LOCUS       NM_031061               2855 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus muscle associated receptor tyrosine kinase
            (Musk), mRNA.
ACCESSION   NM_031061
VERSION     NM_031061.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2855)
  AUTHORS   Bahreinipour,M.A., Joukar,S., Hovanloo,F., Najafipour,H.,
            Naderi,V., Rajiamirhasani,A. and Esmaeili-Mahani,S.
  TITLE     Mild aerobic training with blood flow restriction increases the
            hypertrophy index and MuSK in both slow and fast muscles of old
            rats: Role of PGC-1alpha
  JOURNAL   Life Sci 202, 103-109 (2018)
   PUBMED   29604268
  REMARK    GeneRIF: Low endurance exercise plus blood flow restriction
            improves the MuSK and hypertrophy index of both slow and fast
            muscles of elderly rats probably through the rise of PGC-1alpha
            expression
REFERENCE   2  (bases 1 to 2855)
  AUTHORS   Tan-Sindhunata,M.B., Mathijssen,I.B., Smit,M., Baas,F., de
            Vries,J.I., van der Voorn,J.P., Kluijt,I., Hagen,M.A., Blom,E.W.,
            Sistermans,E., Meijers-Heijboer,H., Waisfisz,Q., Weiss,M.M. and
            Groffen,A.J.
  TITLE     Identification of a Dutch founder mutation in MUSK causing fetal
            akinesia deformation sequence
  JOURNAL   Eur J Hum Genet 23 (9), 1151-1157 (2015)
   PUBMED   25537362
REFERENCE   3  (bases 1 to 2855)
  AUTHORS   Tsonis,A.I., Zisimopoulou,P., Lazaridis,K., Tzartos,J.,
            Matsigkou,E., Zouvelou,V., Mantegazza,R., Antozzi,C., Andreetta,F.,
            Evoli,A., Deymeer,F., Saruhan-Direskeneli,G., Durmus,H.,
            Brenner,T., Vaknin,A., Berrih-Aknin,S., Behin,A., Sharshar,T., De
            Baets,M., Losen,M., Martinez-Martinez,P., Kleopa,K.A.,
            Zamba-Papanicolaou,E., Kyriakides,T., Kostera-Pruszczyk,A.,
            Szczudlik,P., Szyluk,B., Lavrnic,D., Basta,I., Peric,S.,
            Tallaksen,C., Maniaol,A., Casasnovas Pons,C., Pitha,J.,
            Jakubikova,M., Hanisch,F. and Tzartos,S.J.
  TITLE     MuSK autoantibodies in myasthenia gravis detected by cell based
            assay--A multinational study
  JOURNAL   J Neuroimmunol 284, 10-17 (2015)
   PUBMED   26025053
REFERENCE   4  (bases 1 to 2855)
  AUTHORS   Witzemann,V., Chevessier,F., Pacifici,P.G. and Yampolsky,P.
  TITLE     The neuromuscular junction: selective remodeling of synaptic
            regulators at the nerve/muscle interface
  JOURNAL   Mech Dev 130 (6-8), 402-411 (2013)
   PUBMED   23032192
  REMARK    Review article
REFERENCE   5  (bases 1 to 2855)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   6  (bases 1 to 2855)
  AUTHORS   Terrado,J., Burgess,R.W., DeChiara,T., Yancopoulos,G., Sanes,J.R.
            and Kato,A.C.
  TITLE     Motoneuron survival is enhanced in the absence of neuromuscular
            junction formation in embryos
  JOURNAL   J Neurosci 21 (9), 3144-3150 (2001)
   PUBMED   11312299
REFERENCE   7  (bases 1 to 2855)
  AUTHORS   Gautam,M., DeChiara,T.M., Glass,D.J., Yancopoulos,G.D. and
            Sanes,J.R.
  TITLE     Distinct phenotypes of mutant mice lacking agrin, MuSK, or rapsyn
  JOURNAL   Brain Res Dev Brain Res 114 (2), 171-178 (1999)
   PUBMED   10320756
REFERENCE   8  (bases 1 to 2855)
  AUTHORS   Bowen,D.C., Park,J.S., Bodine,S., Stark,J.L., Valenzuela,D.M.,
            Stitt,T.N., Yancopoulos,G.D., Lindsay,R.M., Glass,D.J. and
            DiStefano,P.S.
  TITLE     Localization and regulation of MuSK at the neuromuscular junction
  JOURNAL   Dev Biol 199 (2), 309-319 (1998)
   PUBMED   9698449
REFERENCE   9  (bases 1 to 2855)
  AUTHORS   DeChiara,T.M., Bowen,D.C., Valenzuela,D.M., Simmons,M.V.,
            Poueymirou,W.T., Thomas,S., Kinetz,E., Compton,D.L., Rojas,E.,
            Park,J.S., Smith,C., DiStefano,P.S., Glass,D.J., Burden,S.J. and
            Yancopoulos,G.D.
  TITLE     The receptor tyrosine kinase MuSK is required for neuromuscular
            junction formation in vivo
  JOURNAL   Cell 85 (4), 501-512 (1996)
   PUBMED   8653786
REFERENCE   10 (bases 1 to 2855)
  AUTHORS   Valenzuela,D.M., Stitt,T.N., DiStefano,P.S., Rojas,E., Mattsson,K.,
            Compton,D.L., Nunez,L., Park,J.S., Stark,J.L., Gies,D.R. et al.
  TITLE     Receptor tyrosine kinase specific for the skeletal muscle lineage:
            expression in embryonic muscle, at the neuromuscular junction, and
            after injury
  JOURNAL   Neuron 15 (3), 573-584 (1995)
   PUBMED   7546737
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 27, 2020 this sequence version replaced NM_031061.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U34985.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760386,
                                           SAMEA5760475 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-198               JAXUCZ010000005.1  77853736-77853933
            199-325             JAXUCZ010000005.1  77861675-77861801
            326-477             JAXUCZ010000005.1  77864908-77865059
            478-605             JAXUCZ010000005.1  77869807-77869934
            606-747             JAXUCZ010000005.1  77871813-77871954
            748-872             JAXUCZ010000005.1  77911146-77911270
            873-1032            JAXUCZ010000005.1  77928759-77928918
            1033-1039           JAXUCZ010000005.1  77935426-77935432
            1040-1303           JAXUCZ010000005.1  77941292-77941555
            1304-1479           JAXUCZ010000005.1  77943074-77943249
            1480-1503           JAXUCZ010000005.1  77943887-77943910
            1504-1702           JAXUCZ010000005.1  77957566-77957764
            1703-1894           JAXUCZ010000005.1  77958172-77958363
            1895-2043           JAXUCZ010000005.1  77959767-77959915
            2044-2855           JAXUCZ010000005.1  77963527-77964338
FEATURES             Location/Qualifiers
     source          1..2855
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..2855
                     /gene="Musk"
                     /gene_synonym="Nsk1"
                     /note="muscle associated receptor tyrosine kinase"
                     /db_xref="GeneID:81725"
                     /db_xref="RGD:3211"
     exon            1..198
                     /gene="Musk"
                     /gene_synonym="Nsk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..2726
                     /gene="Musk"
                     /gene_synonym="Nsk1"
                     /EC_number="2.7.10.1"
                     /note="muscle-specific tyrosine kinase receptor MuSK;
                     muscle, skeletal receptor tyrosine protein kinase;
                     muscle-specific kinase receptor; muscle-specific tyrosine
                     protein kinase receptor; muscle specific kinase (neural
                     fold/somite kinase 1); muscle, skeletal, receptor tyrosine
                     kinase"
                     /codon_start=1
                     /product="muscle, skeletal receptor tyrosine protein
                     kinase precursor"
                     /protein_id="NP_112323.2"
                     /db_xref="GeneID:81725"
                     /db_xref="RGD:3211"
                     /translation="MRELVNIPLLQMLTLVAFSGTEKLPKAPVITTPLETVDALVEEV
                     ATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTAN
                     NGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSA
                     LRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKLVKLEVEVFARILRAP
                     ESHNVTFGSFVTLRCTAIGMPVPTISWIENGNAVSSGSIQENVKDRVIDSRLQLFITK
                     PGLYTCIATNKHGEKFSTAKAAATVSIAEWSKSQKESKGYCAQYRGEVCDAVLVKDSL
                     VFFNTSYPDPEEAQELLIHTAWNELKAVSPLCRPAAEALLCNHLFQECSSGVLPTPMP
                     ICREYCLAVKELFCAKEWLAMEGKTHRGLYRSGMHFLPVPECSKLPSMHQDPTACTRL
                     PYLDYKKENITTFPSITSSKPSVDIPNLPASTSSFAVSPAYSMTVIISIMSCFAVFAL
                     LTITTLYCCRRRREWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLS
                     LEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQR
                     EAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDL
                     STRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKI
                     ADFGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYG
                     LQPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRILQ
                     RMCERAEGTVGV"
     exon            199..325
                     /gene="Musk"
                     /gene_synonym="Nsk1"
                     /inference="alignment:Splign:2.1.0"
     exon            326..477
                     /gene="Musk"
                     /gene_synonym="Nsk1"
                     /inference="alignment:Splign:2.1.0"
     exon            478..605
                     /gene="Musk"
                     /gene_synonym="Nsk1"
                     /inference="alignment:Splign:2.1.0"
     exon            606..747
                     /gene="Musk"
                     /gene_synonym="Nsk1"
                     /inference="alignment:Splign:2.1.0"
     exon            748..872
                     /gene="Musk"
                     /gene_synonym="Nsk1"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1032
                     /gene="Musk"
                     /gene_synonym="Nsk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1039
                     /gene="Musk"
                     /gene_synonym="Nsk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1303
                     /gene="Musk"
                     /gene_synonym="Nsk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1479
                     /gene="Musk"
                     /gene_synonym="Nsk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1503
                     /gene="Musk"
                     /gene_synonym="Nsk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1702
                     /gene="Musk"
                     /gene_synonym="Nsk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1894
                     /gene="Musk"
                     /gene_synonym="Nsk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2043
                     /gene="Musk"
                     /gene_synonym="Nsk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2855
                     /gene="Musk"
                     /gene_synonym="Nsk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaacagtca ttagtggacg actctattgt aataaactgt gctttaaaat gtaaaccagg
       61 gagcgttttt ttcctcacat tgtccagaag caacctttct tcctgagcct ggattaatca
      121 tgagagagct cgtcaacatt ccactgttac agatgctcac cctggttgcc ttcagcggga
      181 ccgagaaact tccaaaagcc cctgtcatca ccacgcctct tgaaactgta gatgccttag
      241 ttgaagaagt ggcgactttc atgtgcgccg tggaatccta ccctcagcct gaaatttctt
      301 ggaccagaaa taaaattctc atcaagctgt ttgacacccg ctacagcatc cgagagaacg
      361 gtcagctcct caccatcctg agtgtggagg acagtgatga tggcatctac tgctgcacag
      421 ccaacaatgg agtgggagga gcggtggaaa gttgtggcgc cctgcaagtg aagatgaagc
      481 ctaaaataac tcgtcctccc atcaatgtaa aaataattga gggattgaaa gcagtcctac
      541 cgtgcactac gatgggtaac cccaagccat ccgtgtcctg gattaagggg gacagtgctc
      601 tcagggaaaa ttccaggatt gcagttcttg aatctgggag tttaaggatc cataatgtgc
      661 aaaaggaaga cgcaggacag taccgatgtg tggcaaaaaa cagcctgggc acagcttact
      721 ccaaactggt gaagctggaa gtggaggttt ttgcaagaat cctgcgtgct cctgaatccc
      781 acaatgtcac ctttggttcc tttgtaaccc tacgctgcac agcaataggc atgcctgtcc
      841 ccaccatcag ctggattgaa aacggaaatg ctgtttcttc aggttccatt caagagaatg
      901 tgaaagaccg agtgattgac tcaagactcc agctctttat cacaaagcca ggactctaca
      961 catgcatagc taccaataag catggagaga aattcagtac cgcaaaggct gcagccactg
     1021 tcagtatagc agaatggagc aaatcacaga aagaaagcaa aggctactgt gcccagtaca
     1081 gaggggaggt gtgtgatgcc gtcctggtga aagactctct tgtcttcttc aacacctcct
     1141 atcccgaccc tgaggaggcc caagagctgc tgatccacac tgcgtggaat gaactcaagg
     1201 ctgtgagccc actctgccga ccagctgccg aggctctgct gtgtaatcac ctcttccagg
     1261 agtgcagctc tggagtgcta cctactccta tgcccatttg cagagagtac tgcttggcag
     1321 taaaggagct cttctgtgca aaggaatggc tggcaatgga agggaagacc caccgcggac
     1381 tctacagatc cgggatgcat ttcctcccgg tcccggagtg cagcaagctt cccagcatgc
     1441 accaggaccc cacagcctgc acaagactgc cgtatttaga ttataaaaaa gaaaacataa
     1501 caacattccc gtccataacg tcctccaagc cgagcgtgga cattccaaac ctgcctgcct
     1561 ccacgtcttc cttcgccgtc tcgcctgcgt actccatgac tgtcatcatc tccatcatgt
     1621 cctgctttgc ggtgtttgct ctcctcacca tcactactct ctattgctgc cgaaggagga
     1681 gagagtggaa aaataagaaa agagagtcgg cagcggtgac cctcaccaca ttgccttccg
     1741 agctcctgct ggacaggctg catcccaacc ccatgtacca gaggatgcca ctccttctga
     1801 atcccaagtt gctcagcctg gagtatccga ggaataacat cgagtatgtc agagacatcg
     1861 gagagggagc gtttggaagg gtctttcaag cgagggcccc aggcttgctt ccttatgaac
     1921 ccttcactat ggtggctgtg aagatgctga aggaggaggc ctccgcagat atgcaggcag
     1981 actttcagag ggaggcagcc ctcatggcgg agtttgacaa ccccaacatt gtgaagctct
     2041 taggtgtgtg tgctgttggg aagccaatgt gcctgctctt tgaatatatg gcctatggtg
     2101 acctcaatga gttcctccga agcatgtccc ctcacactgt gtgcagcctc agccacagtg
     2161 acctgtccac gagggctcgg gtgtccagcc ctggtcctcc acccctgtct tgtgcggaac
     2221 agctctgtat tgccaggcaa gtggcagctg gcatggccta cctgtcggag cgcaagtttg
     2281 tccatcggga cttagctacc aggaactgcc tggttggaga gaacatggtg gtgaaaattg
     2341 cagactttgg cctctctagg aacatctact ccgcagacta ctacaaagct gatggaaacg
     2401 atgctatacc tatccgctgg atgccacccg agtctatctt ctacaaccgc tacaccacgg
     2461 agtcagatgt gtgggcttat ggcgtggtcc tctgggagat cttctcctat ggactgcagc
     2521 cctactatgg aatggcccat gaggaggtca tttactatgt gagagatggt aacatccttg
     2581 cctgccctga gaactgtccc ttggaactgt acaaccttat gcgcctatgt tggagcaagc
     2641 tgcctgcaga cagacccagc ttctgcagta tccaccggat cctgcagcgc atgtgcgaga
     2701 gagcagaggg aacggtaggc gtctaaggtt gaccgtgctc aaacaacacc caggaggatc
     2761 ttttcagact gcgagctgga gggatcctaa agcagaggcc ggataagacc agataggaag
     2821 agtttaactc aggcagcacg tgccagttga ttgtt
//
