LOCUS       NM_031063               1750 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus mevalonate kinase (Mvk), transcript variant 1,
            mRNA.
ACCESSION   NM_031063
VERSION     NM_031063.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1750)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1750)
  AUTHORS   McClory,J., Lin,J.T., Timson,D.J., Zhang,J. and Huang,M.
  TITLE     Catalytic mechanism of mevalonate kinase revisited, a QM/MM study
  JOURNAL   Org Biomol Chem 17 (9), 2423-2431 (2019)
   PUBMED   30735219
  REMARK    GeneRIF: This study demonstrated that significant conformational
            change on a flexible loop connecting the alpha6 and alpha7 helix is
            induced by the substrate mevalonate binding. Further, the study
            found that Asp204 is coordinated to the Mg2+ ion.
REFERENCE   3  (bases 1 to 1750)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   4  (bases 1 to 1750)
  AUTHORS   Wei,X., Das,J., Fragoza,R., Liang,J., Bastos de Oliveira,F.M.,
            Lee,H.R., Wang,X., Mort,M., Stenson,P.D., Cooper,D.N., Lipkin,S.M.,
            Smolka,M.B. and Yu,H.
  TITLE     A massively parallel pipeline to clone DNA variants and examine
            molecular phenotypes of human disease mutations
  JOURNAL   PLoS Genet 10 (12), e1004819 (2014)
   PUBMED   25502805
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1750)
  AUTHORS   Menon,B., Sinden,J., Franzo-Romain,M., Botta,R.B. and Menon,K.M.
  TITLE     Regulation of LH receptor mRNA binding protein by miR-122 in rat
            ovaries
  JOURNAL   Endocrinology 154 (12), 4826-4834 (2013)
   PUBMED   24064360
  REMARK    GeneRIF: These results suggest that hCG-induced down-regulation of
            LHR mRNA expression is mediated by activation of cAMP/PKA/ERK
            pathways to increase miR-122 expression, which then increases LRBP
            expression through the activation of SREBPs.
REFERENCE   6  (bases 1 to 1750)
  AUTHORS   Biardi,L., Sreedhar,A., Zokaei,A., Vartak,N.B., Bozeat,R.L.,
            Shackelford,J.E., Keller,G.A. and Krisans,S.K.
  TITLE     Mevalonate kinase is predominantly localized in peroxisomes and is
            defective in patients with peroxisome deficiency disorders
  JOURNAL   J Biol Chem 269 (2), 1197-1205 (1994)
   PUBMED   7904598
REFERENCE   7  (bases 1 to 1750)
  AUTHORS   Schafer,B.L., Bishop,R.W., Kratunis,V.J., Kalinowski,S.S.,
            Mosley,S.T., Gibson,K.M. and Tanaka,R.D.
  TITLE     Molecular cloning of human mevalonate kinase and identification of
            a missense mutation in the genetic disease mevalonic aciduria
  JOURNAL   J Biol Chem 267 (19), 13229-13238 (1992)
   PUBMED   1377680
REFERENCE   8  (bases 1 to 1750)
  AUTHORS   Stamellos,K.D., Shackelford,J.E., Tanaka,R.D. and Krisans,S.K.
  TITLE     Mevalonate kinase is localized in rat liver peroxisomes
  JOURNAL   J Biol Chem 267 (8), 5560-5568 (1992)
   PUBMED   1312092
REFERENCE   9  (bases 1 to 1750)
  AUTHORS   Tanaka,R.D., Lee,L.Y., Schafer,B.L., Kratunis,V.J., Mohler,W.A.,
            Robinson,G.W. and Mosley,S.T.
  TITLE     Molecular cloning of mevalonate kinase and regulation of its mRNA
            levels in rat liver
  JOURNAL   Proc Natl Acad Sci U S A 87 (8), 2872-2876 (1990)
   PUBMED   2158094
REFERENCE   10 (bases 1 to 1750)
  AUTHORS   Ramachandran,C.K. and Shah,S.N.
  TITLE     Studies on mevalonate kinase, phosphomevalonate kinase and
            pyrophosphomevalonate decarboxylase in developing rat brain
  JOURNAL   J Neurochem 28 (4), 751-757 (1977)
   PUBMED   197206
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Mar 4, 2021 this sequence version replaced NM_031063.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M29472.1, SRR26643293.85737.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                JAXUCZ010000012.1  47819409-47819503   c
            96-187              JAXUCZ010000012.1  47818334-47818425   c
            188-335             JAXUCZ010000012.1  47817275-47817422   c
            336-480             JAXUCZ010000012.1  47813293-47813437   c
            481-636             JAXUCZ010000012.1  47810587-47810742   c
            637-740             JAXUCZ010000012.1  47809189-47809292   c
            741-786             JAXUCZ010000012.1  47808656-47808701   c
            787-877             JAXUCZ010000012.1  47806763-47806853   c
            878-994             JAXUCZ010000012.1  47806301-47806417   c
            995-1148            JAXUCZ010000012.1  47803587-47803740   c
            1149-1750           JAXUCZ010000012.1  47802002-47802603   c
FEATURES             Location/Qualifiers
     source          1..1750
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1750
                     /gene="Mvk"
                     /gene_synonym="Lrbp; MK"
                     /note="mevalonate kinase"
                     /db_xref="GeneID:81727"
                     /db_xref="RGD:621295"
     exon            1..95
                     /gene="Mvk"
                     /gene_synonym="Lrbp; MK"
                     /inference="alignment:Splign:2.1.0"
     exon            96..187
                     /gene="Mvk"
                     /gene_synonym="Lrbp; MK"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1297
                     /gene="Mvk"
                     /gene_synonym="Lrbp; MK"
                     /EC_number="2.7.1.36"
                     /note="isoform 1 is encoded by transcript variant 1; LHR
                     mRNA binding protein"
                     /codon_start=1
                     /product="mevalonate kinase isoform 1"
                     /protein_id="NP_112325.1"
                     /db_xref="GeneID:81727"
                     /db_xref="RGD:621295"
                     /translation="MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLVLRPQ
                     SNGKVSLNLPNVGIKQVWDVATLQLLDTGFLEQGDVPAPTLEQLEKLKKVAGLPRDCV
                     GNEGLSLLAFLYLYLAICRKQRTLPSLDIMVWSELPPGAGLGSSAAYSVCVAAALLTA
                     CEEVTNPLKDRGSIGSWPEEDLKSINKWAYEGERVIHGNPSGVDNSVSTWGGALRYQQ
                     GKMSSLKRLPALQILLTNTKVPRSTKALVAGVRSRLIKFPEIMAPLLTSIDAISLECE
                     RVLGEMAAAPVPEQYLVLEELMDMNQHHLNALGVGHASLDQLCQVTAAHGLHSKLTGA
                     GGGGCGITLLKPGLERAKVEAAKQALTGCGFDCWETSIGAPGVSMHSATSIEDPVRQA
                     LGL"
     exon            188..335
                     /gene="Mvk"
                     /gene_synonym="Lrbp; MK"
                     /inference="alignment:Splign:2.1.0"
     exon            336..480
                     /gene="Mvk"
                     /gene_synonym="Lrbp; MK"
                     /inference="alignment:Splign:2.1.0"
     exon            481..636
                     /gene="Mvk"
                     /gene_synonym="Lrbp; MK"
                     /inference="alignment:Splign:2.1.0"
     exon            637..740
                     /gene="Mvk"
                     /gene_synonym="Lrbp; MK"
                     /inference="alignment:Splign:2.1.0"
     exon            741..786
                     /gene="Mvk"
                     /gene_synonym="Lrbp; MK"
                     /inference="alignment:Splign:2.1.0"
     exon            787..877
                     /gene="Mvk"
                     /gene_synonym="Lrbp; MK"
                     /inference="alignment:Splign:2.1.0"
     exon            878..994
                     /gene="Mvk"
                     /gene_synonym="Lrbp; MK"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1148
                     /gene="Mvk"
                     /gene_synonym="Lrbp; MK"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1750
                     /gene="Mvk"
                     /gene_synonym="Lrbp; MK"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacacgcctg cctccttggg gctctgccct ttgatatgga gaagaccggg agctactgcc
       61 ggagtttcgg ctcacctggg cgctggccgg ggcaggagtc tcaggagcca tgttgtcaga
      121 agtcctgctg gtgtctgctc cagggaaagt cattctccat ggagaacatg ctgtggtcca
      181 tggcaaggta gctctggcgg tggccttgaa cttgagaaca tttctcgtgc tgcgaccgca
      241 gagcaatggg aaagtgagcc tcaatttacc aaacgtcggt attaagcagg tctgggatgt
      301 ggccacactt cagctgctgg acacaggctt tcttgagcaa ggcgatgtcc cggcacccac
      361 cttggagcaa ctggagaagc tgaagaaggt ggcgggcctc ccccgagact gtgtaggcaa
      421 cgaaggcctg tctctgcttg cctttctgta cctgtacctg gctatctgcc ggaaacagag
      481 gacactccca agcctggaca tcatggtgtg gtcggaactg ccccctgggg cgggcttggg
      541 ctccagtgca gcctactcgg tgtgtgtggc agccgccctc ctgactgcct gtgaggaggt
      601 caccaacccg ctcaaggaca ggggctccat tggcagttgg cccgaggagg acctgaagtc
      661 aattaacaag tgggcctacg agggggagag agtgatccat gggaacccct ctggcgtgga
      721 caattccgtc agcacctggg gaggagccct gcgctaccag caagggaaga tgtcatcctt
      781 gaagaggctc ccagctctgc agatcctgct caccaacacc aaggtcccac gaagtaccaa
      841 ggccctcgtg gctggcgtca gaagcaggct aatcaagttc cctgagatca tggccccgct
      901 cctgacatca attgacgcaa tctccctgga gtgtgagcgc gtgctgggag agatggcggc
      961 cgcaccagtc ccagaacagt accttgtcct agaagagcta atggacatga accagcacca
     1021 tctgaatgcc cttggtgtgg gccacgcctc cctggaccag ctctgtcagg taacagcagc
     1081 acatggactg cacagcaagc tgactggcgc aggcggcggc ggctgtggca tcaccctcct
     1141 gaagccaggt ctagagcgag caaaagtgga ggccgccaag caggccctga ccggctgcgg
     1201 gtttgactgc tgggagacca gcattggagc gcctggggtc tccatgcact cagccacctc
     1261 catagaggac cctgtccgac aagccctggg cctctgacat gtcatcctgc caagaagctt
     1321 ccacgtatct ggggctggag ttggcccctg tgctggccac taacacattt cctgctggta
     1381 gtgccttgta gactctgaga ggcaccacct ccatggccca tctgtatcct ggcactgctg
     1441 aagccagaca ggcatcagtt gccgggtctt ctgagacagc aggctgacac agtaggcctt
     1501 ccccctgggt gattctgcct gggcctggcc tctgtcggcc tcacacaaac tctccggctc
     1561 ctagccacgc acccttctgt cctcagatgc cggccccttt ggaaccgcct agccagtggc
     1621 tcatgtctcc tgtcctctct cggggatcat cggctgaggc aaggcatgcc gactgcttta
     1681 tccccgtgtg tacctgtgga caagctgccc atggtggggc gagggaaggg ggaataaaat
     1741 gagctcgtac
//
