LOCUS       NM_001398538            2313 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus mucin 1, cell surface associated (Muc1), mRNA.
ACCESSION   NM_001398538 XM_039103761
VERSION     NM_001398538.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2313)
  AUTHORS   Zhou,L.B., Zheng,Y.M., Liao,W.J., Song,L.J., Meng,X., Gong,X.,
            Chen,G., Liu,W.X., Wang,Y.Q., Han,D.M., Zhong,N.S., Lu,W.J.,
            Yang,P.C. and Zhang,X.W.
  TITLE     MUC1 deficiency promotes nasal epithelial barrier dysfunction in
            subjects with allergic rhinitis
  JOURNAL   J Allergy Clin Immunol 144 (6), 1716-1719 (2019)
   PUBMED   31425778
  REMARK    GeneRIF: MUC1 deficiency promotes nasal epithelial barrier
            dysfunction in subjects with allergic rhinitis.
REFERENCE   2  (bases 1 to 2313)
  AUTHORS   Hasan,B., Abudulimu,H., Tian,L. and Ablimit,A.
  TITLE     Changes in mucin 1 expression in a rat model of allergic airway
            inflammation
  JOURNAL   Exp Lung Res 44 (3), 137-142 (2018)
   PUBMED   29847197
  REMARK    GeneRIF: Mucin 1 distributes in the airway epithelial cells with
            ciliates and the expressional increase of Muc1 in lung may imply
            its functions on allergic inflammatory episodes
REFERENCE   3  (bases 1 to 2313)
  AUTHORS   Zhu,Y., Fu,J., You,K., Jin,L., Wang,M., Lu,D. and Xue,X.
  TITLE     Changes in pulmonary tissue structure and KL-6/MUC1 expression in a
            newborn rat model of hyperoxia-induced bronchopulmonary dysplasia
  JOURNAL   Exp Lung Res 39 (10), 417-426 (2013)
   PUBMED   24298937
  REMARK    GeneRIF: Increased lung MUC1 expression appears to be closely
            associated with impairment of alveolarization in a newborn model of
            hyperoxia-induced bronchopulmonary dysplasia.
REFERENCE   4  (bases 1 to 2313)
  AUTHORS   Nguyen,G.K., Hwang,B.H., Zhang,Y., Monahan,J.F., Davis,G.B.,
            Lee,Y.S., Ragina,N.P., Wang,C., Zhou,Z.Y., Hong,Y.K., Spivak,R.M.
            and Wong,A.K.
  TITLE     Novel biomarkers of arterial and venous ischemia in microvascular
            flaps
  JOURNAL   PLoS One 8 (8), e71628 (2013)
   PUBMED   23977093
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2313)
  AUTHORS   Kirby,A., Gnirke,A., Jaffe,D.B., Baresova,V., Pochet,N.,
            Blumenstiel,B., Ye,C., Aird,D., Stevens,C., Robinson,J.T.,
            Cabili,M.N., Gat-Viks,I., Kelliher,E., Daza,R., DeFelice,M.,
            Hulkova,H., Sovova,J., Vylet'al,P., Antignac,C., Guttman,M.,
            Handsaker,R.E., Perrin,D., Steelman,S., Sigurdsson,S.,
            Scheinman,S.J., Sougnez,C., Cibulskis,K., Parkin,M., Green,T.,
            Rossin,E., Zody,M.C., Xavier,R.J., Pollak,M.R., Alper,S.L.,
            Lindblad-Toh,K., Gabriel,S., Hart,P.S., Regev,A., Nusbaum,C.,
            Kmoch,S., Bleyer,A.J., Lander,E.S. and Daly,M.J.
  TITLE     Mutations causing medullary cystic kidney disease type 1 lie in a
            large VNTR in MUC1 missed by massively parallel sequencing
  JOURNAL   Nat Genet 45 (3), 299-303 (2013)
   PUBMED   23396133
REFERENCE   6  (bases 1 to 2313)
  AUTHORS   Seregni,E., Botti,C., Lombardo,C., Cantoni,A., Bogni,A., Cataldo,I.
            and Bombardieri,E.
  TITLE     Pattern of mucin gene expression in normal and neoplastic lung
            tissues
  JOURNAL   Anticancer Res 16 (4B), 2209-2213 (1996)
   PUBMED   8694545
REFERENCE   7  (bases 1 to 2313)
  AUTHORS   Kitamura,H., Yonezawa,S., Tanaka,S., Kim,Y.S. and Sato,E.
  TITLE     Expression of mucin carbohydrates and core proteins in carcinomas
            of the ampulla of Vater: their relationship to prognosis
  JOURNAL   Jpn J Cancer Res 87 (6), 631-640 (1996)
   PUBMED   8766528
REFERENCE   8  (bases 1 to 2313)
  AUTHORS   Wesseling,J., van der Valk,S.W., Vos,H.L., Sonnenberg,A. and
            Hilkens,J.
  TITLE     Episialin (MUC1) overexpression inhibits integrin-mediated cell
            adhesion to extracellular matrix components
  JOURNAL   J Cell Biol 129 (1), 255-265 (1995)
   PUBMED   7698991
REFERENCE   9  (bases 1 to 2313)
  AUTHORS   Ho,S.B., Niehans,G.A., Lyftogt,C., Yan,P.S., Cherwitz,D.L.,
            Gum,E.T., Dahiya,R. and Kim,Y.S.
  TITLE     Heterogeneity of mucin gene expression in normal and neoplastic
            tissues
  JOURNAL   Cancer Res 53 (3), 641-651 (1993)
   PUBMED   7678777
REFERENCE   10 (bases 1 to 2313)
  AUTHORS   Parry,G., Li,J., Stubbs,J., Bissell,M.J., Schmidhauser,C.,
            Spicer,A.P. and Gendler,S.J.
  TITLE     Studies of Muc-1 mucin expression and polarity in the mouse mammary
            gland demonstrate developmental regulation of Muc-1 glycosylation
            and establish the hormonal basis for mRNA expression
  JOURNAL   J Cell Sci 101 (Pt 1), 191-199 (1992)
   PUBMED   1569123
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Dec 20, 2021 this sequence version replaced XM_039103761.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166505.1, SRR26643293.12926.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               JAXUCZ010000002.1  176933750-176933868
            120-1495            JAXUCZ010000002.1  176934639-176936014
            1496-1548           JAXUCZ010000002.1  176936114-176936166
            1549-1682           JAXUCZ010000002.1  176936308-176936441
            1683-1804           JAXUCZ010000002.1  176936552-176936673
            1805-1954           JAXUCZ010000002.1  176936750-176936899
            1955-2313           JAXUCZ010000002.1  176938139-176938497
FEATURES             Location/Qualifiers
     source          1..2313
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2313
                     /gene="Muc1"
                     /note="mucin 1, cell surface associated"
                     /db_xref="GeneID:24571"
                     /db_xref="RGD:3122"
     exon            1..119
                     /gene="Muc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2029
                     /gene="Muc1"
                     /note="Mucin1; mucin 1, transmembrane; mucin-1"
                     /codon_start=1
                     /product="mucin-1 precursor"
                     /protein_id="NP_001385467.1"
                     /db_xref="GeneID:24571"
                     /db_xref="RGD:3122"
                     /translation="MTPGIRVPLLLLLLLASLKVRSGASSSTTSLPGDSFSTAVPSGA
                     SSSATSPPVDSTTSPVHSSTSFPATSPPGDSTSTAVLSGDSDPATSPPGDSSSTAVPN
                     GASSSATSPPVDSTTSPVHSSTSFPATSSPGDSTSTAVTSGTSSSATSPPEDSSSTAV
                     TSGTSSPATSPPGDSSSTAVTSGTSSPATSPILDSSSTAVLSGTSSPATSPPEDSTST
                     AVTSGTSSPATSPPEDSTSTAVTSGTSSPATSPILDSSSTAIHSGTSSPATSPPGDSS
                     STAVLSGASTQTTKAVSDLASTPTHNGIMVPTTWSALSSATSPVYSGSSATTNSSESD
                     MATTPVYSGTPFSSTTATSAITPDHNGSLVRTTSSVLGLATSPAHDTSAVATTPVRND
                     TQSSVPSQQPISPTIPAISSHSTVSSSSYYSTAVFPTFSSNSSPQLSVGVSFFSLSFY
                     IRNHPFNSSLEDPSSRYYQELKRNISGLFLQVFNGDFLGVSTIKFRSGSVVVASTVIF
                     REGTFSASEVKSQLVQHKKEAADYNLTISEVNVNEMQFPSSAQSWPGVPGWGIALLVL
                     VCILVALVIVYLIALALCQCRRKSYGQLDLFPTRDTYHPMSEYPTYHTHGRYVPPATT
                     KRSPYEEVSTGNGSSGLSYTNPAVATTSANL"
     exon            120..1495
                     /gene="Muc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1548
                     /gene="Muc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1682
                     /gene="Muc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1804
                     /gene="Muc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1954
                     /gene="Muc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2313
                     /gene="Muc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacacacgca gcgccagcct tgagtctgtt tctacccctt tcccgcctgt tcaccaccac
       61 catgaccccg ggcatacggg ttcctctcct cctgctgcta cttctagcaa gcctaaaagt
      121 ccgcagtggt gcctcctcct caaccaccag ccttccaggg gactccttca gcactgcagt
      181 ccccagtggt gcctcttcct cagccaccag ccctccagtg gactccacca cctctccagt
      241 tcatagtagc acctcgttcc cagccaccag ccctccagga gactccacca gcactgcagt
      301 cctcagtggt gactcagatc cagccaccag ccctccaggg gactcctcca gcactgcagt
      361 ccccaatggt gcctcttcct cagccaccag ccctccagtg gactccacca cctccccagt
      421 tcatagtagc acctcgttcc cagccaccag ctctccaggg gactccacca gcactgcagt
      481 caccagtggc acctcttcct cagccaccag ccctccagag gactcctcca gcactgcagt
      541 caccagtggc acctcgtccc cagccaccag ccctccaggg gactcctcca gcactgcagt
      601 caccagtggc acctcgtccc cagccaccag ccctatattg gactcctcca gcactgcagt
      661 cctcagtggc acctcgtccc cagccaccag ccctccagag gactccacca gcactgcagt
      721 caccagtggc acctcgtccc cagccaccag ccctccagag gactccacca gcactgcagt
      781 caccagtggc acctcgtccc cagccaccag ccctatattg gactcctcca gcactgcaat
      841 ccacagtggc acctcgtccc cagccaccag ccctccaggg gactcctcca gcactgcagt
      901 cctcagcggt gcttccaccc aaaccaccaa ggctgtatca gacttagcta gcactccaac
      961 ccacaatggc atcatggtcc caactacctg gtctgcattg agctcagcca ccagtccggt
     1021 gtacagtggt tcctcagcta caactaatag ctctgaatca gacatggcca ccactccagt
     1081 gtacagtggc accccattct cttctaccac ggctacgtca gctatcaccc cagaccacaa
     1141 tggctccttg gtgcgaacta ccagttctgt gttgggctta gccaccagtc cagcccatga
     1201 tacctctgcg gtggccacaa ctccagtccg caatgacact cagtcttcag ttccaagtca
     1261 gcagcccatc tctcccacca tccccgccat ctccagccac agtactgtta gcagcagctc
     1321 ttactacagc acagcggtct tccctacctt ctccagtaac agctcacccc agttgtctgt
     1381 cggggtctcc ttcttctcgt tgtcttttta cattcggaac cacccattta attcttccct
     1441 ggaagacccc agctcccgct actaccaaga actgaagagg aacatttccg gattgtttct
     1501 gcaggttttt aacggagact ttctgggggt ctctactatc aagttcaggt caggctcggt
     1561 ggtggtagca tcgactgtga ttttccggga gggcactttc agtgcctctg aagtgaagtc
     1621 acagctcgta caacataaga aggaggcagc tgactataat ctgactatct cggaagtcaa
     1681 tgtgaatgag atgcagttcc cttcctctgc ccagtcttgg cctggggtac caggttgggg
     1741 cattgccctg ctggtactgg tctgtatttt ggtggctttg gtcatcgtct atctcattgc
     1801 cctggcattg tgccagtgcc gcagaaagag ctatgggcag ctggacctct ttccaacccg
     1861 ggacacctac catcctatga gtgaatatcc tacctaccac actcacggac gctatgtgcc
     1921 ccctgccact accaaacgta gcccctatga agaggtttcg acaggcaatg gcagtagcgg
     1981 tctctcttac accaacccgg ctgtggcaac cacttcggcc aacttgtagg agcaagtcac
     2041 cctacccact cgggcagtgg cagttggctc cagcagtcca ctccctcagt ggtcgctgcc
     2101 agacccctgc actctgatct gggctggtga gccaggactc ctgataggct gatcacagcc
     2161 ttcctcagag gctttgtcac cacgttagcc tggtgaagcc cagccctgcc ctgagggaca
     2221 ctggggtagt ggtggttctc agaaggactg gcctagaaaa cctggagatg ggacccaaat
     2281 gtggctgaat aaaagatggc ttcctgttag tta
//
