LOCUS       NM_001106490            4165 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus myosin binding protein C3 (Mybpc3), mRNA.
ACCESSION   NM_001106490 XM_001078025 XM_215771
VERSION     NM_001106490.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4165)
  AUTHORS   Ponnam,S., Sevrieva,I., Sun,Y.B., Irving,M. and Kampourakis,T.
  TITLE     Site-specific phosphorylation of myosin binding protein-C
            coordinates thin and thick filament activation in cardiac muscle
  JOURNAL   Proc Natl Acad Sci U S A 116 (31), 15485-15494 (2019)
   PUBMED   31308242
  REMARK    GeneRIF: cMyBP-C acts as a sarcomeric integrator of multiple
            signaling pathways that determines downstream physiological
            function.
REFERENCE   2  (bases 1 to 4165)
  AUTHORS   Kampourakis,T., Ponnam,S., Sun,Y.B., Sevrieva,I. and Irving,M.
  TITLE     Structural and functional effects of myosin-binding protein-C
            phosphorylation in heart muscle are not mimicked by
            serine-to-aspartate substitutions
  JOURNAL   J Biol Chem 293 (37), 14270-14275 (2018)
   PUBMED   30082313
  REMARK    GeneRIF: Both tris-phosphorylation and Ser-Asp substitutions
            abolished the interaction between C1mC2 and myosin sub-fragment 2
            (myosin S2) in vitro, but yielded different effects on thin
            filament binding.
REFERENCE   3  (bases 1 to 4165)
  AUTHORS   Smyrnias,I., Goodwin,N., Wachten,D., Skogestad,J., Aronsen,J.M.,
            Robinson,E.L., Demydenko,K., Segonds-Pichon,A., Oxley,D.,
            Sadayappan,S., Sipido,K., Bootman,M.D. and Roderick,H.L.
  TITLE     Contractile responses to endothelin-1 are regulated by PKC
            phosphorylation of cardiac myosin binding protein-C in rat
            ventricular myocytes
  JOURNAL   J Mol Cell Cardiol 117, 1-18 (2018)
   PUBMED   29470978
  REMARK    GeneRIF: Serine 302 in cardiac myosin binding protein-C was
            identified as a PKCepsilon substrate that when phosphorylated
            contributed to the suppression of contraction and Ca(2+) transients
            by PKCepsilon following ET-1 stimulation.
REFERENCE   4  (bases 1 to 4165)
  AUTHORS   Toepfer,C.N., Sikkel,M.B., Caorsi,V., Vydyanath,A., Torre,I.,
            Copeland,O., Lyon,A.R., Marston,S.B., Luther,P.K., Macleod,K.T.,
            West,T.G. and Ferenczi,M.A.
  TITLE     A post-MI power struggle: adaptations in cardiac power occur at the
            sarcomere level alongside MyBP-C and RLC phosphorylation
  JOURNAL   Am J Physiol Heart Circ Physiol 311 (2), H465-H475 (2016)
   PUBMED   27233767
  REMARK    GeneRIF: Phosphorylation of myosin regulatory light chain (RLC)
            increased and remained elevated post-MI, while phosphorylation of
            myosin binding protein-C (MyBP-C) was initially depressed but then
            increased as the hearts became decompensated.
REFERENCE   5  (bases 1 to 4165)
  AUTHORS   Wijnker,P.J., Li,Y., Zhang,P., Foster,D.B., dos Remedios,C., Van
            Eyk,J.E., Stienen,G.J., Murphy,A.M. and van der Velden,J.
  TITLE     A novel phosphorylation site, Serine 199, in the C-terminus of
            cardiac troponin I regulates calcium sensitivity and susceptibility
            to calpain-induced proteolysis
  JOURNAL   J Mol Cell Cardiol 82, 93-103 (2015)
   PUBMED   25771144
REFERENCE   6  (bases 1 to 4165)
  AUTHORS   Niimura,H., Bachinski,L.L., Sangwatanaroj,S., Watkins,H.,
            Chudley,A.E., McKenna,W., Kristinsson,A., Roberts,R., Sole,M.,
            Maron,B.J., Seidman,J.G. and Seidman,C.E.
  TITLE     Mutations in the gene for cardiac myosin-binding protein C and
            late-onset familial hypertrophic cardiomyopathy
  JOURNAL   N Engl J Med 338 (18), 1248-1257 (1998)
   PUBMED   9562578
REFERENCE   7  (bases 1 to 4165)
  AUTHORS   Carrier,L., Bonne,G., Bahrend,E., Yu,B., Richard,P., Niel,F.,
            Hainque,B., Cruaud,C., Gary,F., Labeit,S., Bouhour,J.B.,
            Dubourg,O., Desnos,M., Hagege,A.A., Trent,R.J., Komajda,M.,
            Fiszman,M. and Schwartz,K.
  TITLE     Organization and sequence of human cardiac myosin binding protein C
            gene (MYBPC3) and identification of mutations predicted to produce
            truncated proteins in familial hypertrophic cardiomyopathy
  JOURNAL   Circ Res 80 (3), 427-434 (1997)
   PUBMED   9048664
REFERENCE   8  (bases 1 to 4165)
  AUTHORS   Weisberg,A. and Winegrad,S.
  TITLE     Alteration of myosin cross bridges by phosphorylation of
            myosin-binding protein C in cardiac muscle
  JOURNAL   Proc Natl Acad Sci U S A 93 (17), 8999-9003 (1996)
   PUBMED   8799143
REFERENCE   9  (bases 1 to 4165)
  AUTHORS   Schiaffino,S. and Reggiani,C.
  TITLE     Molecular diversity of myofibrillar proteins: gene regulation and
            functional significance
  JOURNAL   Physiol Rev 76 (2), 371-423 (1996)
   PUBMED   8618961
  REMARK    Review article
REFERENCE   10 (bases 1 to 4165)
  AUTHORS   Watkins,H., Conner,D., Thierfelder,L., Jarcho,J.A., MacRae,C.,
            McKenna,W.J., Maron,B.J., Seidman,J.G. and Seidman,C.E.
  TITLE     Mutations in the cardiac myosin binding protein-C gene on
            chromosome 11 cause familial hypertrophic cardiomyopathy
  JOURNAL   Nat Genet 11 (4), 434-437 (1995)
   PUBMED   7493025
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_215771.4, XM_001078025.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN11044071, SAMN16676784
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4165
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..4165
                     /gene="Mybpc3"
                     /note="myosin binding protein C3"
                     /db_xref="GeneID:295929"
                     /db_xref="RGD:1305950"
     exon            1..55
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..3855
                     /gene="Mybpc3"
                     /note="cardiac MyBP-C; myosin binding protein C, cardiac"
                     /codon_start=1
                     /product="myosin-binding protein C, cardiac-type"
                     /protein_id="NP_001099960.1"
                     /db_xref="GeneID:295929"
                     /db_xref="RGD:1305950"
                     /translation="MPEPGKRPVSAFTKKPRSVEVTAGSAAVFEAETERSGLKVQWQR
                     DGSDIAANDKYGLAAEGKRHTLTVRDVGPDDQGSYAVIAGSSKVKFDLKVTEPAPPEK
                     AESAVAPTSMEAPETPKEVPALATQLEGNVSSPEGSVSVTQDGSVAGSQGAPDDPIGL
                     FLMRPQDGEVTVGGSIVFSARVAGASLLKPPVVKWFKGKWVDLSSKVGQHLQLHDSYD
                     RASKVYLFELHITDAQATSAGGYRCEVSTKDKFDSCNFNLTVHEAIGSGDLDLRSAFR
                     RTSLAGTGRRTSDSHEDAGTLDFSSLLKKSSFRRDSKLEAPAEEDVWEILRQAPPSEY
                     ERIAFQHGVTDLRGMLKRLKGMKHDEKKSTAFQKKLEPAYQVNKGHKIRLTVELADPD
                     AEVKWLKNGQEIQMSGRYIFESIGAKRTLTISQCSLADDAAYQCVVGGEKCSTELFVK
                     EPPVLITRSLEDQLVMVGQRVEFECEVSEEGAQVKWLKDGVELTREETFKYRFKKDGR
                     KHHLIINEATLEDAGHYAVRTSGGQALAELIVQEKKLEVYQSIADLAVGAKDQAVFKC
                     EVSDENVRGVWLKNGKELVPDNRIKVSHIGRVHKLTIDDVTPADEADYSFVPEGFACN
                     LSAKLHFMEVKIDFVPRQEPPKIHLDCPGSTPDTIVVVAGNKLRLDVPISGDPAPTVI
                     WQKTITQGKKASAGPPPGAPEDAGADEEWVFDKKLLCETEGRVRVETTKDRSVFTVEG
                     AEKEDEGVYTVTVKNPVGEDQVNLTVKVIDVPDAPAAPKISNVGEDSCIVQWEPPAYD
                     GGQPVLGYILERKKKKSYRWMRLNFDLLRELSHEARRMIEGVAYEMRVYAVNAVGMSR
                     PSPASQPFMPIGPPGEPTHLTVEDVSDTTVSLKWRPPERVGAGGLDGYSVEYCQEGCS
                     EWVTALQGLTERTSLLVKDLPTGARLLFRVRAHNVAGPGGPIITKEPVTVQEILQRPR
                     LQLPRHLRQTIQKKVGEPVNLLIPFQGKPRPQVTWTKEGQPLAGEEVSIRNSPTDTIL
                     FIRAAHRTHSGTYQVTVRIENMEDKATLVLQIVDKPSPPLDIRVVETWGFSVALEWKP
                     PQDDGNTEIWGYTVQKADKKTMEWFTVLEHYRQTHCVVSELIIGNGYYFRVFSHNMVG
                     SSDRAAATKEPIFIPRPGITYEPPKYKALDFSEAPSFTQPLTNRSIIAGYNAILCCAV
                     RGSPKPKISWFKNGLDLGEDARFRMFCKQGVLTLEIRKPCPYDGGVYVCRATNLQGEA
                     QCECRLEVRVPQ"
     exon            56..322
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            323..439
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            440..547
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            548..696
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            697..814
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            815..863
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            864..893
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            894..947
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            948..959
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1123
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1256
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1381
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1487
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1654
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1820
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1927
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..1957
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2097
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2178
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2338
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2443
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2632
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2767
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2935
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2936..3024
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..3220
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3221..3360
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3361..3520
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3521..3657
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3658..3844
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3845..3882
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3883..4165
                     /gene="Mybpc3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcttggtgc gccgtgtgac tgttctcaag atgcctgagc cagggaagag accagtgtca
       61 gccttcacca agaagcccag gtcagtggag gtgaccgcag gcagtgctgc tgtgttcgag
      121 gctgagacgg agcggtcagg cctgaaggtg cagtggcagc gggatggcag tgatatcgct
      181 gccaatgaca agtatggttt ggcagcagag ggcaaacgac acacactgac agtgcgggat
      241 gtgggccctg acgatcaggg ttcctatgcg gtcatcgcag gctcctcaaa ggtcaagttt
      301 gaccttaagg tcacagagcc agcccctcca gagaaggcag agtctgcagt tgctccaacc
      361 tctatggaag ctccagaaac tcccaaagaa gttcctgctc tagccactca gttggaagga
      421 aatgtctcaa gtcctgaagg gtcagtctcg gtaacccagg atggctcagt cgcagggagt
      481 cagggagccc ctgacgaccc tattggcctc tttctgatgc ggccacagga tggcgaggtg
      541 accgtgggcg gcagcatcgt cttctcagcc cgagtggcgg gagccagcct cctgaaaccg
      601 cctgtagtca agtggtttaa gggcaagtgg gtggacctga gcagcaaggt gggccagcac
      661 ctgcagctgc acgacagcta cgacagagcc agcaaggtct acttgtttga gttgcacatc
      721 acagatgcgc aggccacttc tgctgggggc taccgctgtg aggtgtctac caaggacaaa
      781 tttgacagct gcaacttcaa cctcactgta catgaggcca ttggttctgg agacctggac
      841 ctcagatcag ctttccgacg cacgagcctg gctggaacgg gtcggagaac cagtgacagc
      901 catgaagatg ctgggactct ggactttagc tccctgctga agaagagcag tttccggagg
      961 gactcaaagc tagaagcacc cgctgaagaa gatgtgtggg agatcctgag acaggcgcca
     1021 ccgtcagaat atgagcgcat cgccttccag cacggagtca cagacctgcg aggcatgctg
     1081 aagaggctca agggcatgaa gcacgatgaa aagaagagca cagcctttca gaagaagctg
     1141 gagcctgcct accaggtaaa caagggccac aagatccggc ttactgtgga actggctgat
     1201 ccagacgccg aagtcaagtg gcttaagaat ggacaggaga tccagatgag tggcaggtac
     1261 atctttgagt ccatcggtgc caagcgtacc ctgaccatca gccagtgctc actggctgac
     1321 gatgcagcct accagtgtgt ggtggggggt gagaaatgca gcacagagct ctttgtcaaa
     1381 gaacccccgg tgctgatcac tcggtccctg gaagaccagc tagtgatggt gggtcagcgg
     1441 gtggagtttg agtgtgaggt ctcagaagaa ggggcccaag tcaaatggct gaaggatggg
     1501 gttgagctga ctcgggagga gaccttcaaa taccggttca agaaagatgg acggaagcac
     1561 cacttgatca tcaacgaagc gaccctggag gacgcaggac actatgcagt tcgcacaagt
     1621 gggggccaag cactggctga gctcattgtg caagagaaga agctggaggt ctaccaaagc
     1681 atcgcggacc tggcggtggg agcgaaggac caggctgtgt ttaagtgtga ggtttcagat
     1741 gagaacgtgc gtggcgtgtg gctgaagaac gggaaggaac tggtgccgga caaccgcata
     1801 aaggtgtccc atataggccg ggtccacaaa ctgaccattg acgatgtcac acctgccgat
     1861 gaggctgact acagttttgt gcctgaaggg tttgcctgca acctgtctgc caagctccac
     1921 ttcatggagg tcaagattga ctttgtgcct aggcaggaac ctcccaagat ccacttggac
     1981 tgtcctggca gcacaccaga caccattgtg gttgttgctg ggaacaagtt acgcctggat
     2041 gtccctattt ctggggaccc tgctcccact gtaatctggc aaaagactat aacacagggg
     2101 aagaaggcct cagctgggcc accccctggt gccccagaag atgcaggtgc tgatgaggag
     2161 tgggtgtttg ataagaagct gttgtgtgag acggagggcc gtgtccgtgt ggagaccacc
     2221 aaagaccgaa gcgtcttcac ggtcgaaggg gcggagaagg aagatgaggg tgtctacact
     2281 gtcacagtaa agaaccccgt gggcgaggac caggtcaacc tcacagtcaa ggtcattgat
     2341 gtgccagatg ctcctgcagc ccctaagatc agcaacgtgg gcgaggactc ctgcattgtg
     2401 cagtgggaac cacctgccta tgatggtggg cagccggtcc tgggatacat cctggagcgc
     2461 aagaagaaaa agagctacag gtggatgagg ctcaacttcg atctgctgcg ggagctgagc
     2521 cacgaagcca ggcgcatgat tgagggtgta gcctatgaga tgagagtcta cgcggtcaat
     2581 gctgtgggaa tgtccaggcc cagccctgcc tctcagccct tcatgcctat tgggccccct
     2641 ggtgaaccaa ctcacctgac tgtggaggat gtgtcggaca ccacagtctc actcaagtgg
     2701 cggcccccag agcgtgtggg tgcaggtggc ctggacggat acagtgtgga gtattgccag
     2761 gagggctgct ccgagtgggt gactgctctg caggggttga cagagcgcac ttcgctgctg
     2821 gtgaaggacc tacccactgg ggcacggctg ctgttccgag tgcgggcaca caatgtggca
     2881 ggtcctgggg gccctatcat caccaaggag cctgtaacag tgcaggagat actgcagcga
     2941 ccacggctcc aactgcccag acacctgcgc cagaccatcc agaagaaagt tggggagcct
     3001 gtgaacctcc tcatcccttt ccagggcaaa ccccggcctc aagtgacctg gacaaaagag
     3061 gggcagccac tggcaggcga ggaggtgagc atccgcaaca gccccacaga cacaatcttg
     3121 ttcatccgag ctgcccaccg cactcactcg ggcacctacc aggtgacagt tcgcattgag
     3181 aacatggagg acaaggcaac gctggtcctg cagatcgtgg acaagccaag tcctcccctg
     3241 gatatccggg tcgttgagac ttggggcttc agtgtggctc tggagtggaa gccaccccaa
     3301 gatgatggca atacagagat ctggggttat actgtacaga aagccgacaa gaagaccatg
     3361 gagtggttca ctgttttgga acattaccgt cagactcact gtgtggtatc agagcttatc
     3421 attggcaatg gctactactt ccgggtcttc agccataaca tggtgggctc cagtgacaga
     3481 gctgctgcca ccaaggagcc catctttatt ccgagaccag gcatcacata tgagccaccc
     3541 aaatacaagg ccctggactt ctctgaagcc ccaagcttca cccagccctt gacaaaccgc
     3601 tccatcattg caggctacaa tgccatcctc tgctgtgctg tccggggtag tcctaagccc
     3661 aagatttcct ggttcaagaa tggcttggac ctgggagaag atgctcgttt tcgcatgttc
     3721 tgcaagcagg gagtattgac cctggagatc aggaagccct gtccctatga tgggggtgtc
     3781 tatgtctgca gagccaccaa cttgcagggt gaggcacagt gtgagtgccg cctggaggtg
     3841 cgagttcctc agtgaccagg atggctcccc agagatggtt aggtaaatgg atgccagcca
     3901 gtgtaccaga agcccaggag ggagttggag gagcacatct ttctgctgct gcatgtgtat
     3961 gtgtgtgcaa ctgtgcatct tggaaggact ggtcagcagt tttacggggc aggtctggtg
     4021 gattctgcag aaactgatgt cacagctccc aaggagtgct gttaacattg ggagcataaa
     4081 gtgtgcgtgc ctcagaaatg gtgactgggg agaggccctc atggtggctc attgtgtaag
     4141 agcaataaaa aagatgagtg cagtc
//
