LOCUS       NM_001106536            3710 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus MYB proto-oncogene like 2 (Mybl2), mRNA.
ACCESSION   NM_001106536 XM_001070125 XM_215922
VERSION     NM_001106536.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3710)
  AUTHORS   Zhu X and Lu X.
  TITLE     MiR-423-5p inhibition alleviates cardiomyocyte apoptosis and
            mitochondrial dysfunction caused by hypoxia/reoxygenation through
            activation of the wnt/beta-catenin signaling pathway via targeting
            MYBL2
  JOURNAL   J Cell Physiol 234 (12), 22034-22043 (2019)
   PUBMED   31074036
  REMARK    GeneRIF: miR-423-5p suppression reduced
            hypoxia/reoxygenation-induced cardiomyocytes injury through
            activation of the wnt/beta-catenin signaling pathway via targeting
            MYBL2 in cardiomyocytes
REFERENCE   2  (bases 1 to 3710)
  AUTHORS   Shen X, Zhao YF, Xu SQ, Wang L, Cao HM, Cao Y, Zhu Y, Wang Y and
            Liang ZQ.
  TITLE     Cathepsin L induced PC-12 cell apoptosis via activation of B-Myb
            and regulation of cell cycle proteins
  JOURNAL   Acta Pharmacol Sin 40 (11), 1394-1403 (2019)
   PUBMED   31444477
  REMARK    GeneRIF: Reduction of B-Myb in cathepsin L-overexpressing cells
            revealed that regulation of cell cycle-related proteins, including
            cyclin A and cyclin B1, through cathepsin L was mediated by the
            transcription factor B-Myb.
REFERENCE   3  (bases 1 to 3710)
  AUTHORS   Frau M, Ladu S, Calvisi DF, Simile MM, Bonelli P, Daino L, Tomasi
            ML, Seddaiu MA, Feo F and Pascale RM.
  TITLE     Mybl2 expression is under genetic control and contributes to
            determine a hepatocellular carcinoma susceptible phenotype
  JOURNAL   J Hepatol 55 (1), 111-119 (2011)
   PUBMED   21419759
  REMARK    GeneRIF: Mybl2 upregulation induces fast growth and progression of
            premalignant and malignant liver, through cell cycle deregulation
            and activation of genes and pathways related to tumor progression.
REFERENCE   4  (bases 1 to 3710)
  AUTHORS   Tarantino C, Paolella G, Cozzuto L, Minopoli G, Pastore L, Parisi S
            and Russo T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   5  (bases 1 to 3710)
  AUTHORS   Nishiyama A, Xin L, Sharov AA, Thomas M, Mowrer G, Meyers E, Piao
            Y, Mehta S, Yee S, Nakatake Y, Stagg C, Sharova L, Correa-Cerro LS,
            Bassey U, Hoang H, Kim E, Tapnio R, Qian Y, Dudekula D, Zalzman M,
            Li M, Falco G, Yang HT, Lee SL, Monti M, Stanghellini I, Islam MN,
            Nagaraja R, Goldberg I, Wang W, Longo DL, Schlessinger D and Ko MS.
  TITLE     Uncovering early response of gene regulatory networks in ESCs by
            systematic induction of transcription factors
  JOURNAL   Cell Stem Cell 5 (4), 420-433 (2009)
   PUBMED   19796622
REFERENCE   6  (bases 1 to 3710)
  AUTHORS   Yamauchi T, Ishidao T, Nomura T, Shinagawa T, Tanaka Y, Yonemura S
            and Ishii S.
  TITLE     A B-Myb complex containing clathrin and filamin is required for
            mitotic spindle function
  JOURNAL   EMBO J 27 (13), 1852-1862 (2008)
   PUBMED   18548008
REFERENCE   7  (bases 1 to 3710)
  AUTHORS   St Hilaire C, Yang D, Schreiber BM and Ravid K.
  TITLE     B-Myb regulates the A(2B) adenosine receptor in vascular smooth
            muscle cells
  JOURNAL   J Cell Biochem 103 (6), 1962-1974 (2008)
   PUBMED   17979185
  REMARK    GeneRIF: proliferation-inhibiting A(2B)AR is itself an inducible
            receptor regulated by B-Myb.
REFERENCE   8  (bases 1 to 3710)
  AUTHORS   Liu DX, Biswas SC and Greene LA.
  TITLE     B-myb and C-myb play required roles in neuronal apoptosis evoked by
            nerve growth factor deprivation and DNA damage
  JOURNAL   J Neurosci 24 (40), 8720-8725 (2004)
   PUBMED   15470138
REFERENCE   9  (bases 1 to 3710)
  AUTHORS   Horstmann S, Ferrari S and Klempnauer KH.
  TITLE     An alternatively spliced isoform of B-Myb is a transcriptional
            inhibitor
  JOURNAL   Oncogene 19 (48), 5428-5434 (2000)
   PUBMED   11114719
REFERENCE   10 (bases 1 to 3710)
  AUTHORS   Cervellera M, Raschella G, Santilli G, Tanno B, Ventura A, Mancini
            C, Sevignani C, Calabretta B and Sala A.
  TITLE     Direct transactivation of the anti-apoptotic gene apolipoprotein J
            (clusterin) by B-MYB
  JOURNAL   J Biol Chem 275 (28), 21055-21060 (2000)
   PUBMED   10770937
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474005.2.
            
            [WARNING] On May 7, 2024 this sequence was replaced by
            NM_001106536.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_215922.4, XM_001070125.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3710
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..3710
                     /gene="Mybl2"
                     /note="MYB proto-oncogene like 2"
                     /db_xref="GeneID:296344"
                     /db_xref="RGD:1308474"
     exon            1..214
                     /gene="Mybl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..2309
                     /gene="Mybl2"
                     /note="myeloblastosis oncogene-like 2"
                     /codon_start=1
                     /product="myb-related protein B"
                     /protein_id="NP_001100006.1"
                     /db_xref="GeneID:296344"
                     /db_xref="RGD:1308474"
                     /translation="MSRRTRCEELDELRYQDTDSDLLEQRDNKCKVKWTHEEDELLRA
                     LVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKVIELVKKYG
                     TKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEI
                     AKMLPGRTDNAVKNHWNSTIKRKVDTGGFPNESRDCKPVYLLLELEDKDYQQNVQPVE
                     GPGSLVSSWPLAPSTVKEEESSEEEAAVATTSKEHKQEPVPTDLGEVRTPEPLEFLKR
                     EYQEESSPETSLPYKWVVEAANLLIPAVESSLSEALDLIESDPDAWCDLSKFDLPEEP
                     SAEGSVNSSPVQLQTPQQQQQHQQALSFHQAATPGPSVTEYRLDGHTISDLSRSSRGE
                     LIPISPSTEFGGSGIGTPPSVLKRQKKRRVALSPVTENSASLSFLDSCNSLTPKSTPV
                     KTLPFSPSQFLNFWNKQDTLELESPSLTSTPVCSQKVVVTTPLHRDKTPLHQKYPSFV
                     TPDQKYSMDNTPHTPTPFKNALEKYGPLKPLPQTPHLEEDLKEVLRSEAGIELIIEDD
                     MRPEKQKRKPGLRRSPIKKVRKSLALDIVDEDGKMMSSTSPKTLSLPTSVPSSSSGFI
                     LPGIKEDNSLLNQGFLQAKPEKVVATQKPRSHIPAPAPMTRAWKTVACGGTKDQLFMQ
                     EKARQLLGRLKSSHTSRTLILS"
     exon            215..308
                     /gene="Mybl2"
                     /inference="alignment:Splign:2.1.0"
     exon            309..380
                     /gene="Mybl2"
                     /inference="alignment:Splign:2.1.0"
     exon            381..473
                     /gene="Mybl2"
                     /inference="alignment:Splign:2.1.0"
     exon            474..694
                     /gene="Mybl2"
                     /inference="alignment:Splign:2.1.0"
     exon            695..854
                     /gene="Mybl2"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1145
                     /gene="Mybl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1571
                     /gene="Mybl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1711
                     /gene="Mybl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1811
                     /gene="Mybl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1925
                     /gene="Mybl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2030
                     /gene="Mybl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2180
                     /gene="Mybl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..3710
                     /gene="Mybl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagtggttc agtgcgctcc ctaggcagct gcagttcctg ggaacgtgcg acaagacctg
       61 cagacacgct gacgcctcag agcaccgcct ggggcccgga gcggccggtg cagcctgagt
      121 cctgaccccg gcccggctcc cgctccgggc tcggccggcg ggcgtaaggg cgcggcgggg
      181 tccgggccgg ggggatgtct cggcggacgc gctgtgagga actggatgag ttacgctacc
      241 aggacacgga ctcagacctc ctggagcaga gagacaacaa atgtaaggtc aaatggaccc
      301 acgaggagga tgagctactg agggccctgg tgaggcagtt tggacagcaa gactggaagt
      361 tcctggccag tcactttcct aaccgcacag accagcaatg ccagtaccgg tggctgaggg
      421 ttttgaatcc agaccttgtt aagggaccgt ggaccaaaga ggaagatcag aaggtcattg
      481 agctggtcaa gaagtacggc acaaaacagt ggacgctcat tgccaagcac ctgaagggcc
      541 gtcttgggaa gcagtgtcgt gagcgctggc acaaccatct caaccctgag gtgaagaagt
      601 cctgctggac agaggaggaa gatcggatca tctgtgaggc ccataaagtg ctgggcaacc
      661 gctgggctga gatcgccaag atgctgccag ggaggacaga caatgctgtg aagaatcact
      721 ggaattccac catcaaaagg aaagtcgaca cgggagggtt cccaaacgag tccagagact
      781 gcaagcctgt ctacttgctc ttggagctcg aggacaagga ttaccaacag aatgtccagc
      841 ctgtggaagg cccgggaagt cttgtgagca gctggcccct ggcgccctct actgtgaagg
      901 aggaggagag cagcgaggag gaggctgccg tggctactac ttctaaggaa cacaagcagg
      961 agcccgtccc cactgatctg ggggaagtgc gcaccccaga gcccctggaa ttcctcaagc
     1021 gtgaatacca ggaggaatcc tccccagaaa caagcctgcc ctacaagtgg gtggtggagg
     1081 ccgcgaacct cctcatccct gctgtggagt ccagcctctc cgaagctctg gacttgatcg
     1141 agtcggaccc cgatgcttgg tgtgacctca gtaaatttga tcttcctgaa gaaccgtctg
     1201 cagagggcag tgtcaacagt agcccagtgc aactccagac accgcagcag cagcaacagc
     1261 accagcaggc actgtcattc caccaggctg ccacaccagg gcccagtgtg actgagtatc
     1321 gccttgatgg ccacactatt tcagacctga gccggagcag ccggggagag ctgatcccca
     1381 tttccccaag cactgagttt gggggctcag gcattggcac accgccctca gtgctcaagc
     1441 gacagaagaa acggcgcgtg gccctgtcgc ctgtcacaga gaacagtgcc agcttgtcct
     1501 tcctggactc ctgtaatagc cttaccccga agagcacacc tgtcaaaacc cttcccttct
     1561 ctccttccca gtttctgaac ttctggaaca aacaggatac cctggagttg gagagcccct
     1621 ccctgacgtc cactccggtg tgcagccaaa aggtggtagt caccacaccc ttgcacaggg
     1681 ataagacgcc cctgcaccag aagtatccat cgtttgtaac cccagatcag aagtattcca
     1741 tggacaacac tccccacaca ccaaccccgt tcaagaatgc tctggagaaa tatggaccac
     1801 tgaaacccct gccccaaacc ccacacctgg aagaggactt gaaggaggtg cttcgttccg
     1861 aggctggcat tgagctcatc attgaggatg acatgagacc cgagaaacag aagagaaagc
     1921 ctgggctccg gcgaagccct atcaagaagg ttcggaagtc tctggctctt gacattgtgg
     1981 atgaggatgg gaagatgatg tcatcgacct cgcccaagac tctgtccttg ccaaccagtg
     2041 tcccatccag ctcctctggc ttcatcttgc cgggtatcaa ggaggataac agcctgctca
     2101 accagggctt cctacaggcc aaacccgaga aggtggtggc cacccagaag ccccggagcc
     2161 acattccagc ccctgctcct atgacccgtg cctggaagac ggtggcctgt gggggcacta
     2221 aagaccagct cttcatgcaa gagaaggccc ggcagctcct gggccgtctg aagtccagcc
     2281 acacatctcg gaccctcatt ctgtcctgag gggcttgcag ggaacaagcc agctctcatg
     2341 tttacagggg tagggtgtgg ggtaaggtgt gcgttgaagt cacattaaat gaccagcttc
     2401 aggaagtctt ctgccagccc ctcagtctgc tcaggtggca gaagtcacat ggtacatctc
     2461 ttcccccggt ctagcctttg tgaagttcct ggtggtgcta atagaacaaa gtcccactcc
     2521 tgggcctgcc tgccctccgc ccagtgccac aaggagccct attaggttct cccaggctct
     2581 catccagact cctgcttagg atgggggtgt ggcgaggggt gctccttccc tcgtttgttg
     2641 gtacactgtc tccacaataa aataccgttc tccctatgca gccccgactc tgccctctga
     2701 gtcttgaagt gccttgaagg ccctctcctg acacgtaggc ctgtagacct ctgttcttgg
     2761 gtacagcttt acccagtgag catctctgca aagctcccaa gagctctgag tggatgaaga
     2821 tgggttctga gaacctgtta gaacggtgta ttcacctttg ccctgatgcc tcagggccat
     2881 ggcttggggc atgggtggtt cttatggctt ccacggagca gctgctgcct taagccgagc
     2941 ctgccatagg taagaccatt aatataggta gagggatgga tggcaggcct ttcgactctg
     3001 gccaatgtgt ggaaggctgc ccagctcctg gatcttttat cctgaattgg tggcagccat
     3061 ggcctgggct gtcacctccc ttggagtcag tgggtagagc gtggtccata gttcagtcag
     3121 ttaagagctt gactagggag atgctgagcc taatgtctac gttaggaagt gttgttttct
     3181 gtagcctgcc tgggtgtccc tgggttggga gttagatgga cctatgggag gtctagactt
     3241 agtcctggtt aaagggagac ttgaggcaaa tgttctccaa ctgggcaaga gataacgtct
     3301 gaagaagact gcgctagcac accggagtcc aggcgctctc ctgtaaaaga tacgggagcc
     3361 gggctgtgct ctcacactgt gcctactgca gcctccttgt ctgagcccca tgctcagtga
     3421 gcagcacctg cctcacccct ggctctctag ttcttttctc agaatggcta aggcgactag
     3481 cagccacgcg tgtgtgcggt ctgtgcttga gaaggcatgg tggaggacag gctgtcaagc
     3541 agaggataaa ggctgctggt gcctaccagg ctctcctaca gtcggggctc tctaaggggt
     3601 gccgcagcct gcatttaggg gggctctttt aaccctggaa tttcctcata gacacacgca
     3661 aatgtgtgcc ttcttgtcag ccaagttgac aataaagagt agcaaattgt
//
