functions as a novel tumour
            suppressor via MYCBP2 in methylator colon cancers
  JOURNAL   Br J Cancer 119 (10), 1267-1277 (2018)
   PUBMED   30318507
REFERENCE   4  (residues 1 to 4749)
  AUTHORS   Pao,K.C., Wood,N.T., Knebel,A., Rafie,K., Stanley,M., Mabbitt,P.D.,
            Sundaramoorthy,R., Hofmann,K., van Aalten,D.M.F. and Virdee,S.
  TITLE     Activity-based E3 ligase profiling uncovers an E3 ligase with
            esterification activity
  JOURNAL   Nature 556 (7701), 381-385 (2018)
   PUBMED   29643511
REFERENCE   5  (residues 1 to 4749)
  AUTHORS   Bento,C.F., Ashkenazi,A., Jimenez-Sanchez,M. and Rubinsztein,D.C.
  TITLE     The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate
            autophagy via a common pathway
  JOURNAL   Nat Commun 7, 11803 (2016)
   PUBMED   27278822
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 4749)
  AUTHORS   Lewcock,J.W., Genoud,N., Lettieri,K. and Pfaff,S.L.
  TITLE     The ubiquitin ligase Phr1 regulates axon outgrowth through
            modulation of microtubule dynamics
  JOURNAL   Neuron 56 (4), 604-620 (2007)
   PUBMED   18031680
REFERENCE   7  (residues 1 to 4749)
  AUTHORS   Bloom,A.J., Miller,B.R., Sanes,J.R. and DiAntonio,A.
  TITLE     The requirement for Phr1 in CNS axon tract formation reveals the
            corticostriatal boundary as a choice point for cortical axons
  JOURNAL   Genes Dev 21 (20), 2593-2606 (2007)
   PUBMED   17901218
REFERENCE   8  (residues 1 to 4749)
  AUTHORS   Etournay,R., El-Amraoui,A., Bahloul,A., Blanchard,S., Roux,I.,
            Pezeron,G., Michalski,N., Daviet,L., Hardelin,J.P., Legrain,P. and
            Petit,C.
  TITLE     PHR1, an integral membrane protein of the inner ear sensory cells,
            directly interacts with myosin 1c and myosin VIIa
  JOURNAL   J Cell Sci 118 (Pt 13), 2891-2899 (2005)
   PUBMED   15976448
REFERENCE   9  (residues 1 to 4749)
  AUTHORS   Murthy,V., Han,S., Beauchamp,R.L., Smith,N., Haddad,L.A., Ito,N.
            and Ramesh,V.
  TITLE     Pam and its ortholog highwire interact with and may negatively
            regulate the TSC1.TSC2 complex
  JOURNAL   J Biol Chem 279 (2), 1351-1358 (2004)
   PUBMED   14559897
  REMARK    GeneRIF: Pam, through its interaction with tuberin, could regulate
            the ubiquitination and proteasomal degradation of the
            tuberin-hamartin complex particularly in the CNS [Mycbp2]
REFERENCE   10 (residues 1 to 4749)
  AUTHORS   Scholich,K., Pierre,S. and Patel,T.B.
  TITLE     Protein associated with Myc (PAM) is a potent inhibitor of adenylyl
            cyclases
  JOURNAL   J Biol Chem 276 (50), 47583-47589 (2001)
   PUBMED   11590159
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Oct 27, 2010 this sequence version replaced NP_001099525.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on computational evidence
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4749
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q21"
     Protein         1..4749
                     /product="E3 ubiquitin-protein ligase MYCBP2"
                     /note="protein associated with Myc; pam, highwire, rpm 1;
                     probable E3 ubiquitin-protein ligase MYCBP2; probable E3
                     ubiquitin-protein ligase MYCBP2-like; MYC binding protein
                     2, E3 ubiquitin protein ligase"
                     /calculated_mol_wt=520726
     Region          <534..717
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..712
                     /region_name="RCC1_2"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam13540"
                     /db_xref="CDD:463914"
     Region          <941..1025
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          1235..1385
                     /region_name="PHR"
                     /note="PHR domain; pfam08005"
                     /db_xref="CDD:462339"
     Region          1723..1880
                     /region_name="PHR"
                     /note="PHR domain; pfam08005"
                     /db_xref="CDD:462339"
     Region          <2392..2443
                     /region_name="IG_FLMN"
                     /note="Filamin-type immunoglobulin domains; smart00557"
                     /db_xref="CDD:214720"
     Region          2475..2537
                     /region_name="SH3_3"
                     /note="Bacterial SH3 domain; pfam08239"
                     /db_xref="CDD:462405"
     Region          3822..>3914
                     /region_name="APC10-like"
                     /note="APC10-like DOC1 domains in E3 ubiquitin ligases
                     that mediate substrate ubiquitination; cl02148"
                     /db_xref="CDD:382862"
     Site            order(3842,3872,3879,3881)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:176488"
     Region          4330..4378
                     /region_name="Bbox2_MYCBP2"
                     /note="B-box-type 2 zinc finger found in Myc-binding
                     protein 2 (MYCBP2) and similar proteins; cd19799"
                     /db_xref="CDD:380857"
     Region          4496..4550
                     /region_name="RING-H2_PHR"
                     /note="RING finger, H2 subclass, found in the PHR
                     (Pam/Highwire/RPM-1) protein family; cd16463"
                     /db_xref="CDD:438126"
     CDS             1..4749
                     /gene="Mycbp2"
                     /gene_synonym="Pam; Phr1"
                     /coded_by="NM_001106055.2:349..14598"
                     /db_xref="GeneID:290447"
                     /db_xref="RGD:1312048"
ORIGIN      
        1 mmmcaatasp aaassgpggd gffaaatiss spapgalfmp vpdgsvaasg lglglpatds
       61 rgqyqlllsg raladryrri yttalsdrdq agsstgypas rnkkilnkkk lkrkqksksk
      121 vktrsksenl entviipdik lhsnpsafni ycnvrhcvle wqkkeaslaa asrnsvqsge
      181 sdsdeeeesr elpiklpkii evglcevfel iketrfshps lclrslqall nvlqgqqpeg
      241 lqseppevle slfqllleit vrstgvndst gqsltalsca clfslvaswg etgrtlqais
      301 ailtnngsha cqtiqvptil nslqrsvqav lvgkiqvqdw fsngikkaal mhkwplkeis
      361 vdeddqcllq ndgfflyllc kdglykigsg ysgtvrghiy nstsrirnrk ekkswlgyaq
      421 gyllyrdvnn hsmtairisp etleqdgtvm lpdchtegqn ilftdgeyin qiaasrddgf
      481 vvrifatste pvlqqelqlk larkclhacg islfdlekdl hiistgfdee sailgagref
      541 almktangki yytgkyqslg ikqggpsagk wvelpitksp kivhfsvghd gshallvaed
      601 gsvfftgsas kgedgesaks rrqskpykpk kiikmegkiv vctacnngss sviskdgely
      661 mfgkdaiysd ssslvsdlkg hfvtqvamgk ahtcvlmkng evwtfgvnnk gqcgrdtgam
      721 nqggkgfgve nmatamdedl eeeldekdek smmcppgmhk wkleqcmvct vcgdctgyga
      781 scvssgrpdr vpggicgcgs gesgcavcgc ckacareldg qearqrgild avkemipldl
      841 llavpvpgvn ieehlqlrqe ekrqrvirrh rledgrgplv fagpifmnhr eqalarlrsh
      901 paqlkhkrdk hkdasgerge kdaskvttyp pgsvrfdcev ravqvscgfh hsvvlmengd
      961 vytfgygqhg qlghgdvnsr gcptlvqalp gpstqvtags nhtavlvmdg qvftfgsfsk
     1021 gqlgrpildv pywnakpapm pnigskygrk atwigasgdq tflrideali nshvlatsei
     1081 faskhiiglv pasisepppf kcllinkvdg scktfndseq edlqgfgvcl dpvydvlwrf
     1141 rpstrelwcy navvadarlp satdmqsscc ilspelalpt gsralttrsh aalhilgcld
     1201 tlaamqdlkm giasieeetq avmkvysked ysivnrfesh gggwgysahs veairfsadt
     1261 dillgglglf ggrgeytaki klfelgpdgg dhetdgdlla etdvlaydca arekyammfd
     1321 epvllqagww yvawarvsgp ssdcgshgqa sittddgvif qfksskksnn gtdvnagqip
     1381 qllyrlptcd gstskgkqqt sepvhilkrs fartvsvecf esllsilhws wttlvlgvee
     1441 lrglkgfqft atlldlerlr fvgtcclrll rvytceiypv savgkavvee tsklaecigk
     1501 trtllrkils egvdhcmvkl dndpqgylsq plsllesvlq echntftacf hsfyptpalq
     1561 waclcdllnc ldqeanfkts ssrllaavms alchtsvklt slfpiaydge vllrsivkqv
     1621 stenestlvh rfpllvghme klsqseenis gmtsfrevle kmlvivvlpv rnslrresel
     1681 fsshlvsntc gllasivsel tasalgsevd glnslhsvka sanrftktsq grswntgngs
     1741 pdaicfavdk pgivvvgfsv yggggiheye levlvddseh sgdsthshrw tslelvkgty
     1801 ttddspsdia eirldkvvpl kenvkyavrl rnygsrtang dggmttvqcp dgvtftfstc
     1861 slssngtnqt rgqipqilyy rsefdgdlqs qlvskaneed kncsralsvv stvvraakdl
     1921 lhralavdad dipellssss lfsmllplii ayigpvaaai pkvavevfgl vqqllpsvav
     1981 lnqkyappaf npnqstdstt gnqpeqglsa cttsnhyavi esehpykpac vmhykvtfpe
     2041 cvrwmtiefd pqcgtaqsed vlrlltpvrt iqnagygakv tsahenlnsw ielkkysgss
     2101 gwptmvlvlp gnealfslet asdyvkddka sfygfkcfai gyefspgpde gviqlekela
     2161 nlggvcaaal mkkdlalpig neleedleil eeaalqvckt hsgilgkgla lshsptilea
     2221 legnlplqiq sneqsflddf iacvpgssgg rlarwlqpds yadpqktsli lnkddircgw
     2281 pttitvqtkd qygdvvhvpn mkvevkavpv sqkktslqqe qvkksqrvpg spaaaaaasc
     2341 ttdmtfggla spkldvsyep mivkearyia itmmkvyeny sfeelrfasp tpkrpsenml
     2401 irvnndgtyc anwtpgaigl ytvhvtidgi eidaglevkv kdppkgmipp gtqlvkpkad
     2461 pqpnkirkfv akdsaglrir shpslqseqi givkvngtit fideihnddg vwlrlneeti
     2521 rkyvpnmngy teawclsfnq hlgksllvpv dnifnasqgv rdldvlswts kaffpqepkt
     2581 ttddffkdvn tccpqeaavr erdhpflrgg pgmykvvktg psghnirscp nlrgipigml
     2641 vlgnkvkavg evtsaegtwv qldknsmvef cesdegeaws lardrggnqy lrhedeqvll
     2701 dqnsqtppps pfsvqafskg ascsaqgfdy glgnnkgdql sailnsiqsr pnlpapsifd
     2761 qaakppsslv hspfvfgqpl sfqqrqlqsd rgtvstssrp vstsakselp sknsrsvkpd
     2821 grvsrttadq kkprgtegls aseslmlksd aaklrsdshs rslspnhntl qtlksdgrvs
     2881 ssfraespgp gsrssspkpk tlptprssps gassprsssp qdknlpqkst apaktkldpp
     2941 rersksdsyt ldpdtlrkkk mplteplrgr stspkpkpvp kdpkgspgse nrapsphvvq
     3001 enlhsevvev ctsstlktng vtdstcddsn dfksvdegsn kvhfsigkap lkdeqemras
     3061 pkisrkcanr htrpkkeksn flfkgdgaks lepakqamsp svaecaravf asflwhegiv
     3121 hdamacssfl kfnpelskeh apirsslnsq ppteekeikl knrhsleiss alnmfnisph
     3181 gpdiskmgsi nknkvlsmlk epplhekced gkseatfems mhhsvksrsp lpltlqhlva
     3241 fwedislati kaasqnmifp spgscavlkk kecekenkkt kkekkkkekt eirprgnlfg
     3301 emaqlavggp ekdticelcg eshpypvtyh mrqahpgcgr yaggqgynsi ghfcggwagn
     3361 cgdggmggst wylvcdrcre kylrekqaaa rekvkqsrrk pmqvktpral ptmeahqvik
     3421 analfllsls saaepsilcy hpakpfqsql pivkegvsea lpvkmpclyl qtlarhhhen
     3481 fvgyqddnlf qdemrylrst svpapyisvt pdaspnvfee pesnmksmpp sletspitdt
     3541 dlakrtvfqr sysvvaseyd kqhsilparv kaiprrrvns gdtvgssllr hpspelsrli
     3601 sahsslskge rnfqwpvlaf viqhhdlegl eiamkqalrk sacrvfamea fnwllcnviq
     3661 ttslhdilwh fvaaltpspv eaeedededn ksskenaeqe kdtrvcehpl sdiviageaa
     3721 hplphtfhrl lqtisdlmms lpsgsslqqm alrcwslkfk qsdhqflhqs nvfhhinnil
     3781 sksddgdsee sfsisiqsgf eamnqelciv mclkdltsiv diktssrpam igsltdgste
     3841 tfwesgdedk nktktitinc vkginaryvs vhvdnsrdlg nkvtsmtflt gkavedlcri
     3901 kqvdldsrhi gwvtselpgg dnhiikielk gpentlrvrq vkvlgwkdge stkiagqisa
     3961 svaqqrscea etlrvfrlit sqvfgklisg daeptpeqee kallsspege ekatsdadlk
     4021 ehmvgiifsr skltnlqkqv cahivqairm eatrvreewe haisskenan sqpsdedass
     4081 daycfellsm vlalsgsnvg rqylaqqltl lqdlcsllht asprvqrqvt sllrrvlpev
     4141 tpnrlasiig vkslppadis diihstekgd wnklgildmf lgciakaltv qlkakgttit
     4201 gtagttvgkg vttvtlpmif nssylrrges hwwmkgstpt qiseiiikli kdmaaghlse
     4261 awsrvtknai aetiialtkm eeefrspvrc iattrlwlal aslcvldqdh vdrlssgrwm
     4321 gkdgqqkqmp mcdnhddget aaiilcnicg nlctdcdrfl hlhrrtkthq rqvfkeeeea
     4381 ikvdlhegcg rtklfwlmal adsktmkamv efrehtgkpt tssseacrfc gsrsgtelsa
     4441 vgsvcsdadc qeyakiacsk thpcghpcgg vrneehclpc lhgcdknatt lkqdaddmcm
     4501 icftealsaa paiqldcshv fhlqccrrvl enrwlgprit fgfiscpick nkinhivlkd
     4561 lldpikelye dvrrkalmrl eyeglhksea ittpgvrfyn dpagyamnry ayyvcykcrk
     4621 ayfggearcd aeagqgddyd prelicgacs dvsraqmcpk hgtdfleykc ryccsvavff
     4681 cfgtthfcna chddfqrmts ipkeelphcp agpkgkqleg tecplhvvhp ptgeefalgc
     4741 gvcrnahtf
//
