LOCUS       NM_023103               4620 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus murinoglobulin 1 (Mug1), mRNA.
ACCESSION   NM_023103 XM_346724
VERSION     NM_023103.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4620)
  AUTHORS   Ganaie,I.A., Malik,M.Z., Naqvi,S.H., Jain,S.K. and Wajid,S.
  TITLE     Differential levels of Alpha-1-inhibitor III, Immunoglobulin heavy
            chain variable region, and Hypertrophied skeletal muscle protein
            GTF3 in rat mammary tumorigenesis
  JOURNAL   Biochimie 174, 57-68 (2020)
   PUBMED   32325114
  REMARK    GeneRIF: Differential levels of Alpha-1-inhibitor III,
            Immunoglobulin heavy chain variable region, and Hypertrophied
            skeletal muscle protein GTF3 in rat mammary tumorigenesis.
REFERENCE   2  (bases 1 to 4620)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   3  (bases 1 to 4620)
  AUTHORS   Stamer,W.D., Hoffman,E.A., Luther,J.M., Hachey,D.L. and Schey,K.L.
  TITLE     Protein profile of exosomes from trabecular meshwork cells
  JOURNAL   J Proteomics 74 (6), 796-804 (2011)
   PUBMED   21362503
REFERENCE   4  (bases 1 to 4620)
  AUTHORS   Esadeg,S., He,H., Pijnenborg,R., Van Leuven,F. and Croy,B.A.
  TITLE     Alpha-2 macroglobulin controls trophoblast positioning in mouse
            implantation sites
  JOURNAL   Placenta 24 (10), 912-921 (2003)
   PUBMED   14580373
REFERENCE   5  (bases 1 to 4620)
  AUTHORS   Regler,R., Sickinger,S. and Schweizer,M.
  TITLE     Differential regulation of the two mRNA species of the rodent
            negative acute phase protein alpha 1-inhibitor 3
  JOURNAL   FEBS Lett 282 (2), 368-372 (1991)
   PUBMED   1709877
REFERENCE   6  (bases 1 to 4620)
  AUTHORS   Sugiyama,K., Izumi,S., Tomino,S. and Nagase,S.
  TITLE     Tumor-associated expression of a serum protein, termed aX protein
            (alpha 1-inhibitor III), and its mRNA in rat liver
  JOURNAL   Jpn J Cancer Res 80 (8), 759-764 (1989)
   PUBMED   2511184
REFERENCE   7  (bases 1 to 4620)
  AUTHORS   Braciak,T.A., Northemann,W., Hudson,G.O., Shiels,B.R., Gehring,M.R.
            and Fey,G.H.
  TITLE     Sequence and acute phase regulation of rat alpha 1-inhibitor III
            messenger RNA
  JOURNAL   J Biol Chem 263 (8), 3999-4012 (1988)
   PUBMED   2831216
REFERENCE   8  (bases 1 to 4620)
  AUTHORS   Schweizer,M., Takabayashi,K., Geiger,T., Laux,T., Biermann,G.,
            Buhler,J.M., Gauthier,F., Roberts,L.M. and Heinrich,P.C.
  TITLE     Identification and sequencing of cDNA clones for the rodent
            negative acute-phase protein alpha 1-inhibitor 3
  JOURNAL   Eur J Biochem 164 (2), 375-381 (1987)
   PUBMED   2436907
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X52984.1.
            
            On Jan 9, 2004 this sequence version replaced XM_346724.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X52984.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4620
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..4620
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /note="murinoglobulin 1"
                     /db_xref="GeneID:497794"
                     /db_xref="RGD:621366"
     exon            1..137
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..4515
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /note="plasma proteinase inhibitor alpha-1-inhibitor III;
                     murinoglobulin-1-like; alpha-X protein; alpha x protein;
                     Murinoglobulin 1 homolog"
                     /codon_start=1
                     /product="murinoglobulin-1 precursor"
                     /protein_id="NP_075591.1"
                     /db_xref="GeneID:497794"
                     /db_xref="RGD:621366"
                     /translation="MKKNREAQLCLFSALLAFLPFASLLNGNSKYMVLVPSQLYTETP
                     EKICLHLYHLNETVTVTASLISQRGTRKLFDELVVDKDLFHCLSFTIPRLPSSEEEES
                     LDINIEGAKHKFSERRVVLVKNKESVVFVQTDKPVYKPGQSVKFRVVSMDKNLHPLNE
                     LFPLAYIEDPKMNRIMQWQDIKTENGLKQLSFSLSAEPIQGPYKIVILKQSGVKEEHS
                     FTVMEFVLPRFGVDVKVPNAISVYDEIINVTACAIYTYGKPVPGHVKISLCHGNPSFS
                     SETKSACKEEDSELDNNGCSTQEVNITEFQLKENYLKMHQAFHVNATVTEEGTGSEFS
                     GSGRIEVERTRNKFLFLKADSHFRHGIPFFVKIRLVDIKGDPIPNEQVFIKAQEAGYT
                     NATTTDQHGLAKFSIDTSSISGYSLNIKVYHKEESSCIHSSCTAERHAEEHHTAYAVY
                     SLSKSYIYLDTEAGVLPCNQIHTVQAHFILKGQVLGVLPQIVFHYLVMAQGSILQTGN
                     HTHQVEPGVSQVQGNFALEIPVEFSMVPVAKMLIYTILPDGEVIADSVTFQVEKCLRN
                     KVHLSFSPSQSLPASQTHMRVTASPQSLCGLRAVDQSVLLLKPEAELSPSLIYDLPGM
                     QDSNFIPSSYHPFEDEYDCLMYQPRDTEELTYSVPYGREKDVYRYVRDMGLTAFTNLK
                     IKHPTYCYEMNMVVLSAPAVESELSPRGGEFEMMPLGVNKSPLPKEPPRKDPPPKDPV
                     IETIRNYFPETWIWDLVTVNSSGVTEVEMTVPDTITEWKAGALCLSNDTGLGLSSVAT
                     LQAFQPFFVELTMPYSVIRGEAFMLKATVMNYLPTSLPMAVQLEASPDFTAVPVGNDQ
                     DSYCLGANGRHTSSWLVTPKSLGNVNFSVSVEAQQSPELCGSQVATVPETGRKDTVVK
                     VLIVEPEGIKKEHTFSSLLCASDAELSETLSLLLPPTVVKDSARAHFSVMGDILSSAI
                     KNTQNLIQMPYGCGEQNMVLFAPNIYVLKYLNETQQLTEKIKSKALGYLRAGYQRELN
                     YKHKDGSYSAFGDHNGQGQGNTWLTAFVLKSFAQARAFIFIDESHITDAFTWLSKQQK
                     DSGCFRSSGSLFNNAMKGGVDDEITLSAYITMALLESSLPDTDPVVSKALGCLEASWE
                     TIEQGRNGSFVYTKTLMAYAFALAGNQEKRNEILKSLDKEAIREDNSIHWERPQKPTK
                     SEGYLYTPQASSAEVEMSAYVVLARLTAQPAPSPEDLALSMGTIKWLTKQQNSHGGFS
                     STQDTVVALDALSKYGAATFSKSQKTPLVTIQSSGSFSQKFQVDNSNRLLLQQVSLPD
                     IPGNYTVSVSGEGCVYAQTTLRYNMPLEKQQPAFALKVQTVPLTCNNPKGQNSFQISL
                     EISYTGSRPASNMVIADVKMLSGFIPLKPTVKKLERLEHVSRTEVTTNNVLLYLDQVT
                     NQTLSFSFIIQQDIPVKNLQPAIVKVYDYYETDEVAFAEYSSPCSSDKQNV"
     exon            138..321
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            322..481
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            482..534
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            535..555
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            556..724
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            725..809
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            810..918
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1039
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1149
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1311
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1539
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1603
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1752
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1902
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2064
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2146
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2330
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2559
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2686
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2808
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..2860
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            2861..2944
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            2945..3121
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            3122..3209
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..3366
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            3367..3441
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            3442..3622
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            3623..3846
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            3847..4065
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            4066..4193
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            4194..4284
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            4285..4353
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            4354..4456
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            4457..4498
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
     exon            4499..4620
                     /gene="Mug1"
                     /gene_synonym="A1i3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taagctctgt cctcctgtcc tcctgtcatc ctgtcctcct gtccttccat catgaagaag
       61 aatagagagg ctcagctgtg ccttttttca gctcttcttg ccttcctgcc ctttgcttcc
      121 ttgctcaatg gaaactcgaa gtatatggtg ctggtccctt cccagctcta caccgagacc
      181 cctgagaaaa tctgcctgca tctataccat ctgaatgaga cagtgactgt gacagcttcc
      241 ttgatatctc aaaggggaac gagaaaactg ttcgatgagc ttgtggttga caaggacttg
      301 ttccactgtc tttccttcac tatccctaga ttgccctctt ctgaagagga ggagtcactc
      361 gacatcaaca ttgaaggggc aaagcataaa ttcagcgaaa ggcgtgtggt gcttgtgaag
      421 aacaaagaaa gtgttgtctt tgtccagact gataagcccg tgtacaagcc aggacagtca
      481 gttaaatttc gggttgtctc tatggataaa aatctacacc ccctgaatga gttgtttcct
      541 ctggcttaca ttgaggatcc gaaaatgaac cgaattatgc agtggcagga cattaagaca
      601 gagaatgggc ttaagcaatt gtccttcagc ctgtcagcag agcccattca gggcccctac
      661 aagatagtga ttctcaaaca gtcaggagtg aaggaagagc attccttcac cgtcatggaa
      721 ttcgtgcttc ccagatttgg tgtcgatgtg aaggtcccaa acgccatctc tgtgtacgat
      781 gaaataatca atgtgactgc ctgtgcgata tatacctatg ggaagcctgt tccaggacat
      841 gtaaagataa gtctttgcca tggaaatcct tcctttagct ctgagacaaa gtctgcatgc
      901 aaagaagagg actccgagct agacaacaac ggctgcagca cacaagaagt gaacatcact
      961 gagttccaat taaaggaaaa ttacctcaaa atgcaccagg ctttccatgt gaatgcaact
     1021 gttacagaag aagggacagg gtcagagttc agtggatctg gaagaattga agtcgaaaga
     1081 accagaaaca aattcctatt tctgaaagca gactcacact tcagacacgg gatcccattc
     1141 tttgtgaaaa tccgcctagt ggatatcaag ggagatccta tcccaaatga gcaggtcttc
     1201 atcaaagcac aagaagctgg ctacaccaat gctactacca ctgatcagca tggcttggca
     1261 aagttctcca tagataccag cagcatctca ggctattccc tcaatatcaa agtctaccac
     1321 aaggaggaaa gttcatgtat ccattcctct tgcacagcag aaagacacgc agaggaacat
     1381 catacggcct atgctgttta ctccctcagc aagagctaca tctaccttga cacagaagct
     1441 ggcgtcttgc cctgcaacca gatccacaca gttcaggcgc attttattct gaaggggcag
     1501 gtcttgggag tgctgccaca gattgttttc cactacctgg tcatggccca gggcagcatc
     1561 ctccagactg gaaaccacac tcatcaagtg gagccaggag tatctcaagt acaaggcaac
     1621 ttcgccttgg agatccctgt ggagttcagc atggttcccg tggctaaaat gctcatctac
     1681 accatcttgc ctgatggaga agtgattgca gattctgtaa cgtttcaagt tgaaaaatgt
     1741 cttcgcaaca aagtgcacct gagcttcagc ccatcccaaa gtcttccagc ctcacaaacc
     1801 catatgcggg ttacagcttc tcctcagtcc ctctgtggcc tgagagctgt ggaccaaagc
     1861 gtgctgctgc tgaagcctga ggctgagctc tccccttcct tgatatatga tctaccaggt
     1921 atgcaagaca gcaacttcat tccaagttct tatcatccat ttgaagacga atatgattgt
     1981 ttgatgtacc aaccaagaga cactgaagag ctcacatact cagtaccata tggacgagag
     2041 aaggatgtct acagatatgt gagggacatg ggtttaacag cattcaccaa cttgaagatc
     2101 aaacatccta catattgtta tgaaatgaac atggttgtac tatcagcacc tgctgtggaa
     2161 tctgaacttt caccaagagg gggagagttt gaaatgatgc ccttgggagt aaataaaagt
     2221 ccactaccta aagagccacc acgtaaagat ccaccaccta aagatccagt tattgagacc
     2281 attaggaatt attttcctga aacctggatc tgggatttag tcacagtaaa ctcctcagga
     2341 gtgactgaag tggaaatgac agtccctgac accatcactg agtggaaggc tggagccctc
     2401 tgcctgtcta atgacactgg tcttggcctc tcttctgtgg caactctcca agccttccag
     2461 cccttctttg tggagctcac aatgccctac tctgtgatcc gtggagaagc cttcatgctc
     2521 aaggccacag tgatgaacta cctccctaca agcttgccga tggctgtgca gctggaagct
     2581 tctcctgatt tcacagctgt cccagtggga aatgaccaag attcttattg ccttggtgcc
     2641 aatgggaggc acacctcatc ctggttggta actcccaaat ctttagggaa tgtgaatttc
     2701 tctgtgtctg tggaagcaca acagtcccca gagctctgtg gttctcaggt agccacagtg
     2761 cctgaaaccg ggagaaagga cacagtagtc aaagtcttga tagttgagcc tgaaggaatc
     2821 aagaaagagc ataccttcag ctcacttctc tgcgcatcag atgctgagct gtcagaaaca
     2881 ttgtctctgc tgcttccacc aacagtagtg aaagattcag ccagagcaca tttctctgtg
     2941 atgggtgata tcttgagttc agccataaaa aacacacaaa atcttatcca aatgccctat
     3001 ggctgtgggg agcagaacat ggtccttttt gctccaaaca tctatgttct gaaatatctg
     3061 aatgaaactc aacagctgac agagaagatc aagtccaagg cccttggtta cctcagagct
     3121 ggttatcaga gagaactgaa ctacaaacac aaagatggct cctacagtgc ttttggggat
     3181 cacaatggcc agggtcaagg aaacacttgg ctcacagcct ttgtgctcaa gtcttttgcc
     3241 caagctcgag ccttcatctt catcgacgaa tcacacatca ccgacgcctt cacctggctc
     3301 tccaagcagc agaaggacag tggctgcttc aggagctccg gatcactgtt caacaatgcc
     3361 atgaaggggg gagtcgatga tgaaatcacc ctctctgcct atataaccat ggcccttctg
     3421 gaaagttcac tcccagacac ggatcctgtt gtctccaaag ccctgggctg cctagaggca
     3481 tcttgggaga ccatagagca aggaagaaat ggcagctttg tgtacaccaa gacactgatg
     3541 gcctatgctt tcgctcttgc gggaaaccag gaaaagagaa acgaaatcct gaaatccctt
     3601 gataaggaag ctataaggga agacaactcc atccactggg aaagacctca gaaacccaca
     3661 aaatcagagg gttatctgta cacaccccag gcttcctctg ctgaagtaga gatgagtgcc
     3721 tatgtcgtct tagctcgcct cactgcccag ccagccccat cccctgagga cctggctttg
     3781 tcaatgggca ccatcaagtg gctcacaaag cagcagaatt cccatggcgg cttctcctcc
     3841 acacaggaca ctgtggtggc ccttgatgct ctgtccaaat acggagcagc tactttttcc
     3901 aaaagccaga aaactccttt ggtgaccatt caatcttcag ggtcattttc ccaaaagttc
     3961 caagtagaca acagtaatcg cctgttactg cagcaggtct cattaccaga cattcctggg
     4021 aactataccg tcagtgtgtc aggggaagga tgtgtgtatg ctcagaccac gctgagatac
     4081 aacatgccct tggagaagca gcagcctgca tttgctctaa aggtgcagac agtacccctg
     4141 acttgtaaca accccaaagg ccagaacagc ttccagatct cactagaaat cagttacacg
     4201 gggagccgtc cagcctccaa catggtgatt gctgatgtga agatgctctc tggcttcatc
     4261 ccattgaaac caacagtgaa gaagcttgaa agattagagc acgtaagcag aacagaagtg
     4321 accaccaaca acgtcctgtt atatttggac caggtaacca atcagacact gtccttctcc
     4381 ttcatcattc aacaagacat cccagtaaag aacctgcagc ctgccattgt gaaagtgtat
     4441 gactactatg agacagatga agtggctttt gctgaataca gcagcccctg cagctcagac
     4501 aaacaaaatg tttgaaactc atatctgtgg acaaggcatt gctggaatcc ccaaaccaga
     4561 gaactttcaa ggtggtgatt tgtgtttgtc tctgaaatac aaatactgaa caatcttggt
//
