LOCUS       NM_001395728            4670 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus murinoglobulin 2 (Mug2), mRNA.
ACCESSION   NM_001395728
VERSION     NM_001395728.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4670)
  AUTHORS   Cheong,S.S., Hentschel,L., Davidson,A.E., Gerrelli,D., Davie,R.,
            Rizzo,R., Pontikos,N., Plagnol,V., Moore,A.T., Sowden,J.C.,
            Michaelides,M., Snead,M., Tuft,S.J. and Hardcastle,A.J.
  TITLE     Mutations in CPAMD8 Cause a Unique Form of Autosomal-Recessive
            Anterior Segment Dysgenesis
  JOURNAL   Am J Hum Genet 99 (6), 1338-1352 (2016)
   PUBMED   27839872
REFERENCE   2  (bases 1 to 4670)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
REFERENCE   3  (bases 1 to 4670)
  AUTHORS   Enghild,J.J., Salvesen,G., Thogersen,I.B. and Pizzo,S.V.
  TITLE     Proteinase binding and inhibition by the monomeric
            alpha-macroglobulin rat alpha 1-inhibitor-3
  JOURNAL   J Biol Chem 264 (19), 11428-11435 (1989)
   PUBMED   2472396
REFERENCE   4  (bases 1 to 4670)
  AUTHORS   Northemann,W., Shiels,B.R., Braciak,T.A. and Fey,G.H.
  TITLE     Structure and negative transcriptional regulation by
            glucocorticoids of the acute-phase rat alpha 1-inhibitor III gene
  JOURNAL   Biochemistry 28 (1), 84-95 (1989)
   PUBMED   2495816
REFERENCE   5  (bases 1 to 4670)
  AUTHORS   Braciak,T.A., Northemann,W., Hudson,G.O., Shiels,B.R., Gehring,M.R.
            and Fey,G.H.
  TITLE     Sequence and acute phase regulation of rat alpha 1-inhibitor III
            messenger RNA
  JOURNAL   J Biol Chem 263 (8), 3999-4012 (1988)
   PUBMED   2831216
REFERENCE   6  (bases 1 to 4670)
  AUTHORS   Schweizer,M., Takabayashi,K., Geiger,T., Laux,T., Biermann,G.,
            Buhler,J.M., Gauthier,F., Roberts,L.M. and Heinrich,P.C.
  TITLE     Identification and sequencing of cDNA clones for the rodent
            negative acute-phase protein alpha 1-inhibitor 3
  JOURNAL   Eur J Biochem 164 (2), 375-381 (1987)
   PUBMED   2436907
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.14873.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               JAXUCZ010000004.1  156836155-156836308
            155-338             JAXUCZ010000004.1  156837449-156837632
            339-498             JAXUCZ010000004.1  156844586-156844745
            499-551             JAXUCZ010000004.1  156844853-156844905
            552-572             JAXUCZ010000004.1  156853437-156853457
            573-741             JAXUCZ010000004.1  156853724-156853892
            742-826             JAXUCZ010000004.1  156854260-156854344
            827-935             JAXUCZ010000004.1  156862082-156862190
            936-1056            JAXUCZ010000004.1  156866360-156866480
            1057-1166           JAXUCZ010000004.1  156866620-156866729
            1167-1328           JAXUCZ010000004.1  156867399-156867560
            1329-1556           JAXUCZ010000004.1  156876660-156876887
            1557-1620           JAXUCZ010000004.1  156877265-156877328
            1621-1763           JAXUCZ010000004.1  156878295-156878437
            1764-1913           JAXUCZ010000004.1  156880297-156880446
            1914-2075           JAXUCZ010000004.1  156882817-156882978
            2076-2157           JAXUCZ010000004.1  156883595-156883676
            2158-2356           JAXUCZ010000004.1  156885975-156886173
            2357-2585           JAXUCZ010000004.1  156886757-156886985
            2586-2712           JAXUCZ010000004.1  156887678-156887804
            2713-2834           JAXUCZ010000004.1  156888062-156888183
            2835-2886           JAXUCZ010000004.1  156889090-156889141
            2887-2970           JAXUCZ010000004.1  156890926-156891009
            2971-3147           JAXUCZ010000004.1  156891274-156891450
            3148-3235           JAXUCZ010000004.1  156891665-156891752
            3236-3392           JAXUCZ010000004.1  156892792-156892948
            3393-3467           JAXUCZ010000004.1  156893171-156893245
            3468-3648           JAXUCZ010000004.1  156894072-156894252
            3649-3872           JAXUCZ010000004.1  156902368-156902591
            3873-4091           JAXUCZ010000004.1  156903376-156903594
            4092-4219           JAXUCZ010000004.1  156903747-156903874
            4220-4310           JAXUCZ010000004.1  156905701-156905791
            4311-4379           JAXUCZ010000004.1  156906398-156906466
            4380-4482           JAXUCZ010000004.1  156907275-156907377
            4483-4524           JAXUCZ010000004.1  156908474-156908515
            4525-4670           JAXUCZ010000004.1  156908827-156908972
FEATURES             Location/Qualifiers
     source          1..4670
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..4670
                     /gene="Mug2"
                     /note="murinoglobulin 2"
                     /db_xref="GeneID:408236"
                     /db_xref="RGD:1302962"
     exon            1..154
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..4541
                     /gene="Mug2"
                     /codon_start=1
                     /product="murinoglobulin-2 precursor"
                     /protein_id="NP_001382657.1"
                     /db_xref="GeneID:408236"
                     /db_xref="RGD:1302962"
                     /translation="MWKNREAQLCLFSVLLAFLPSASLLFGNSKYMVLVPSQLYTETP
                     EKICLHLYHLNETVTVTASLISQRGTRKLFDEPVVDKDLFHCVSFTIPRLPSSEEEES
                     LDINIEGAKHKFSKRHVVLVKNKESVVFVQTDKPMYKPGQSVKFRVVSMDKNLYPLKE
                     LFPLAYIEDPKMNRIMQWQDVKTENGLKQLSFSLSAEPIQGPYKIVVLKQSGVKEEHS
                     FTVMEFVLPRFGVDVKVPNAISVYDEIISVTACATYTYGKPVLGRVKVRLCHGNPSFS
                     SETKSACKEENSKLDNNGCSTQEVNITEFQLKENYLKVRQAFHVNATVTEEGTGSEFG
                     GYGRIEVERTRNKFLFLKADSHFRHGIPFFVKVRLVDIKGDPIPNEQVFIKAQEAGYT
                     NATTTDQHGLAKFSIDTSSISGYSLNIKVYHKEENLCIHSSCTAERHAEAHHTAYAVY
                     SLSKSYIYLDTEAGVLPCNQIHTVQAHFILKGQVLGVLPQIVFHYLVMAQGSILQTGN
                     HTHQVESGVLQGNFALEIPVEFSMVPMAKMLIYTILPDGEVIADSVKFQVEKCLRNKV
                     HLSFSPSQSLPASQTHMRVTASPQSLCGLRAVDQSVLLLRPEAELSPSLIYDLPGMQD
                     SNFIPRSHHPFEDEDDCLMYQPRDTEELTYSVPYGREKDVYRYVRDMGLTAFTNLKIK
                     HPTYCYDDEIFEIFEPTVELNTSPMWEKIEIMALIANENPLPKEPPRKDPPRKDPEPK
                     DTVVETIRNYFPETWVWDLVTVNSSGVTEVEMTVPDTITEWKAGALCLSNDTGLGLSS
                     VATLQAFQPFFVELTMPYSVIRGEAFTLKATVMNYLPTSLPMTVQLEASPDFTAVPVG
                     NDQDSYCLGANGRHTSSWLVTPKSLGNVNFSVSVEAQQSPEPCGSEVATVPETGRKDT
                     VIKVLIVEPEGIKKEHTFSSLLCASDAELSETLSLLLPPRVVKDSARAHFSVMGDILS
                     SAIKNTQNLIQMPYGCGEQNMVLFAPNIYVLKYLNETQQLTENIKSKALGYLRAGYQR
                     ELNYKHKDGSYSAFGDHNGQGQGNTWLTAFVLKSFAQARAFIFIDESHITDAFTWLSK
                     QQKDSGCFRSSGSLFNNAMKGGVDDEITLSAYITMALLESSLPDADPVVSKALGCLEA
                     SWETIEQGRNGSFVYTKALMAYAFTLAGNQEKRNEILKSLDKEAIKEDNSIHWERPQK
                     PMKSEHYLYTPQASSVEVEMSAYVVLARLTAHPAPSPEDLALSTGTIKWLTKQQNSHG
                     GFSSTQDTVVALDALSKYGAATFSKSQKTPSVTVQSSGSFSQKFQVDKSNRLLLQQVS
                     LPDIPGNYTIRVSGEGCVYAQTTLRYNLPLEKQQPAFALKVKTVPLTCNNPKGQNSFQ
                     ISLEISYTGSRPASNMVIADVKMLSGFIPLKPTVKKLERLEHVSRTEVTTNNVLLYLD
                     QVTNQTLSFSFIIQQDIPVKNLQPAIVKVYDYYETDEVAFAEYSSPCSSDKQNV"
     exon            155..338
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            339..498
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            499..551
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            552..572
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            573..741
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            742..826
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            827..935
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1056
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1166
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1328
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1556
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1620
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1763
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1913
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2075
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2157
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2356
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2585
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2712
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2834
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..2886
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..2970
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            2971..3147
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            3148..3235
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3392
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            3393..3467
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            3468..3648
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            3649..3872
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            3873..4091
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            4092..4219
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            4220..4310
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            4311..4379
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            4380..4482
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            4483..4524
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
     exon            4525..4670
                     /gene="Mug2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaacagtg ttaaggaaaa gaatagcata agctttgtcc tgtcgtcctg tcctcttgtc
       61 cttccatcat gtggaagaat agagaggctc agctgtgcct tttttcagtt ctgcttgctt
      121 tcctaccttc tgcttcctta ctctttggaa attcgaagta tatggtgctg gtcccttccc
      181 agctctacac cgagacccct gagaaaatct gcctgcatct ataccatctg aatgagacag
      241 tgactgtgac agcttccttg atatctcaaa ggggaacgag aaaactgttc gatgagcctg
      301 tggttgacaa ggacttgttc cactgtgttt ccttcactat ccctagattg ccctcttctg
      361 aagaggagga gtcactcgac atcaacattg aaggggcaaa gcataaattc agcaaaaggc
      421 atgtggtgct tgtgaagaac aaagaaagtg ttgtctttgt ccagactgat aagcccatgt
      481 acaagccagg acagtcagtt aaatttcggg ttgtctctat ggataaaaat ctataccccc
      541 tgaaggagtt gtttcctctg gcttacattg aggatccgaa aatgaaccga attatgcagt
      601 ggcaagacgt taagactgag aatgggctta agcaactgtc cttcagcctg tcagcagagc
      661 ccattcaggg cccctacaag atagtggttc tcaaacagtc aggagtgaag gaagagcatt
      721 ccttcaccgt catggaattc gtgcttccca gatttggtgt cgatgtgaag gttccaaacg
      781 ccatctctgt gtacgatgag ataatcagtg tgactgcctg tgcaacatat acctatggga
      841 agcctgtcct gggacgtgta aaggtaagac tttgccatgg aaatccgtcc tttagctctg
      901 agacaaagtc tgcatgcaaa gaagagaact ccaagctaga caacaatggc tgcagcacac
      961 aagaagtgaa catcactgag ttccaattaa aggaaaatta cctcaaagtg cgccaggctt
     1021 tccatgtgaa cgcaactgtt acagaagaag gaacagggtc agagttcggt ggatatggaa
     1081 gaattgaagt cgaaagaacc aggaacaaat tcctatttct gaaagcagac tcacacttca
     1141 gacatgggat cccattcttt gtgaaagtcc gcctagtgga tatcaaggga gatcctatcc
     1201 caaatgagca agtcttcatc aaagcacaag aagctggcta caccaatgct actaccactg
     1261 atcagcatgg cttggcaaag ttctccatag ataccagcag catctcaggc tattccctca
     1321 atatcaaagt ctaccacaag gaggaaaatt tatgcatcca ttcctcttgc acagcagaaa
     1381 gacacgcaga ggcacatcat acggcctatg ctgtttactc cctcagcaag agctacatct
     1441 acctcgacac agaagctggc gtcttgccct gcaaccagat ccacacagtt caggcacatt
     1501 ttattctgaa ggggcaggtc ttgggagtgc tgccacagat tgttttccac tacctggtca
     1561 tggcccaggg cagcatcctc cagactggaa accacactca tcaagtggag tcaggagtat
     1621 tacagggcaa cttcgccttg gagatccctg tggagttcag catggttccc atggctaaaa
     1681 tgctcatcta caccatcttg cctgatggag aagtgattgc agactctgta aagtttcaag
     1741 ttgaaaaatg tcttcgcaac aaagtgcacc tgagcttcag cccatcccaa agtcttccag
     1801 cctcacaaac ccatatgcgg gttacagctt ctcctcagtc cctctgtgga ctgagagctg
     1861 tggaccaaag cgtgctgctg ctgaggcctg aggctgagct ctccccttcc ttgatatatg
     1921 atctaccagg tatgcaagac agcaacttca ttccacgttc ccaccatcca tttgaagacg
     1981 aagatgactg tttgatgtac caaccaagag acactgaaga gctcacgtac tcagtaccat
     2041 atggacgaga gaaggatgtc tacagatacg tgagggacat gggtttaaca gcattcacca
     2101 acttgaagat caaacatcct acatattgtt atgatgatga aatatttgaa atatttgaac
     2161 ctactgtgga actgaatact tcacctatgt gggaaaagat tgaaatcatg gccttgatag
     2221 caaatgaaaa tcccctacct aaagagccac cacgtaaaga tccaccacgt aaagatccag
     2281 aacctaaaga tacagttgtt gagaccatta ggaattattt tcctgaaact tgggtctggg
     2341 atttagtcac agtaaactcc tcaggagtga ctgaagtgga aatgacagtc cctgacacca
     2401 tcactgagtg gaaggctgga gccctctgcc tgtctaatga cactggtctt ggcctctctt
     2461 ctgtggcaac tctccaagcc ttccagccct tctttgtgga gctcacaatg ccctactctg
     2521 tgatccgtgg agaagccttc acgctcaagg ccacagtgat gaactacctc cctacaagct
     2581 tgccgatgac agtgcagctg gaagcttctc ctgatttcac agctgtccca gtgggaaatg
     2641 accaagattc ttactgcctt ggtgccaatg ggaggcacac ctcatcctgg ttggtaactc
     2701 ccaaatcttt agggaatgtg aatttctctg tgtctgtgga agcacaacag tccccagagc
     2761 cctgtggttc cgaggtggcc acagtgcctg aaactgggag aaaggacaca gtcatcaaag
     2821 tcttgatagt tgagcctgaa ggaatcaaga aagagcatac cttcagctca cttctctgcg
     2881 catcagatgc tgagctatca gaaacattgt ctctgttgct tccaccaaga gtagtgaaag
     2941 attcagccag agcacatttc tctgtgatgg gtgatatctt gagttcagcc ataaaaaata
     3001 cacaaaatct tatccaaatg ccctatggct gtggggagca gaacatggtc ctttttgctc
     3061 caaacatcta tgttctgaaa tatctgaatg aaacccaaca gctgacagag aatatcaagt
     3121 ccaaggccct tggctacctc agagctggtt atcagagaga gctgaactac aaacacaagg
     3181 atggctccta cagtgccttt ggggatcaca atggccaggg tcaaggaaac acttggctca
     3241 cagcctttgt gctcaaatct tttgcccaag ctcgagcctt catcttcatc gacgaatcac
     3301 acatcaccga tgccttcacc tggctctcca agcagcagaa ggacagtggc tgcttcagga
     3361 gctccggatc actgttcaac aatgccatga aggggggagt cgatgatgaa atcaccctct
     3421 ctgcctatat aaccatggcc cttctggaaa gttcactccc agacgcggat cctgttgtct
     3481 ccaaagccct gggctgccta gaggcatctt gggagaccat agagcaagga agaaatggca
     3541 gctttgtgta cacaaaggca ctgatggcct atgctttcac tcttgcggga aaccaggaga
     3601 aaagaaacga aatcctgaaa tcccttgata aggaagctat aaaggaagat aactccatcc
     3661 actgggaaag acctcagaaa cccatgaaat cagagcacta tctgtacaca ccccaggctt
     3721 cttctgttga agtagagatg agtgcctatg ttgtcttagc tcgcctcact gcccacccag
     3781 ccccatcccc tgaggacctg gctttgtcaa cgggcaccat caagtggctc acaaagcagc
     3841 agaattccca tggcggcttc tcctccacac aggacactgt ggtggccctt gatgctctgt
     3901 ccaaatatgg agcagctact ttttccaaaa gccagaaaac tccttcggtg accgtccaat
     3961 cttcagggtc attttcccaa aagttccaag tggacaagag taatcgcctg ttactgcagc
     4021 aggtctcatt accagacatt cctgggaact acaccatccg tgtgtcaggg gaaggatgtg
     4081 tgtatgctca gactacgctg agatacaacc tgcccttgga gaagcagcag cctgcgtttg
     4141 ctctaaaggt gaagaccgta cccctgactt gtaacaaccc caaaggccag aacagcttcc
     4201 agatctcact agaaatcagt tacacgggga gccgtccagc ctccaacatg gtgattgccg
     4261 atgtgaagat gctctctggt ttcatcccat tgaaaccaac agtgaagaag cttgaaagat
     4321 tagagcacgt gagcagaaca gaagtgacca ccaacaacgt cctgttatat ttggaccagg
     4381 taaccaatca gacactgtcc ttctccttca tcattcaaca agacatccca gtaaagaacc
     4441 tgcagcctgc cattgtgaaa gtgtatgact actatgagac agatgaagtg gcttttgctg
     4501 aatatagcag cccctgcagc tcagacaaac aaaatgtttg aaactcatat ctgtggacaa
     4561 ggcattgctg gaatccccaa accagagaac tttcaaggtt gtgatttgtg tttgtctctg
     4621 aaatacaact actgaacaat cttggtaaat aaagacataa ttctagcgaa
//
