LOCUS       NM_199375               1102 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus multivesicular body subunit 12A (Mvb12a), mRNA.
ACCESSION   NM_199375 XM_214303
VERSION     NM_199375.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1102)
  AUTHORS   Boura,E. and Hurley,J.H.
  TITLE     Structural basis for membrane targeting by the MVB12-associated
            beta-prism domain of the human ESCRT-I MVB12 subunit
  JOURNAL   Proc Natl Acad Sci U S A 109 (6), 1901-1906 (2012)
   PUBMED   22232651
REFERENCE   2  (bases 1 to 1102)
  AUTHORS   Tsunematsu,T., Yamauchi,E., Shibata,H., Maki,M., Ohta,T. and
            Konishi,H.
  TITLE     Distinct functions of human MVB12A and MVB12B in the ESCRT-I
            dependent on their posttranslational modifications
  JOURNAL   Biochem Biophys Res Commun 399 (2), 232-237 (2010)
   PUBMED   20654576
  REMARK    Erratum:[Biochem Biophys Res Commun. 2011 Mar 4;406(1):158-9]
REFERENCE   3  (bases 1 to 1102)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1102)
  AUTHORS   Morita,E., Sandrin,V., Alam,S.L., Eckert,D.M., Gygi,S.P. and
            Sundquist,W.I.
  TITLE     Identification of human MVB12 proteins as ESCRT-I subunits that
            function in HIV budding
  JOURNAL   Cell Host Microbe 2 (1), 41-53 (2007)
   PUBMED   18005716
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061799.1.
            
            On Jan 11, 2004 this sequence version replaced XM_214303.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061799.1, FQ233380.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1102
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..1102
                     /gene="Mvb12a"
                     /gene_synonym="Fam125a"
                     /note="multivesicular body subunit 12A"
                     /db_xref="GeneID:290635"
                     /db_xref="RGD:735220"
     exon            1..130
                     /gene="Mvb12a"
                     /gene_synonym="Fam125a"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..862
                     /gene="Mvb12a"
                     /gene_synonym="Fam125a"
                     /note="ESCRT-I complex subunit MVB12A; family with
                     sequence similarity 125, member A"
                     /codon_start=1
                     /product="multivesicular body subunit 12A"
                     /protein_id="NP_955407.1"
                     /db_xref="GeneID:290635"
                     /db_xref="RGD:735220"
                     /translation="MDPGTDSTPLAALVWSSASAPPPPGFSAITCTVEGATASFGRGF
                     AQKAGYFLCLSTLGIPENPQDNVVVDMQIVMDKGPLPPGFSTVNDPQDARTSVSKKKR
                     MCVKLMPLGTADVVVSDVKLSGKTKTVPGYLRVGDIGGFAIWCKKSKAPKLVPKPGTL
                     SQDMRGLSLDQPKEPSKGSHPERTLSRLGSRASTLRRNDSIYEASSLYGISAMDGVPF
                     TLHPRFEGKSCGPLNLSAFGDLTIKSLADIEKEYNYGFVVEKTAAARLPPSVS"
     exon            131..229
                     /gene="Mvb12a"
                     /gene_synonym="Fam125a"
                     /inference="alignment:Splign:2.1.0"
     exon            230..326
                     /gene="Mvb12a"
                     /gene_synonym="Fam125a"
                     /inference="alignment:Splign:2.1.0"
     exon            327..453
                     /gene="Mvb12a"
                     /gene_synonym="Fam125a"
                     /inference="alignment:Splign:2.1.0"
     exon            454..573
                     /gene="Mvb12a"
                     /gene_synonym="Fam125a"
                     /inference="alignment:Splign:2.1.0"
     exon            574..680
                     /gene="Mvb12a"
                     /gene_synonym="Fam125a"
                     /inference="alignment:Splign:2.1.0"
     exon            681..742
                     /gene="Mvb12a"
                     /gene_synonym="Fam125a"
                     /inference="alignment:Splign:2.1.0"
     exon            743..799
                     /gene="Mvb12a"
                     /gene_synonym="Fam125a"
                     /inference="alignment:Splign:2.1.0"
     exon            800..1059
                     /gene="Mvb12a"
                     /gene_synonym="Fam125a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggaccctc cgagggcgtt agctgccttt tgaactccca gggaggatgg atcccgggac
       61 ggattcaacg ccgcttgccg ccctggtttg gtcgtccgcc tcggcgccgc cgccgccggg
      121 tttcagcgcg atcacctgta ccgtggaggg cgcgacggcc agcttcggcc gaggcttcgc
      181 gcagaaggcc ggctacttcc tgtgcctgag cacactgggt atcccagaga accctcagga
      241 caatgtggta gtggacatgc agatcgtgat ggacaagggg cccctgccac caggcttctc
      301 tacagtcaac gaccctcagg atgccaggac ctctgtgtcc aagaagaagc gcatgtgtgt
      361 gaagctgatg cccctgggga cggcagacgt ggtagtgagt gacgtgaagc tcagtgggaa
      421 aaccaagacc gtgcctgggt atctgcgagt gggggacatt ggtggctttg ccatctggtg
      481 caagaaatcc aaagccccaa agctggtgcc caagcccggc acactcagcc aggacatgcg
      541 aggcctctca ctggaccaac ccaaagagcc cagcaaaggt agccacccag agcggacact
      601 gtccagactg ggctctcggg cttccaccct aaggaggaac gactccatct atgaggcatc
      661 cagtctctat ggcatttcag ccatggatgg ggttcccttt accctgcacc cgagatttga
      721 gggcaagagc tgcggaccct tgaacttgtc tgcctttggg gacctgacga ttaaatcact
      781 ggcagacatt gagaaggagt ataactatgg cttcgtggtg gagaagaccg cagctgcacg
      841 cctgcccccc agtgtctcat agcccagcca caggtgtcac ctggcgccac ctgcctcaca
      901 gacactgctg atcagcccca gcctctcagc ccggctactt gcacaagggg tctcttgcct
      961 ggtggtgcag gggcggcctg ggcagagcag tgaccttctc tcagaagtct gagtctagca
     1021 gccacatatg caccagcagt aaacactacc tggaacctaa aaaaaaaaaa aaaaaaaaaa
     1081 aaaaaaaaaa aaaaaaaaaa aa
//
