LOCUS       NM_001419613           10508 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus mucin 4, cell surface associated (Muc4), mRNA.
ACCESSION   NM_001419613 XM_039088927
VERSION     NM_001419613.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10508)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   2  (bases 1 to 10508)
  AUTHORS   Tian,F., Cheng,L., Li,D., Liu,Z., Zeng,Y., Xu,J., Li,X. and Wang,S.
  TITLE     Downregulation of mucins in graft bile ducts after liver
            transplantation in rats
  JOURNAL   Transplantation 92 (5), 529-535 (2011)
   PUBMED   21775928
REFERENCE   3  (bases 1 to 10508)
  AUTHORS   Hasnain,S.Z., Thornton,D.J. and Grencis,R.K.
  TITLE     Changes in the mucosal barrier during acute and chronic Trichuris
            muris infection
  JOURNAL   Parasite Immunol 33 (1), 45-55 (2011)
   PUBMED   21155842
REFERENCE   4  (bases 1 to 10508)
  AUTHORS   Mimeault,M., Johansson,S.L., Senapati,S., Momi,N., Chakraborty,S.
            and Batra,S.K.
  TITLE     MUC4 down-regulation reverses chemoresistance of pancreatic cancer
            stem/progenitor cells and their progenies
  JOURNAL   Cancer Lett 295 (1), 69-84 (2010)
   PUBMED   20303649
REFERENCE   5  (bases 1 to 10508)
  AUTHORS   Lomako,J., Lomako,W.M., Carothers Carraway,C.A. and Carraway,K.L.
  TITLE     Regulation of the membrane mucin Muc4 in corneal epithelial cells
            by proteosomal degradation and TGF-beta
  JOURNAL   J Cell Physiol 223 (1), 209-214 (2010)
   PUBMED   20054827
  REMARK    GeneRIF: Muc4 precursor is synthesized in all layers of the corneal
            epithelium, but Muc4 is degraded in basal and intermediate layers
            by a proteosomal mechanism at least partly dependent on TGF-beta
            inhibition of Muc4 processing.
REFERENCE   6  (bases 1 to 10508)
  AUTHORS   Balague,C., Gambus,G., Carrato,C., Porchet,N., Aubert,J.P.,
            Kim,Y.S. and Real,F.X.
  TITLE     Altered expression of MUC2, MUC4, and MUC5 mucin genes in pancreas
            tissues and cancer cell lines
  JOURNAL   Gastroenterology 106 (4), 1054-1061 (1994)
   PUBMED   8143972
REFERENCE   7  (bases 1 to 10508)
  AUTHORS   Sheng,Z., Wu,K., Carraway,K.L. and Fregien,N.
  TITLE     Molecular cloning of the transmembrane component of the 13762
            mammary adenocarcinoma sialomucin complex. A new member of the
            epidermal growth factor superfamily
  JOURNAL   J Biol Chem 267 (23), 16341-16346 (1992)
   PUBMED   1379596
REFERENCE   8  (bases 1 to 10508)
  AUTHORS   Bharathan,S., Moriarty,J., Moody,C.E. and Sherblom,A.P.
  TITLE     Effect of tunicamycin on sialomucin and natural killer
            susceptibility of rat mammary tumor ascites cells
  JOURNAL   Cancer Res 50 (17), 5250-5256 (1990)
   PUBMED   2386935
REFERENCE   9  (bases 1 to 10508)
  AUTHORS   Sheng,Z., Vanderpuye,O.A., Hull,S.R., Carraway,C.A. and
            Carraway,K.L.
  TITLE     Topography and microfilament core association of a cell surface
            glycoprotein of ascites tumor cell microvilli
  JOURNAL   J Cell Biochem 40 (4), 453-466 (1989)
   PUBMED   2674161
REFERENCE   10 (bases 1 to 10508)
  AUTHORS   Jung,G., Helm,R.M., Carraway,C.A. and Carraway,K.L.
  TITLE     Mechanism of concanavalin A-induced anchorage of the major cell
            surface glycoproteins to the submembrane cytoskeleton in 13762
            ascites mammary adenocarcinoma cells
  JOURNAL   J Cell Biol 98 (1), 179-187 (1984)
   PUBMED   6538571
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 13, 2023 this sequence version replaced XM_039088927.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN17050754
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               JAXUCZ010000011.1  81558130-81558314   c
            186-6719            JAXUCZ010000011.1  81537047-81543580   c
            6720-6848           JAXUCZ010000011.1  81536691-81536819   c
            6849-6988           JAXUCZ010000011.1  81535078-81535217   c
            6989-7153           JAXUCZ010000011.1  81534152-81534316   c
            7154-7309           JAXUCZ010000011.1  81533069-81533224   c
            7310-7440           JAXUCZ010000011.1  81532227-81532357   c
            7441-7529           JAXUCZ010000011.1  81530720-81530808   c
            7530-7709           JAXUCZ010000011.1  81528825-81529004   c
            7710-7826           JAXUCZ010000011.1  81528540-81528656   c
            7827-7946           JAXUCZ010000011.1  81527728-81527847   c
            7947-8158           JAXUCZ010000011.1  81527245-81527456   c
            8159-8243           JAXUCZ010000011.1  81525277-81525361   c
            8244-8411           JAXUCZ010000011.1  81524772-81524939   c
            8412-8513           JAXUCZ010000011.1  81524223-81524324   c
            8514-8747           JAXUCZ010000011.1  81523640-81523873   c
            8748-8885           JAXUCZ010000011.1  81522347-81522484   c
            8886-9067           JAXUCZ010000011.1  81519580-81519761   c
            9068-9227           JAXUCZ010000011.1  81518459-81518618   c
            9228-9407           JAXUCZ010000011.1  81517406-81517585   c
            9408-9481           JAXUCZ010000011.1  81516655-81516728   c
            9482-9552           JAXUCZ010000011.1  81515592-81515662   c
            9553-9788           JAXUCZ010000011.1  81515277-81515512   c
            9789-9951           JAXUCZ010000011.1  81514691-81514853   c
            9952-10508          JAXUCZ010000011.1  81513321-81513877   c
FEATURES             Location/Qualifiers
     source          1..10508
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..10508
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /note="mucin 4, cell surface associated"
                     /db_xref="GeneID:303887"
                     /db_xref="RGD:621331"
     exon            1..185
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..10147
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /note="mucin-4; sialomucin ascites sialoglycoprotein-1;
                     sialomucin complex; ASGP; MUC-4; testis mucin;
                     pre-sialomucin complex; pancreatic adenocarcinoma mucin"
                     /codon_start=1
                     /product="mucin-4 precursor"
                     /protein_id="NP_001406542.1"
                     /db_xref="GeneID:303887"
                     /db_xref="RGD:621331"
                     /translation="MRGPHGVSWRVPWLCLSCLCSCLLLLPVNTSTTSAPKTSTALPS
                     STNPSQMTSQVSNPTASPYRMTKNTGQASPMVTSSSITTLPQSQHTGSMKTTRNPQTT
                     GTTEVTTTLSASSSDHVQAETSSQTTLSPDPTTTSHAPRESSSPPSTSVILTTTASTE
                     GTSGDTGHTMAVTTQGSTPATTEISVTPSTQKMSPVSTFSTSTQEITTLSQSQHTGGM
                     KTTRNPQTTGTTEVTTTLSASSSEQVQAETSSQTTLSPDATTTSHAPRESSSPPSTSD
                     MLTTTASTEGTSGDTGHTTAVTTQGSIPATTQLSATFASQKMSTVSTPTISIQELSTL
                     PQSQHTGSMEISSRPQTTSVTSTLSSSPSGSTPVQTRSQVTSSSDERTNPTSSGVSNT
                     SPATTEVLTPTSSPESAPGNTAPRTTETSTTTTTKVLTTSLQQKLPTGSTLGTSTQEL
                     TTLPQSQHTGIMKTTSRTQTTTPTEVTTSTLSVSSSDQLQTGTSSQRTSSPDTTTTSH
                     APSVSSSSPSPPSTEGTSVDTGLTTAVTTQDSTPATTQGSLTSSSQTLSTVSPLSTST
                     QELTSSQSQHTGSMKTTHNPQTTRNTEVTTTLSASSSEQVQVETTSQTALSPDTTTTS
                     HAPRESSSPPSTSVILTTTASTEGTSGDTGHTMAVTTQGSKPDTTQVSPTASSQRLST
                     VSPLSTSTQEITTLSQSQHTGGMKTTRNPQRTTPTEVTTSTLSASSSDQLQTGTGSQR
                     TSSPDSTTTSHAPSVRSSPPSTPSTEVTSVDTGLKTAISTQGSTPATTQGSLTSSSQT
                     LSTVSPLSTSTQELTTLPQSQHTGGMKTTRNPQTTRNTEVTTALSASSSDQVQVETTS
                     QTTLSPDATTTSHAPRESSSPPSTSDILTTMASTEGTSGDTGHTMAVTTQGSTPATTE
                     ISVTPSTQKMSPVSTFSTSTQEITTLSQSQHTGGMKTTRNPQTTGTTEVTTTLSASSS
                     DQVQTKTSSQTTLSPDTTTTSHAPRESSSPPSTSDMLTTTASTEGTSGDTGHTTAVTT
                     QGSIPATTQLSATFASQKMSTVSTPTTSIQELSTLPQSQHTGSMEISSRPQTTSVTST
                     LSSSPSGSTPVQTRSQVTSSSDERTNPTSSGVSNTSPATTEVLTPTSSPESAPGNTAP
                     RTTETSTTTTTKVLTTSLQQKLPTGSTLGTSTQELTTLPQSQHTGIMKTTSRTQTTTP
                     TEVTTSTLSVSSSDQLQTGTSSQRTSSPDTTTTSHAPSVSSSSPSPPSTEGTSVDTGL
                     TTAVTTQDSTPATTQGSLTSSSQTLSTVSPLSTSTQELTSSQSQHTGSMKTTRNPQTT
                     RNTEVTTTLSASSSEQVQVETTSQTALSPDTTTTSHAPRESSSPPSTSVILTTTASTE
                     GTSGDTGHTMAVTTQGSKPDTTQVSPTASSQRLSTVSPLSTSTQEITTLSQSQHTGGM
                     KTTRNPQRTTPTEVTTSTLSASSSDQLQTGTGSQRTSSPDSTTTSHAPSVRSSPPSTP
                     STEVTSVDTGLKTAISTQGSTPATTQGSLTSSSQTLSTVSPLSTSTQELTTLPQSQHT
                     GGMKTTRNPQTTRNTEVTTTLSASSSDQVQVETTSQTTLSPDATTTSHAPRESSSPPS
                     TSDMLTTTASTGSTLGDTGHTTAVTTQGSIPATTLFSPTLSSQKMSTVSTPTTSIQEL
                     STLPQSQHTGSMEISSRPQTTSVTSTLSSSPSGSTPVQTRSQVTSSSDERTNPTSSGV
                     SNTSPATTEVLTPTSSPESTPGNTAPRTTETSTTTTTKVLMTSLQQKLPTGSTLGTST
                     QELTTLPQSQHTGIMKTTSRTQTTTPTEVTTTLSASSSDQVQVETTSQTTLSPDATTT
                     SHAPRESSSPPSTSVILTTMASTEGTSGDTGHTTAVTVQGSTPATTEISVTPSTQKMS
                     PVSTFSTSTQEITSSQSQRTGSMKTTHNPQTTRNTEVTTTLSASSSEQVQAETTSQTT
                     LSPDATTTSHAPRESSSPPSTSDMLTTTASTEGTSGDTGHTMAVTTQGSTPATTEISV
                     TPSTQTLSTVSTLSTSTQELTSSQSQRTGSMGTSSKPQATTPTEVTTSTLSSFSRGST
                     QTQTVSWETSSSGKITAPSTSSRRTPSVATSDIFTTTDSTSGNAGHTLLTGSHSVITS
                     RVASTTLGRLSTVAHSKSTQRSSTHSQSYLTESMGASSTSETSLLTEATTEKQFASSP
                     GPTVTETFSRGTSSSGLTTKTDNDRSTALSATSLTLPAPSTSTASRSTVPPAPLPPDQ
                     GISLFPYGSSSEVRDKQLFARTVDFTSPIFKIQIGFPLGSSLRDSFYFTDNGQIIFPE
                     SDYDVFSYPNPPQRGFTGRERVAIVAPFWGDADFSSSRGTIFYQDYITFYDEQHQLIR
                     KVESLINEFTSDWSFKAKWTLKVTWVNVPAYPAQGSFGTNTYQAILSTDGSRSYALFL
                     YQSGGMRWDVTQGLYNRVLMGFSSGDGYFENSPLIFRPAVEKYRPDRFLNSKLGIRGL
                     QVYRLHREVWPNYRLKCLQWLESQPQQPSWGWNKISCPCSWQQGRWDFRFWLINTGLW
                     GRQLCSFSSGRGGVCCSYGTWGEFREGWRMHSPWQFDEEQEAQNWCCRWNDKPSFCVQ
                     YQLRRPRVSCAGYRPPRPAWTFGDPHITTLDNAKYTFNGLGDFLLVQAQDRNSSFLLE
                     GRTAQTDSANATNFIAFAAQYNTSSLKSPITVQWFLEPNDTIRVVHNNQTVAFNTSDT
                     EDLPVFNATGVLLIQNGSQVSANFDGTVTISVIALSNILHASSSLSEEYRNHTKGLLG
                     VWNDNPEDDFRMPNGSTIPSNSSEETLFHYGMTWQINGTGLLGVRTDPLPSEFTPIFL
                     SQLWNKSGAGEDLISGCNEDAQCKFDILATGNRDIGQSTNSILRTFRHVNGTLNQYPP
                     PIHYSSKIQAYKGRTVAIEITSNSKDVVFSLSNKCSGFELFENGSLQWTPTSPEACTL
                     EILARDVKTNLSSVLQPETVACFCSKEEQCLYNETSKEGNSSTEVTSCKCDGNSFGRL
                     CEHSKDLCTEPCFPNVDCIPGKGCQACPPNMTGDGRHCVAVEISEFCQNHSCPVNYCY
                     NHGHCDISGPPDCQPTCTCAPAFTGNRCFLAGNNFTPIIYKELPLRTITLSLREDENA
                     SNADVNASVANVLENLDMRAFLSNSLVELIRTSPGAQSLGKPIHHWKVVSHFKYRPRG
                     PLIHYLNNQLISAVMEAFLLQARQERRKRSGEARKNVRFFPISRADVQDGMALNLSML
                     DEYFTCDGYKGYHLVYSPQDGVTCVSPCSEGYCHNGGQCKHLPDGPQCSCATFSIYTS
                     WGERCEHLSVKLGAFFGILFGALGALLLLAILACVVFHFCGCSMNKFSYPLDSEL"
     exon            186..6719
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /inference="alignment:Splign:2.1.0"
     exon            6720..6848
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /inference="alignment:Splign:2.1.0"
     exon            6849..6988
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /inference="alignment:Splign:2.1.0"
     exon            6989..7153
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /inference="alignment:Splign:2.1.0"
     exon            7154..7309
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /inference="alignment:Splign:2.1.0"
     exon            7310..7440
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /inference="alignment:Splign:2.1.0"
     exon            7441..7529
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /inference="alignment:Splign:2.1.0"
     exon            7530..7709
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /inference="alignment:Splign:2.1.0"
     exon            7710..7826
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /inference="alignment:Splign:2.1.0"
     exon            7827..7946
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /inference="alignment:Splign:2.1.0"
     exon            7947..8158
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /inference="alignment:Splign:2.1.0"
     exon            8159..8243
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /inference="alignment:Splign:2.1.0"
     exon            8244..8411
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /inference="alignment:Splign:2.1.0"
     exon            8412..8513
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /inference="alignment:Splign:2.1.0"
     exon            8514..8747
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /inference="alignment:Splign:2.1.0"
     exon            8748..8885
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /inference="alignment:Splign:2.1.0"
     exon            8886..9067
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /inference="alignment:Splign:2.1.0"
     exon            9068..9227
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /inference="alignment:Splign:2.1.0"
     exon            9228..9407
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /inference="alignment:Splign:2.1.0"
     exon            9408..9481
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /inference="alignment:Splign:2.1.0"
     exon            9482..9552
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /inference="alignment:Splign:2.1.0"
     exon            9553..9788
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /inference="alignment:Splign:2.1.0"
     exon            9789..9951
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /inference="alignment:Splign:2.1.0"
     exon            9952..10508
                     /gene="Muc4"
                     /gene_synonym="ASGP-1; Psmc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttggggcca gcagccagta gggacaggct cacctctgct cctcctgctg ccacctctgt
       61 gctgtggaga ttcctgaggg agcctaaggg attctctgga gccatgcgag ggcctcatgg
      121 agtctcatgg agagttccct ggctgtgtct gagctgcctg tgttcttgcc tcctcctgct
      181 acctgtaaat acatcaacta catcagcccc gaagacttct acagcccttc ccagcagcac
      241 caacccatct caaatgacct cacaggtgtc caacccaaca gcctctccat atagaatgac
      301 aaaaaacaca ggacaagcat caccgatggt tacttcaagt tccataacaa cacttcctca
      361 gagccaacac actggcagca tgaagaccac ccgcaatcct caaaccaccg gaaccacaga
      421 ggtgactaca actctttcag cctcctcaag tgaccacgtt caggcagaga caagttccca
      481 gacaacacta tctcctgatc caacaacgac ctcacatgct cccagagaga gcagctcacc
      541 tccaagtaca tcagttatat taaccaccac ggcctccaca gaaggcacct caggagacac
      601 aggacacaca atggcagtaa ctactcaagg ttccacacct gccaccacag agatctcagt
      661 gacaccttca acccagaaaa tgtcacctgt gtcaacattc agcacttcta cacaggaaat
      721 aacaacactt tcccaaagtc aacacactgg aggcatgaag accacccgca atcctcaaac
      781 caccggaacc acagaggtga ctacaactct ttcagcctcc tcaagtgaac aagttcaggc
      841 agagacaagt tcccagacaa cactatctcc tgatgcaaca accacctcac atgctcccag
      901 agagagcagc tcacctccaa gtacttcaga catgttaacc accacggcct ccacagaagg
      961 cacctcagga gacacaggac acacaacggc agtaactact cagggttcta tacctgctac
     1021 cacacagtta tcagcaacat tcgcatctca aaaaatgtca acagtgtcaa cacccaccat
     1081 ctcaattcag gaattgtcaa cacttcctca gagccaacac actggcagca tggagatcag
     1141 tagcagacct caaaccacct cagtcacatc aactctttca tcctctccaa gtggctcaac
     1201 tcctgtacag actcggtccc aagtgacatc atcctcagat gaaagaacca acccaacttc
     1261 ttctggtgtc agtaacacat ccccagctac aacagaagtg ctcaccccaa catcctctcc
     1321 agagtctgct ccaggaaaca cagctccgag gacaactgag acctctacaa caaccacgac
     1381 aaaagtctta acgacatctt tacaacagaa actgccaaca gggtcaacac tcggcacttc
     1441 tacacaggaa ttaacaacac ttcctcagag tcaacacact ggaatcatga agaccaccag
     1501 cagaactcaa actaccacac ccacagaggt gactacatcg actctttcag tctcctcaag
     1561 tgaccaactt cagacaggca caagttccca gagaacgtcc tctcctgata cgacaaccac
     1621 ctcacatgct cccagtgtga gcagctcatc tccaagtcca ccctccacag aaggaacctc
     1681 agtagacaca ggactcacaa cggcagtgac tactcaagat tctacccctg ccaccactca
     1741 gggctcactg acatcttcct cccagacact gtcaactgtg tcaccactca gcacttctac
     1801 acaggaatta acatcttctc agagccaaca cactggtagc atgaagacca cccacaatcc
     1861 tcaaaccacc agaaacacag aggtgactac aactctttca gcctcctcaa gtgaacaagt
     1921 tcaggtagag acaacttccc agacagcact atctcctgat acaacaacca cctcacatgc
     1981 tcccagagag agcagctcac ctccaagtac atcagttata ttaaccacca cggcctccac
     2041 agaaggcacc tcaggagaca caggacacac aatggcagta actactcagg gttctaaacc
     2101 tgacaccaca caggtctcac caacagcctc atcccagaga ctgtcaacag tgtcaccact
     2161 cagcacttct acacaggaaa taacaactct ttctcaaagt caacacactg gaggcatgaa
     2221 gaccacccgc aatcctcaaa gaaccacacc cacagaggtg actacatcga ctctttcagc
     2281 ctcctcgagt gaccaacttc agacaggaac aggttcccag agaacatcct ctcctgattc
     2341 aacaaccacc tcacatgctc ccagtgtgag aagctcacct ccaagtacac cctccacaga
     2401 agtcacctca gtagacacag gactcaaaac agcaatatct acccagggtt ctacccctgc
     2461 caccactcag ggctcactga catcttcctc ccagacactg tcaactgtgt caccactcag
     2521 cacttctaca caggaattaa caacacttcc tcagagccaa cacactggag gcatgaagac
     2581 cacccgcaat cctcaaacca ccagaaacac agaggtgact accgctcttt cagcctcctc
     2641 aagtgaccaa gttcaggtag agacaacttc ccagacaaca ctatctcctg atgcaacaac
     2701 gacctcacat gctcccagag agagcagctc acctccaagt acatcagata ttttaaccac
     2761 catggcctcc acagaaggca cctcaggaga cacaggacac acaatggcag taactactca
     2821 aggttccaca cctgccacca cagagatctc agtgacacct tcaacccaga aaatgtcacc
     2881 tgtgtcaaca ttcagcactt ctacacagga aataacaaca ctttcccaaa gtcaacacac
     2941 tggaggcatg aagaccaccc gcaatcctca aaccaccgga accacagagg tgactacaac
     3001 tctttcagcc tcctcaagtg accaagttca gacaaagaca agttcccaga caacactatc
     3061 tcctgataca acaaccacct cacatgctcc cagagagagc agctcacctc caagtacttc
     3121 agacatgtta accaccacgg cctccacaga aggcacctca ggagacacag gacacacaac
     3181 ggcagtaact actcagggtt ctatacctgc taccacacag ttatcagcaa cattcgcatc
     3241 tcaaaaaatg tcaacagtgt caacacccac cacctcaatt caggaattgt caacacttcc
     3301 tcagagccaa cacactggca gcatggagat cagtagcaga cctcaaacca cctcagtcac
     3361 atcaactctt tcatcctctc caagtggctc aactcctgta cagactcggt cccaagtgac
     3421 atcatcctca gatgaaagaa ccaacccaac ttcttctggt gtcagtaaca catccccagc
     3481 tacaacagaa gtgctcaccc caacatcctc tccagagtct gctccaggaa acacagctcc
     3541 gaggacaact gagacctcta caacaaccac gacaaaagtc ttaacgacat ctttacaaca
     3601 gaaactgcca acagggtcaa cactcggcac ttctacacag gaattaacaa cacttcctca
     3661 gagtcaacac actggaatca tgaagaccac cagcagaact caaactacca cacccacaga
     3721 ggtgactaca tcgactcttt cagtctcctc aagtgaccaa cttcagacag gcacaagttc
     3781 ccagagaacg tcctctcctg atacgacaac cacctcacat gctcccagtg tgagcagctc
     3841 atctccaagt ccaccctcca cagaaggaac ctcagtagac acaggactca caacggcagt
     3901 gactactcaa gattctaccc ctgccaccac tcagggctca ctgacatctt cctcccagac
     3961 actgtcaact gtgtcaccac tcagcacttc tacacaggaa ttaacatctt ctcagagcca
     4021 acacactggt agcatgaaga ccacccgcaa tcctcaaacc accagaaaca cagaggtgac
     4081 tacaactctt tcagcctcct caagtgaaca agttcaggta gagacaactt cccagacagc
     4141 actatctcct gatacaacaa ccacctcaca tgctcccaga gagagcagct cacctccaag
     4201 tacatcagtt atattaacca ccacggcctc cacagaaggc acctcaggag acacgggaca
     4261 cacaatggca gtaactactc agggttctaa acctgacacc acacaggtct caccaacagc
     4321 ctcatcccag agactgtcaa cagtgtcacc actcagcact tctacacagg aaataacaac
     4381 tctttctcaa agtcaacaca ctggaggcat gaagaccacc cgcaatcctc aaagaaccac
     4441 acccacagag gtgactacat cgactctttc agcctcctcg agtgaccaac ttcagacagg
     4501 aacaggttcc cagagaacat cctctcctga ttcaacaacc acctcacatg ctcccagtgt
     4561 gagaagctca cctccaagta caccctccac agaagtcacc tcagtagaca caggactcaa
     4621 aacagcaata tctacccagg gttctacccc tgccaccact cagggctcac tgacatcttc
     4681 ctcccagaca ctgtcaactg tgtcaccact cagcacttct acacaggaat taacaacact
     4741 tcctcagagc caacacactg gaggcatgaa gaccacccgc aatcctcaaa ccaccagaaa
     4801 cacagaggtg actacaactc tttcagcctc ctcaagtgac caagttcagg tagagacaac
     4861 ttcccagaca acactatctc ctgatgcaac aacgacctca catgctccca gagagagcag
     4921 ctcacctcca agtacttcag acatgttaac caccacggcc tccacaggaa gcaccttagg
     4981 agacacagga cacacaacgg cagtaactac tcagggttct atacctgcta ccacactgtt
     5041 ctcaccaaca ctctcatctc agaaaatgtc aacagtgtca acacccacca cctcaattca
     5101 ggaattgtca acacttcctc agagccaaca cactggcagc atggagatca gtagcagacc
     5161 tcaaaccacc tcagtcacat caactctttc atcctctcca agtggctcaa ctcctgtaca
     5221 gactcggtcc caagtgacat catcctcaga tgaaagaacc aacccaactt cttctggtgt
     5281 cagtaacaca tccccagcta caacagaagt gctcacccca acatcctctc cagagtctac
     5341 tccaggaaac acagctccga ggacaactga gacctctaca acaaccacga caaaggtctt
     5401 aatgacatct ttacaacaga aactgccaac agggtcaaca ctcggcactt ctacacagga
     5461 attaacaaca cttcctcaga gtcaacacac tggaatcatg aagaccacca gcagaactca
     5521 aactaccaca cccacagagg tgactacaac tctttcagcc tcctcaagtg accaagttca
     5581 ggtagagaca acttcccaga caacactatc tcctgatgca acaaccacct cacatgctcc
     5641 cagagagagc agctcacctc caagtacatc agttatatta accaccatgg cctccacaga
     5701 aggcacctca ggagacacag gacacacaac agcagtaact gtccaaggtt ccacacctgc
     5761 caccacagag atctcagtga caccttcaac ccagaaaatg tcacctgtgt caacattcag
     5821 cacttctaca caggaaataa catcttctca gagccaacgc actggtagca tgaagaccac
     5881 ccacaatcct caaaccacca gaaacacaga ggtgactaca actctttcag cctcctcaag
     5941 tgaacaagtt caggcagaga caacttccca gacaacacta tctcctgatg caacaaccac
     6001 ctcacatgct cccagagaga gcagctcacc tccaagtact tcagacatgt taaccaccac
     6061 ggcctccaca gaaggcacct caggagacac aggacacaca atggcagtaa ctactcaagg
     6121 ttccacacct gccaccacag agatctcagt gacaccttca acccagacac tgtcaactgt
     6181 gtcaacactt agcacttcta ctcaagaatt aacttcttct cagagccaac gcactggaag
     6241 catggggacc agcagcaaac ctcaagccac cacaccgaca gaggtgacca catccactct
     6301 ttcatcattt tcaaggggat ccactcaaac ccagacagtt tcttgggaaa catcctcctc
     6361 aggaaaaata actgccccat ctacttccag taggaggacc ccatccgtag ccacatcaga
     6421 catattcacc accacagact ccacctcagg aaacgcgggg cacacacttt taacgggaag
     6481 ccacagtgtg atcacatcaa gagtcgcaag cacaactcta ggccgattgt caacagtagc
     6541 gcacagcaag tctactcagc gatcatctac acattctcag agttacttga ctgaaagcat
     6601 gggggcatcc agcacgtctg aaaccagcct cctcacagag gctaccacag agaagcagtt
     6661 tgcctcttca cctggaccca ctgtgacaga gaccttctct cgtgggacgt cctcttcagg
     6721 attgaccacg aaaacagaca atgacagaag tacagcactc tcagccacct ccttgaccct
     6781 tccggctccc agcacgtcca cagcctccag gtccacagtg cctccagccc ctcttccacc
     6841 agatcagggt atttccctct tcccctacgg gtcaagctct gaagttagag acaagcaatt
     6901 gtttgccagg actgtggatt ttacctcacc aatcttcaag atccagattg gctttcccct
     6961 cggctcctcc ctgcgggatt ccttctattt tacagataac ggtcagatca ttttccccga
     7021 gtcagactac gatgtcttct cctaccccaa cccacctcaa agaggcttca caggaaggga
     7081 gcgtgtggcc atagtggccc cattctgggg tgatgctgat ttctctagct ccaggggaac
     7141 catattttac caggactaca tcacatttta cgatgagcag caccagctaa ttcggaaggt
     7201 ggagtctctg attaatgagt ttacaagtga ctggagcttc aaagccaagt ggacactgaa
     7261 ggtcacctgg gtcaatgttc ctgcctatcc agcccagggg agctttggga ccaataccta
     7321 ccaagccatc ctctccacag atgggagcag gtcctacgcc ctgtttctct accagagcgg
     7381 tggcatgagg tgggatgtga cccagggact gtacaaccga gtgctcatgg gcttctccag
     7441 tggagatggg tattttgaaa acagcccgct gatattccgg ccagcagtgg agaagtaccg
     7501 tccagatcga ttcctgaact ccaaattagg catccgggga ctgcaggtct acaggctaca
     7561 cagggaggtg tggcccaact acaggctcaa gtgtctgcag tggttggaaa gtcagcctca
     7621 gcagcccagc tggggctgga acaagatttc ctgcccttgc tcctggcagc agggacgatg
     7681 ggactttcgg ttctggctca tcaacacagg tctgtggggc aggcagctat gcagcttctc
     7741 ctccgggcga gggggcgtgt gctgtagcta tggcacctgg ggtgagtttc gagaaggctg
     7801 gagaatgcac agtccttggc agtttgatga ggagcaggag gcacagaact ggtgctgccg
     7861 ctggaacgac aagccctctt tctgcgtcca gtaccagctc aggcggcccc gagttagttg
     7921 tgctgggtac aggccccccc ggcccgcttg gacatttggt gatccccaca tcaccacttt
     7981 ggataacgcc aaatacacct tcaacgggct aggggacttc ctgctggttc aggcccagga
     8041 cagaaattct tccttcctgc tggagggccg cactgcccag actgattctg ccaatgccac
     8101 gaacttcatt gcctttgcgg cccaatacaa caccagcagc ctgaagtctc ccatcacagt
     8161 tcagtggttt cttgagccca atgacacaat ccgagttgta cacaataacc aaacggtggc
     8221 ctttaacacc agcgacactg aagacttgcc cgtattcaat gccactggtg tcctactgat
     8281 ccaaaatggc tcccaagtct cagccaactt tgatgggaca gtgaccatct ctgtgattgc
     8341 tctctccaac atccttcacg cctcctccag cctgtcagag gagtaccgca accacacaaa
     8401 gggccttctg ggagtctgga atgacaatcc agaagatgac ttcagaatgc ccaatggctc
     8461 caccatcccc tccaacagct ccgaggagac tcttttccac tatggaatga catggcaaat
     8521 caacgggaca ggcctccttg gggtgaggac agaccctctg ccttctgagt ttactcccat
     8581 cttcttgtcc caactgtgga acaagagcgg cgccggtgaa gacttgatct ctgggtgcaa
     8641 cgaggacgca cagtgcaagt ttgacatcct ggccacagga aacagagaca tcggacaaag
     8701 caccaactca atccttagaa cattccggca cgtgaatggc acgctcaacc agtacccacc
     8761 ccctatccac tacagcagca agattcaagc ctacaagggg cgaacagtgg ccattgagat
     8821 caccagcaac tctaaggatg tcgtattcag cctctccaac aagtgcagtg gctttgagct
     8881 ctttgaaaac gggagtttgc agtggacacc aacatcccca gaagcatgta ccctggagat
     8941 tctagcaagg gatgtcaaga ctaacttgtc atcggtactc cagcctgaga cggtggcttg
     9001 cttctgtagt aaggaggaac agtgtttgta caacgagacc agcaaagagg gcaactcttc
     9061 cactgaggtg accagctgca agtgcgatgg gaactccttc ggccgcttgt gtgaacactc
     9121 taaggacctc tgcactgagc catgcttccc taatgtggac tgcattcctg ggaagggctg
     9181 tcaggcctgc cctccaaaca tgactggaga tgggcgtcat tgtgtagctg tggagatctc
     9241 tgaattctgc cagaaccatt cctgtcctgt gaattactgc tataaccatg gccattgcga
     9301 catctctggg cctccagact gccagcccac ttgcacctgc gcccctgcct tcactggtaa
     9361 ccgctgcttc ctggccggga acaatttcac tcccatcatc tataaagagc ttcccttgag
     9421 gaccatcacg ctctctctca gggaggacga aaacgcctct aacgctgacg tcaatgcctc
     9481 ggtggcaaac gtactagaga acttggacat gcgggctttt ctctccaaca gcttagtgga
     9541 gctgatacga acctctcccg gagcacagtc cttgggcaag cccattcatc actggaaggt
     9601 cgtctcccac ttcaagtacc gtcccagggg acccctcatc cactatctga acaaccaact
     9661 gataagcgcc gtgatggagg ccttcctcct ccaggctcgg caggagaggc ggaagaggag
     9721 tggagaagcc aggaagaacg tccgcttctt ccccatctcg agggcagacg tccaggacgg
     9781 gatggccctg aacctaagta tgctggacga gtacttcacg tgcgatggct acaaaggcta
     9841 ccacttggtc tacagccccc aggatggcgt cacctgtgtg tccccatgta gtgagggcta
     9901 ctgtcacaat ggaggccaat gcaagcacct gccagatggg ccccagtgca gctgcgcaac
     9961 cttcagcatc tacacatcct ggggcgaacg ctgtgagcat ctaagcgtga aacttggggc
    10021 attcttcggg atcctctttg gagccctggg tgccctcttg ctactggcca tcttagcatg
    10081 tgtggtcttt cacttctgcg gctgctccat gaacaagttc tcctaccctc tggactcaga
    10141 actgtgaggc ctcgtcccag atgggcagct gcacctagaa tacctcagga cccgcccacc
    10201 ggtctgcccc tgctctaggg agactggaaa gggccgactg catgaagatg atttgagatt
    10261 cttcaagcat gaataaaggg agtgaaacca gactctacca ttttagtagg ccatgggtat
    10321 aggaaaaggc cagatgacca aatgtagaga tggatggatt cctatacagc acatgggaaa
    10381 ggatattgcc tatgtacaca cacacacaca cacacaccag agttaatgga tgactggctt
    10441 tatattcacc aaaatgtttt tacttataaa accagcatac ttctcattaa aatctattta
    10501 aatataaa
//
