LOCUS       NM_012603               2355 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus MYC proto-oncogene, bHLH transcription factor
            (Myc), mRNA.
ACCESSION   NM_012603
VERSION     NM_012603.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2355)
  AUTHORS   Katz,L.S., Brill,G., Wang,P., Lambertini,L., Zhang,P.,
            Haldeman,J.M., Liu,H., Newgard,C.B., Stewart,A.F., Garcia-Ocana,A.
            and Scott,D.K.
  TITLE     Transcriptional activation of the Myc gene by glucose in beta-cells
            requires a ChREBP-dependent 3-D chromatin interaction between the
            Myc and Pvt1 genes
  JOURNAL   Mol Metab 79, 101848 (2024)
   PUBMED   38042369
  REMARK    GeneRIF: Transcriptional activation of the Myc gene by glucose in
            beta-cells requires a ChREBP-dependent 3-D chromatin interaction
            between the Myc and Pvt1 genes.
REFERENCE   2  (bases 1 to 2355)
  AUTHORS   Yang,Y., Wang,Z., Xu,Y., Liu,X., Sun,Y. and Li,W.
  TITLE     Knockdown of lncRNA H19 alleviates ox-LDL-induced HCAECs
            inflammation and injury by mediating miR-20a-5p/HDAC4 axis
  JOURNAL   Inflamm Res 71 (9), 1109-1121 (2022)
   PUBMED   35854140
  REMARK    Erratum:[Inflamm Res. 2023 Apr;72(4):893. doi:
            10.1007/s00011-023-01701-7. PMID: 36806965]
REFERENCE   3  (bases 1 to 2355)
  AUTHORS   Wu,Z., Cheng,S., Wang,S., Li,W. and Liu,J.
  TITLE     C-MYC ameliorates ventricular remodeling of myocardial infarction
            rats via binding to the promoter of microRNA-29a-3p to facilitate
            TET2 expression
  JOURNAL   Int J Cardiol 357, 105-112 (2022)
   PUBMED   35016888
  REMARK    GeneRIF: C-MYC ameliorates ventricular remodeling of myocardial
            infarction rats via binding to the promoter of microRNA-29a-3p to
            facilitate TET2 expression.
REFERENCE   4  (bases 1 to 2355)
  AUTHORS   Ilyas,S., Simanullang,R.H., Hutahaean,S., Rosidah,R. and
            Situmorang,P.C.
  TITLE     Correlation of Myc Expression with Wee1 Expression by Zanthoxylum
            acanthopodium in Cervical Carcinoma Histology
  JOURNAL   Pak J Biol Sci 25 (11), 1014-1020 (2022)
   PUBMED   36591933
  REMARK    GeneRIF: Correlation of Myc Expression with Wee1 Expression by
            Zanthoxylum acanthopodium in Cervical Carcinoma Histology.
REFERENCE   5  (bases 1 to 2355)
  AUTHORS   Shin,H.Y., Kwon,M.J., Lee,E.M., Kim,K., Oh,Y.J., Kim,H.S.,
            Hwang,D.H. and Kim,B.G.
  TITLE     Role of Myc Proto-Oncogene as a Transcriptional Hub to Regulate the
            Expression of Regeneration-Associated Genes following
            Preconditioning Peripheral Nerve Injury
  JOURNAL   J Neurosci 41 (3), 446-460 (2021)
   PUBMED   33262248
  REMARK    GeneRIF: Role of Myc Proto-Oncogene as a Transcriptional Hub to
            Regulate the Expression of Regeneration-Associated Genes following
            Preconditioning Peripheral Nerve Injury.
REFERENCE   6  (bases 1 to 2355)
  AUTHORS   Morimura,S., Kato,K., Tashiro,F. and Ueno,Y.
  TITLE     Modulation of c-myc gene expression by extracellular stimuli in rat
            hepatoma cells
  JOURNAL   Jpn J Exp Med 60 (2), 51-56 (1990)
   PUBMED   2200903
REFERENCE   7  (bases 1 to 2355)
  AUTHORS   Steffen,D.L. and Nacar,E.Q.
  TITLE     Nucleotide sequence of the first exon of the rat c-myc gene:
            proviral insertions in murine leukemia virus-induced lymphomas do
            not affect exon 1
  JOURNAL   Virology 164 (1), 55-63 (1988)
   PUBMED   3284178
REFERENCE   8  (bases 1 to 2355)
  AUTHORS   Hayashi,K., Makino,R., Kawamura,H., Arisawa,A. and Yoneda,K.
  TITLE     Characterization of rat c-myc and adjacent regions
  JOURNAL   Nucleic Acids Res 15 (16), 6419-6436 (1987)
   PUBMED   3306601
REFERENCE   9  (bases 1 to 2355)
  AUTHORS   Leibovitch,S.A., Leibovitch,M.P., Guillier,M., Hillion,J. and
            Harel,J.
  TITLE     Differential expression of protooncogenes related to transformation
            and cancer progression in rat myoblasts
  JOURNAL   Cancer Res 46 (8), 4097-4103 (1986)
   PUBMED   2425941
REFERENCE   10 (bases 1 to 2355)
  AUTHORS   Kerckaert,J.P., Bayard,B., Debray,H., Sautiere,P. and Biserte,G.
  TITLE     Rat alpha-fetoprotein heterogeneity. Comparative chemical study of
            the two electrophoretic variants and their Ricinus lectin-binding
            properties
  JOURNAL   Biochim Biophys Acta 493 (2), 293-303 (1977)
   PUBMED   70227
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY679730.1.
            
            On Aug 23, 2004 this sequence version replaced NM_012603.1.
            
            Summary: The protein encoded by this gene is a multifunctional,
            nuclear phosphoprotein that plays a role in cell cycle progression,
            apoptosis and cellular transformation. It functions as a
            transcription factor that regulates transcription of specific
            target genes. Mutations, overexpression, rearrangement and
            translocation of this gene have been associated with a variety of
            hematopoietic tumors, leukemias and lymphomas, including Burkitt
            lymphoma, in human. There is evidence to show that alternative
            translation initiations from an upstream, in-frame non-AUG (CUG)
            and a downstream AUG start site result in the production of two
            isoforms with distinct N-termini, in human and mouse. Rat mRNA also
            has a similarly placed CUG upstream of the AUG start site,
            suggesting that it may also produce two Myc proteins. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY679730.1, BC091699.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132265
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: inferred from conservation
            RefSeq Select criteria   :: based on single protein-coding
                                        transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2355              AY679730.1         1-2355
FEATURES             Location/Qualifiers
     source          1..2355
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     gene            1..2355
                     /gene="Myc"
                     /gene_synonym="c-myc; mMyc; RNCMYC"
                     /note="MYC proto-oncogene, bHLH transcription factor"
                     /db_xref="GeneID:24577"
                     /db_xref="RGD:3130"
     exon            1..566
                     /gene="Myc"
                     /gene_synonym="c-myc; mMyc; RNCMYC"
                     /inference="alignment:Splign:2.1.0"
     CDS             537..1898
                     /gene="Myc"
                     /gene_synonym="c-myc; mMyc; RNCMYC"
                     /note="non-AUG (CUG) translation initiation codon;
                     transcription factor p64; proto-oncogene c-Myc;
                     myelocytomatosis viral oncogene homolog; Avian
                     myelocytomatosis viral (v-myc) oncogene homolog; v-myc
                     avian myelocytomatosis viral oncogene homolog;
                     myelocytomatosis oncogene"
                     /codon_start=1
                     /product="myc proto-oncogene protein"
                     /protein_id="NP_036735.2"
                     /db_xref="GeneID:24577"
                     /db_xref="RGD:3130"
                     /translation="MNFLWEVENPTVTTMPLNVSFANRNYDLDYDSVQPYFICDEEEN
                     FYHQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVATSFSPREDDD
                     GGGGNFSTADQLEMMTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLV
                     SEKLASYQAARKDSTSLSPARGHSVCSTSSLYLQDLTAAASECIDPSVVFPYPLNDSS
                     SPKSCTSSDSTAFSSSSDSLLSSESSPRATPEPLVLHEETPPTTSSDSEEEQDDEEEI
                     DVVSVEKRQPPAKRSESGSSPSRGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYP
                     AAKRAKLDSGRVLKQISNNRKCSSPRSSDTEENDKRRTHNVLERQRRNELKRSFFALR
                     DQIPELENNEKAPKVVILKKATAYILSVQADEHKLISEKDLLRKRREQLKHKLEQLRN
                     SGA"
     exon            567..1335
                     /gene="Myc"
                     /gene_synonym="c-myc; mMyc; RNCMYC"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..2342
                     /gene="Myc"
                     /gene_synonym="c-myc; mMyc; RNCMYC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2183..2188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myc"
                     /gene_synonym="c-myc; mMyc; RNCMYC"
     regulatory      2301..2306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Myc"
                     /gene_synonym="c-myc; mMyc; RNCMYC"
     polyA_site      2342
                     /gene="Myc"
                     /gene_synonym="c-myc; mMyc; RNCMYC"
                     /experiment="experimental evidence, no additional details
                     recorded"
ORIGIN      
        1 acccccgggc tgcgctgctc tccgctgccg cctccgccgc gcccactccg ctcgcctcct
       61 gcctccaaaa gggcagggct tcgccgaggc ttggcgggaa aaagaagcga ggggagggat
      121 ccggagtcgc agtataaaag aagcttttcg ggcgtttttt ttctgactcg ctgtagtaat
      181 tccagcgaga gacagaggga gtgagcgggc gggttggaag agcccagtgt gcagagcccc
      241 actccgggct tcctaggaag gcagctctgg agtgagaagg gctttgcctc caggcttgct
      301 gcctcctcga cccaatcctc ccgctgaccc aacatcagcg gtcgcaaccc tcgccgcctc
      361 tgggaaactt tgcccattgc aacgggcaga cacttctcac tggaacttac aatctgcgag
      421 ccaggacagg actccccagg cgcaggggag ggaatttttg tctatttggg gacagtgttc
      481 tctgcctctg cccgcgatcg gctcccctga aaagagctcc tcgcgttatt tgaagcctga
      541 atttcctttg ggaggtggaa aacccgacag tcacgacgat gcccctcaac gtgagcttcg
      601 ctaacaggaa ctatgacctc gactacgact cggtgcagcc ctatttcatc tgcgacgagg
      661 aagagaattt ctatcaccag caacagcaga gcgagctgca gccgcccgca cccagtgagg
      721 atatctggaa gaaattcgag ctgctgccca ccccgcccct gtcccccagc cgccgctccg
      781 ggctctgctc tccgtcctat gttgcggtcg ctacgtcctt ctccccaagg gaggacgatg
      841 acggtggcgg tggcaacttc tccaccgccg atcagctgga gatgatgacc gagctacttg
      901 gaggagacat ggtgaatcag agcttcatct gcgatcctga cgatgagacc ttcatcaaga
      961 acatcatcat ccaggactgt atgtggagcg gcttctcggc cgctgccaaa ctggtctccg
     1021 agaagctggc ctcttaccag gctgcgcgca aagacagcac cagcctgagc cccgcccgcg
     1081 ggcacagcgt ctgctccacc tccagcctgt acctgcagga cctcaccgcc gcagcgtccg
     1141 agtgcatcga cccctcagtg gtcttcccct acccgctcaa cgacagcagc tcgcccaaat
     1201 cctgtacctc gtccgattcc acggccttct cttcttcctc ggactcgctg ctgtcctccg
     1261 agtcctcccc acgggccacc cctgagcccc tagtgctgca tgaagagaca ccgcccacca
     1321 ccagcagcga ctctgaagaa gaacaagatg atgaggaaga aattgatgtg gtgtctgtgg
     1381 aaaagaggca accccctgcc aagaggtccg agtcagggtc atccccatca agaggccaca
     1441 gcaaacctcc acacagccca ctggtcctca agaggtgcca tgtctctact caccagcaca
     1501 attatgcagc acccccctcc acaaggaagg actatccagc tgccaagagg gccaagttgg
     1561 acagtggcag ggtcctgaaa cagatcagca acaaccgcaa atgctccagc cccaggtcct
     1621 cagacaccga ggaaaacgac aagaggcgga cacacaacgt cttggaacgt cagaggagaa
     1681 acgagctgaa gcgtagcttt tttgccctgc gcgaccagat ccctgagttg gaaaacaacg
     1741 aaaaggcccc caaggtagtt atcctcaaaa aagccaccgc ctacatcctg tccgttcaag
     1801 cagatgagca caaactcatc tcagaaaagg acttactgag gaaacggcga gaacagttga
     1861 aacacaaact cgaacagctt cgaaactctg gtgcataaac tgaccggaag tgaggaggag
     1921 ctggaatctc gagtgtaagg agaacggttc cttctgacag aacttggact tcaaaaaatg
     1981 catgctcaaa gcctaacctc acaaccttgg ctggggcttt gggacttcag ccataatgtt
     2041 aactgcctca aagttaaggc ataaaagaac ttttttttat gcttcccatc ttctttcttt
     2101 ttcctttaac agatttgtat ttaattgttt tttttaaaaa aatcttccgg tgtacatagg
     2161 gcctttaaat gtaaataact ttaataaaac gtttataaca gttatacaag attttaagac
     2221 atgtatgata aaccataatt ttttttattt aaagaccttt tcatttttaa agttgatttt
     2281 tttctattgt ttttagaaaa aataaaataa ttggaaaaaa tataattgag ccaactctta
     2341 aaaaaaaaaa aaaaa
//
