LOCUS       NM_022715               2757 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus major vault protein (Mvp), mRNA.
ACCESSION   NM_022715
VERSION     NM_022715.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2757)
  AUTHORS   Yu,K., Yau,Y.H., Sinha,A., Tan,T., Kickhoefer,V.A., Rome,L.H.,
            Lee,H., Shochat,S.G. and Lim,S.
  TITLE     Modulation of the Vault Protein-Protein Interaction for Tuning of
            Molecular Release
  JOURNAL   Sci Rep 7 (1), 14816 (2017)
   PUBMED   29093465
  REMARK    GeneRIF: The predicted docking shows that the vault-interacting
            domain of vault poly(ADP-ribose)-polymerase (INT) interaction sites
            are located between MVP domains 3 and 5.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2757)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2757)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107.. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2757)
  AUTHORS   Stamer,W.D., Hoffman,E.A., Luther,J.M., Hachey,D.L. and Schey,K.L.
  TITLE     Protein profile of exosomes from trabecular meshwork cells
  JOURNAL   J Proteomics 74 (6), 796-804 (2011)
   PUBMED   21362503
REFERENCE   5  (bases 1 to 2757)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   6  (bases 1 to 2757)
  AUTHORS   Kim,E., Lee,S., Mian,M.F., Yun,S.U., Song,M., Yi,K.S., Ryu,S.H. and
            Suh,P.G.
  TITLE     Crosstalk between Src and major vault protein in epidermal growth
            factor-dependent cell signalling
  JOURNAL   FEBS J 273 (4), 793-804 (2006)
   PUBMED   16441665
  REMARK    GeneRIF: Data show that the interaction between Src and major vault
            protein (MVP) is critically dependent on Src activity and protein
            (MVP) tyrosyl phosphorylation, which are induced by epidermal
            growth factor stimulation.
            Erratum:[FEBS J. 2006 Jun;273(11):2577]
REFERENCE   7  (bases 1 to 2757)
  AUTHORS   Kolli,S., Zito,C.I., Mossink,M.H., Wiemer,E.A. and Bennett,A.M.
  TITLE     The major vault protein is a novel substrate for the tyrosine
            phosphatase SHP-2 and scaffold protein in epidermal growth factor
            signaling
  JOURNAL   J Biol Chem 279 (28), 29374-29385 (2004)
   PUBMED   15133037
REFERENCE   8  (bases 1 to 2757)
  AUTHORS   Ehrnsperger,C. and Volknandt,W.
  TITLE     Major vault protein is a substrate of endogenous protein kinases in
            CHO and PC12 cells
  JOURNAL   Biol Chem 382 (10), 1463-1471 (2001)
   PUBMED   11727830
  REMARK    GeneRIF: casein kinase II enhances the phosphorylation of MVP in
            PC12 cells.Our results suggest that cell-specific phosphorylation
            of MVP may play a critical role in vault function.
REFERENCE   9  (bases 1 to 2757)
  AUTHORS   Kickhoefer,V.A., Stephen,A.G., Harrington,L., Robinson,M.O. and
            Rome,L.H.
  TITLE     Vaults and telomerase share a common subunit, TEP1
  JOURNAL   J Biol Chem 274 (46), 32712-32717 (1999)
   PUBMED   10551828
REFERENCE   10 (bases 1 to 2757)
  AUTHORS   Kickhoefer,V.A. and Rome,L.H.
  TITLE     The sequence of a cDNA encoding the major vault protein from Rattus
            norvegicus
  JOURNAL   Gene 151 (1-2), 257-260 (1994)
   PUBMED   7828886
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U09870.2.
            
            On Jan 21, 2004 this sequence version replaced NM_022715.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U09870.2, BC071174.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2757
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..2757
                     /gene="Mvp"
                     /note="major vault protein"
                     /db_xref="GeneID:64681"
                     /db_xref="RGD:70932"
     exon            1..33
                     /gene="Mvp"
                     /inference="alignment:Splign:2.1.0"
     exon            34..186
                     /gene="Mvp"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2647
                     /gene="Mvp"
                     /codon_start=1
                     /product="major vault protein"
                     /protein_id="NP_073206.2"
                     /db_xref="GeneID:64681"
                     /db_xref="RGD:70932"
                     /translation="MATEEAIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVL
                     FAPVRMVTVPPRHYCIVANPVSRDTQSSVLFDITGQVRLRHADQEIRLAQDPFPLYPG
                     EVLEKDITPLQVVLPNTALHLKALLDFEDKNGDKVMAGDEWLFEGPGTYIPQKEVEVV
                     EIIQATVIKQNQALRLRARKECFDREGKGRVTGEEWLVRSVGAYLPAVFEEVLDLVDA
                     VILTEKTALHLRALQNFRDLRGVLHRTGEEWLVTVQDTEAHVPDVYEEVLGVVPITTL
                     GPRHYCVILDPMGPDGKNQLGQKRVVKGEKSFFLQPGERLERGIQDVYVLSEQQGLLL
                     KALQPLEEGESEEKVSHQAGDCWLIRGPLEYVPSAKVEVVEERQAIPLDQNEGIYVQD
                     VKTGKVRAVIGSTYMLTQDEVLWEKELPSGVEELLNLGHDPLADRGQKGTAKPLQPSA
                     PRNKTRVVSYRVPHNAAVQVYDYRAKRARVVFGPELVTLDPEEQFTVLSLSAGRPKRP
                     HARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFELKNRNDPAEAAKLFSVPD
                     FVGDACKAIASRVRGAVASVTFDDFHKNSARIIRMAVFGFEMSEDTGPDGTLLPKARD
                     QAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQ
                     EARGRLERQKILDQSEAEKARKELLELEAMSMAVESTGNAKAEAESRAEAARIEGEGS
                     VLQAKLKAQALAIETEAELERVKKVREMELIYARAQLELEVSKAQQLANVEAKKFKEM
                     TEALGPGTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSSPINLFSTAFGLLGLGSDGQ
                     PPAQK"
     exon            187..382
                     /gene="Mvp"
                     /inference="alignment:Splign:2.1.0"
     exon            383..506
                     /gene="Mvp"
                     /inference="alignment:Splign:2.1.0"
     exon            507..638
                     /gene="Mvp"
                     /inference="alignment:Splign:2.1.0"
     exon            639..733
                     /gene="Mvp"
                     /inference="alignment:Splign:2.1.0"
     exon            734..970
                     /gene="Mvp"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1252
                     /gene="Mvp"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1497
                     /gene="Mvp"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1695
                     /gene="Mvp"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..2082
                     /gene="Mvp"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2199
                     /gene="Mvp"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2326
                     /gene="Mvp"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2515
                     /gene="Mvp"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2757
                     /gene="Mvp"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2757
                     /gene="Mvp"
                     /note="11 A nucleotides"
ORIGIN      
        1 tgtggcttgc agctgccagc taccctgcta aatgtttggt gggaaaagct tgggattcac
       61 catggcaact gaagaggcca tcatccgcat ccccccatac cactacatcc atgtgctgga
      121 ccagaacagt aatgtgtccc gtgtggaggt tggaccaaag acctacatcc ggcaggacaa
      181 tgagagggta ctgtttgccc cagttcgcat ggtgaccgtc cccccacgcc actactgcat
      241 agtggccaac cctgtgtccc gggacaccca gagttctgtg ttatttgaca tcacaggaca
      301 agtccgactc cggcacgctg accaggagat ccgactagcc caggacccct tccccctgta
      361 tccaggggag gtgctggaaa aggacatcac cccactgcag gtggttctgc ccaacacagc
      421 actgcatctt aaggcgttgc tggactttga ggataagaat ggagacaagg tcatggcagg
      481 agacgagtgg ctatttgagg gacctggcac ctacatccca cagaaggaag tggaagtcgt
      541 ggagatcatt caggccacag tcatcaaaca gaaccaagca ctgcggctaa gggcccgaaa
      601 ggagtgcttt gaccgggagg gcaaggggcg cgtgacaggt gaggagtggc tggtccgatc
      661 cgtgggggct tacctcccag ctgtctttga agaggtgctg gatctggtgg atgctgtgat
      721 ccttacagaa aagactgccc tgcacctccg ggctctgcag aacttcaggg accttcgggg
      781 agtgctccac cgcaccgggg aggaatggtt agtgacagtg caggacacag aagcccatgt
      841 tccagatgtc tatgaggagg tgcttggggt agtacccatc accaccctgg gacctcgaca
      901 ctactgtgtc attcttgacc caatgggacc agacggcaag aaccagctgg gacaaaagcg
      961 tgttgtcaag ggagagaagt cctttttcct ccagccagga gagaggctgg agcgaggcat
     1021 ccaggatgtg tatgtgctgt cagagcagca ggggctgcta ctgaaggcac tgcagcccct
     1081 ggaggaggga gagagcgagg agaaggtctc ccatcaggcc ggagactgct ggctcatccg
     1141 tgggcccctg gagtatgtgc catctgcaaa agtggaggtg gtggaggagc gtcaggctat
     1201 ccctctggac caaaatgagg gcatctatgt gcaggatgtc aagacgggga aggtgcgggc
     1261 tgtgattgga agcacctaca tgctgactca ggatgaagtc ctgtgggaaa aggagctgcc
     1321 ttctggggtg gaggagctgc tgaacttggg gcatgaccct ctggcagaca ggggtcagaa
     1381 gggcacagcc aagccccttc agccctcagc tccaaggaac aagacccgag tggtcagcta
     1441 ccgtgtcccg cacaatgcag cggtgcaggt ctatgactac agagccaaga gagcccgtgt
     1501 ggtctttggg cccgagctag tgacactgga tcctgaggag cagttcacag tattgtccct
     1561 ttctgccggg cgacccaagc gtcctcatgc ccgccgtgca ctctgcctac tgctgggacc
     1621 tgatttcttt actgatgtca tcaccatcga aactgcagat catgccaggt tgcagctgca
     1681 gcttgcctac aactggcact ttgaactgaa gaaccggaat gaccctgcag aggcagccaa
     1741 gcttttctcc gtgcctgact tcgtgggtga cgcctgcaag gccattgcat cccgagtccg
     1801 gggggctgta gcctctgtca cctttgatga cttccataaa aactcagccc ggatcattcg
     1861 aatggctgtt tttggctttg agatgtctga agacacaggt cctgatggca cactcctgcc
     1921 caaggctcga gaccaggcag tctttcccca aaacgggctg gtagtcagca gtgtggatgt
     1981 gcagtcagtg gagcccgtgg accagaggac ccgggatgcc cttcagcgca gcgttcagct
     2041 ggccatcgaa attaccacca actcccagga ggcagcagcc aagcacgagg ctcagagact
     2101 ggaacaggaa gcccgtggtc ggcttgagag gcagaagatc ttggaccagt cagaagctga
     2161 aaaagcccgc aaggaactct tggagcttga ggctatgagc atggctgtgg agagcacggg
     2221 taatgccaaa gcagaggctg agtcccgtgc agaggcagcg aggatcgaag gagaaggctc
     2281 tgtgctgcag gccaagctca aggcacaggc gctagccatt gagacggagg ctgagttgga
     2341 gcgagtaaag aaagtacgag agatggaact gatctatgcc cgggcccagt tggagctgga
     2401 ggtgagcaag gcgcagcagc ttgccaatgt ggaggcaaag aagttcaagg agatgacaga
     2461 ggcactgggc cccggcacca tcagggacct ggctgtggcc gggccagaga tgcaggtgaa
     2521 acttctccag tccctgggcc tgaaatccac tctcatcacc gatggctcgt ctcccatcaa
     2581 cctcttcagc acagccttcg ggttgctggg gctggggtct gatggtcagc cgccagcaca
     2641 gaagtgatcc ggcagcccgg ggaagacttg ctctcccagg ctctccgaag cagccatgct
     2701 gtgccttagg tcaacactga ctgcactgac aatggataaa ataaattgac aactgta
//
