LOCUS       NM_001025645            1924 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus MUS81 structure-specific endonuclease subunit
            (Mus81), mRNA.
ACCESSION   NM_001025645 XM_215180
VERSION     NM_001025645.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1924)
  AUTHORS   Xing,M., Wang,X., Palmai-Pallag,T., Shen,H., Helleday,T.,
            Hickson,I.D. and Ying,S.
  TITLE     Acute MUS81 depletion leads to replication fork slowing and a
            constitutive DNA damage response
  JOURNAL   Oncotarget 6 (35), 37638-37646 (2015)
   PUBMED   26415217
REFERENCE   2  (bases 1 to 1924)
  AUTHORS   Fugger,K., Chu,W.K., Haahr,P., Kousholt,A.N., Beck,H., Payne,M.J.,
            Hanada,K., Hickson,I.D. and Sorensen,C.S.
  TITLE     FBH1 co-operates with MUS81 in inducing DNA double-strand breaks
            and cell death following replication stress
  JOURNAL   Nat Commun 4, 1423 (2013)
   PUBMED   23361013
REFERENCE   3  (bases 1 to 1924)
  AUTHORS   Svendsen,J.M., Smogorzewska,A., Sowa,M.E., O'Connell,B.C.,
            Gygi,S.P., Elledge,S.J. and Harper,J.W.
  TITLE     Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and
            is required for DNA repair
  JOURNAL   Cell 138 (1), 63-77 (2009)
   PUBMED   19596235
REFERENCE   4  (bases 1 to 1924)
  AUTHORS   Munoz,I.M., Hain,K., Declais,A.C., Gardiner,M., Toh,G.W.,
            Sanchez-Pulido,L., Heuckmann,J.M., Toth,R., Macartney,T.,
            Eppink,B., Kanaar,R., Ponting,C.P., Lilley,D.M. and Rouse,J.
  TITLE     Coordination of structure-specific nucleases by human SLX4/BTBD12
            is required for DNA repair
  JOURNAL   Mol Cell 35 (1), 116-127 (2009)
   PUBMED   19595721
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098853.1.
            
            On Jul 22, 2005 this sequence version replaced XM_215180.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1924
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1924
                     /gene="Mus81"
                     /note="MUS81 structure-specific endonuclease subunit"
                     /db_xref="GeneID:293678"
                     /db_xref="RGD:1311957"
     exon            1..267
                     /gene="Mus81"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1788
                     /gene="Mus81"
                     /EC_number="3.1.22.-"
                     /note="MUS81 endonuclease homolog"
                     /codon_start=1
                     /product="crossover junction endonuclease MUS81"
                     /protein_id="NP_001020816.1"
                     /db_xref="GeneID:293678"
                     /db_xref="RGD:1311957"
                     /translation="MAEPVRLGRKRPLPVCPNPLFVRWLTEWRDEAASRGRHTRFVFQ
                     KALRSLQRYPLPLRNGKEAKILQHFGDRLCRMLDERLKEHLASGGDHAPSSPSGKKRA
                     SKGPPAQVQGSSMPVPTQPQAGSTNAGYWPAQNSGAREILLQLYREHLNSDGHSFLTK
                     EELLQKCAQKTPRVVPESSRPWPALRGLLHRNLVLRTHRPARYALTPEGLELAQKLAE
                     AEGLSTLNTAFQPEEHHEESPVPEAILSEPGTTEVGVQQRPLELRPSEYRVLLCVDIG
                     ETRGAGHRPEMLRELQRLRVPHTVRKLHVGDFVWVAQETRPRDPERPGELVLDHIVER
                     KRLDDLCSSIIDGRFREQKFRLKRCGLGHRIYLVEEHGSVQNLSLPESTLLQAVTNTQ
                     VIDGFFVKRTMDIKESAGYLALLTKGLERLYQGHTLHSRPWGTPGDAESEAKPSTNPL
                     CSLLTFSDFNAEAVKNKAQSVREVFARQLMQVRGLSGEKAAALVDRYSTPASLLAAYD
                     ACATTKEQEMLLSTVKCGRLQRNLGPALSRTLYQLYCSHSPLT"
     exon            268..397
                     /gene="Mus81"
                     /inference="alignment:Splign:2.1.0"
     exon            398..480
                     /gene="Mus81"
                     /inference="alignment:Splign:2.1.0"
     exon            481..582
                     /gene="Mus81"
                     /inference="alignment:Splign:2.1.0"
     exon            583..651
                     /gene="Mus81"
                     /inference="alignment:Splign:2.1.0"
     exon            652..737
                     /gene="Mus81"
                     /inference="alignment:Splign:2.1.0"
     exon            738..875
                     /gene="Mus81"
                     /inference="alignment:Splign:2.1.0"
     exon            876..971
                     /gene="Mus81"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1093
                     /gene="Mus81"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1191
                     /gene="Mus81"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1308
                     /gene="Mus81"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1404
                     /gene="Mus81"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1533
                     /gene="Mus81"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1637
                     /gene="Mus81"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1721
                     /gene="Mus81"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1898
                     /gene="Mus81"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaatcctt gatctagtgc cctactaggc tggagaggtc ctaccctcaa acaagtgtcc
       61 ttataccaat tgaaccgtcg agatcccagt ctcagggttt tttgagactc cgaaagaacc
      121 agtgtagatc ttatggcgga gccggtccgc ttgggccgga agcgtccgct gcctgtttgc
      181 cccaacccgc tcttcgttcg ttggctaacc gagtggcggg acgaggcagc cagcagaggg
      241 cgccacacgc gctttgtgtt tcaaaaggca ctgcgctccc tccagcggta cccgctacca
      301 ttgcgcaacg ggaaagaagc caagatactc cagcacttcg gagacaggct ctgtcgcatg
      361 ctggacgaaa ggctgaagga gcacctagca tcaggcggtg accatgcccc cagctcacca
      421 tctggaaaga agagagccag caaagggcca cctgcccagg tccagggctc ttccatgcca
      481 gttcccaccc agcctcaagc aggaagcacc aatgctggct attggccagc tcagaactca
      541 ggtgctcgag agatcctgct gcagctctac agggagcacc tgaattctga tggccacagc
      601 tttctaacca aagaggagct gctgcagaaa tgtgcccaga agacccccag ggtagtgcct
      661 gaaagttcaa gaccctggcc tgccctccga gggctcctcc acaggaacct agtcctcaga
      721 actcatcggc cagccaggta tgcactgaca ccagagggcc tggagctggc ccagaagctg
      781 gctgaggcag aaggcctgag cactctgaac actgcctttc agccagagga gcatcatgaa
      841 gagtcaccag ttccagaagc catcttgtca gaacctggca ctactgaggt gggcgtccaa
      901 cagagaccac tggagctaag gcctagcgag tacagagtgc tgttgtgtgt ggacattggc
      961 gaaaccagag gggcaggaca caggccagaa atgctccgag agttacaaag actgcgtgtg
     1021 ccccatacag ttcgcaaact gcatgttggg gactttgtgt gggtggcaca ggagaccagg
     1081 cccagagacc cagaaagacc tggggagtta gtcctggacc acattgtgga acgcaagcgg
     1141 ctagatgacc tgtgcagcag catcattgac ggccgctttc gagagcagaa gttccgcctg
     1201 aagcgctgtg gcctggggca ccggatatac ttggtagagg aacatgggtc tgtccaaaac
     1261 cttagccttc ctgagagtac attgctgcag gctgtcacaa acacccaggt cattgatggt
     1321 ttttttgtga agcgtaccat ggatattaag gagtcagctg gctacctggc gcttttgaca
     1381 aagggcctgg aaagactgta ccagggccac accctacaca gccgcccttg gggaacccca
     1441 ggggatgctg aatcagaagc aaagccttcc acaaaccctc tctgctcact cctcaccttc
     1501 agtgacttca atgcagaagc tgtcaagaac aaggcccagt ctgtgcgaga ggtatttgcc
     1561 cggcagctga tgcaggtgcg tggactgagt ggggagaagg cagcagccct ggtggatcga
     1621 tacagcaccc ctgccagtct cctggctgcc tatgatgcct gtgccaccac caaggagcag
     1681 gagatgctgc tgagcaccgt caagtgtggg cgtctgcaga gaaatctggg acctgctctg
     1741 agcaggaccc tgtaccagct gtattgcagc cacagccctt tgacctgagc tatacctgga
     1801 aatgctcccc agcacccatc ttcatctcta ccaaggctag ccttttaaca ggtcctctgg
     1861 gctttaataa aaatccaaat gtgtgtggtg ttaaggaaaa aaaaaaaaaa aaaaaaaaaa
     1921 aaaa
//
