LOCUS       NM_001107727            3997 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Rattus norvegicus microsomal triglyceride transfer protein (Mttp),
            mRNA.
ACCESSION   NM_001107727 XM_001076172 XM_227765
VERSION     NM_001107727.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3997)
  AUTHORS   Miotto,P.M., Horbatuk,M., Proudfoot,R., Matravadia,S., Bakovic,M.,
            Chabowski,A. and Holloway,G.P.
  TITLE     alpha-Linolenic acid supplementation and exercise training reveal
            independent and additive responses on hepatic lipid accumulation in
            obese rats
  JOURNAL   Am J Physiol Endocrinol Metab 312 (6), E461-E470 (2017)
   PUBMED   28270444
  REMARK    GeneRIF: Data suggest that Mttp content of liver microsomes can be
            altered by dietary factors; here, Mttp is up-regulated in liver
            microsomes of obese rats with dietary supplementation of the fatty
            acid alpha-linolenic acid; animal physical conditioning (exercise)
            appears to up-regulate Mttp in liver microsomes in an independent
            manner.
REFERENCE   2  (bases 1 to 3997)
  AUTHORS   Walsh,M.T., Iqbal,J., Josekutty,J., Soh,J., Di Leo,E., Ozaydin,E.,
            Gunduz,M., Tarugi,P. and Hussain,M.M.
  TITLE     Novel Abetalipoproteinemia Missense Mutation Highlights the
            Importance of the N-Terminal beta-Barrel in Microsomal Triglyceride
            Transfer Protein Function
  JOURNAL   Circ Cardiovasc Genet 8 (5), 677-687 (2015)
   PUBMED   26224785
REFERENCE   3  (bases 1 to 3997)
  AUTHORS   Bonfleur,M.L., Borck,P.C., Ribeiro,R.A., Caetano,L.C., Soares,G.M.,
            Carneiro,E.M. and Balbo,S.L.
  TITLE     Improvement in the expression of hepatic genes involved in fatty
            acid metabolism in obese rats supplemented with taurine
  JOURNAL   Life Sci 135, 15-21 (2015)
   PUBMED   26092479
  REMARK    GeneRIF: Tau supplementation prevented obesity and hepatic TG
            deposition by upregulating MTP mRNA, ameliorating hepatic lipid
            efflux, and consequently enhancing PPAR-alpha which increases lipid
            oxidation through ACO and CPT-1a gene expressions.
REFERENCE   4  (bases 1 to 3997)
  AUTHORS   Dettlaff-Pokora,A., Sledzinski,T. and Swierczynski,J.
  TITLE     Up-Regulation Mttp and Apob Gene Expression in Rat Liver is Related
            to Post-Lipectomy Hypertriglyceridemia
  JOURNAL   Cell Physiol Biochem 36 (5), 1767-1777 (2015)
   PUBMED   26184122
  REMARK    GeneRIF: Coordinated up-regulation of Mttp, Apob, Hnf1a, Hnf4a,
            Fasn, Gpam and Dgat (1 and 2) gene expressions may contribute to
            the increase in circulating and liver concentrations of TAGs after
            lipectomy in an experimental rat model
REFERENCE   5  (bases 1 to 3997)
  AUTHORS   Miller,S.A., Burnett,J.R., Leonis,M.A., McKnight,C.J., van
            Bockxmeer,F.M. and Hooper,A.J.
  TITLE     Novel missense MTTP gene mutations causing abetalipoproteinemia
  JOURNAL   Biochim Biophys Acta 1842 (10), 1548-1554 (2014)
   PUBMED   25108285
REFERENCE   6  (bases 1 to 3997)
  AUTHORS   Levy,E., Stan,S., Delvin,E., Menard,D., Shoulders,C., Garofalo,C.,
            Slight,I., Seidman,E., Mayer,G. and Bendayan,M.
  TITLE     Localization of microsomal triglyceride transfer protein in the
            Golgi: possible role in the assembly of chylomicrons
  JOURNAL   J Biol Chem 277 (19), 16470-16477 (2002)
   PUBMED   11830580
  REMARK    GeneRIF: Localization of microsomal triglyceride transfer protein
            in the Golgi: possible role in the assembly of chylomicrons
            [microsomal triglyceride transfer protein (MTP)]
REFERENCE   7  (bases 1 to 3997)
  AUTHORS   St-Pierre,J., Lemieux,I., Miller-Felix,I., Prud'homme,D.,
            Bergeron,J., Gaudet,D., Nadeau,A., Despres,J.P. and Vohl,M.C.
  TITLE     Visceral obesity and hyperinsulinemia modulate the impact of the
            microsomal triglyceride transfer protein -493G/T polymorphism on
            plasma lipoprotein levels in men
  JOURNAL   Atherosclerosis 160 (2), 317-324 (2002)
   PUBMED   11849654
REFERENCE   8  (bases 1 to 3997)
  AUTHORS   Ohashi,K., Ishibashi,S., Osuga,J., Tozawa,R., Harada,K., Yahagi,N.,
            Shionoiri,F., Iizuka,Y., Tamura,Y., Nagai,R., Illingworth,D.R.,
            Gotoda,T. and Yamada,N.
  TITLE     Novel mutations in the microsomal triglyceride transfer protein
            gene causing abetalipoproteinemia
  JOURNAL   J Lipid Res 41 (8), 1199-1204 (2000)
   PUBMED   10946006
REFERENCE   9  (bases 1 to 3997)
  AUTHORS   Leung,G.K., Veniant,M.M., Kim,S.K., Zlot,C.H., Raabe,M.,
            Bjorkegren,J., Neese,R.A., Hellerstein,M.K. and Young,S.G.
  TITLE     A deficiency of microsomal triglyceride transfer protein reduces
            apolipoprotein B secretion
  JOURNAL   J Biol Chem 275 (11), 7515-7520 (2000)
   PUBMED   10713055
REFERENCE   10 (bases 1 to 3997)
  AUTHORS   Narcisi,T.M., Shoulders,C.C., Chester,S.A., Read,J., Brett,D.J.,
            Harrison,G.B., Grantham,T.T., Fox,M.F., Povey,S., de Bruin,T.W. et
            al.
  TITLE     Mutations of the microsomal triglyceride-transfer-protein gene in
            abetalipoproteinemia
  JOURNAL   Am J Hum Genet 57 (6), 1298-1310 (1995)
   PUBMED   8533758
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473952.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_227765.4, XM_001076172.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760400
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3997
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..3997
                     /gene="Mttp"
                     /gene_synonym="MTP"
                     /note="microsomal triglyceride transfer protein"
                     /db_xref="GeneID:310900"
                     /db_xref="RGD:1308388"
     exon            1..159
                     /gene="Mttp"
                     /gene_synonym="MTP"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..2789
                     /gene="Mttp"
                     /gene_synonym="MTP"
                     /note="microsomal triglyceride transfer protein large
                     subunit"
                     /codon_start=1
                     /product="microsomal triglyceride transfer protein large
                     subunit precursor"
                     /protein_id="NP_001101197.1"
                     /db_xref="GeneID:310900"
                     /db_xref="RGD:1308388"
                     /translation="MILLAVLFLCFFSSYSASVKGHTTGLSLNNERLYKLTYSTEVFL
                     DGGKGKLQDSVGYRISSDVDVVLLWRNPDGDDDQLIQVTITAVNVENAGQQRGEKSIF
                     KGKSTPKIVGKDNLEALRRPMLLHLVRGKVKEFYSYENEPVGIENLKRGLASLFQMQL
                     TSGTTNEVDISGDCKVTYQAQQDKVVKIKALDTCKIERSGFTTANQVLGVTSKATSVT
                     TYKIEDSFVTAVVAEETRAFALNFLQTVAGKIVSKQKLELKTTEAGPRMVPGKQVAGV
                     IKAIDSKYKAIPIVGQVLQSVCKGCPSLAEHWQSIRKHLEPENLSNAEAVQSFLAFIQ
                     HLRTSRREEILQILKAEKKEVLPQLVDAVTSAQTPASLEAILDFLDFKSDSSIILQER
                     FLYACGFASHPDEELLQALLSKFKGSFASNDIRESVMIIIGALVRKLCQNEGCKLKAV
                     VEAKKLILGGLEKPEKKEDTTMYLLALKNALLPEGIPLLLKYAEAGEGPVSHLATTVL
                     QRYDASFITDEVKKTLNRIYHQNRKVHEKTVRTTAAAVILKNNPSYMDVKNILLSIGE
                     LPKEMNKYMLTIVQDILHFEMPASKMIRRVLKEMIVHNYDRFSKSGSSSAYTGYVERS
                     PHAASTYSLDILYSGSGILRRSNLNIFQYIGKAELHGSQVVIEAQGLEGLIAATPDEG
                     EENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPVSVVKGLILLIDHSQD
                     IQLQSGLKANMDIQGGLAIDISGSMEFSLWYRESKTRVKNRVAVVITSDITVDSSFVK
                     AGLESRAETEAGLEFISTVQFSQYPFLVCMQMDKAEAPLRQFETKYERLSTGRGYVSR
                     RRKESLVPGCELPLHQENSEMCNVVFPPQPESGNSGGGWF"
     exon            160..347
                     /gene="Mttp"
                     /gene_synonym="MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            348..491
                     /gene="Mttp"
                     /gene_synonym="MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            492..599
                     /gene="Mttp"
                     /gene_synonym="MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            600..716
                     /gene="Mttp"
                     /gene_synonym="MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            717..856
                     /gene="Mttp"
                     /gene_synonym="MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1007
                     /gene="Mttp"
                     /gene_synonym="MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1165
                     /gene="Mttp"
                     /gene_synonym="MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1334
                     /gene="Mttp"
                     /gene_synonym="MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1442
                     /gene="Mttp"
                     /gene_synonym="MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1655
                     /gene="Mttp"
                     /gene_synonym="MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1867
                     /gene="Mttp"
                     /gene_synonym="MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1965
                     /gene="Mttp"
                     /gene_synonym="MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2087
                     /gene="Mttp"
                     /gene_synonym="MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2315
                     /gene="Mttp"
                     /gene_synonym="MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2440
                     /gene="Mttp"
                     /gene_synonym="MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..2611
                     /gene="Mttp"
                     /gene_synonym="MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..3997
                     /gene="Mttp"
                     /gene_synonym="MTP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agattctgag gagggtcact tccttgctgg ctgccaccag aagagtccac tgctcagtga
       61 ctcctgggac tggatgcggt agaggggagc caggcagtat gatcctctta gctgtgcttt
      121 tcctctgttt cttctcctcg tattctgctt ctgtcaaagg tcacacaact ggcctctcat
      181 taaataatga gcggctatac aagctcacgt actccaccga agtgtttctc gatgggggca
      241 aaggaaaact gcaggacagc gtgggctacc ggatctcatc ggacgtggac gttgtgttac
      301 tgtggaggaa tcccgacggt gacgatgatc aactgatcca agtcacgata acggctgtca
      361 atgtcgaaaa tgcgggtcag cagagaggag agaagagcat cttcaagggc aaaagtacac
      421 ctaagatcgt aggaaaggac aacttggagg ctctacggag acccatgctt cttcatctgg
      481 tccgggggaa ggtcaaagag ttctactcct atgaaaatga gcccgtgggc atagaaaatc
      541 tcaagagagg cttggctagc ttattccaga tgcagttaac ctctggaacc accaatgagg
      601 tagatatctc tggggattgt aaagtcacct accaggctca gcaagacaaa gtggtcaaaa
      661 ttaaggctct ggatacatgc aaaattgaga ggtccggatt tacaacagca aatcaggtgc
      721 tgggtgtcac ttcaaaagcc acctctgtca ctacctataa gatagaggac agctttgtca
      781 cagcagtggt tgcagaagag accagggctt ttgccttgaa cttcctacaa accgtggcag
      841 gaaaaatagt gtcgaagcag aaattggagc tgaagacaac ggaagccggc ccaagaatgg
      901 tacctgggaa gcaagtggca ggagtaatta aggcaattga ttccaagtac aaagccattc
      961 ccattgtggg acaggtcctc cagagtgtct gtaaaggctg tccttctctg gcggagcact
     1021 ggcaatctat caggaagcac ctagaacctg agaacctgtc caacgccgag gccgtccaga
     1081 gcttcctggc cttcattcag cacctccgca cttcgaggag agaagagatc cttcagattc
     1141 tgaaggcaga gaagaaagaa gttctccctc agctggtgga cgccgtcacc tctgctcaga
     1201 ctccagcctc actggaagcc atcctggact ttttggattt caaaagcgac agcagtatca
     1261 ttctccagga aaggttcctc tatgcatgtg gatttgcctc ccatcctgat gaagaactcc
     1321 tgcaagccct ccttagcaag ttcaaaggtt cctttgcaag caacgacatc agagagtcgg
     1381 ttatgatcat cattggagcc ctagtcagga agctgtgtca gaatgaaggc tgcaagctca
     1441 aggcagtggt tgaagctaag aagctaatcc tgggaggact tgaaaaacca gagaagaaag
     1501 aggacaccac gatgtacctg ctggctctga agaacgccct gcttcctgaa ggcatcccgc
     1561 tccttttgaa gtacgctgag gctggggaag ggcccgtcag tcacctggct accactgttc
     1621 tccagagata cgatgcctcc ttcatcacag acgaggtgaa gaagaccttg aacaggatat
     1681 accatcagaa tcgtaaggtt catgaaaaga ctgtacgcac aacggctgct gctgtcatct
     1741 taaagaacaa cccctcctac atggatgtga agaacattct gctgtctatt ggggaacttc
     1801 ctaaagaaat gaacaaatac atgctcacca tcgtgcaaga catcctgcat ttcgaaatgc
     1861 ctgcaagcaa aatgatccgt cgggttctca aggagatgat tgttcacaat tatgaccgtt
     1921 tctccaagag tggatcctct tctgcctaca ctggctacgt agaacgcagt ccccacgcgg
     1981 cgtccaccta cagccttgat atcctctact ctgggtctgg cattctgagg agaagtaacc
     2041 tgaacatctt ccagtacatc ggaaaggcgg agctgcatgg cagccaggtg gtcattgaag
     2101 cccaagggct ggaaggctta attgcagcca ctccagatga gggagaggag aaccttgact
     2161 cgtatgctgg tatgtcagcc atcctgtttg atgttcagct tagacctgtc acgttcttta
     2221 acggatacag tgatttgatg tccaaaatgc tgtcggcgtc cggcgaccct gtcagtgtgg
     2281 tgaaaggact tattctgcta atagaccatt ctcaggatat tcagctgcaa tctggactaa
     2341 aggccaatat ggacatccag ggtggtctag ccattgacat ttctggttca atggaattca
     2401 gtctgtggta ccgcgagtct aaaacccgag tgaaaaatcg ggtggctgtg gtaataacca
     2461 gcgacatcac agtggactcg tcttttgtga aagctggtct ggaaagcaga gcagagacag
     2521 aggctggcct ggagttcatc tccacagtgc agttctccca gtacccgttc ttggtctgca
     2581 tgcagatgga caaagccgag gctccactca ggcaatttga gacaaagtat gaaaggctat
     2641 ccacagggag gggctatgtc tctcggagaa gaaaagagag cctagtgccc ggatgtgaac
     2701 tcccgctcca tcaagagaac tctgagatgt gcaacgtggt attcccgcct cagccagaga
     2761 gcggcaactc cggtggtgga tggttttgat tcccctgggt ccatttcctc gagaacgaaa
     2821 tgctttgacg tgcctaatcc ttgctctccg ggagcacagt gtttacatat ttacctgtat
     2881 ttaagatgtt tttaaagagc aatggagaac ttcagttgat taaagtcgag cctagtcagg
     2941 agatgaccca cagtgtccct ctgagtcacc gtacgacgct tacagcaaca tgcctacttc
     3001 ttacactttg caaaagtcct aacaagtaca gtgagtctag ttttgcgccg agaaactagt
     3061 attcgtataa aaacaaaggc aaaaacaaag aaacaacaaa cagaaccaaa acccacacca
     3121 taaaagctta ggcaaatgtg aatttgattc aaccaccctt cagtgaaagt gaacccgtga
     3181 cagaacccca agcttgcttt ctataaaaca catttcctga gaagggcagg gtggatggaa
     3241 ccaagcaaac tatttccctt ttgttgttgt tttgtttgtt cttcttctct ttctttactt
     3301 tctttttctt ctggcgtagc tgggaaggtt ccaagaaagg acagagataa gacttaagag
     3361 aattgtgtta gttaatctca agaattaata tttatgtttt ctgatagttt tataagcatg
     3421 gaggtaagag acagaattaa aacacactgt gacacgtctc tgctggcctc acagtgaggc
     3481 cacttggaaa ttattcaccc ttttaaaaaa aatggaatta tcatatggga ataaaataat
     3541 tgagtcttag agcagccatt aaatttttct ctggatgtgt tgttttgata ccgtaatgtg
     3601 atacattgtt ctttgtgggg gacccccttg tagctatcat tttctctatg catcggttgc
     3661 tgggtggtag gaactccatc tatttgattg caatttatgc aacatccagt aacaattggg
     3721 ataattgttg ttcaagaaaa tgatggatgt gtattccaaa actatgaaat taaacaaaga
     3781 ccatgtttat gtgtatgaat taaaaggcca caccaagcat ttaaacatat ttattaatag
     3841 agcagatgtg tttattataa tgtccacccc ccccatcaat gtcaggtgct tgtttgacca
     3901 cagatgggag tttagaacgg aagtggaaac acgtaaatgc aagtttaact gaagtagaaa
     3961 ataaattgtg atgatgaaaa ataaagacgt gtaattt
//
