LOCUS       NM_001003409             916 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus major urinary protein 4 like 1 (Mup4l1),
            transcript variant 2, mRNA.
ACCESSION   NM_001003409 XM_039109480 XM_216424
VERSION     NM_001003409.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 916)
  AUTHORS   Borghoff,S.J., Poet,T.S., Green,S., Davis,J., Hughes,B.,
            Mensing,T., Sarang,S.S., Lynch,A.M. and Hard,G.C.
  TITLE     Methyl isobutyl ketone exposure-related increases in specific
            measures of alpha2u-globulin (alpha2u) nephropathy in male rats
            along with in vitro evidence of reversible protein binding
  JOURNAL   Toxicology 333, 1-13 (2015)
   PUBMED   25797582
  REMARK    GeneRIF: Methyl isobutyl ketone exerts nephrotoxic effects through
            a protein droplet alpha2u nephropathy-mediated mode of action.
REFERENCE   2  (bases 1 to 916)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   3  (bases 1 to 916)
  AUTHORS   Saito,K., Nishikawa,J., Imagawa,M., Nishihara,T. and Matsuo,M.
  TITLE     Molecular evidence of complex tissue- and sex-specific mRNA
            expression of the rat alpha(2u)-globulin multigene family
  JOURNAL   Biochem Biophys Res Commun 272 (2), 337-344 (2000)
   PUBMED   10833415
REFERENCE   4  (bases 1 to 916)
  AUTHORS   Bayard,C., Holmquist,L. and Vesterberg,O.
  TITLE     Purification and identification of allergenic alpha (2u)-globulin
            species of rat urine
  JOURNAL   Biochim Biophys Acta 1290 (2), 129-134 (1996)
   PUBMED   8645715
  REMARK    Erratum:[Biochim Biophys Acta 1996 Dec 6;1291(3):253-5]
REFERENCE   5  (bases 1 to 916)
  AUTHORS   Bocskei,Z., Groom,C.R., Flower,D.R., Wright,C.E., Phillips,S.E.,
            Cavaggioni,A., Findlay,J.B. and North,A.C.
  TITLE     Pheromone binding to two rodent urinary proteins revealed by X-ray
            crystallography
  JOURNAL   Nature 360 (6400), 186-188 (1992)
   PUBMED   1279439
REFERENCE   6  (bases 1 to 916)
  AUTHORS   Kimura,H., Odani,S., Nishi,S., Sato,H., Arakawa,M. and Ono,T.
  TITLE     Primary structure and cellular distribution of two fatty
            acid-binding proteins in adult rat kidneys
  JOURNAL   J Biol Chem 266 (9), 5963-5972 (1991)
   PUBMED   2005132
REFERENCE   7  (bases 1 to 916)
  AUTHORS   Ichiyoshi,Y., Endo,H. and Yamamoto,M.
  TITLE     Length polymorphism in the 3' noncoding region of rat hepatic alpha
            2u-globulin mRNAs
  JOURNAL   Biochim Biophys Acta 910 (1), 43-51 (1987)
   PUBMED   2443176
REFERENCE   8  (bases 1 to 916)
  AUTHORS   Winderickx,J., van Dijck,P., Dirckx,L., Volckaert,G., Rombauts,W.,
            Heyns,W. and Verhoeven,G.
  TITLE     Comparison of the 5' upstream putative regulatory sequences of
            three members of the alpha 2u-globulin gene family
  JOURNAL   Eur J Biochem 165 (3), 521-529 (1987)
   PUBMED   2439333
REFERENCE   9  (bases 1 to 916)
  AUTHORS   Osorio-Almeida,M.L., Sinogas,C., Ludovice,M. and Lechner,M.C.
  TITLE     Induction of alpha 2u globulin mRNA by phenobarbital in rat liver:
            characterization of a cDNA clone
  JOURNAL   Biochem Biophys Res Commun 134 (3), 1182-1189 (1986)
   PUBMED   2418834
REFERENCE   10 (bases 1 to 916)
  AUTHORS   Kondo,Y. and Yamada,J.
  TITLE     Male urinary protein-1 (Mup-1) expression in the female rat
  JOURNAL   J Hered 74 (4), 280-282 (1983)
   PUBMED   6886376
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Feb 15, 2023 this sequence version replaced
            XM_039109480.1, NM_001003409.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M26835.1, M26836.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               JAXUCZ010000005.1  80226372-80226534   c
            164-297             JAXUCZ010000005.1  80225930-80226063   c
            298-371             JAXUCZ010000005.1  80225629-80225702   c
            372-482             JAXUCZ010000005.1  80224840-80224950   c
            483-584             JAXUCZ010000005.1  80224392-80224493   c
            585-655             JAXUCZ010000005.1  80224151-80224221   c
            656-916             JAXUCZ010000005.1  80223093-80223353   c
FEATURES             Location/Qualifiers
     source          1..916
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..916
                     /gene="Mup4l1"
                     /gene_synonym="Mup; Mup4l2; RGD1566134"
                     /note="major urinary protein 4 like 1"
                     /db_xref="GeneID:298109"
                     /db_xref="RGD:1566134"
     exon            1..163
                     /gene="Mup4l1"
                     /gene_synonym="Mup; Mup4l2; RGD1566134"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..610
                     /gene="Mup4l1"
                     /gene_synonym="Mup; Mup4l2; RGD1566134"
                     /note="alpha-2u globulin PGCL2; alpha-2u globulin PGCL1;
                     allergen n I; alpha-2u-globulin; alpha(2)-euglobulin;
                     allergen Rat n I; alpha-2u-globulin (L type); major
                     urinary protein 4 like 2"
                     /codon_start=1
                     /product="major urinary protein precursor"
                     /protein_id="NP_001003409.2"
                     /db_xref="GeneID:298109"
                     /db_xref="RGD:1566134"
                     /translation="MKLLLLLLCLGLTLVCGHAEEASSTRGNLDVAKLNGDWFSIVVA
                     SNKREKIEENGSMRVFMQHIDVLENSLGFKFRIKENGECRELYLVAYKTPEDGEYFVE
                     YDGGNTFTILKTDYDRYVMFHLINFKNGETFQLMVLYGRTKDLSSDIKEKFAKLCEAH
                     GITRDNIIDLTKTDRCLQARG"
     exon            164..297
                     /gene="Mup4l1"
                     /gene_synonym="Mup; Mup4l2; RGD1566134"
                     /inference="alignment:Splign:2.1.0"
     exon            298..371
                     /gene="Mup4l1"
                     /gene_synonym="Mup; Mup4l2; RGD1566134"
                     /inference="alignment:Splign:2.1.0"
     exon            372..482
                     /gene="Mup4l1"
                     /gene_synonym="Mup; Mup4l2; RGD1566134"
                     /inference="alignment:Splign:2.1.0"
     exon            483..584
                     /gene="Mup4l1"
                     /gene_synonym="Mup; Mup4l2; RGD1566134"
                     /inference="alignment:Splign:2.1.0"
     exon            585..655
                     /gene="Mup4l1"
                     /gene_synonym="Mup; Mup4l2; RGD1566134"
                     /inference="alignment:Splign:2.1.0"
     exon            656..916
                     /gene="Mup4l1"
                     /gene_synonym="Mup; Mup4l2; RGD1566134"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagtgtggg catcatcagc agagagattg tcccaacaga gaggcaattc tattccctac
       61 caacatgaag ctgttgctgc tgctgctgtg tctgggcctg acactggtct gtggccatgc
      121 agaagaagct agttccacaa gagggaacct cgatgtggct aagctcaatg gggattggtt
      181 ttctattgtc gtggcctcta acaaaagaga aaagatagaa gagaatggca gcatgagagt
      241 ttttatgcag cacatcgatg tcttggagaa ttccttaggc ttcaagttcc gtattaagga
      301 aaatggagag tgcagggaac tatatttggt tgcctacaaa acgccagagg atggcgaata
      361 ttttgttgag tatgacggag ggaatacatt tactatactt aagacagact atgacagata
      421 tgtcatgttt catctcatta atttcaagaa cggggaaacc ttccagctga tggtgctcta
      481 cggcagaaca aaggatctga gttcagacat caaggaaaag tttgcaaaac tatgtgaggc
      541 gcatggaatc actagggaca atatcattga tctaaccaag actgatcgct gtctccaggc
      601 ccgaggatga agaaaggcct gagcctccag gtgggcaatc tccagtgaga gcaagtgctg
      661 agtggagact tctcaccagg actctagcat caccatttcc tgtccatgga gcatcctgag
      721 acaaattctg cgatctgatt tccatcctct gtcacagaaa agtgcaatcc tggtctctcc
      781 agcatcttcc ctagttaccc aggacaacac atcgagaatt aaaagctttc ttaaatttct
      841 cttggcccca cccatgatca ttccgcacaa atatcttgct cttgcagttc aataaatgat
      901 tacccttgca cttaaa
//
