LOCUS       NM_001374100            7506 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus microtubule associated scaffold protein 2
            (Mtus2), transcript variant 1, mRNA.
ACCESSION   NM_001374100 XM_017598433
VERSION     NM_001374100.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7506)
  AUTHORS   Du Puy,L., Beqqali,A., Monshouwer-Kloots,J., Haagsman,H.P.,
            Roelen,B.A. and Passier,R.
  TITLE     CAZIP, a novel protein expressed in the developing heart and
            nervous system
  JOURNAL   Dev Dyn 238 (11), 2903-2911 (2009)
   PUBMED   19806667
REFERENCE   2  (bases 1 to 7506)
  AUTHORS   Jiang,K., Wang,J., Liu,J., Ward,T., Wordeman,L., Davidson,A.,
            Wang,F. and Yao,X.
  TITLE     TIP150 interacts with and targets MCAK at the microtubule plus ends
  JOURNAL   EMBO Rep 10 (8), 857-865 (2009)
   PUBMED   19543227
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Feb 10, 2021 this sequence version replaced NM_001374100.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. This RefSeq transcript is based on
            transcript alignments from orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.150148.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-674               JAXUCZ010000012.1  12113830-12114503   c
            675-3046            JAXUCZ010000012.1  11975538-11977909   c
            3047-3287           JAXUCZ010000012.1  11971029-11971269   c
            3288-3482           JAXUCZ010000012.1  11945558-11945752   c
            3483-3644           JAXUCZ010000012.1  11850883-11851044   c
            3645-3743           JAXUCZ010000012.1  11828709-11828807   c
            3744-3955           JAXUCZ010000012.1  11820748-11820959   c
            3956-4022           JAXUCZ010000012.1  11775386-11775452   c
            4023-4237           JAXUCZ010000012.1  11764415-11764629   c
            4238-4343           JAXUCZ010000012.1  11757952-11758057   c
            4344-4417           JAXUCZ010000012.1  11755245-11755318   c
            4418-4516           JAXUCZ010000012.1  11751983-11752081   c
            4517-4636           JAXUCZ010000012.1  11750105-11750224   c
            4637-4734           JAXUCZ010000012.1  11747105-11747202   c
            4735-7506           JAXUCZ010000012.1  11742713-11745484   c
FEATURES             Location/Qualifiers
     source          1..7506
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..7506
                     /gene="Mtus2"
                     /gene_synonym="RGD1562533"
                     /note="microtubule associated scaffold protein 2"
                     /db_xref="GeneID:498136"
                     /db_xref="RGD:1562533"
     exon            1..674
                     /gene="Mtus2"
                     /gene_synonym="RGD1562533"
                     /inference="alignment:Splign:2.1.0"
     exon            675..3046
                     /gene="Mtus2"
                     /gene_synonym="RGD1562533"
                     /inference="alignment:Splign:2.1.0"
     CDS             896..4948
                     /gene="Mtus2"
                     /gene_synonym="RGD1562533"
                     /note="isoform 1 is encoded by transcript variant 1;
                     microtubule associated tumor suppressor candidate 2"
                     /codon_start=1
                     /product="microtubule-associated tumor suppressor
                     candidate 2 isoform 1"
                     /protein_id="NP_001361029.1"
                     /db_xref="GeneID:498136"
                     /db_xref="RGD:1562533"
                     /translation="MSVPLAPKKSCFSQLRDHREGAKNNNDNILRTGDTNANQIMLEV
                     SASCDEPKSRDLDDEIGNANLSRPQYHGHFQKEPLHLQGLGKGSQAGSASQRDSQSSL
                     TVHRQLSEEHTVKRGTLQTPQSIQGPSFSSWRNAVGQASPEVSAEIPRHTPKDKLAKT
                     LDNEELKRASRSAAAAGGITPTTNPQPAQPDISEPQGHVPGHGEGPQGTPASHSPGKV
                     FSPGDGTSEGNGVSLPKPSTSEAKGSSPSDTKVEGTRGPDVHNQCTARAELTPSLASA
                     LRENPSLCHPEVYLGQGTGKPKVELKYIQPRNEEGLTSAQAQALVCREERSTSPVDRK
                     ELLEKEYREATGQLNSSQHQLGVGRGGSQEDGIGVSAGVEGSLQATPAPSAAPAGEAG
                     TGLTGKASAGAGRMARETASGKAAPDDGQVTPVLRDPNESAPSEVSGEERRLGSGNSG
                     SAKLLASGPFVGGNRTDASELLSPRSSSLEARKSKETVTSVAEDKNLPENAAQTDVTP
                     AGVDSVFSTPAPLHPETTVNLTEYLTPPSSSSQELGVFSVDTGSLSVASAPTGGGQVL
                     NTSPKVPDKTTCPSGIPKSLTHPKDTPSSQEALEKPETEKTEERTEAKPILMPKPKHV
                     RPKIITYIRRNPQALSQGDASLVPVGLPYAPPACGMPLPQEEKASSLQPPANMYEKLK
                     PDLQKPRVFPSGLMVSGIKPPAHHFSQMSEKFLQEVTDHPGKEEFCSPPYTHYEVPPT
                     FYRSAMLLKPQLGLGAMSRLPSTKSRILIASQRSSAGSIHPPGSIATATSFYGSDPSD
                     LKRASNSNAAKSGLPKSGLRPPGYSRLPAAKLAAFGFVRSSSVSAVPSTQSLDSAQQE
                     QSRPVTRPTFGSEEQVSLKQAVPSKDTPKGAGRAAPASSSNATPPRRSLLPAPKSTST
                     PAGAKKEPQKDPEAKKPAVSSPKRTASATTKLHSPGYPKQRTTAPRNEVPPKPDLQAR
                     EAERQLAQRLRDRCEWQARQLGLARRELKKAIQGFDAMAVSAKHFFGKSERALAKEKE
                     LSIELANIRDEVAFNTAKCEKLQKEKEALERRFEEELRRLGWQQQAEVQELQERLQQQ
                     FQAESARLQAEHQDQMLRMRCQHQEQVEDITASHEAALLEMENNHTVAITILQDDHDH
                     KVQELMSTHEFEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRAQRFEEALRKTTEE
                     QLEIALAPYQHLEEDMQSLKQVLEMKNQQIHLQEKKIIELEKLVEKNIILEEKIQVLQ
                     QQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELLWKLQTGDPT
                     SPIKLSPTSPVYRGSSSGPSSPARVSTTPR"
     exon            3047..3287
                     /gene="Mtus2"
                     /gene_synonym="RGD1562533"
                     /inference="alignment:Splign:2.1.0"
     exon            3288..3482
                     /gene="Mtus2"
                     /gene_synonym="RGD1562533"
                     /inference="alignment:Splign:2.1.0"
     exon            3483..3644
                     /gene="Mtus2"
                     /gene_synonym="RGD1562533"
                     /inference="alignment:Splign:2.1.0"
     exon            3645..3743
                     /gene="Mtus2"
                     /gene_synonym="RGD1562533"
                     /inference="alignment:Splign:2.1.0"
     exon            3744..3955
                     /gene="Mtus2"
                     /gene_synonym="RGD1562533"
                     /inference="alignment:Splign:2.1.0"
     exon            3956..4022
                     /gene="Mtus2"
                     /gene_synonym="RGD1562533"
                     /inference="alignment:Splign:2.1.0"
     exon            4023..4237
                     /gene="Mtus2"
                     /gene_synonym="RGD1562533"
                     /inference="alignment:Splign:2.1.0"
     exon            4238..4343
                     /gene="Mtus2"
                     /gene_synonym="RGD1562533"
                     /inference="alignment:Splign:2.1.0"
     exon            4344..4417
                     /gene="Mtus2"
                     /gene_synonym="RGD1562533"
                     /inference="alignment:Splign:2.1.0"
     exon            4418..4516
                     /gene="Mtus2"
                     /gene_synonym="RGD1562533"
                     /inference="alignment:Splign:2.1.0"
     exon            4517..4636
                     /gene="Mtus2"
                     /gene_synonym="RGD1562533"
                     /inference="alignment:Splign:2.1.0"
     exon            4637..4734
                     /gene="Mtus2"
                     /gene_synonym="RGD1562533"
                     /inference="alignment:Splign:2.1.0"
     exon            4735..7506
                     /gene="Mtus2"
                     /gene_synonym="RGD1562533"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacctcact ggagggtggg cgggagcggc gtctttgtcc ggcgaggcgt cctcagcccg
       61 ggccatccct gtaatcggag ccgggtggcc tgggcggtgc ccagcggtga agtgcgcggg
      121 cggagggctg gctgcggcca cggccccagg taccctggtg ccccaagctc gccacctgcg
      181 ccacctctgc ccgcgctctg tcaagttgca gaagacccgg gtgggtcagg agtctggacg
      241 cgtgggcgcg ttgcaaactc cagctgcgaa ggagctgcga gcggaggtag cccggccggg
      301 gatgctcccg gaggctgccc tggtctctct gcacatcctt cttggctcct ccagactcag
      361 gtgagcgact gtcgtccgcg cgtcccgatc tggctggaga caggtgcaga gcggggcgga
      421 ggcggtgcct ttccctggct tctctggcat cagagcgccc gctccccgct gcccacatct
      481 tctgctccgc cggagagagg ctgcagccca ctcgcacctt ccggggatgc caggttgagc
      541 acggtgtttc agaggcgaca gcgggttagc ctaaacgagc tcccacccct ctccaccccc
      601 agctcgggat aattcggtcc gtgccttcgt cttaatttag caccgatgtg ttatttcctt
      661 ggagctctag aatggtctcc tgaacccact ggtttgcact gaacagcaat ggagcatgaa
      721 gagttgtcct actgtgtgtc aagacagtgg ttggttctga aactcatctg aagaggttca
      781 aagaatcttc tagatgtgac attgtcagag gaggacagag aaggtgacag ctgcctgttg
      841 ccctgcagct tgaagggagg ccgcatggcc agcagccctc attgaagacg tgaccatgag
      901 tgtcccactc gcgccaaaga aatcctgttt cagtcagttg cgagatcacc gagaaggagc
      961 aaaaaataat aacgacaata ttctgaggac gggggataca aatgccaatc aaatcatgtt
     1021 ggaggttagc gcctcttgcg atgagcccaa gtcacgtgat ctggatgatg agatcggaaa
     1081 tgcaaattta agcaggccac aataccacgg ccacttccaa aaggagcctc ttcaccttca
     1141 gggcctcggg aaagggtctc aggctggctc tgccagccag agggattctc agtcttctct
     1201 gactgttcat aggcaactga gtgaggagca cacagtaaaa agaggtaccc tgcagacccc
     1261 ccagagtatt cagggaccaa gtttctccag ctggaggaac gcagtgggtc aagccagtcc
     1321 agaggtttct gctgagattc ccaggcacac tcccaaggac aaattggcaa agactcttga
     1381 caacgaagag ctgaagcgag caagcaggtc agcagctgca gctggtggca tcactccaac
     1441 gacgaaccca cagccagcgc agccggacat ctcggagcct cagggtcacg tgcctgggca
     1501 tggggagggg ccacaaggga caccagccag tcactctcca gggaaagttt tttctccagg
     1561 tgacggaacc tcagagggga acggtgtgtc tcttcctaaa ccatctacct cagaagccaa
     1621 gggctccagc ccatcagaca ccaaggtgga ggggacacgt ggcccagatg ttcacaacca
     1681 gtgcaccgct cgtgcagaac tgactcccag tctagcttca gcactgaggg aaaaccccag
     1741 cctctgtcat ccagaagtgt atttaggtca aggaacaggg aagcccaaag tggagctcaa
     1801 atatatccaa cccaggaatg aggagggact aacatcagcc caggcccaag ctctggtatg
     1861 tcgtgaggaa agaagcacgt cacctgtaga caggaaggag ctacttgaga aggaataccg
     1921 agaagccacc ggtcaactga acagcagcca gcaccagctt ggagtgggac gaggcggcag
     1981 ccaggaagac gggattggag tcagtgctgg tgtggagggg tctctgcaag ccacccctgc
     2041 accgagcgcc gctcccgcgg gagaggcagg gactggactc accgggaaag cgtcagcagg
     2101 tgcgggtagg atggcgaggg aaacagcatc cggcaaagct gcacctgatg acggacaagt
     2161 aactcctgtt ctccgtgatc caaatgagag cgcgccctcc gaggtcagtg gggaggagag
     2221 gaggctgggt agcgggaact cgggcagtgc caaactgttg gcctcaggtc cttttgtggg
     2281 tgggaacaga accgacgcct ccgagctctt gagccctcga agtagcagct tggaagccag
     2341 gaaaagcaaa gagacggtaa catctgtagc tgaagataag aaccttccag aaaatgcggc
     2401 ccaaactgac gtcactccgg ctggagtaga ttccgtgttc agtaccccgg ctcccctcca
     2461 cccagagaca actgtgaact tgactgagta cctgactcct ccaagtagca gttctcagga
     2521 gctcggagtg ttcagtgtgg acacagggtc actctcagtg gcctcagccc ccactggtgg
     2581 tgggcaggta ctgaacacat cgccgaaagt gcctgacaag accacctgcc ccagtggaat
     2641 ccccaagtct cttacgcacc ccaaggacac gccctcctcc caggaagcac tggagaaacc
     2701 ggagacagag aaaacagaag aaaggacaga ggcaaagccc atcctcatgc ccaaacccaa
     2761 acatgtgagg cccaagatca tcacttacat acgcaggaac ccccaggcgc tgagtcaggg
     2821 agatgcttcc cttgtcccag tagggcttcc gtatgcccct cctgcatgtg gtatgcctct
     2881 tccccaagaa gagaaggcgt cgagccttca gccgcctgca aatatgtacg agaaactgaa
     2941 gcctgacttg cagaagccaa gggtcttccc ttccggattg atggtgtctg ggatcaagcc
     3001 cccagcgcac catttcagtc agatgagcga gaagttcctg caggaggtca cagaccaccc
     3061 tgggaaagaa gaattttgct ctcctcccta cacccactac gaagtccctc ccactttcta
     3121 ccgctctgca atgctcctta agcctcagct ggggttgggc gccatgtccc gactcccatc
     3181 aaccaagagc aggattctga tcgcaagcca gaggtcctca gcgggttcca tccatccacc
     3241 cggatcaatc gcaacagcca ccagtttcta cggttctgat ccttcagacc tcaagagagc
     3301 ctccaattcg aatgctgcaa agtccggtct accaaaatct ggactccgtc ctcctggtta
     3361 ctcacgtctc ccagcagcca agctggcggc cttcggcttt gtgaggagct ccagtgtctc
     3421 tgcggtgccc agcacccagt ccctggacag cgcacagcag gagcagagca ggccagtcac
     3481 ccgcccgacc ttcgggagtg aagagcaggt ctctctgaag caggctgtgc cttctaagga
     3541 cacacccaag ggagctggcc gggcggcccc cgcgtcttcg tccaatgcaa caccaccacg
     3601 caggagttta cttccagcac caaaatccac ttccacgccc gctggagcga agaaagagcc
     3661 gcagaaagat ccagaagcta agaagcctgc cgtttcgtcg cccaagagaa ctgcatctgc
     3721 taccacgaag cttcactcgc caggttaccc aaagcagagg accacggctc cccggaatga
     3781 ggtcccaccc aagcctgacc tgcaggcccg agaggccgag cggcagctgg cccagcgact
     3841 gagggacaga tgtgagtggc aggccaggca gctgggtctg gctcgaaggg agctgaagaa
     3901 agccatccag ggcttcgatg ccatggccgt atccgctaag catttctttg gaaagagcga
     3961 aagggccctc gcgaaagaga aagagctgtc gatcgaactc gccaacatca gggatgaagt
     4021 ggccttcaac accgccaagt gtgagaagct gcagaaggag aaggaggcgc tggagcggcg
     4081 gttcgaggag gagctgagga ggttgggctg gcagcagcag gctgaggtgc aggagctgca
     4141 ggagcggctg cagcagcagt tccaggccga gagcgcgcgt ctgcaggcgg agcatcagga
     4201 ccagatgctg cgcatgcgct gccaacacca ggagcaggtg gaagacatca ctgccagcca
     4261 tgaggctgcc ctgctggaga tggaaaataa ccacaccgtc gccatcacca tcctacagga
     4321 tgaccacgac cacaaagtcc aagaactgat gtctacccat gaatttgaga agaaggagct
     4381 ggaagaaaac tttgaaaagc tgaggctgtc attgcaggac caggtggaca cactaacctt
     4441 tcagagccaa tctctgcggg acagagccca gcgctttgag gaagctctaa ggaaaaccac
     4501 ggaggaacag ctggagatcg cgctggctcc gtatcagcat ctggaggaag acatgcagag
     4561 cctgaagcag gtgctggaga tgaagaacca gcaaattcac ctgcaggaga agaagattat
     4621 cgagctggag aagctggtgg aaaagaacat catcctggaa gaaaagatcc aggtactcca
     4681 gcagcagaac gaagacctca aagcgaggat cgaccagaac acggttgtta ccagacaact
     4741 gtcggaggaa aatgctaatc tccaggaata cgtggagaaa gagacccagg aaaagaagag
     4801 actgagccga accaacgagg aactactttg gaagctccag actggggacc cgaccagccc
     4861 gattaaactc tcccccacat ctccggtgta caggggctcc tcctctggac cctcctctcc
     4921 agccagagtc agtaccacac ctagatgaca tcaccctgcc acccacagga gctcaagctt
     4981 ctgtccgtcc gagggagtgc tggccggtgc tggtggctgc cctgtgcgca tgctcagtag
     5041 ctgcatactg catcttaggc agagtcctct ctgaccctcg tgtgagaccg tcctggtatt
     5101 ggcgcttagg aaggcgtaag cagcagagtc tggtgtccaa aagcaaaaca caaaaacaaa
     5161 aacaaaatgc tttagtatag ttagaagcaa aagagaaaca gctccaattg ttcctgagag
     5221 acggagttcc gcagcggaac tttaggtcag ccacaaacag ctccgttttt cgaatactcg
     5281 aaaaccctcc ttgcaccgct gcgggtgtgt attcagatgc gtgggtacac acctgcggcg
     5341 actccgaatt gctttttttt atatatatat acatatataa cacacgatgc gctgacatat
     5401 tttagcgacg gtcagcagtt ttctaacttg tgcctaagaa ttattgggaa atgaaaaacg
     5461 catttctatc tagtttcctg gagatatttc tacccaaaat agaaaaaaga aaaaaaaaaa
     5521 agaaaaaaga aaaagcaagc aagcaagcat gagaccaagt ggtaccctgc ttaccctaaa
     5581 caccagcgat ttgtagatgg taaccgcctt tggagcaact agcttcttag tccaacgcga
     5641 ggtggggtca ctctcagccc attgcaggat ttaattatga cttctcccat cccaaggagg
     5701 taaaatgtcg cagggtgtgg gggagggggg gaccggaggg atcacatggt ctggccaatg
     5761 tttttcccct tatcaattca ttataatctt gaaaacacca gttttgctcc ccacccccaa
     5821 ccccaaatgg caccttgcaa atccaccatt aagatattat tgcatcctca ggaaaacacg
     5881 gacgcatgcg acctttgcga tgagggtaag catgaactcg gagactatct agaccatgca
     5941 tgacccatcc tcatggagga ggagttctgg taggggccga catggcccca accatcgcct
     6001 ctcataggca acacccccat ttttcagttt ggttctatga ctcgacccca tcactgcaca
     6061 tcaagatggc tcaggggttc tagtcaaggc ttccggaaac cagcctttct ctcttgggga
     6121 aagggggggg ggaagccagt tctaaaggtg ctagatcatg tcccttctgc tggagggtta
     6181 ccaggactgc acctggctgt ggtcccgtct tagccccaga aggctctccc aaacaaggga
     6241 acgcagtgaa acggccagtc agcatccatc agccgctgga ctggccttcg tctctaatga
     6301 ggtagagtta gaacatgaaa ggtattcatg tagtgctatg gaagattaga agcatgaccc
     6361 acaaaagaga agtagtttta actggcagta ccgtgccgcg ctgaatgata cctttgtttc
     6421 ctgtatgtga caagagaccc tccgttttct aagcatgggc ctgtctgtct gtgagcaggc
     6481 ccaagatgag aagagccacg gagccaagaa gacggtgtca gccactccaa ggacacacat
     6541 atctgacacc gagacaagtg tggtcaacat ccctcctgtg gctccaagtt gggcttcctt
     6601 ggtctcgggt gcatctaact gtagtcaacc tccgcgggtc ttgcccattc tggaggcaca
     6661 cacggtagat acacagagaa gaaacaggtc tttttttttt cctttggctc tgcatgatcc
     6721 tgggataccg agctgggcat cccataagag tagctcatgc catgtcagtt caacacacac
     6781 aactatttgt tcttttagca ggcacaacct gcggacgtta agttcggttg gccgtttagc
     6841 tctccgagtt aggacccgcc tcctcagctg tgcccgccga cggcaggttc tcagcaatac
     6901 agagttcgat gtgattatag gatgtggtac agtacgttag gctgttgtgc tcaaagtggt
     6961 agcgatgtta gatctgtgta ccctcattag gtggactaga gctttgccct aatcagcctc
     7021 gaccttgggc acttgaataa atctccccat ggccctggct ttgtttctcc atcccagaca
     7081 cccatcaagt atggtacccc atttgaatta agttctgaga tccaggtggc cagagctgct
     7141 attgcctctt ccatgattcc tctgtctcca tgctggtacc atccggacct ctcagcgtgg
     7201 aaaccccgag tctgtcttcc ttcccaggtt gggacactgc atcctcccgt cctgccacag
     7261 acaggcctgc caaacagcta ggttcttcat ggagtcagga ggtcctgctg gcctgcacta
     7321 actcagttgc ctcgggctgg gactacattc ctgcgatgtc aggatgggtt tggggcttga
     7381 ggtcaggtac tctgggatta gttgaagggg gcacagtgtt ctttgtcctg cccccttcca
     7441 gttaactgtt ccttatttgt gttgaactct aaagattatt aaaatgaacc tgggggactt
     7501 cccatg
//
