LOCUS       NM_001271060            3238 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus MX dynamin like GTPase 1 (Mx1), transcript
            variant 4, mRNA.
ACCESSION   NM_001271060
VERSION     NM_001271060.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3238)
  AUTHORS   Lee,S., Ishitsuka,A., Noguchi,M., Hirohama,M., Fujiyasu,Y.,
            Petric,P.P., Schwemmle,M., Staeheli,P., Nagata,K. and Kawaguchi,A.
  TITLE     Influenza restriction factor MxA functions as inflammasome sensor
            in the respiratory epithelium
  JOURNAL   Sci Immunol 4 (40) (2019)
   PUBMED   31653718
REFERENCE   2  (bases 1 to 3238)
  AUTHORS   Jung,H.E., Oh,J.E. and Lee,H.K.
  TITLE     Cell-Penetrating Mx1 Enhances Anti-Viral Resistance against Mucosal
            Influenza Viral Infection
  JOURNAL   Viruses 11 (2), 109 (2019)
   PUBMED   30696001
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3238)
  AUTHORS   Ciminski,K., Pulvermuller,J., Adam,J. and Schwemmle,M.
  TITLE     Human MxA is a potent interspecies barrier for the novel
            bat-derived influenza A-like virus H18N11
  JOURNAL   Emerg Microbes Infect 8 (1), 556-563 (2019)
   PUBMED   30945621
REFERENCE   4  (bases 1 to 3238)
  AUTHORS   Zang,F., Yue,M., Yao,Y., Liu,M., Fan,H., Feng,Y., Xia,X., Huang,P.
            and Yu,R.
  TITLE     Influence of IL28B and MxA gene polymorphisms on HCV clearance in
            Han Chinese population
  JOURNAL   Epidemiol Infect 146 (3), 379-385 (2018)
   PUBMED   29271328
REFERENCE   5  (bases 1 to 3238)
  AUTHORS   Saadeh,D., Kurban,M. and Abbas,O.
  TITLE     Plasmacytoid dendritic cells and type I interferon in the
            immunological response against warts
  JOURNAL   Clin Exp Dermatol 42 (8), 857-862 (2017)
   PUBMED   28736973
REFERENCE   6  (bases 1 to 3238)
  AUTHORS   Glymph,S., Mandal,S., Knowell,A.E., Abebe,F. and Chaudhary,J.
  TITLE     The myxovirus resistance A (MxA) gene -88G>T single nucleotide
            polymorphism is associated with prostate cancer
  JOURNAL   Infect Genet Evol 16, 186-190 (2013)
   PUBMED   23438650
REFERENCE   7  (bases 1 to 3238)
  AUTHORS   Melaine,N., Lienard,M.O., Guillaume,E., Ruffault,A.,
            Dejucq-Rainsford,N. and Jegou,B.
  TITLE     Production of the antiviral proteins 2'5'oligoadenylate synthetase,
            PKR and Mx in interstitial cells and spermatogonia
  JOURNAL   J Reprod Immunol 59 (1), 53-60 (2003)
   PUBMED   12892903
  REMARK    GeneRIF: IFN treatment induced Mx production and increased PKR
            production in immature germ cells
REFERENCE   8  (bases 1 to 3238)
  AUTHORS   Tazi-Ahnini,R., di Giovine,F.S., McDonagh,A.J., Messenger,A.G.,
            Amadou,C., Cox,A., Duff,G.W. and Cork,M.J.
  TITLE     Structure and polymorphism of the human gene for the
            interferon-induced p78 protein (MX1): evidence of association with
            alopecia areata in the Down syndrome region
  JOURNAL   Hum Genet 106 (6), 639-645 (2000)
   PUBMED   10942113
REFERENCE   9  (bases 1 to 3238)
  AUTHORS   Kolb,E., Laine,E., Strehler,D. and Staeheli,P.
  TITLE     Resistance to influenza virus infection of Mx transgenic mice
            expressing Mx protein under the control of two constitutive
            promoters
  JOURNAL   J Virol 66 (3), 1709-1716 (1992)
   PUBMED   1371172
REFERENCE   10 (bases 1 to 3238)
  AUTHORS   Meier,E., Kunz,G., Haller,O. and Arnheiter,H.
  TITLE     Activity of rat Mx proteins against a rhabdovirus
  JOURNAL   J Virol 64 (12), 6263-6269 (1990)
   PUBMED   2173790
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1 and BC099784.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. All six variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ226931.1, SRR26643296.29535.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840107,
                                           SAMN12840117 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                JAXUCZ010000011.1  50292814-50292904   c
            92-3238             BC099784.1         203-3349
FEATURES             Location/Qualifiers
     source          1..3238
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q12"
     gene            1..3238
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /note="MX dynamin like GTPase 1"
                     /db_xref="GeneID:24575"
                     /db_xref="RGD:3127"
     exon            1..91
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
     exon            92..275
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..2156
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /note="myxovirus resistance protein 1; myxoma resistance
                     protein 1; Myxovirus (influenza) resistance, homolog of
                     murine Mx (also interferon-inducible protein IFI78);
                     myxovirus (influenza virus) resistance 1"
                     /codon_start=1
                     /product="interferon-induced GTP-binding protein Mx1"
                     /protein_id="NP_001257989.1"
                     /db_xref="GeneID:24575"
                     /db_xref="RGD:3127"
                     /translation="MKEQTSACRHQTPQKHPDTSEESQAMESVDNLCSQYEEKVRPCI
                     DLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKL
                     KQLKQGEKWSGKVIYKDTEIEISHPSLVEREINKAQNLIAGEGLKISSDLISLEVSSP
                     HVPDLTLIDLPGITRVAVGDQPADIEHKIKRLITEYIQKQETINLVVVPSNVDIATTE
                     ALKMAQEVDPQGDRTIGILTKPDLVDRGTEDKVVDVVRNLVCHLKKGYMIVKCRGQQD
                     IQEQLSLAEALQKEQVFFKEHPQFRVLLEDGKATVPCLAKRLTMELTSHICKSLPILE
                     NQINVNHQIASEELQKYGADIPEDDSKRLSFLMNKINVFNKDILSLVQAQENISWEES
                     RLFTKLRNEFLAWNDYIEEHFKKTLGSSEKHSQMEKFESHYRGRELPGFVDYKAFENI
                     IKKEVKALEEPALNMLHRVTTMVKNAFTKVSSNNFGDFLNLHSTAKSKIEDIRFSQEK
                     EAEKLIRLHFQMEHIVYCQDQAYKKALKEIREKEAEKEKSTFGVFQQNSPRKELTTTE
                     MTQHLNAYYQECGRNIGRQIPLIIQYSILQTFGQEMEKAMLQLLQDTSKCNWFLTEQS
                     DSREKKKFLKRRLLRLDEAQRKLAKFSN"
     exon            276..468
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
     exon            469..606
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
     exon            607..761
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
     exon            762..900
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1099
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1178
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1301
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1443
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1608
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1685
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1925
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..3198
                     /gene="Mx1"
                     /gene_synonym="IFI78"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acactcagtc accaacccag gagctgtgag tattgcactg gattctgtgg gaggatagag
       61 gataccttgt aaggctcctt tgcagacatt gtgcctgacc ccagtggcaa ggcttccaga
      121 ttcttctgaa tcaaaccctt tatgtccaac cgaatccacc tggaaaacac gcaagagtga
      181 gttcctagaa cgtcaaaatg aaggagcaga cctctgcatg ccgtcaccag acaccacaga
      241 aacatcctga tacctctgaa gagagccagg caatggagtc tgtggataac ctctgcagtc
      301 agtatgagga gaaggtgcgg ccctgcattg acctcatcga ctccctgcga gctctgggtg
      361 tggagcaaga cctggccctg cctgccatcg ctgtcatcgg ggaccagagt tcagggaaga
      421 gctctgtgct ggaagcactg tctggagtgg ccctccccag aggcagtggt attgttacca
      481 ggtgtcctct ggtgctgaaa ttgaagcaac tgaagcaggg agaaaaatgg agcggcaagg
      541 tcatttataa ggacaccgag attgagatct cacacccttc actggtagaa agggaaatca
      601 ataaagccca gaacttgatt gctggggaag ggttgaagat tagctctgat ctcattagct
      661 tggaggttag ctctccacat gtcccagacc tgactctgat tgaccttcct ggtatcacaa
      721 gagtggctgt gggtgaccag cctgcagaca tcgaacacaa gatcaagaga cttatcactg
      781 aatacatcca gaaacaggag accatcaacc tggtggtggt ccccagcaat gtggacattg
      841 ccaccacaga ggccctgaaa atggctcagg aggtggaccc tcaaggggat agaaccatag
      901 ggatcttgac caagcccgat ctggtggaca gagggactga agacaaggtc gtggatgtgg
      961 tgcggaacct cgtgtgccac ctgaagaagg gctacatgat agtcaagtgc aggggtcagc
     1021 aggacatcca ggagcagctg agcctggctg aggctcttca gaaggagcaa gtcttcttca
     1081 aggaacaccc tcaattcaga gttcttctcg aggatgggaa ggccacagtg ccctgcttgg
     1141 caaagagact gaccatggag ctcacctccc acatctgtaa atcgctgcca atattggaaa
     1201 atcaaataaa tgtgaatcat cagattgcga gtgaggagct gcagaagtac ggagcagaca
     1261 taccagaaga tgacagtaag aggctgtcct ttctgatgaa taaaatcaat gtcttcaata
     1321 aggatatcct aagtttggta caagcacaag aaaacatatc atgggaagaa agccggctgt
     1381 tcaccaaact gcgaaatgag tttcttgctt ggaatgatta tattgaggaa catttcaaaa
     1441 aaaccctagg ttcttctgag aaacacagcc agatggaaaa atttgaaagt cattatcgtg
     1501 gccgggaact gccagggttt gtggactata aggcatttga gaacattatc aagaaggaag
     1561 tcaaggccct ggaagaaccc gctctgaaca tgctgcacag ggtcactacc atggtcaaaa
     1621 atgccttcac aaaggtttca tcaaacaatt ttggtgattt tttaaacctc cacagtactg
     1681 ccaagtccaa aattgaagac atcagattta gccaagaaaa agaagccgaa aaactgatcc
     1741 gacttcactt ccagatggaa cacattgtct actgccagga ccaggcttac aagaaagcct
     1801 tgaaggagat cagagagaag gaagctgaga aagagaagtc aacctttggt gtctttcaac
     1861 aaaactctcc tcgaaaggag ttgactacca ctgagatgac ccagcacctg aatgcctact
     1921 accaggagtg cggaaggaac attgggagac agatccctct gatcatccag tactccatcc
     1981 tgcaaacatt tgggcaggaa atggagaaag caatgcttca gcttctacag gacaccagta
     2041 agtgcaactg gttcctgact gagcagagtg acagcagaga gaagaagaag ttcctgaaga
     2101 ggcggctttt aaggctggat gaggctcagc ggaagcttgc caaattctcc aattaatcag
     2161 gcttgctatg tgacttccct ggtcacagct agcgtcccct gcacaatgac cctttagctg
     2221 tttaccttat gttagtatgt tgcctttaga ctgtggaagc atgccctctg caaactctga
     2281 ggagacgaag agaggagcca tggagagtca ttctacttca gcagtaagac acgaccctct
     2341 caaagcacag gaggctggca cctctcaggg tccttcctgc tcctaactgc catttctttg
     2401 tcaggaggat gtcctggctg agtacttcag aagggatgtc tcctggcttt gtactgctct
     2461 gcctggagta gtgctagagg tgtgacagag tcctagcagg acagctcttt gtaggcataa
     2521 attttttgca acctaatttt agcaagggtt caacctcact tttagcccac cacccatcag
     2581 aggtagtggg acagaaaagt tattaggata tgggggaagt gctcagcaat agttctttgg
     2641 gggtgagctc aactttcttt ggcagcataa caaacaccaa ataagactca gaagttgcag
     2701 atcagtcctc taggcaggca gacaccaggc acgaaccagc agctgtagat caatcttaaa
     2761 gaaagctcgc cagccagcct gaggtaaggc tgtggaagca gcaaacttcc tcagcaacct
     2821 cacaagtagt tcttaggcaa gtttcttcta atggtagtgt taccacaagt tgagcccaac
     2881 aatgctatgc aaggcaaacc attacatgca cgttgttagt gaagaataag taggcagagc
     2941 aaaccaacgc tcagttgctc gtctcccagt gttttgtggg gccgtattta tctccttcat
     3001 catgggtcct ttcacatgtt tgcaatatta aatcatcctt tcacctgtgt ccgcttcagg
     3061 acaacagtct ttcacaagtt tgcttcagca agacaccctt tcacctgtgt gccccagcaa
     3121 aacatcattt gacataactt tctaaagaaa ctagaagttt ccacttcaag ttcttccaat
     3181 aaaattcttg ctaaatgaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
