LOCUS       NM_031813               1856 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus myosin binding protein H (Mybph), mRNA.
ACCESSION   NM_031813
VERSION     NM_031813.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1856)
  AUTHORS   Zhu,T., He,Y., Yang,J., Fu,W., Xu,X. and Si,Y.
  TITLE     MYBPH inhibits vascular smooth muscle cell migration and attenuates
            neointimal hyperplasia in a rat carotid balloon-injury model
  JOURNAL   Exp Cell Res 359 (1), 154-162 (2017)
   PUBMED   28800959
  REMARK    GeneRIF: PDGF-induced VSMC migration was inhibited by
            adenovirus-mediated expression of MYBPH whereas it was enhanced by
            small interfering RNA knockdown of MYBPH.
REFERENCE   2  (bases 1 to 1856)
  AUTHORS   Mouton,J., Loos,B., Moolman-Smook,J.C. and Kinnear,C.J.
  TITLE     Ascribing novel functions to the sarcomeric protein, myosin binding
            protein H (MyBPH) in cardiac sarcomere contraction
  JOURNAL   Exp Cell Res 331 (2), 338-351 (2015)
   PUBMED   25449695
  REMARK    GeneRIF: This study provides evidence for a potential role of MyBPH
            in hypertrophic cardiomyopathy.
REFERENCE   3  (bases 1 to 1856)
  AUTHORS   Flister,M.J., Hoffman,M.J., Reddy,P., Jacob,H.J. and Moreno,C.
  TITLE     Congenic mapping and sequence analysis of the Renin locus
  JOURNAL   Hypertension 61 (4), 850-856 (2013)
   PUBMED   23460292
REFERENCE   4  (bases 1 to 1856)
  AUTHORS   Jung,J., Oh,J. and Lee,K.
  TITLE     Nucleotide and deduced amino acid sequences of rat myosin binding
            protein H (MyBP-H)
  JOURNAL   Arch Pharm Res 21 (6), 712-717 (1998)
   PUBMED   9868543
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 25, 2020 this sequence version replaced NM_031813.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF077338.1, SRR26643295.46471.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-292               JAXUCZ010000013.1  48205269-48205560
            293-427             JAXUCZ010000013.1  48205648-48205782
            428-595             JAXUCZ010000013.1  48206447-48206614
            596-684             JAXUCZ010000013.1  48208811-48208899
            685-880             JAXUCZ010000013.1  48209196-48209391
            881-1020            JAXUCZ010000013.1  48209558-48209697
            1021-1180           JAXUCZ010000013.1  48210184-48210343
            1181-1317           JAXUCZ010000013.1  48211411-48211547
            1318-1504           JAXUCZ010000013.1  48211660-48211846
            1505-1557           JAXUCZ010000013.1  48212074-48212126
            1558-1856           JAXUCZ010000013.1  48212630-48212928
FEATURES             Location/Qualifiers
     source          1..1856
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..1856
                     /gene="Mybph"
                     /note="myosin binding protein H"
                     /db_xref="GeneID:83708"
                     /db_xref="RGD:620287"
     exon            1..292
                     /gene="Mybph"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1521
                     /gene="Mybph"
                     /note="myBP-H; H-protein; norvegicus myosin binding
                     protein H"
                     /codon_start=1
                     /product="myosin-binding protein H"
                     /protein_id="NP_114001.2"
                     /db_xref="GeneID:83708"
                     /db_xref="RGD:620287"
                     /translation="MTGKATPEASVSTSEGTAPEPAKVPTPEPSGQVAASESTGQEQA
                     PEPQKQPQAQDPAAHEAPATPATIKPEAPSEDVPSAPLQLTLEDVSHSSLTVSWEPPE
                     NLGKLGLQGYVLELCREGASEWVPVNPRPVMVTQQTVRNLALGDKFFLRVTAVNSAGA
                     GPPAVLDQPVHIQEITEAPKIRVPRHLRQTYIRQVGESVNLQIPFQGKPKPQASWTHN
                     GHALDSQRVNVRSGDQDSILFIRSAQRSDSGRYELTVRLEGLEAKAAIDILVIEKPGP
                     PSSIKLLDVWGCNAALEWMPPQDTGNTELLGYTVQKADKKTGQWFTVLERYHPTTCTV
                     SDLIIGNSYSFRVFSENLCGLSDLATTTKELAHIHKAAITAKPREFTERDFSEAPSFT
                     QPLADRTSTPGYSTQLFCSVRASPKPKIIWMKNKMSIQGDPKYRAVSEQGVCTLEIRK
                     PSPFDSGVYTCKAINVLGEASVDCRLEVKASATH"
     exon            293..427
                     /gene="Mybph"
                     /inference="alignment:Splign:2.1.0"
     exon            428..595
                     /gene="Mybph"
                     /inference="alignment:Splign:2.1.0"
     exon            596..684
                     /gene="Mybph"
                     /inference="alignment:Splign:2.1.0"
     exon            685..880
                     /gene="Mybph"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1020
                     /gene="Mybph"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1180
                     /gene="Mybph"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1317
                     /gene="Mybph"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1504
                     /gene="Mybph"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1557
                     /gene="Mybph"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1856
                     /gene="Mybph"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacctcccg ctgaccctta aacactccac cttgaacccc caccacacac atacaccagc
       61 tcagaaatga caggaaaagc cacccctgag gcttctgtct ctacttcaga ggggacagca
      121 cctgagcctg ccaaggtgcc cactccagag ccttctggac aggtggcagc atcagagtcc
      181 acggggcaag agcaggctcc agagccacag aagcagcctc aggcacagga ccctgcagcc
      241 cacgaagctc ccgccacacc tgccaccatt aagcctgaag ctccgagcga agatgtcccc
      301 agtgccccac tgcagctgac cttggaggat gtgagccaca gctccttgac tgtgagctgg
      361 gagcctccgg agaacctggg gaagctgggg ctccagggct atgtgttgga gctctgtcga
      421 gagggagcct cagaatgggt acctgtgaat ccccggcccg tgatggtgac ccagcagaca
      481 gttcgaaacc tggctctggg agacaagttc ttcctgcgcg tgactgcagt aaactccgca
      541 ggggcgggcc ctccagctgt gctagaccag cctgtccaca tccaggagat cacagaagcc
      601 cccaagatcc gtgttccccg acaccttcgt cagacctata tccgccaggt gggagagtct
      661 gtcaacttgc aaatcccctt ccaggggaag cccaagccgc aggcctcttg gacccacaat
      721 ggccacgccc tggacagcca gagagttaat gtgcgcagtg gggaccagga ctccatcctc
      781 ttcattcgct cagctcagcg ctcagactca ggccgctatg agctcactgt ccgtctggaa
      841 ggcttggaag ccaaggccgc cattgacatc ctggtgatcg agaagcccgg ccccccgagt
      901 agcatcaagc tattggatgt ctggggttgc aatgctgccc ttgagtggat gccaccccag
      961 gacacgggaa acacagagct cctgggctac acagtgcaga aggcagacaa aaagacaggg
     1021 caatggttca cagtgttgga gcgataccac cccaccacct gcaccgtctc agacctcatc
     1081 attggcaact cgtactcttt tcgggtcttc tcagaaaacc tgtgtggcct cagtgactta
     1141 gccaccacca ccaaggagct ggctcacatc cacaaggcag ctatcactgc caaacctaga
     1201 gagtttactg agcgagactt ctcagaagcg ccctccttca cccagccgct ggctgaccgt
     1261 acctccactc ctggctatag cacgcagctt ttctgcagcg tccgagcgtc acctaagccc
     1321 aagatcatct ggatgaaaaa caagatgagt atccaggggg accccaagta tcgtgctgtc
     1381 tccgagcaag gggtctgcac cctggagatc cggaagccca gcccttttga ttctggggtc
     1441 tacacttgca aggccatcaa cgtgctagga gaggcctccg tggattgtcg gttggaggtt
     1501 aaagcctctg ccacacactg aagaccaaca caggcagaga ctgggacaag gagacagctt
     1561 ggtcacatac caggacgcag acggacattc tctgccaggt cctgcagacc tgaggatcag
     1621 gcgcccaggc atccccaaga ccaagatacc acaagaacag ctaatggggg tgaacctcca
     1681 gaacctgctg gctctctcca ccagaggttg ggtccagacc caggagtggg cctggcgggc
     1741 cccaggtcat acctcctggg tatgagaggg ccccaagggt gcagagactg gcacccctct
     1801 gcagaattgt acactgtgtg agaagcattc aaataaaggt gtgtggtgtt atagca
//
