LOCUS       NM_001100758            3914 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus myosin binding protein C1 (Mybpc1), mRNA.
ACCESSION   NM_001100758
VERSION     NM_001100758.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3914)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   2  (bases 1 to 3914)
  AUTHORS   Ackermann,M.A., Hu,L.Y., Bowman,A.L., Bloch,R.J. and
            Kontrogianni-Konstantopoulos,A.
  TITLE     Obscurin interacts with a novel isoform of MyBP-C slow at the
            periphery of the sarcomeric M-band and regulates thick filament
            assembly
  JOURNAL   Mol Biol Cell 20 (12), 2963-2978 (2009)
   PUBMED   19403693
  REMARK    GeneRIF: A new ligand of obscurin at the M-band, MyBP-C slow
            variant-1 and suggest that their interaction contributes to the
            assembly of M-and A-bands, is identified.
REFERENCE   3  (bases 1 to 3914)
  AUTHORS   Luther,P.K., Bennett,P.M., Knupp,C., Craig,R., Padron,R.,
            Harris,S.P., Patel,J. and Moss,R.L.
  TITLE     Understanding the organisation and role of myosin binding protein C
            in normal striated muscle by comparison with MyBP-C knockout
            cardiac muscle
  JOURNAL   J Mol Biol 384 (1), 60-72 (2008)
   PUBMED   18817784
  REMARK    GeneRIF: The distribution of MyBP-C in the A-bands of cardiac and
            skeletal muscles and compare this to the A-band structure in
            cardiac muscle of MyBP-C-deficient mice, was investigated.
REFERENCE   4  (bases 1 to 3914)
  AUTHORS   Matsumoto,Y., Kohyama,K., Park,I.K., Nakajima,M. and Hiraki,K.
  TITLE     Characterization of pathogenic T cells and autoantibodies in
            C-protein-induced autoimmune polymyositis
  JOURNAL   J Neuroimmunol 190 (1-2), 90-100 (2007)
   PUBMED   17900708
  REMARK    GeneRIF: These findings suggest that C-protein-induced EAM is
            formed by activation of C-protein-specific T cells along with
            antibodies against conformational epitopes in C-protein but that
            there are undetermined factors related to the disease progression.
REFERENCE   5  (bases 1 to 3914)
  AUTHORS   Winegrad,S.
  TITLE     Myosin-binding protein C (MyBP-C) in cardiac muscle and
            contractility
  JOURNAL   Adv Exp Med Biol 538, 31-40 (2003)
   PUBMED   15098652
  REMARK    GeneRIF: Myosin-binding protein C (MyBP-C) has roles in cardiac
            muscle and contractility [review]
            Review article
REFERENCE   6  (bases 1 to 3914)
  AUTHORS   Schiaffino,S. and Reggiani,C.
  TITLE     Molecular diversity of myofibrillar proteins: gene regulation and
            functional significance
  JOURNAL   Physiol Rev 76 (2), 371-423 (1996)
   PUBMED   8618961
  REMARK    Review article
REFERENCE   7  (bases 1 to 3914)
  AUTHORS   Akopian,A.N. and Wood,J.N.
  TITLE     Peripheral nervous system-specific genes identified by subtractive
            cDNA cloning
  JOURNAL   J Biol Chem 270 (36), 21264-21270 (1995)
   PUBMED   7673161
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 25, 2020 this sequence version replaced NM_001100758.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.19326.1,
                                           SRR26643295.27622.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               JAXUCZ010000007.1  24903247-24903373   c
            128-163             JAXUCZ010000007.1  24883985-24884020   c
            164-205             JAXUCZ010000007.1  24880698-24880739   c
            206-244             JAXUCZ010000007.1  24873771-24873809   c
            245-280             JAXUCZ010000007.1  24872813-24872848   c
            281-394             JAXUCZ010000007.1  24871015-24871128   c
            395-543             JAXUCZ010000007.1  24869114-24869262   c
            544-661             JAXUCZ010000007.1  24868266-24868383   c
            662-713             JAXUCZ010000007.1  24866519-24866570   c
            714-770             JAXUCZ010000007.1  24864390-24864446   c
            771-937             JAXUCZ010000007.1  24859157-24859323   c
            938-1070            JAXUCZ010000007.1  24857446-24857578   c
            1071-1195           JAXUCZ010000007.1  24855487-24855611   c
            1196-1301           JAXUCZ010000007.1  24854587-24854692   c
            1302-1468           JAXUCZ010000007.1  24853102-24853268   c
            1469-1631           JAXUCZ010000007.1  24850538-24850700   c
            1632-1738           JAXUCZ010000007.1  24848584-24848690   c
            1739-1872           JAXUCZ010000007.1  24847904-24848037   c
            1873-2032           JAXUCZ010000007.1  24844955-24845114   c
            2033-2137           JAXUCZ010000007.1  24841255-24841359   c
            2138-2326           JAXUCZ010000007.1  24839681-24839869   c
            2327-2461           JAXUCZ010000007.1  24838348-24838482   c
            2462-2515           JAXUCZ010000007.1  24835139-24835192   c
            2516-2683           JAXUCZ010000007.1  24834001-24834168   c
            2684-2772           JAXUCZ010000007.1  24831402-24831490   c
            2773-2968           JAXUCZ010000007.1  24830353-24830548   c
            2969-3108           JAXUCZ010000007.1  24827865-24828004   c
            3109-3268           JAXUCZ010000007.1  24826622-24826781   c
            3269-3405           JAXUCZ010000007.1  24825164-24825300   c
            3406-3592           JAXUCZ010000007.1  24822963-24823149   c
            3593-3635           JAXUCZ010000007.1  24819185-24819227   c
            3636-3914           JAXUCZ010000007.1  24817770-24818048   c
FEATURES             Location/Qualifiers
     source          1..3914
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..3914
                     /gene="Mybpc1"
                     /note="myosin binding protein C1"
                     /db_xref="GeneID:362867"
                     /db_xref="RGD:735102"
     exon            1..127
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..3606
                     /gene="Mybpc1"
                     /note="muscle C-protein; slow MyBP-C; myosin binding
                     protein C, slow type"
                     /codon_start=1
                     /product="myosin-binding protein C, slow-type"
                     /protein_id="NP_001094228.3"
                     /db_xref="GeneID:362867"
                     /db_xref="RGD:735102"
                     /translation="MPEPTKKEENEVPAPAPPPEEPNKDKEAGTTPAKEEDEASPPSA
                     LPPGLGSRALERKDSEWSLGESPAGGEEQDKQNANSQLSTLFVEKPQTGSVKVGANIT
                     FIAKVKAEDLLRKPTVKWFKGKWMDLASKAGKHLQLKETFERQTRIYTFEMQIIKAKE
                     NYAGNYRCEVTYKDKFDSCSFDLEVHESTGTTPNIDIRSAFKRSGEGQEDAGELDFSG
                     LLKRREVKQQEEEPEIDVWELLKNANPNEYEKIAFQYGITDLRGMLKRLKRMRRVEKK
                     SAAFAKILDPAYQIDKGGRVRFVVELADPKLEVKWFKNGQEIRPSTKYIFEHKGNERI
                     MFINNCALTDDSEYYVTAGDEKCSTELFVREPPIMVTKQLEDMNAYCGERVELEVEVS
                     EDDANVKWFKNGEEIVPGPKSRYRIKVEGKKHTLIIEGATKADSAEYSVMTTGGQSSA
                     KLSVDLRPLKITTPLTDQTVKLGKEVCLKCEISENVPGKWTKNGLPVQEGERLKVVHK
                     GRIHKLVIANALIEDEGEYVFTPDAYNVPLSAKVHVIDPPKIILDGLDADNTVTVIAG
                     SKLRLEIPVTGEPPPKAIWSRADKAIMEGSGRIRAESYPDSSTLVIDVAERDDSGVYN
                     INLKNEAGEAHASIKIKVVDIPDPPVAPNVTEVGDDWCIMNWEPPVYDGGSPILGYFI
                     ERKKKQSSRWMRLNFDLCKETTFEPKKMIEGVAYEVRIFAVNAIGISKPSMPSKPFVP
                     LAVTSPPTLLAVDSVTDSSVTMKWRPPDQIGAAGLDGYVLEYCFEGSTSAKQSNENGE
                     AAYDLPAEDWITANTDLIDKTKFTITGLPTDAKIFVRVKAINAAGASEPKYYSQPILV
                     KEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQINIR
                     NSETDTIIFIRKAERSHSGKYDLEVKVDKYVENASIDIQIVDRPGPPQAVTIEDVWGE
                     NVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHRTNATITELVIGNEYYFR
                     VFAENMCGLSEDATMTKESAVIAKDGKIYKNPVYEDFDFTEAPMFTQPLVNTYAIAGY
                     NATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCK
                     AVNDLGTVEIECKLEVKVVAQ"
     exon            128..163
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            164..205
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            206..244
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            245..280
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            281..394
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            395..543
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            544..661
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            662..713
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            714..770
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..937
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1070
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1195
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1301
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1468
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1631
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1738
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1872
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2032
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2137
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2326
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2461
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2515
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2683
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2772
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2968
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2969..3108
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3109..3268
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3269..3405
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3406..3592
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3593..3635
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3636..3914
                     /gene="Mybpc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttgtcgagct gacccgcacc atctctctgc tgccctcggg gtttctgtca actgctgcta
       61 gaaaggaaaa aaccctttgg agagtaatct tttactgtgg tcatgccaga acccactaag
      121 aaagaggaaa atgaagtgcc cgccccagcc cctcccccag aagaaccaaa taaagacaaa
      181 gaggcgggaa ccactccagc aaaagaggaa gatgaggcct ctccgccgag tgccctgcct
      241 ccaggtttgg gtagtcgggc cctggagaga aaagattcag aatggtctct tggtgagtca
      301 cctgctggcg gggaggagca ggacaaacag aatgccaact cacagctgtc caccctgttt
      361 gttgaaaaac cgcaaaccgg atcggtgaaa gtcggtgcaa acatcacctt tatagccaaa
      421 gttaaggctg aagatcttct taggaaaccc actgtcaaat ggttcaaggg gaaatggatg
      481 gaccttgcca gcaaagcagg gaaacacctg cagctgaagg agaccttcga gaggcaaact
      541 cggatataca catttgaaat gcagatcatc aaggccaaag agaactatgc aggaaattac
      601 aggtgtgagg tcacctacaa ggataaattt gacagctgtt catttgatct tgaagtacat
      661 gaatctactg ggactactcc aaacattgac atcagatctg ccttcaaaag aagtggagaa
      721 ggtcaagaag atgcagggga gcttgacttt agtggtctcc tgaaacgtag ggaggtgaaa
      781 cagcaggagg aggagcccga gatagacgtg tgggagctgc tgaaaaatgc caacccaaac
      841 gagtacgaga agatcgcttt ccagtacggc atcaccgacc tgcgtggcat gcttaagcgg
      901 ctcaagcgca tgcgcagggt ggaaaagaag agtgcagctt ttgcgaaaat cctcgaccct
      961 gcatatcaga tcgataaagg gggccgagta agattcgttg tggaattagc agacccaaag
     1021 ctggaagtga aatggtttaa aaatggccaa gagattcgac ccagcaccaa atacatcttt
     1081 gagcacaaag gaaatgagag aatcatgttt attaataact gtgcactgac agatgattcg
     1141 gagtactacg tgacagctgg agatgagaaa tgttctactg agctctttgt aagagagcct
     1201 ccaattatgg taacaaagca gctggaagac atgaacgctt actgtgggga gagagtagag
     1261 ctggaagtcg aggtgtctga agatgacgcc aatgtgaagt ggtttaagaa tggtgaagag
     1321 attgtccctg gtccaaagtc aaggtacaga attaaagtgg aaggcaaaaa gcacactttg
     1381 atcatagaag gagcgacaaa ggctgacagt gcggagtact cggtcatgac aaccggagga
     1441 cagtcatcgg ctaaactaag tgttgacttg agacctctaa agatcacaac gcctctgact
     1501 gatcagactg taaaacttgg gaaagaagta tgcctgaagt gtgaaatctc tgaaaatgta
     1561 ccaggaaaat ggacaaaaaa tggactccct gttcaggagg gggaacgtct gaaggtcgtt
     1621 cacaagggaa ggatccacaa gttagtcata gccaatgctc tcattgaaga cgaaggtgaa
     1681 tatgtgttta caccagatgc ctacaatgtt cctttgtctg ccaaagttca cgtcatcgac
     1741 cctcccaaga tcatccttga cggcctggat gctgataaca ccgtgacagt gattgccgga
     1801 agcaagcttc gtctggagat tcccgtcaca ggggaaccac ctcccaaagc catctggagc
     1861 agagcagata aggctatcat ggagggcagt ggtcggataa gggcagaatc ctaccccgac
     1921 agcagcacgc tggtcattga cgtggcagag agagatgact ctggtgtgta caacataaat
     1981 ctgaaaaatg aagctggaga agcacacgca agcatcaaga ttaaggttgt ggatatccct
     2041 gatcctccgg tggcaccaaa tgtgacagaa gtgggagatg actggtgcat catgaactgg
     2101 gagcctcctg tctatgatgg agggtctcca attttaggat actttattga gaggaaaaag
     2161 aagcaaagct ccaggtggat gagactgaat tttgatctct gcaaagagac aacttttgag
     2221 cccaagaaga tgattgaagg ggtggcctac gaggtccgca tatttgcggt caatgccatt
     2281 ggcatctcca agcccagtat gccctccaag ccctttgttc ctttggctgt gaccagccct
     2341 ccaactcttc tggctgtcga ctccgtgacc gactcctctg tgacaatgaa gtggaggccc
     2401 ccagaccaga ttggtgctgc aggtttagat ggctatgtgc tagagtattg ctttgaagga
     2461 agtacatcag caaaacagtc taatgaaaat ggggaggctg cgtatgatct accagctgag
     2521 gactggatca ctgcaaacac agacctgatc gacaagacca agttcaccat cactggtctg
     2581 cccacggatg caaagatctt tgtacgcgtg aaggctatta acgcggctgg ggccagtgag
     2641 cccaagtact attctcagcc catccttgtg aaggaaatca ttgagccacc aaagattcgc
     2701 atcccaaggc acctgaagca aacttacatc cgtagagttg gagaagctgt aaatctggtg
     2761 attcctttcc agggcaaacc aagaccagaa ctgacctgga agaaggacgg tgcagaaatc
     2821 gacaagaatc aaataaacat tcgcaactca gagactgata ccatcatatt cattaggaaa
     2881 gcagagcgca gccactcagg caaatacgac ctggaggtca aggtggataa gtacgtggaa
     2941 aacgcctcga tcgacatcca gatcgttgac cgcccaggcc caccccaggc tgtgactatt
     3001 gaagatgtgt ggggagagaa tgttgctcta acatggacac caccaaagga tgatgggaat
     3061 gctgccatca cagggtacac catccagaag gccgacaaga aaagcatgga atggttcacc
     3121 gtcattgagc attaccaccg aaccaatgcc accattaccg agctggtcat aggaaacgag
     3181 tattacttcc gggtctttgc tgaaaacatg tgcggcctta gcgaggacgc gaccatgacg
     3241 aaggagagtg ctgtgattgc caaggacggt aagatctata aaaatccggt gtacgaagac
     3301 ttcgatttca cagaggcccc catgtttact cagcctttgg ttaacaccta tgccatcgct
     3361 ggttacaatg ccaccctgaa ctgcagcgtc cgaggaaatc ccaagcccaa aatcacctgg
     3421 atgaaaaaca aagtggcgat tgtggatgac ccaagataca gaatgttcag caaccaagga
     3481 gtctgtaccc tggagatccg taagcctagt ccctatgacg gaggcacgta ctgctgcaaa
     3541 gcagtcaatg acctcgggac agtggagatc gaatgcaaac tggaggtgaa agttgtagca
     3601 cagtaaggat gtttgaatgt atattgtcac ccaaggtggg ctgtccttct gcaggctcct
     3661 cctgcaaggc gtgcctccaa acataatcga ttcatatttg cgagacttac agtcaagcaa
     3721 tccggaggaa tactgagggc tgggcacggc ctctacacac accagtgcct tgacattcga
     3781 ttgaaaacgg aaagcatttt ctggttttct cccaggcccc caaatgtggt cattttctct
     3841 cctcctaacc ttgaagaaag aaagaaaaat aaattgtttg cacagatggc ttgattaaaa
     3901 atcgcaaaca gtta
//
