LOCUS       NP_835194                440 aa            linear   ROD 27-APR-2025
DEFINITION  microtubule-associated tumor suppressor 1 homolog isoform 2 [Rattus
            norvegicus].
ACCESSION   NP_835194 XP_001064538 XP_573915
VERSION     NP_835194.2
DBSOURCE    REFSEQ: accession NM_178093.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 440)
  AUTHORS   Sim,J., Kim,Y., Kim,H., Bang,S., Jee,S., Park,S., Shin,S.J. and
            Jang,K.
  TITLE     Loss of MTUS1 Expression Is Associated With Poor Prognosis in
            Patients With Gallbladder Carcinoma
  JOURNAL   In Vivo 34 (1), 125-132 (2020)
   PUBMED   31882471
REFERENCE   2  (residues 1 to 440)
  AUTHORS   Zhao,T., Ding,X., Chang,B., Zhou,X. and Wang,A.
  TITLE     MTUS1/ATIP3a down-regulation is associated with enhanced migration,
            invasion and poor prognosis in salivary adenoid cystic carcinoma
  JOURNAL   BMC Cancer 15, 203 (2015)
   PUBMED   25885343
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 440)
  AUTHORS   Varghayee,N., Krezel,M.A., Rezmann,L., Chow,L., Frauman,A.G.,
            Louis,W.J. and Louis,S.N.
  TITLE     Function and expression of ATIP and its variants in cardiomyoblast
            cell line H9c2
  JOURNAL   J Renin Angiotensin Aldosterone Syst 16 (1), 79-91 (2015)
   PUBMED   23559668
  REMARK    GeneRIF: This is the first report to identify that ATIP may have a
            similar role in other disease states characterised by excessive
            growth
REFERENCE   4  (residues 1 to 440)
  AUTHORS   Jing,F., Mogi,M., Min,L.J., Ohshima,K., Nakaoka,H., Tsukuda,K.,
            Wang,X., Iwanami,J. and Horiuchi,M.
  TITLE     Effect of angiotensin II type 2 receptor-interacting protein on
            adipose tissue function via modulation of macrophage polarization
  JOURNAL   PLoS One 8 (4), e60067 (2013)
   PUBMED   23565185
REFERENCE   5  (residues 1 to 440)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   6  (residues 1 to 440)
  AUTHORS   Rodrigues-Ferreira,S., Di Tommaso,A., Dimitrov,A., Cazaubon,S.,
            Gruel,N., Colasson,H., Nicolas,A., Chaverot,N., Molinie,V.,
            Reyal,F., Sigal-Zafrani,B., Terris,B., Delattre,O., Radvanyi,F.,
            Perez,F., Vincent-Salomon,A. and Nahmias,C.
  TITLE     8p22 MTUS1 gene product ATIP3 is a novel anti-mitotic protein
            underexpressed in invasive breast carcinoma of poor prognosis
  JOURNAL   PLoS One 4 (10), e7239 (2009)
   PUBMED   19794912
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 440)
  AUTHORS   Li,J.M., Mogi,M., Tsukuda,K., Tomochika,H., Iwanami,J., Min,L.J.,
            Nahmias,C., Iwai,M. and Horiuchi,M.
  TITLE     Angiotensin II-induced neural differentiation via angiotensin II
            type 2 (AT2) receptor-MMS2 cascade involving interaction between
            AT2 receptor-interacting protein and Src homology 2
            domain-containing protein-tyrosine phosphatase 1
  JOURNAL   Mol Endocrinol 21 (2), 499-511 (2007)
   PUBMED   17068200
REFERENCE   8  (residues 1 to 440)
  AUTHORS   Pils,D., Horak,P., Gleiss,A., Sax,C., Fabjani,G., Moebus,V.J.,
            Zielinski,C., Reinthaller,A., Zeillinger,R. and Krainer,M.
  TITLE     Five genes from chromosomal band 8p22 are significantly
            down-regulated in ovarian carcinoma: N33 and EFA6R have a potential
            impact on overall survival
  JOURNAL   Cancer 104 (11), 2417-2429 (2005)
   PUBMED   16270321
REFERENCE   9  (residues 1 to 440)
  AUTHORS   Wruck,C.J., Funke-Kaiser,H., Pufe,T., Kusserow,H., Menk,M.,
            Schefe,J.H., Kruse,M.L., Stoll,M. and Unger,T.
  TITLE     Regulation of transport of the angiotensin AT2 receptor by a novel
            membrane-associated Golgi protein
  JOURNAL   Arterioscler Thromb Vasc Biol 25 (1), 57-64 (2005)
   PUBMED   15539617
REFERENCE   10 (residues 1 to 440)
  AUTHORS   Seibold,S., Rudroff,C., Weber,M., Galle,J., Wanner,C. and Marx,M.
  TITLE     Identification of a new tumor suppressor gene located at chromosome
            8p21.3-22
  JOURNAL   FASEB J 17 (9), 1180-1182 (2003)
   PUBMED   12692079
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC072537.1.
            
            On or before Feb 12, 2007 this sequence version replaced
            XP_573915.2, XP_001064538.1, NP_835194.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072537.1, BC166591.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.1"
     Protein         1..440
                     /product="microtubule-associated tumor suppressor 1
                     homolog isoform 2"
                     /note="microtubule-associated tumor suppressor 1 homolog;
                     growth factor inhibitor; angiotensin-II type 2
                     receptor-interacting protein; transcription factor MTSG1;
                     microtubule associated tumor suppressor 1; mitochondrial
                     tumor suppressor 1"
                     /calculated_mol_wt=50614
     Region          <66..385
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            373
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6IMY1.1)"
     Site            394
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6IMY1.1)"
     Region          407..440
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IMY1.1)"
     Site            415
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9ULD2; propagated from
                     UniProtKB/Swiss-Prot (Q6IMY1.1)"
     Site            425
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5HZI1; propagated from
                     UniProtKB/Swiss-Prot (Q6IMY1.1)"
     Site            429
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6IMY1.1)"
     Site            431
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6IMY1.1)"
     Site            433
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5HZI1; propagated from
                     UniProtKB/Swiss-Prot (Q6IMY1.1)"
     Site            434
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6IMY1.1)"
     Site            438
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6IMY1.1)"
     CDS             1..440
                     /gene="Mtus1"
                     /gene_synonym="Atip3b; ATIP4; Mtsg1"
                     /coded_by="NM_178093.2:233..1555"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:306487"
                     /db_xref="RGD:631381"
ORIGIN      
        1 mllspkfsls tihvrltakg llrnlrlpsg lrkntvifht vekgrqknpr slciqtqtap
       61 dvlstertle ladyktkcen qsgfilhlkq llscgntkfe altvviqhll sereealkqh
      121 ktlsqelvsl rgelvaasst ceklekarnd lqtayegfvq klnqqhqtdq telenrlkef
      181 ytaeceklqs iyieeaekyk tqlqeqfdnl naahettkle ieashsekve llkktyetsl
      241 seikksheme kkllenllne kqeslekqin dlksendaln erlkseeqkq lsrekanskn
      301 pqvmyleqel eslkavleik neklhqqdlk lmkmeklvdn nttlvdkltr fqqeneelka
      361 rmdrhmaisr qlsteqaalq eslekeskvn krlsmeneel lwklhngdlc spkrsptssa
      421 ipfqsprnsg sfsspsispr
//
