LOCUS       NM_133316               1669 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus mutY DNA glycosylase (Mutyh), mRNA.
ACCESSION   NM_133316
VERSION     NM_133316.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1669)
  AUTHORS   Tran,A.H.V., Han,S.H., Kim,J., Grasso,F., Kim,I.S. and Han,Y.S.
  TITLE     MutY DNA Glycosylase Protects Cells From Tumor Necrosis Factor
            Alpha-Induced Necroptosis
  JOURNAL   J Cell Biochem 118 (7), 1827-1838 (2017)
   PUBMED   28059467
REFERENCE   2  (bases 1 to 1669)
  AUTHORS   Goto,M., Shinmura,K., Nakabeppu,Y., Tao,H., Yamada,H.,
            Tsuneyoshi,T. and Sugimura,H.
  TITLE     Adenine DNA glycosylase activity of 14 human MutY homolog (MUTYH)
            variant proteins found in patients with colorectal polyposis and
            cancer
  JOURNAL   Hum Mutat 31 (11), E1861-E1874 (2010)
   PUBMED   20848659
REFERENCE   3  (bases 1 to 1669)
  AUTHORS   Kim,C.J., Cho,Y.G., Park,C.H., Kim,S.Y., Nam,S.W., Lee,S.H.,
            Yoo,N.J., Lee,J.Y. and Park,W.S.
  TITLE     Genetic alterations of the MYH gene in gastric cancer
  JOURNAL   Oncogene 23 (40), 6820-6822 (2004)
   PUBMED   15273732
REFERENCE   4  (bases 1 to 1669)
  AUTHORS   Lee,H.M., Hu,Z., Ma,H., Greeley,G.H. Jr., Wang,C. and
            Englander,E.W.
  TITLE     Developmental changes in expression and subcellular localization of
            the DNA repair glycosylase, MYH, in the rat brain
  JOURNAL   J Neurochem 88 (2), 394-400 (2004)
   PUBMED   14690527
  REMARK    GeneRIF: Levels of MutY DNA glycosylase are detected in rat brain
            at the embryonic stage, decrease during embryonic and neonatal
            development, while new isoforms appear and gradually increase in
            the neonate and adult brain.
REFERENCE   5  (bases 1 to 1669)
  AUTHORS   Englander,E.W., Hu,Z., Sharma,A., Lee,H.M., Wu,Z.H. and
            Greeley,G.H.
  TITLE     Rat MYH, a glycosylase for repair of oxidatively damaged DNA, has
            brain-specific isoforms that localize to neuronal mitochondria
  JOURNAL   J Neurochem 83 (6), 1471-1480 (2002)
   PUBMED   12472901
REFERENCE   6  (bases 1 to 1669)
  AUTHORS   Gu,Y., Parker,A., Wilson,T.M., Bai,H., Chang,D.Y. and Lu,A.L.
  TITLE     Human MutY homolog, a DNA glycosylase involved in base excision
            repair, physically and functionally interacts with mismatch repair
            proteins human MutS homolog 2/human MutS homolog 6
  JOURNAL   J Biol Chem 277 (13), 11135-11142 (2002)
   PUBMED   11801590
REFERENCE   7  (bases 1 to 1669)
  AUTHORS   Lee,H.M., Wang,C., Hu,Z., Greeley,G.H., Makalowski,W.,
            Hellmich,H.L. and Englander,E.W.
  TITLE     Hypoxia induces mitochondrial DNA damage and stimulates expression
            of a DNA repair enzyme, the Escherichia coli MutY DNA glycosylase
            homolog (MYH), in vivo, in the rat brain
  JOURNAL   J Neurochem 80 (5), 928-937 (2002)
   PUBMED   11948257
  REMARK    GeneRIF: respiratory hypoxia leads to increased expression of MYH
            in the rat brain
REFERENCE   8  (bases 1 to 1669)
  AUTHORS   Al-Tassan,N., Chmiel,N.H., Maynard,J., Fleming,N., Livingston,A.L.,
            Williams,G.T., Hodges,A.K., Davies,D.R., David,S.S., Sampson,J.R.
            and Cheadle,J.P.
  TITLE     Inherited variants of MYH associated with somatic G:C-->T:A
            mutations in colorectal tumors
  JOURNAL   Nat Genet 30 (2), 227-232 (2002)
   PUBMED   11818965
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 26, 2020 this sequence version replaced NM_133316.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF478683.1, SRR26360190.2976914.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                JAXUCZ010000005.1  135510754-135510801
            49-166              JAXUCZ010000005.1  135517695-135517812
            167-315             JAXUCZ010000005.1  135519067-135519215
            316-355             JAXUCZ010000005.1  135519287-135519326
            356-429             JAXUCZ010000005.1  135519450-135519523
            430-471             JAXUCZ010000005.1  135519625-135519666
            472-543             JAXUCZ010000005.1  135519742-135519813
            544-657             JAXUCZ010000005.1  135520013-135520126
            658-755             JAXUCZ010000005.1  135520204-135520301
            756-900             JAXUCZ010000005.1  135520381-135520525
            901-955             JAXUCZ010000005.1  135520606-135520660
            956-1147            JAXUCZ010000005.1  135520803-135520994
            1148-1284           JAXUCZ010000005.1  135521090-135521226
            1285-1437           JAXUCZ010000005.1  135521310-135521462
            1438-1479           JAXUCZ010000005.1  135521658-135521699
            1480-1669           JAXUCZ010000005.1  135522588-135522777
FEATURES             Location/Qualifiers
     source          1..1669
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..1669
                     /gene="Mutyh"
                     /gene_synonym="Myh"
                     /note="mutY DNA glycosylase"
                     /db_xref="GeneID:170841"
                     /db_xref="RGD:620045"
     exon            1..48
                     /gene="Mutyh"
                     /gene_synonym="Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            49..166
                     /gene="Mutyh"
                     /gene_synonym="Myh"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1605
                     /gene="Mutyh"
                     /gene_synonym="Myh"
                     /EC_number="3.2.2.31"
                     /note="a/G-specific adenine DNA glycosylase; rMYH; mutY
                     homolog"
                     /codon_start=1
                     /product="adenine DNA glycosylase"
                     /protein_id="NP_579850.2"
                     /db_xref="GeneID:170841"
                     /db_xref="RGD:620045"
                     /translation="MKKLRASVRSHKKQPANHKRRGKCALSSSQAKPSGLDGLAKQKR
                     EELLKTPVSPYHLFSDIADVTAFRRNLLSWYDQEKRDLPWRKRVKEEANLDRRAYAVW
                     VSEVMLQQTQVATVIDYYTRWMQKWPTLQDLASASLEEVNQLWSGLGYYSRGRRLQEG
                     ARKVVEELGGHVPRTAETLQQLLPGVGRYTAGAIASIAFDQVTGVVDGNVIRVLCRVR
                     AIGADPTSSFVSHHLWDLAQQLVDPARPGDFNQAAMELGATVCTPQRPLCSHCPVQSL
                     CRAHQRVGQGQLSALPGSPDIEECALNTRQCQLCLPSTNPWDPNMGVVNFPRKASRRP
                     PREEYSATCVVEQPGATGGPLILLVQRPNSGLLAGLWEFPSVTLEPSGQHQHKALLQE
                     LQHWSAPLPTTPLQHLGEVIHVFSHIKLTYQVYSLALEGQTPASTTPPGARWLTWEEF
                     RNAAVSTAMKKVFRVYEEHRQGTCKGSKRPQVCTPSSRKKPSRGQQVLDRFFQRHIPT
                     HKPNSTTQ"
     exon            167..315
                     /gene="Mutyh"
                     /gene_synonym="Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            316..355
                     /gene="Mutyh"
                     /gene_synonym="Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            356..429
                     /gene="Mutyh"
                     /gene_synonym="Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            430..471
                     /gene="Mutyh"
                     /gene_synonym="Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            472..543
                     /gene="Mutyh"
                     /gene_synonym="Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            544..657
                     /gene="Mutyh"
                     /gene_synonym="Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            658..755
                     /gene="Mutyh"
                     /gene_synonym="Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            756..900
                     /gene="Mutyh"
                     /gene_synonym="Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            901..955
                     /gene="Mutyh"
                     /gene_synonym="Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1147
                     /gene="Mutyh"
                     /gene_synonym="Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1284
                     /gene="Mutyh"
                     /gene_synonym="Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1437
                     /gene="Mutyh"
                     /gene_synonym="Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1479
                     /gene="Mutyh"
                     /gene_synonym="Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1669
                     /gene="Mutyh"
                     /gene_synonym="Myh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccccttgtg gggttctctg gagcgtccag ccggagacgg cgcaggaggt catcatgaag
       61 aagttacgag catctgtaag gagtcacaag aagcaaccag ccaaccacaa gagaagggga
      121 aaatgtgctc ttagcagcag ccaggccaaa ccttctggcc tcgatggcct ggccaagcag
      181 aagagagagg agttactgaa gacccctgtc tctccatatc acctcttcag tgacatagcc
      241 gatgtcacag ctttccgaag gaacctgctc agctggtatg accaagagaa gcgtgacctt
      301 ccttggagaa aacgggtaaa ggaggaggcc aacttggaca ggagagccta tgcagtctgg
      361 gtgtcagagg tcatgctgca gcagacccaa gttgccacag tgatcgacta ttatacccga
      421 tggatgcaga agtggccaac gctacaagac ctggccagtg cttccctgga ggaggtgaac
      481 cagctctggt ctggcctggg ctactattct cgaggtcgtc ggctccaaga aggagctagg
      541 aaggtggtag aggagctagg aggccacgta ccacgtacag cagagaccct gcagcagctc
      601 ctgcctgggg tggggcggta cacggctgga gccatcgctt ctattgcctt tgaccaggta
      661 accggtgtgg tggatgggaa cgtcatacgg gtgctgtgcc gtgtccgcgc cattggtgct
      721 gatcccacca gctcctttgt ctctcatcat ctctgggact tagcccagca gctggtggac
      781 ccagcccggc ctggggattt caaccaagca gccatggagc tgggagccac agtgtgtacc
      841 ccacagcgcc ctctctgcag ccattgtcct gtgcagagtt tatgccgggc acaccagagg
      901 gtgggacagg gacagctctc agccttgcca ggcagtcctg acatagagga gtgcgctctc
      961 aacactagac agtgccagct ttgcctccct tccacaaacc cctgggaccc caacatggga
     1021 gtggtcaact tccctcgaaa ggccagccgc agacctccca gggaggagta ctctgccacc
     1081 tgtgttgtag agcagcccgg agccactggg ggtcccctca tcctcctggt gcaaaggcct
     1141 aactcaggtc tgctggcagg actgtgggag ttcccgtctg tcaccttgga gccctcagga
     1201 cagcatcagc acaaagccct actgcaggag ctgcagcact ggtctgcacc cctccccacc
     1261 actcctctcc agcacctggg ggaggtgatc catgtcttct ctcacatcaa actgacatat
     1321 caggtataca gtctggctct cgaaggacag accccagcaa gcaccacacc tcctggcgct
     1381 cgatggttga cctgggagga attccgaaat gcagcggtgt ctactgccat gaaaaaggtg
     1441 ttccgcgtgt atgaggaaca tcggcaaggg acctgcaagg gttccaaaag gccccaggtg
     1501 tgtactccat caagccggaa aaaacccagc cggggacagc aagtcctgga tcgtttcttt
     1561 cagcgtcata tccccacaca caaacccaac agtactaccc agtgataccc tgccattccc
     1621 caccccaagt ccagtctaat aaaatgctta tttttgtagt tcctttgga
//
