LOCUS       NM_001271062            3281 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus MX dynamin like GTPase 1 (Mx1), transcript
            variant 6, mRNA.
ACCESSION   NM_001271062
VERSION     NM_001271062.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3281)
  AUTHORS   Lee,S., Ishitsuka,A., Noguchi,M., Hirohama,M., Fujiyasu,Y.,
            Petric,P.P., Schwemmle,M., Staeheli,P., Nagata,K. and Kawaguchi,A.
  TITLE     Influenza restriction factor MxA functions as inflammasome sensor
            in the respiratory epithelium
  JOURNAL   Sci Immunol 4 (40) (2019)
   PUBMED   31653718
REFERENCE   2  (bases 1 to 3281)
  AUTHORS   Jung,H.E., Oh,J.E. and Lee,H.K.
  TITLE     Cell-Penetrating Mx1 Enhances Anti-Viral Resistance against Mucosal
            Influenza Viral Infection
  JOURNAL   Viruses 11 (2), 109 (2019)
   PUBMED   30696001
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3281)
  AUTHORS   Ciminski,K., Pulvermuller,J., Adam,J. and Schwemmle,M.
  TITLE     Human MxA is a potent interspecies barrier for the novel
            bat-derived influenza A-like virus H18N11
  JOURNAL   Emerg Microbes Infect 8 (1), 556-563 (2019)
   PUBMED   30945621
REFERENCE   4  (bases 1 to 3281)
  AUTHORS   Zang,F., Yue,M., Yao,Y., Liu,M., Fan,H., Feng,Y., Xia,X., Huang,P.
            and Yu,R.
  TITLE     Influence of IL28B and MxA gene polymorphisms on HCV clearance in
            Han Chinese population
  JOURNAL   Epidemiol Infect 146 (3), 379-385 (2018)
   PUBMED   29271328
REFERENCE   5  (bases 1 to 3281)
  AUTHORS   Saadeh,D., Kurban,M. and Abbas,O.
  TITLE     Plasmacytoid dendritic cells and type I interferon in the
            immunological response against warts
  JOURNAL   Clin Exp Dermatol 42 (8), 857-862 (2017)
   PUBMED   28736973
REFERENCE   6  (bases 1 to 3281)
  AUTHORS   Glymph,S., Mandal,S., Knowell,A.E., Abebe,F. and Chaudhary,J.
  TITLE     The myxovirus resistance A (MxA) gene -88G>T single nucleotide
            polymorphism is associated with prostate cancer
  JOURNAL   Infect Genet Evol 16, 186-190 (2013)
   PUBMED   23438650
REFERENCE   7  (bases 1 to 3281)
  AUTHORS   Melaine,N., Lienard,M.O., Guillaume,E., Ruffault,A.,
            Dejucq-Rainsford,N. and Jegou,B.
  TITLE     Production of the antiviral proteins 2'5'oligoadenylate synthetase,
            PKR and Mx in interstitial cells and spermatogonia
  JOURNAL   J Reprod Immunol 59 (1), 53-60 (2003)
   PUBMED   12892903
  REMARK    GeneRIF: IFN treatment induced Mx production and increased PKR
            production in immature germ cells
REFERENCE   8  (bases 1 to 3281)
  AUTHORS   Tazi-Ahnini,R., di Giovine,F.S., McDonagh,A.J., Messenger,A.G.,
            Amadou,C., Cox,A., Duff,G.W. and Cork,M.J.
  TITLE     Structure and polymorphism of the human gene for the
            interferon-induced p78 protein (MX1): evidence of association with
            alopecia areata in the Down syndrome region
  JOURNAL   Hum Genet 106 (6), 639-645 (2000)
   PUBMED   10942113
REFERENCE   9  (bases 1 to 3281)
  AUTHORS   Kolb,E., Laine,E., Strehler,D. and Staeheli,P.
  TITLE     Resistance to influenza virus infection of Mx transgenic mice
            expressing Mx protein under the control of two constitutive
            promoters
  JOURNAL   J Virol 66 (3), 1709-1716 (1992)
   PUBMED   1371172
REFERENCE   10 (bases 1 to 3281)
  AUTHORS   Meier,E., Kunz,G., Haller,O. and Arnheiter,H.
  TITLE     Activity of rat Mx proteins against a rhabdovirus
  JOURNAL   J Virol 64 (12), 6263-6269 (1990)
   PUBMED   2173790
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1 and BC099784.1.
            
            Transcript Variant: This variant (6) differs in the 5' UTR compared
            to variant 1. All six variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ230542.1, SRR26643292.45385.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN06621351,
                                           SAMN06680413 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000011.1  50292771-50292904   c
            135-3281            BC099784.1         203-3349
FEATURES             Location/Qualifiers
     source          1..3281
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q12"
     gene            1..3281
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /note="MX dynamin like GTPase 1"
                     /db_xref="GeneID:24575"
                     /db_xref="RGD:3127"
     exon            1..134
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
     exon            135..318
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..2199
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /note="myxovirus resistance protein 1; myxoma resistance
                     protein 1; Myxovirus (influenza) resistance, homolog of
                     murine Mx (also interferon-inducible protein IFI78);
                     myxovirus (influenza virus) resistance 1"
                     /codon_start=1
                     /product="interferon-induced GTP-binding protein Mx1"
                     /protein_id="NP_001257991.1"
                     /db_xref="GeneID:24575"
                     /db_xref="RGD:3127"
                     /translation="MKEQTSACRHQTPQKHPDTSEESQAMESVDNLCSQYEEKVRPCI
                     DLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKL
                     KQLKQGEKWSGKVIYKDTEIEISHPSLVEREINKAQNLIAGEGLKISSDLISLEVSSP
                     HVPDLTLIDLPGITRVAVGDQPADIEHKIKRLITEYIQKQETINLVVVPSNVDIATTE
                     ALKMAQEVDPQGDRTIGILTKPDLVDRGTEDKVVDVVRNLVCHLKKGYMIVKCRGQQD
                     IQEQLSLAEALQKEQVFFKEHPQFRVLLEDGKATVPCLAKRLTMELTSHICKSLPILE
                     NQINVNHQIASEELQKYGADIPEDDSKRLSFLMNKINVFNKDILSLVQAQENISWEES
                     RLFTKLRNEFLAWNDYIEEHFKKTLGSSEKHSQMEKFESHYRGRELPGFVDYKAFENI
                     IKKEVKALEEPALNMLHRVTTMVKNAFTKVSSNNFGDFLNLHSTAKSKIEDIRFSQEK
                     EAEKLIRLHFQMEHIVYCQDQAYKKALKEIREKEAEKEKSTFGVFQQNSPRKELTTTE
                     MTQHLNAYYQECGRNIGRQIPLIIQYSILQTFGQEMEKAMLQLLQDTSKCNWFLTEQS
                     DSREKKKFLKRRLLRLDEAQRKLAKFSN"
     exon            319..511
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
     exon            512..649
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
     exon            650..804
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
     exon            805..943
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1142
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1221
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1344
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1486
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1651
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1728
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1968
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..3241
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acactcagtc accaacccag gagctgtgag tattgcactg gattctgtgg gaggatagag
       61 gataccttgt aaggctcctt tgcagacatt ggtgagcact gcagggcatt tgttggtgct
      121 gttacaataa tgagtgcctg accccagtgg caaggcttcc agattcttct gaatcaaacc
      181 ctttatgtcc aaccgaatcc acctggaaaa cacgcaagag tgagttccta gaacgtcaaa
      241 atgaaggagc agacctctgc atgccgtcac cagacaccac agaaacatcc tgatacctct
      301 gaagagagcc aggcaatgga gtctgtggat aacctctgca gtcagtatga ggagaaggtg
      361 cggccctgca ttgacctcat cgactccctg cgagctctgg gtgtggagca agacctggcc
      421 ctgcctgcca tcgctgtcat cggggaccag agttcaggga agagctctgt gctggaagca
      481 ctgtctggag tggccctccc cagaggcagt ggtattgtta ccaggtgtcc tctggtgctg
      541 aaattgaagc aactgaagca gggagaaaaa tggagcggca aggtcattta taaggacacc
      601 gagattgaga tctcacaccc ttcactggta gaaagggaaa tcaataaagc ccagaacttg
      661 attgctgggg aagggttgaa gattagctct gatctcatta gcttggaggt tagctctcca
      721 catgtcccag acctgactct gattgacctt cctggtatca caagagtggc tgtgggtgac
      781 cagcctgcag acatcgaaca caagatcaag agacttatca ctgaatacat ccagaaacag
      841 gagaccatca acctggtggt ggtccccagc aatgtggaca ttgccaccac agaggccctg
      901 aaaatggctc aggaggtgga ccctcaaggg gatagaacca tagggatctt gaccaagccc
      961 gatctggtgg acagagggac tgaagacaag gtcgtggatg tggtgcggaa cctcgtgtgc
     1021 cacctgaaga agggctacat gatagtcaag tgcaggggtc agcaggacat ccaggagcag
     1081 ctgagcctgg ctgaggctct tcagaaggag caagtcttct tcaaggaaca ccctcaattc
     1141 agagttcttc tcgaggatgg gaaggccaca gtgccctgct tggcaaagag actgaccatg
     1201 gagctcacct cccacatctg taaatcgctg ccaatattgg aaaatcaaat aaatgtgaat
     1261 catcagattg cgagtgagga gctgcagaag tacggagcag acataccaga agatgacagt
     1321 aagaggctgt cctttctgat gaataaaatc aatgtcttca ataaggatat cctaagtttg
     1381 gtacaagcac aagaaaacat atcatgggaa gaaagccggc tgttcaccaa actgcgaaat
     1441 gagtttcttg cttggaatga ttatattgag gaacatttca aaaaaaccct aggttcttct
     1501 gagaaacaca gccagatgga aaaatttgaa agtcattatc gtggccggga actgccaggg
     1561 tttgtggact ataaggcatt tgagaacatt atcaagaagg aagtcaaggc cctggaagaa
     1621 cccgctctga acatgctgca cagggtcact accatggtca aaaatgcctt cacaaaggtt
     1681 tcatcaaaca attttggtga ttttttaaac ctccacagta ctgccaagtc caaaattgaa
     1741 gacatcagat ttagccaaga aaaagaagcc gaaaaactga tccgacttca cttccagatg
     1801 gaacacattg tctactgcca ggaccaggct tacaagaaag ccttgaagga gatcagagag
     1861 aaggaagctg agaaagagaa gtcaaccttt ggtgtctttc aacaaaactc tcctcgaaag
     1921 gagttgacta ccactgagat gacccagcac ctgaatgcct actaccagga gtgcggaagg
     1981 aacattggga gacagatccc tctgatcatc cagtactcca tcctgcaaac atttgggcag
     2041 gaaatggaga aagcaatgct tcagcttcta caggacacca gtaagtgcaa ctggttcctg
     2101 actgagcaga gtgacagcag agagaagaag aagttcctga agaggcggct tttaaggctg
     2161 gatgaggctc agcggaagct tgccaaattc tccaattaat caggcttgct atgtgacttc
     2221 cctggtcaca gctagcgtcc cctgcacaat gaccctttag ctgtttacct tatgttagta
     2281 tgttgccttt agactgtgga agcatgccct ctgcaaactc tgaggagacg aagagaggag
     2341 ccatggagag tcattctact tcagcagtaa gacacgaccc tctcaaagca caggaggctg
     2401 gcacctctca gggtccttcc tgctcctaac tgccatttct ttgtcaggag gatgtcctgg
     2461 ctgagtactt cagaagggat gtctcctggc tttgtactgc tctgcctgga gtagtgctag
     2521 aggtgtgaca gagtcctagc aggacagctc tttgtaggca taaatttttt gcaacctaat
     2581 tttagcaagg gttcaacctc acttttagcc caccacccat cagaggtagt gggacagaaa
     2641 agttattagg atatggggga agtgctcagc aatagttctt tgggggtgag ctcaactttc
     2701 tttggcagca taacaaacac caaataagac tcagaagttg cagatcagtc ctctaggcag
     2761 gcagacacca ggcacgaacc agcagctgta gatcaatctt aaagaaagct cgccagccag
     2821 cctgaggtaa ggctgtggaa gcagcaaact tcctcagcaa cctcacaagt agttcttagg
     2881 caagtttctt ctaatggtag tgttaccaca agttgagccc aacaatgcta tgcaaggcaa
     2941 accattacat gcacgttgtt agtgaagaat aagtaggcag agcaaaccaa cgctcagttg
     3001 ctcgtctccc agtgttttgt ggggccgtat ttatctcctt catcatgggt cctttcacat
     3061 gtttgcaata ttaaatcatc ctttcacctg tgtccgcttc aggacaacag tctttcacaa
     3121 gtttgcttca gcaagacacc ctttcacctg tgtgccccag caaaacatca tttgacataa
     3181 ctttctaaag aaactagaag tttccacttc aagttcttcc aataaaattc ttgctaaatg
     3241 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
