LOCUS       NM_001271232            1376 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus multivesicular body subunit 12B (Mvb12b), mRNA.
ACCESSION   NM_001271232 XM_001080165 XM_342420
VERSION     NM_001271232.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1376)
  AUTHORS   Boura,E. and Hurley,J.H.
  TITLE     Structural basis for membrane targeting by the MVB12-associated
            beta-prism domain of the human ESCRT-I MVB12 subunit
  JOURNAL   Proc Natl Acad Sci U S A 109 (6), 1901-1906 (2012)
   PUBMED   22232651
REFERENCE   2  (bases 1 to 1376)
  AUTHORS   Tsunematsu,T., Yamauchi,E., Shibata,H., Maki,M., Ohta,T. and
            Konishi,H.
  TITLE     Distinct functions of human MVB12A and MVB12B in the ESCRT-I
            dependent on their posttranslational modifications
  JOURNAL   Biochem Biophys Res Commun 399 (2), 232-237 (2010)
   PUBMED   20654576
  REMARK    Erratum:[Biochem Biophys Res Commun. 2011 Mar 4;406(1):158-9]
REFERENCE   3  (bases 1 to 1376)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1376)
  AUTHORS   Morita,E., Sandrin,V., Alam,S.L., Eckert,D.M., Gygi,S.P. and
            Sundquist,W.I.
  TITLE     Identification of human MVB12 proteins as ESCRT-I subunits that
            function in HIV budding
  JOURNAL   Cell Host Microbe 2 (1), 41-53 (2007)
   PUBMED   18005716
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Sep 9, 2012 this sequence version replaced
            XM_342420.5, XM_001080165.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.11333.1,
                                           SRR26643290.11194.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840106,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               JAXUCZ010000003.1  37590147-37590276   c
            131-253             JAXUCZ010000003.1  37577269-37577391   c
            254-361             JAXUCZ010000003.1  37544163-37544270   c
            362-458             JAXUCZ010000003.1  37538382-37538478   c
            459-588             JAXUCZ010000003.1  37532105-37532234   c
            589-711             JAXUCZ010000003.1  37529048-37529170   c
            712-806             JAXUCZ010000003.1  37506216-37506310   c
            807-862             JAXUCZ010000003.1  37456961-37457016   c
            863-922             JAXUCZ010000003.1  37453980-37454039   c
            923-1376            JAXUCZ010000003.1  37434664-37435117   c
FEATURES             Location/Qualifiers
     source          1..1376
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..1376
                     /gene="Mvb12b"
                     /gene_synonym="Fam125b; RGD1309709"
                     /note="multivesicular body subunit 12B"
                     /db_xref="GeneID:362118"
                     /db_xref="RGD:1309709"
     exon            1..130
                     /gene="Mvb12b"
                     /gene_synonym="Fam125b; RGD1309709"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1009
                     /gene="Mvb12b"
                     /gene_synonym="Fam125b; RGD1309709"
                     /note="family with sequence similarity 125, member B"
                     /codon_start=1
                     /product="multivesicular body subunit 12B"
                     /protein_id="NP_001258161.1"
                     /db_xref="GeneID:362118"
                     /db_xref="RGD:1309709"
                     /translation="MRSCFCVRRSRDPPPPQPPPPQRGTDQATMPEVKELSEALPETP
                     MDPITGVGVVASRNRAPTGYDVVAQTADGVDADLWKDGLFKSKVTRYLCFTRSFSKEN
                     SHLGNVLVDMKLIDVKDTLPVGFIPIQETVDTQEVVFRKKRLCIKFIPRDSTEAAICD
                     IRIMGRTKQAPPQYTFIGELNSMGIWYRMGRVPRNHDSSQPTTPSQSSAASTPAPNLP
                     RHISLTLPATFRGRNNTSTDYEYQLSNLYAISAMDGVPFMISEKFSCIPESMQPFDLL
                     GITIKSLAEIEKEYEYSFRTEQSAAARLPPSPTRCQQIPQS"
     exon            131..253
                     /gene="Mvb12b"
                     /gene_synonym="Fam125b; RGD1309709"
                     /inference="alignment:Splign:2.1.0"
     exon            254..361
                     /gene="Mvb12b"
                     /gene_synonym="Fam125b; RGD1309709"
                     /inference="alignment:Splign:2.1.0"
     exon            362..458
                     /gene="Mvb12b"
                     /gene_synonym="Fam125b; RGD1309709"
                     /inference="alignment:Splign:2.1.0"
     exon            459..588
                     /gene="Mvb12b"
                     /gene_synonym="Fam125b; RGD1309709"
                     /inference="alignment:Splign:2.1.0"
     exon            589..711
                     /gene="Mvb12b"
                     /gene_synonym="Fam125b; RGD1309709"
                     /inference="alignment:Splign:2.1.0"
     exon            712..806
                     /gene="Mvb12b"
                     /gene_synonym="Fam125b; RGD1309709"
                     /inference="alignment:Splign:2.1.0"
     exon            807..862
                     /gene="Mvb12b"
                     /gene_synonym="Fam125b; RGD1309709"
                     /inference="alignment:Splign:2.1.0"
     exon            863..922
                     /gene="Mvb12b"
                     /gene_synonym="Fam125b; RGD1309709"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1376
                     /gene="Mvb12b"
                     /gene_synonym="Fam125b; RGD1309709"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccggctgc agccgcctgg gccccgggcc cggctcctcc cgcgccgccc gggcgatgag
       61 aagctgcttc tgcgtgagac ggagccggga cccgccgccg ccgcagccgc cgccgcccca
      121 gcggggaaca gaccaagcca ccatgcctga agtcaaagag ctttcagaag ccttgccaga
      181 gacaccaatg gaccccatca cgggagtcgg ggtggtagcc tcccggaacc gagcgccgac
      241 aggctacgat gtggttgcac agacagcaga tggtgtggac gctgacctct ggaaggacgg
      301 cttattcaaa tccaaggtta ccagatacct gtgtttcaca agatcatttt ctaaagaaaa
      361 cagtcatttg gggaatgtgc tggtggacat gaaactcatc gacgtcaagg acacgttgcc
      421 tgtgggcttc attcccatcc aggagacggt ggatacacag gaggtggtct tcaggaagaa
      481 gaggctatgc attaagttca ttccccggga ttcaaccgaa gccgccattt gtgacattcg
      541 catcatgggc cggaccaagc aggctcctcc ccagtacaca tttatcgggg aactgaacag
      601 catgggcatc tggtatcgaa tgggcagagt gccaagaaac catgactcat ctcaacccac
      661 cacgccctcc cagtcatcag ctgcttccac cccagcccca aaccttccca ggcacatctc
      721 cctgacactc ccggctacct tccgaggcag aaacaacacc agcacagact atgagtacca
      781 gctctccaac ctgtatgcca tatcagcaat ggacggtgtg ccttttatga tttcagagaa
      841 gttttcctgc atcccagaaa gtatgcagcc ctttgatctc ttgggaatca ccatcaagtc
      901 tctggcggaa attgaaaagg agtacgagta cagtttccgc accgagcaga gcgcggcagc
      961 tcggctccca cccagcccta cccggtgcca gcagatcccc cagtcctgag gagcccacag
     1021 cctacccggt gcccagacta ctgatgaggt ggctggggtg agagtcacgc cctccctcac
     1081 ctgcccattc tgcttgcccc tgctcactga ccaagagact ctgggcagct gcttggtcag
     1141 atacggtcat cagctcgcct aacgagactt ccctccctcc ccgggaacgt tgttcataat
     1201 tgtgactaat gtgtgtgctg ttagtgacca gaggctcctg tgtgatgacc acttacccca
     1261 ccaagaaaga aaactcctcc cttacctgga gtcacccatg agggcctggg cacatactcc
     1321 atccacccag tgacactcac tggctaccct ccaactgacc atcactgacc acagaa
//
