LOCUS       NM_134350               2623 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus MX dynamin like GTPase 2 (Mx2), mRNA.
ACCESSION   NM_134350 NM_017028
VERSION     NM_134350.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2623)
  AUTHORS   Redina,O.E., Smolenskaya,S.E., Fedoseeva,L.A. and Markel,A.L.
  TITLE     [Differentially expressed genes in the locus associated with
            relative kidney weight and resting blood pressure in hypertensive
            rats of the ISIAH strain]
  JOURNAL   Mol Biol (Mosk) 50 (6), 944-952 (2016)
   PUBMED   28064310
  REMARK    GeneRIF: Six differentially expressed genes (Kcne1, Rcan1, Mx1,
            Mx2, Tmprss2, and RGD1559516) were identified in the renal cortex,
            and three genes (Rcan1, Mx2, and Tmprss2) were identified in the
            renal medulla.
REFERENCE   2  (bases 1 to 2623)
  AUTHORS   Rennie,M.L., McKelvie,S.A., Bulloch,E.M. and Kingston,R.L.
  TITLE     Transient dimerization of human MxA promotes GTP hydrolysis,
            resulting in a mechanical power stroke
  JOURNAL   Structure 22 (10), 1433-1445 (2014)
   PUBMED   25295396
REFERENCE   3  (bases 1 to 2623)
  AUTHORS   He,D.N., Zhang,X.M., Liu,K., Pang,R., Zhao,J., Zhou,B. and
            Chen,P.Y.
  TITLE     In vitro inhibition of the replication of classical swine fever
            virus by porcine Mx1 protein
  JOURNAL   Antiviral Res 104, 128-135 (2014)
   PUBMED   24500530
REFERENCE   4  (bases 1 to 2623)
  AUTHORS   Wisskirchen,C., Ludersdorfer,T.H., Muller,D.A., Moritz,E. and
            Pavlovic,J.
  TITLE     Interferon-induced antiviral protein MxA interacts with the
            cellular RNA helicases UAP56 and URH49
  JOURNAL   J Biol Chem 286 (40), 34743-34751 (2011)
   PUBMED   21859714
REFERENCE   5  (bases 1 to 2623)
  AUTHORS   Schoggins,J.W., Wilson,S.J., Panis,M., Murphy,M.Y., Jones,C.T.,
            Bieniasz,P. and Rice,C.M.
  TITLE     A diverse range of gene products are effectors of the type I
            interferon antiviral response
  JOURNAL   Nature 472 (7344), 481-485 (2011)
   PUBMED   21478870
  REMARK    Erratum:[Nature. 2015 Sep 3;525(7567):144. doi:
            10.1038/nature14554.. PMID: 26153858]
REFERENCE   6  (bases 1 to 2623)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   7  (bases 1 to 2623)
  AUTHORS   Andersson,I., Bladh,L., Mousavi-Jazi,M., Magnusson,K.E.,
            Lundkvist,A., Haller,O. and Mirazimi,A.
  TITLE     Human MxA protein inhibits the replication of Crimean-Congo
            hemorrhagic fever virus
  JOURNAL   J Virol 78 (8), 4323-4329 (2004)
   PUBMED   15047845
REFERENCE   8  (bases 1 to 2623)
  AUTHORS   Bridgen,A., Dalrymple,D.A., Weber,F. and Elliott,R.M.
  TITLE     Inhibition of Dugbe nairovirus replication by human MxA protein
  JOURNAL   Virus Res 99 (1), 47-50 (2004)
   PUBMED   14687945
REFERENCE   9  (bases 1 to 2623)
  AUTHORS   Johannes,L., Kambadur,R., Lee-Hellmich,H., Hodgkinson,C.A.,
            Arnheiter,H. and Meier,E.
  TITLE     Antiviral determinants of rat Mx GTPases map to the
            carboxy-terminal half
  JOURNAL   J Virol 71 (12), 9792-9795 (1997)
   PUBMED   9371647
REFERENCE   10 (bases 1 to 2623)
  AUTHORS   Meier,E., Kunz,G., Haller,O. and Arnheiter,H.
  TITLE     Activity of rat Mx proteins against a rhabdovirus
  JOURNAL   J Virol 64 (12), 6263-6269 (1990)
   PUBMED   2173790
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099808.1.
            
            On Jul 31, 2005 this sequence version replaced NM_134350.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099808.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132293
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2623
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q12"
     gene            1..2623
                     /gene="Mx2"
                     /gene_synonym="Mx3"
                     /note="MX dynamin like GTPase 2"
                     /db_xref="GeneID:286918"
                     /db_xref="RGD:628821"
     exon            1..10
                     /gene="Mx2"
                     /gene_synonym="Mx3"
                     /inference="alignment:Splign:2.1.0"
     exon            11..93
                     /gene="Mx2"
                     /gene_synonym="Mx3"
                     /inference="alignment:Splign:2.1.0"
     exon            94..220
                     /gene="Mx2"
                     /gene_synonym="Mx3"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..2101
                     /gene="Mx2"
                     /gene_synonym="Mx3"
                     /note="interferon-induced GTP-binding protein Mx3;
                     myxovirus resistance protein 2; myxovirus resistance
                     protein 3; myxovirus (influenza virus) resistance 3;
                     myxovirus (influenza virus) resistance 2"
                     /codon_start=1
                     /product="interferon-induced GTP-binding protein Mx2"
                     /protein_id="NP_599177.2"
                     /db_xref="GeneID:286918"
                     /db_xref="RGD:628821"
                     /translation="MVLSTEENRSVDLVNLPSVPLPDGEAGVGENNKDSLNNLCSQYE
                     EKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTR
                     CPLVLKLKKLNQGEEWKGKVTYDDIEVELSDPSEVEEAINTGQNHIAGVGLGISDKLI
                     SLDVSSPHVPDLTLIDLPGITRVAVGNQPADIGRQIKRLITNYIQKQETINLVVVPSN
                     VDIATTEALSMAQKVDPDGDRTIGILTKPDLVDRGTEDKVVDVVRNLVCHLKKGYMIV
                     KCRGQQDIQEQLSLAEALQKEQVFFKEHPQFRALLEDGKATVPCLAERLTMELISHIC
                     KSLPLLENQIKESHQSTSEELQKYGADIPEDENEKTLFLIEKINAFNQDITAIVEGEE
                     IVREKECRLFTKLRKEFFLWSEEIERNFQKGSDALYKEVYTFEMQYRGRELPGFVNYK
                     TFENIIRRQIKTLEEPAMEMLHKVTEIVRAAFTTVSEKNFSEFFNLHRTTKSKLEDIR
                     LEQETEAEKAIRLHFQMEQIIYCQDQIYRKALQKVREEEAEEEERKHGKSRSAQSPNL
                     QTSSMDEIFQHLNAYRQEAHNCISSHIPLIIQYFILKMFAEKLQKGMLQLLQDKDSCS
                     WLLKEKSDTSEKRRFLKERLARLAQAQRRLAKFPG"
     exon            221..413
                     /gene="Mx2"
                     /gene_synonym="Mx3"
                     /inference="alignment:Splign:2.1.0"
     exon            414..551
                     /gene="Mx2"
                     /gene_synonym="Mx3"
                     /inference="alignment:Splign:2.1.0"
     exon            552..706
                     /gene="Mx2"
                     /gene_synonym="Mx3"
                     /inference="alignment:Splign:2.1.0"
     exon            707..845
                     /gene="Mx2"
                     /gene_synonym="Mx3"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1044
                     /gene="Mx2"
                     /gene_synonym="Mx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1123
                     /gene="Mx2"
                     /gene_synonym="Mx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1246
                     /gene="Mx2"
                     /gene_synonym="Mx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1388
                     /gene="Mx2"
                     /gene_synonym="Mx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1547
                     /gene="Mx2"
                     /gene_synonym="Mx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1624
                     /gene="Mx2"
                     /gene_synonym="Mx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1870
                     /gene="Mx2"
                     /gene_synonym="Mx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2566
                     /gene="Mx2"
                     /gene_synonym="Mx3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccaggagct ttctctctgg gaaggggtgg agacagctgt ttaaagacac tgcaaccaga
       61 aagccaagca ttctgtcact aagcaggaga ctgagtgccc acttggaaga agaaataaaa
      121 gatggttctt agcacagagg aaaacaggag tgttgattta gtcaacttac ccagtgtccc
      181 actgcccgat ggagaggctg gcgtagggga gaacaacaag gattccttga acaacctctg
      241 cagtcagtat gaggagaagg tgcggccctg cattgacctc atcgactccc tgcgagctct
      301 gggtgtggag caagacctgg ccctgcctgc catcgctgtc atcggggacc agagttcagg
      361 gaagagctct gtgctggaag cactgtctgg agtggccctc cccagaggca gtggtattgt
      421 caccagatgt cccctggtgc tgaaattgaa gaagctgaat cagggagagg agtggaaagg
      481 caaagtcacc tatgatgaca tcgaagtgga gctctctgat ccttcagagg tggaagaggc
      541 catcaacaca ggtcagaacc atattgctgg ggtagggctg gggatcagtg ataaactcat
      601 tagcctggat gtcagctccc cacacgtccc agacctgact ctgattgacc ttcctggaat
      661 caccagggtg gctgtaggca accagcctgc agacatagga cggcagatca agagacttat
      721 cactaactac atccaaaaac aagagaccat caacctggtg gtggtcccca gcaatgtgga
      781 cattgccacc acagaggccc tgagcatggc tcagaaggtg gaccctgatg gggataggac
      841 catagggatc ttgaccaagc ctgatctggt ggacagaggg actgaagaca aggtcgtgga
      901 tgtggtgagg aacctcgtgt gccacctgaa gaagggctac atgatagtca agtgcagggg
      961 tcagcaggac atccaggagc agctgagcct ggctgaggct cttcagaagg agcaagtctt
     1021 cttcaaggaa caccctcaat tcagagctct tctggaggat gggaaggcca cagtgccctg
     1081 cctggcagag aggctgacca tggagctcat ctcacacatc tgtaaatctc ttcctttgtt
     1141 agaaaatcaa ataaaggaaa gtcaccagag tacaagtgag gagctgcaga agtatggtgc
     1201 agacatacca gaagatgaga atgaaaaaac tctcttcctg attgaaaaaa tcaatgcttt
     1261 taaccaggac atcactgcca tagtagaagg ggaagagatt gtgagggaga aagaatgtcg
     1321 cctattcacc aagctccgta aagagttctt cttgtggagt gaggagatcg aaaggaattt
     1381 ccaaaaaggt tctgatgctt tatataaaga agtctacaca ttcgaaatgc agtatcgtgg
     1441 ccgagaacta ccagggtttg tgaattacaa aacatttgag aacatcataa gaagacaaat
     1501 caaaaccctg gaagaaccag ctatggaaat gcttcacaag gtcactgaaa ttgtacgggc
     1561 tgcctttaca acggtttctg agaaaaattt ctctgagttt tttaatctcc acagaactac
     1621 caagtccaaa cttgaagaca tcagattaga acaggaaacg gaagcagaga aggcgatccg
     1681 gcttcacttc cagatggaac aaatcatcta ctgccaggac caaatttata ggaaagcctt
     1741 gcagaaggtg agagaggagg aagctgagga ggaggagagg aagcatggca aaagcaggtc
     1801 cgctcagtcc ccaaatttac agacctcatc catggatgaa atcttccagc atctgaatgc
     1861 ctaccgccag gaggctcaca actgcatctc cagccacatt ccattgatca tccagtattt
     1921 catcttgaag atgtttgctg agaagctgca gaagggcatg ctccagctcc tgcaggacaa
     1981 ggattcctgc agctggctcc tgaaggaaaa gagtgacacc agtgagaaga ggagattcct
     2041 gaaggagcgg ttggcaaggc tggcccaagc tcagcgcagg ctagccaaat tccctggtta
     2101 agctggccct gtcctttcct gtgtctcctg gataattaaa tattcaggga cagaagggtt
     2161 ccagccttgt tgtggtttgc cctaagatat ctgtattttg atgctaattc cactgcccca
     2221 gggacagctg cctagtcctg tactcaggaa tcaggtgact tcaccagaaa cttctcccca
     2281 ttgaatttgt aaaatacagg tgaggggcac atagaggata gaaagaggcc tgtaattgga
     2341 ccagaagtaa ggattggtgg gagagaagtt taaaggaagg ggaggatact ggaagggaaa
     2401 gaaggagagg agagagatag agagaagcca tggcaggaca atatggcagg tgacattaag
     2461 attccatgct gtacctttac aggttgttac aaatgttctt aagggatgga tggtactggg
     2521 ctttgtatgt ttaggtgggc aattatatct taccaattgg gtcaaaaaaa aaaaaaaaaa
     2581 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
