LOCUS       NM_178093               4065 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus microtubule associated scaffold protein 1
            (Mtus1), transcript variant 2, mRNA.
ACCESSION   NM_178093 XM_001064538 XM_573915
VERSION     NM_178093.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4065)
  AUTHORS   Sim,J., Kim,Y., Kim,H., Bang,S., Jee,S., Park,S., Shin,S.J. and
            Jang,K.
  TITLE     Loss of MTUS1 Expression Is Associated With Poor Prognosis in
            Patients With Gallbladder Carcinoma
  JOURNAL   In Vivo 34 (1), 125-132 (2020)
   PUBMED   31882471
REFERENCE   2  (bases 1 to 4065)
  AUTHORS   Zhao,T., Ding,X., Chang,B., Zhou,X. and Wang,A.
  TITLE     MTUS1/ATIP3a down-regulation is associated with enhanced migration,
            invasion and poor prognosis in salivary adenoid cystic carcinoma
  JOURNAL   BMC Cancer 15, 203 (2015)
   PUBMED   25885343
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4065)
  AUTHORS   Varghayee,N., Krezel,M.A., Rezmann,L., Chow,L., Frauman,A.G.,
            Louis,W.J. and Louis,S.N.
  TITLE     Function and expression of ATIP and its variants in cardiomyoblast
            cell line H9c2
  JOURNAL   J Renin Angiotensin Aldosterone Syst 16 (1), 79-91 (2015)
   PUBMED   23559668
  REMARK    GeneRIF: This is the first report to identify that ATIP may have a
            similar role in other disease states characterised by excessive
            growth
REFERENCE   4  (bases 1 to 4065)
  AUTHORS   Jing,F., Mogi,M., Min,L.J., Ohshima,K., Nakaoka,H., Tsukuda,K.,
            Wang,X., Iwanami,J. and Horiuchi,M.
  TITLE     Effect of angiotensin II type 2 receptor-interacting protein on
            adipose tissue function via modulation of macrophage polarization
  JOURNAL   PLoS One 8 (4), e60067 (2013)
   PUBMED   23565185
REFERENCE   5  (bases 1 to 4065)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   6  (bases 1 to 4065)
  AUTHORS   Rodrigues-Ferreira,S., Di Tommaso,A., Dimitrov,A., Cazaubon,S.,
            Gruel,N., Colasson,H., Nicolas,A., Chaverot,N., Molinie,V.,
            Reyal,F., Sigal-Zafrani,B., Terris,B., Delattre,O., Radvanyi,F.,
            Perez,F., Vincent-Salomon,A. and Nahmias,C.
  TITLE     8p22 MTUS1 gene product ATIP3 is a novel anti-mitotic protein
            underexpressed in invasive breast carcinoma of poor prognosis
  JOURNAL   PLoS One 4 (10), e7239 (2009)
   PUBMED   19794912
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4065)
  AUTHORS   Li,J.M., Mogi,M., Tsukuda,K., Tomochika,H., Iwanami,J., Min,L.J.,
            Nahmias,C., Iwai,M. and Horiuchi,M.
  TITLE     Angiotensin II-induced neural differentiation via angiotensin II
            type 2 (AT2) receptor-MMS2 cascade involving interaction between
            AT2 receptor-interacting protein and Src homology 2
            domain-containing protein-tyrosine phosphatase 1
  JOURNAL   Mol Endocrinol 21 (2), 499-511 (2007)
   PUBMED   17068200
REFERENCE   8  (bases 1 to 4065)
  AUTHORS   Pils,D., Horak,P., Gleiss,A., Sax,C., Fabjani,G., Moebus,V.J.,
            Zielinski,C., Reinthaller,A., Zeillinger,R. and Krainer,M.
  TITLE     Five genes from chromosomal band 8p22 are significantly
            down-regulated in ovarian carcinoma: N33 and EFA6R have a potential
            impact on overall survival
  JOURNAL   Cancer 104 (11), 2417-2429 (2005)
   PUBMED   16270321
REFERENCE   9  (bases 1 to 4065)
  AUTHORS   Wruck,C.J., Funke-Kaiser,H., Pufe,T., Kusserow,H., Menk,M.,
            Schefe,J.H., Kruse,M.L., Stoll,M. and Unger,T.
  TITLE     Regulation of transport of the angiotensin AT2 receptor by a novel
            membrane-associated Golgi protein
  JOURNAL   Arterioscler Thromb Vasc Biol 25 (1), 57-64 (2005)
   PUBMED   15539617
REFERENCE   10 (bases 1 to 4065)
  AUTHORS   Seibold,S., Rudroff,C., Weber,M., Galle,J., Wanner,C. and Marx,M.
  TITLE     Identification of a new tumor suppressor gene located at chromosome
            8p21.3-22
  JOURNAL   FASEB J 17 (9), 1180-1182 (2003)
   PUBMED   12692079
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC072537.1.
            
            On or before Feb 12, 2007 this sequence version replaced
            XM_573915.2, XM_001064538.1, NM_178093.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072537.1, BC166591.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..4065
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.1"
     gene            1..4065
                     /gene="Mtus1"
                     /gene_synonym="Atip3b; ATIP4; Mtsg1"
                     /note="microtubule associated scaffold protein 1"
                     /db_xref="GeneID:306487"
                     /db_xref="RGD:631381"
     exon            1..353
                     /gene="Mtus1"
                     /gene_synonym="Atip3b; ATIP4; Mtsg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..1555
                     /gene="Mtus1"
                     /gene_synonym="Atip3b; ATIP4; Mtsg1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     microtubule-associated tumor suppressor 1 homolog; growth
                     factor inhibitor; angiotensin-II type 2
                     receptor-interacting protein; transcription factor MTSG1;
                     microtubule associated tumor suppressor 1; mitochondrial
                     tumor suppressor 1"
                     /codon_start=1
                     /product="microtubule-associated tumor suppressor 1
                     homolog isoform 2"
                     /protein_id="NP_835194.2"
                     /db_xref="GeneID:306487"
                     /db_xref="RGD:631381"
                     /translation="MLLSPKFSLSTIHVRLTAKGLLRNLRLPSGLRKNTVIFHTVEKG
                     RQKNPRSLCIQTQTAPDVLSTERTLELADYKTKCENQSGFILHLKQLLSCGNTKFEAL
                     TVVIQHLLSEREEALKQHKTLSQELVSLRGELVAASSTCEKLEKARNDLQTAYEGFVQ
                     KLNQQHQTDQTELENRLKEFYTAECEKLQSIYIEEAEKYKTQLQEQFDNLNAAHETTK
                     LEIEASHSEKVELLKKTYETSLSEIKKSHEMEKKLLENLLNEKQESLEKQINDLKSEN
                     DALNERLKSEEQKQLSREKANSKNPQVMYLEQELESLKAVLEIKNEKLHQQDLKLMKM
                     EKLVDNNTTLVDKLTRFQQENEELKARMDRHMAISRQLSTEQAALQESLEKESKVNKR
                     LSMENEELLWKLHNGDLCSPKRSPTSSAIPFQSPRNSGSFSSPSISPR"
     exon            354..568
                     /gene="Mtus1"
                     /gene_synonym="Atip3b; ATIP4; Mtsg1"
                     /inference="alignment:Splign:2.1.0"
     exon            569..635
                     /gene="Mtus1"
                     /gene_synonym="Atip3b; ATIP4; Mtsg1"
                     /inference="alignment:Splign:2.1.0"
     exon            636..850
                     /gene="Mtus1"
                     /gene_synonym="Atip3b; ATIP4; Mtsg1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..956
                     /gene="Mtus1"
                     /gene_synonym="Atip3b; ATIP4; Mtsg1"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1030
                     /gene="Mtus1"
                     /gene_synonym="Atip3b; ATIP4; Mtsg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1126
                     /gene="Mtus1"
                     /gene_synonym="Atip3b; ATIP4; Mtsg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1243
                     /gene="Mtus1"
                     /gene_synonym="Atip3b; ATIP4; Mtsg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1341
                     /gene="Mtus1"
                     /gene_synonym="Atip3b; ATIP4; Mtsg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..4043
                     /gene="Mtus1"
                     /gene_synonym="Atip3b; ATIP4; Mtsg1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcagacgga gggcattgtt tttttagcaa catctgggag tgcgaacgga agcctggagc
       61 cctaggatag ctttatttcc ccctctgggt ggcctggcgt cagctatgta agcttgtttt
      121 gctctggctg tgtctcttgg cctggaagaa caccgagttg caaagggaca gtatgtgatg
      181 gtccctggaa aagctgcttc ccctgcgaag ttctcccact ggcttcgaag agatgctgtt
      241 gtctcccaaa ttctccttat ccaccattca cgtccgccta accgccaagg gactgcttcg
      301 aaacctccgg cttccttctg ggctcaggaa aaacactgtc attttccaca cagttgaaaa
      361 aggcaggcag aaaaacccca gaagcctgtg catccagacg cagacagctc cagatgtgct
      421 gtccaccgaa aggacccttg agttggctga ttacaagaca aaatgtgaaa atcaaagtgg
      481 atttatcttg cacctcaagc agcttctctc ctgtggtaat accaagtttg aagcactcac
      541 agtcgtgatc cagcacctcc tgtctgagcg ggaggaagca ctgaagcaac acaaaaccct
      601 ctctcaagaa cttgtcagcc tccggggaga gctagttgct gcttccagca cctgtgagaa
      661 gctagaaaag gccaggaatg acttgcaaac agcgtatgaa ggcttcgtcc agaaactaaa
      721 ccagcagcat cagacggacc agacggaact ggagaaccgg ctgaaggagt tttacacggc
      781 agagtgtgag aagctccaga gcatttacat tgaggaggca gaaaaataca aaactcaact
      841 gcaagagcag tttgacaact taaatgccgc ccatgaaacc acgaagttgg agattgaagc
      901 tagccactca gagaaagtgg agttactgaa gaagacctat gaaacctccc tttcagaaat
      961 caagaaaagc catgaaatgg aaaagaagtt actggagaat ctacttaatg agaagcagga
     1021 atcactagag aaacaaatca atgatctgaa gagtgagaac gatgctttaa acgaaaggtt
     1081 gaaatcagag gaacaaaagc aactgtcaag agagaaggca aactcaaaaa accctcaggt
     1141 catgtatctg gagcaagaac tagaaagcct gaaagctgtg ttggagatca agaatgagaa
     1201 gctgcatcag caggacctga agctaatgaa gatggaaaag ctggtggaca acaacacaac
     1261 attggttgac aagctgacga gattccagca ggaaaacgag gagctgaaag ctcgcatgga
     1321 cagacacatg gcaatttcaa gacaactttc cacagagcag gcagcgctgc aagagtccct
     1381 tgagaaggag tcaaaggtca acaagaggtt gtccatggag aatgaggagc tgctgtggaa
     1441 actgcacaac ggagacctct gcagccccaa gagatccccc acatcctcgg ccatcccttt
     1501 ccagtccccc aggaattctg gttccttctc cagccccagc atctcaccca gatgacggtt
     1561 tctgaacaca ggagactctc ggaaggcact gaggtgtggt tctgcaggac tgaccctctc
     1621 gtgggaacta ggcctgtgtt agctttctgg gctgtccaca ggataactgg agagcagcca
     1681 ccaaccgtat cagctcctta cacatcgaga gctccagagg atgactttta acttggtcca
     1741 aaagcctcct ccaaagacag atttcggaac tgaagtggac atagttgcac aaagcactta
     1801 tggaacgagg gaaccttgtt ctttgccttc cttcacctaa gcataagggg aaaactctca
     1861 ggggcctatt aagataaaga tttataacct ttataatgtt cttcaccaga gacaccttct
     1921 tgtgattttt atttcggtct gactgtgggc aggggtgtgt gtgtgtgagt gaattgggtg
     1981 tactggtgtg tcacatgact gtcaaccctg ccccccactg ctgtgtatta aaagttaaca
     2041 gctggataca gctgtgcctg tattaatcaa gtcatcatca gcatacacgt gtcaacaaaa
     2101 gccatagaag agagagcaat agtgcttgaa tttctcccca ctcgtctcag cgctatgaca
     2161 tggcagggct agggtaagac aaggaaaagc ctttggttca ttgatgtctg tacatttctc
     2221 tgttagtttt tctgtgttta gcattatcca ttgatagcag tttgattttt ttttccccct
     2281 gtagatttct atgagcctaa tgactgtact ctgattcatt ttctcaggct acgagcaaat
     2341 gtaccctaat ttttctaaac acaaatctgt ataaagaata agagggcagt accaatggat
     2401 gtttctgact tattatcccc cttgaaccca agctatcttc acagtggcaa tcctccatct
     2461 tccctcctgt tattctaacc tccgcttttc ctcctccacg tagagccaca gaggcaagcc
     2521 tacctcctac ctaattacag aatgggcttt tccagggcca gtttatcttt gaggtgctga
     2581 acctattttg caaataaact aagctctggt tctgacacta caaatttttg gaaacccttg
     2641 gggaaaatca gtaaaggctt ttagcatgta ctaatccact caagcacggt ggtaagccag
     2701 cattcccatg gtgactagat ctagagaagt ctgagcagta atgctgaccg aggcccctct
     2761 gagcattctt cctgctattg gaatgcaaca agccagccaa agagtgagaa gtatggctta
     2821 tgcaactctt tcaccctgca ttcgaatttg aaacgttcac ttaccatctc ctgagactcc
     2881 aagactttgt gaaagttagg aggacagctg tgactcccca ccacccgacc ccacgagatt
     2941 ccctgtgcat gtcagcgttc cgatgtcagt atttactagt ccatggtcaa tgctggtcaa
     3001 ataacccctt tagcaaggat agatttaaga cactagaggt gggtatttga ccccgagacc
     3061 cctacacaca gagctaattg gtactcatga gcatgctttt cattgctggc tgtgtttgaa
     3121 gtcatttatc tcccctagtt tatgacgtat ggaaccttcc atgtttgctc ctgataaata
     3181 ggaatgtagc ttcactgcca cctcctggaa tatctctgct cctggtccca agttgttctc
     3241 aacgaagtca gccaaagtca ggtttgtcat tgataccctc gttatggtta aagttcatgt
     3301 gattacccac catccctcat accgtctaga tatctgggaa gtcaaacctt acagcaatta
     3361 aaacgcctga agagcttaga agacaggaga gaagatagca tttaagggtt ttttcttttt
     3421 ttgtttaaac caaatgtttt atgtagaata caaaattgtt gacacatcgt aaaaaaatgt
     3481 gggtgtgtga acaactgtag tttatagcag tggaaagtgt attttacttt gatcaaataa
     3541 aatatttgaa atattcagta tgagaatggc agcctctgac ctacttcact cttccaaagt
     3601 gttaggttat gtactccctc ccccttcttc tccctcctta attaagacaa gaaggccccc
     3661 tgtgctattt tacggaactt agaacccaat gccaattttt ttttttaggg ctgaaattag
     3721 ctcacagagc ttgagtttta aggttaagct tttcaaagtt catgtatcag agaactaaac
     3781 tttggctagt ttaaagagtt tcttctgtac ggcataagaa aattggaaga gctgtggtct
     3841 aagtattctt gaagacaggt cttagccaaa gctgaatctt cttcggtctg ttcatctgtg
     3901 ttctgttaat agtgtacata cagttatttt gaatagagga atttaaaatc agtactgagt
     3961 gtggcaattt aatgtaaaaa gatgtgattt ttgatacctt tataaatgaa ctcacattag
     4021 ctttgataaa atggcgtatc taaaaaaaaa aaaaaaaaaa aaaaa
//
