LOCUS       NM_001130563            4691 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus MTSS I-BAR domain containing 1 (Mtss1), mRNA.
ACCESSION   NM_001130563 XM_001064860 XM_343248
VERSION     NM_001130563.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4691)
  AUTHORS   Shi,N., Tian,C., Liang,X., Jiang,P., Liang,L., Zhou,L., Shu,Y.,
            Chen,P. and Wang,Y.
  TITLE     Proteome analysis of actin filament-associated proteins in the
            postnatal rat cerebellum
  JOURNAL   Neuroscience 227, 90-101 (2012)
   PUBMED   23032931
  REMARK    GeneRIF: This study demonistrated that demonstrated that the
            metastasis suppressor 1 was specifically upregulated in granule
            neurons and Purkinje cells during morphogenesis of axons and
            dendrites.
REFERENCE   2  (bases 1 to 4691)
  AUTHORS   Saarikangas,J., Mattila,P.K., Varjosalo,M., Bovellan,M.,
            Hakanen,J., Calzada-Wack,J., Tost,M., Jennen,L., Rathkolb,B.,
            Hans,W., Horsch,M., Hyvonen,M.E., Perala,N., Fuchs,H.,
            Gailus-Durner,V., Esposito,I., Wolf,E., de Angelis,M.H.,
            Frilander,M.J., Savilahti,H., Sariola,H., Sainio,K., Lehtonen,S.,
            Taipale,J., Salminen,M. and Lappalainen,P.
  TITLE     Missing-in-metastasis MIM/MTSS1 promotes actin assembly at
            intercellular junctions and is required for integrity of kidney
            epithelia
  JOURNAL   J Cell Sci 124 (Pt 8), 1245-1255 (2011)
   PUBMED   21406566
REFERENCE   3  (bases 1 to 4691)
  AUTHORS   Xia,S., Li,X., Johnson,T., Seidel,C., Wallace,D.P. and Li,R.
  TITLE     Polycystin-dependent fluid flow sensing targets histone deacetylase
            5 to prevent the development of renal cysts
  JOURNAL   Development 137 (7), 1075-1084 (2010)
   PUBMED   20181743
REFERENCE   4  (bases 1 to 4691)
  AUTHORS   Lee,S.H., Kerff,F., Chereau,D., Ferron,F., Klug,A. and Dominguez,R.
  TITLE     Structural basis for the actin-binding function of
            missing-in-metastasis
  JOURNAL   Structure 15 (2), 145-155 (2007)
   PUBMED   17292833
REFERENCE   5  (bases 1 to 4691)
  AUTHORS   Yamagishi,A., Masuda,M., Ohki,T., Onishi,H. and Mochizuki,N.
  TITLE     A novel actin bundling/filopodium-forming domain conserved in
            insulin receptor tyrosine kinase substrate p53 and missing in
            metastasis protein
  JOURNAL   J Biol Chem 279 (15), 14929-14936 (2004)
   PUBMED   14752106
REFERENCE   6  (bases 1 to 4691)
  AUTHORS   Woodings,J.A., Sharp,S.J. and Machesky,L.M.
  TITLE     MIM-B, a putative metastasis suppressor protein, binds to actin and
            to protein tyrosine phosphatase delta
  JOURNAL   Biochem J 371 (Pt 2), 463-471 (2003)
   PUBMED   12570871
REFERENCE   7  (bases 1 to 4691)
  AUTHORS   Mattila,P.K., Salminen,M., Yamashiro,T. and Lappalainen,P.
  TITLE     Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics,
            interacts with ATP-actin monomers through its C-terminal WH2 domain
  JOURNAL   J Biol Chem 278 (10), 8452-8459 (2003)
   PUBMED   12482861
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473950.2.
            
            On or before Jul 28, 2008 this sequence version replaced
            XM_343248.3, XM_001064860.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132261, SAMD00132262
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4691
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     gene            1..4691
                     /gene="Mtss1"
                     /note="MTSS I-BAR domain containing 1"
                     /db_xref="GeneID:362918"
                     /db_xref="RGD:1309883"
     exon            1..184
                     /gene="Mtss1"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..2526
                     /gene="Mtss1"
                     /note="metastasis suppressor protein 1; metastasis
                     suppressor 1; MTSS1, I-BAR domain containing"
                     /codon_start=1
                     /product="protein MTSS 1"
                     /protein_id="NP_001124035.1"
                     /db_xref="GeneID:362918"
                     /db_xref="RGD:1309883"
                     /translation="MGFAVSVMGTPRPRAQCSRPESVSCPRRAGKMEAVIEKECSALG
                     GLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGG
                     TREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKE
                     YKKARQEIKKKSSDTLKLQKKAKKVDAQGRGDIQPQLDSALQDVNDKYLLLEETEKQA
                     VRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSE
                     QVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHSHSPSSHY
                     RYRSSNLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAANQLSNGFSHYSLSS
                     ESHAGPVGAGPFPHCLPASRLLPRVTSIHLPDYAHYYTIGPGMFPSSQIPSWKDWAKP
                     GPYDQPLVNTLQRRKEKREADSSGGGPTATAGPPAAAEEAQRPRSMTVSAAPRPGEDM
                     EACDELALALSRGLQLDAQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSV
                     SGDQEAEQQEFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATI
                     RRTPSTKPSVRRGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPSPPDGPEERGEHSPES
                     PSVGEGPQGVSNIPSSLWSGHAPINPPLPGPKPSIPEEHRQAIPESEAEDQERDPSST
                     SVSPGPIPESDPADLSPRESPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS"
     exon            185..318
                     /gene="Mtss1"
                     /inference="alignment:Splign:2.1.0"
     exon            319..380
                     /gene="Mtss1"
                     /inference="alignment:Splign:2.1.0"
     exon            381..454
                     /gene="Mtss1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..539
                     /gene="Mtss1"
                     /inference="alignment:Splign:2.1.0"
     exon            540..631
                     /gene="Mtss1"
                     /inference="alignment:Splign:2.1.0"
     exon            632..706
                     /gene="Mtss1"
                     /inference="alignment:Splign:2.1.0"
     exon            707..718
                     /gene="Mtss1"
                     /inference="alignment:Splign:2.1.0"
     exon            719..876
                     /gene="Mtss1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..984
                     /gene="Mtss1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1082
                     /gene="Mtss1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1293
                     /gene="Mtss1"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1488
                     /gene="Mtss1"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1662
                     /gene="Mtss1"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1825
                     /gene="Mtss1"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..4691
                     /gene="Mtss1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgacgcgagc tgacctcgtc tgctgctgcc ctatttcgtt ctctctttct ttattttgga
       61 gtttcggaaa aaatatattt ggaaaaaata tctttttttt ttttcttaaa tggcgctggc
      121 cccgggtcag cgggcggttt tctctgcacc aagatgggct ttgccgtttc cgtcatgggc
      181 accccccggc cccgtgcgca gtgcagccgc cccgagagcg tgtcctgtcc ccgccgcgcc
      241 gggaaaatgg aggctgtgat cgagaaggaa tgcagcgcgc tcggaggcct cttccagacc
      301 atcatcagcg acatgaaggg gagctatcca gtttgggaag acttcataaa caaagcaggg
      361 aagcttcagt cccagcttcg gacaacagta gtagcagcag ctgccttctt ggacgccttt
      421 cagaaagtgg ctgacatggc caccaacaca cgtggtggta cccgggagat cggctcagcg
      481 ctcaccagaa tgtgcatgcg acacaggagc atcgaggcca agctaaggca gttctccagc
      541 gctctgatcg attgcctgat aaacccacta caagaacaga tggaggagtg gaagaaagtg
      601 gccaaccagc tggacaagga ccacgcaaaa gaatataaga aagctcgcca agagataaaa
      661 aagaagtcct ctgacacgct gaaactgcag aagaaggcca aaaaagtgga cgctcagggg
      721 agaggtgaca tccagcctca gttggacagc gctctccagg atgtcaacga taaatatctc
      781 ctcctggagg aaacagaaaa gcaggctgtg cgcaaagcac tgatcgaaga acgtggccgg
      841 ttctgcacct tcatttctat gctgcggcca gtgattgagg aagagatttc catgttagga
      901 gaaattaccc accttcagac catatcagaa gatctgaaga gcctgaccat ggaccctcac
      961 aaactgccct cctcgagtga acaggtgatt ctggacttga aaggttctga ttacagctgg
     1021 tcctatcaga cgccaccttc ttcccccagc acaaccatgt ccagaaagtc aagtgtctgc
     1081 agcagcctga acagtgtcaa cagcagtgac tcccggtcca gcggttccca ttcgcattcc
     1141 cccagctcgc attaccgata tcgcagctcc aacctggccc agcaggcccc tgtgaggctg
     1201 tccagcgtgt cctcccacga ctcaggattt atatcccagg acgccttcca gtccaagtcc
     1261 ccctctccca tgccacctga ggctgccaac cagttgtcta atgggttttc tcactatagt
     1321 ttatcaagtg agtcccatgc agggcccgtg ggtgcaggcc ctttccctca ttgcctgcct
     1381 gcctcccgcc tgctccctcg ggtcacctct atccaccttc ctgactacgc tcattattac
     1441 accattgggc ccggcatgtt cccgtcatct cagatcccta gctggaagga ctgggcaaag
     1501 ccaggaccct acgaccagcc actggtgaac actctccagc gccgcaaaga gaagcgcgag
     1561 gcggactcca gtgggggagg ccccacggcc acagcaggtc cacctgcagc tgctgaagag
     1621 gcacagagac ccaggagcat gaccgtgtca gccgccccca ggcctggcga ggatatggag
     1681 gcctgtgatg aactggccct cgccctgtca cggggcctcc agctggacgc gcagaggagc
     1741 agccgggact cactacagtg ctccagcggc tatagcaccc agaccaccac cccgtgctgc
     1801 tcggaggata ccatcccctc ccaagtttca gattacgatt atttctctgt aagtggtgac
     1861 caggaggcag agcagcagga atttgacaag tcctccacca ttccaaggaa cagtgacatc
     1921 agccagtctt acaggcggat gttccaagcc aagcgtccgg cctcaacggc tggccttccc
     1981 accactcttg gacctgctat ggtcacacca ggggttgcga ccatccgaag gaccccttcc
     2041 accaagcctt ctgttcgccg ggggaccatt ggagctggtc ctattcctat caagacacca
     2101 gtgatccctg tcaaaacccc aactgtccca gacctccctg gggttttgcc atcccctcca
     2161 gatgggccag aggagagggg tgagcacagc cctgagtctc catctgtggg ggagggaccc
     2221 cagggtgtca gcaatatacc ctcttccttg tggagtggcc atgcgccgat caaccctcca
     2281 cttccaggcc caaagcccag tatacctgag gagcacagac aagcaattcc agagagcgag
     2341 gctgaagacc aggaaagaga cccctcaagc accagtgtct ccccaggccc gattccagag
     2401 agtgacccag cagacctgag cccaagggaa agccctcagg gagaagacat gctgaacgcc
     2461 atccggaggg gagtgaagct gaagaagacg accaccaacg atcgctcagc ccctcgcttc
     2521 tcttaggttc tcatagttcc caggaagtgc tgccagtggg aacgaactct aattaataaa
     2581 gcctaatttg tcttgatcca ttccagtcta taatcaagca aaagattttg taggcagttc
     2641 ggaattctgc tcttttcaaa ctattcaaca tctttagata agaactaaaa gcaacatatg
     2701 taattgacat aatcttgatc ttttaatttg taaatattga cgatttcttt ctgcatattt
     2761 taaccttagt ttcccttttg atttttctga aggtgccaaa ttccatttaa cttttttaca
     2821 ggtctttgta aaattttaaa agcataaagg ggaggggtgg gttgggacag ggagccttgg
     2881 ggtcatttca cagaagggtt acttacttag ttctttttct ttcttccctc actcacgctc
     2941 cgtagatgca ctgtagtcta gtttagaagc aaatcaagtt attttaatgg ataaacacaa
     3001 cggataagag gtaaaagcct cattcacata tactgtgttc tggaggagaa atgcagataa
     3061 cagttgagca atatgcagag aagaaaacct ggacgtggtg gatggactgt gttgggattg
     3121 gggggagggc tgggggaggg gcacactgtc aacatagcca atcctgttac atttaagagt
     3181 agcctcgtag gttgaatttc cagtagcttc atggttaacg catccgatta agccatacta
     3241 gattgcagtg tttgtttctg taaggttttt aaggacatcc tttctcccag cattcctctc
     3301 gaccacacac acggcaccca catccagtcc tgcgcatgct gctgccacgg gtagacatag
     3361 tcccttcctt actttctcgt ctcttatact cacttccact gaatccagat acatccagag
     3421 gggtaaggca attcagaaaa tgttaaaaca ttttaaagta atagcaggga attcttagat
     3481 atagaagatg ccttttactt aactgtgccc agcaggctgg gtgcgttgaa aagcccagat
     3541 attttgaaga aaaaaaaaat tcaaacagat ttatcaaggg taaccagctt ggagtctagc
     3601 aattctgcca atgtgcttac caatctgggg gcttgttttt cttcccttcc ttaaataagg
     3661 gcagttggtt ggcttctaaa caccggagcg aaaaggattt atttactgtc aactgggagc
     3721 ctgatttcaa gtcaggcaac gtcttttctt tgtttaaaga tgaatgtctt ttttttaagt
     3781 ggaagttaaa tttgttacaa cgcccatccc taaagtcaac agagatttgt agattccaag
     3841 agctcacatt taaagacagc tgttaagaag gcaaggccct cagcagttca gtaactgata
     3901 gtgcacgttt gaaatttggg caagaaaaag gtgggtcctg tgtgctctgc agatctcggt
     3961 tggctctagc ctctgatgac ataatcttat actttaacac atagccacgt tggatgtgag
     4021 agtaacgttc ctctagtcat tgttctatat attaacattt aacactgctg tgattgctca
     4081 aaggacattt tatgttatgg ctttaaagca aaggcatgat tattagaaat gacttaagct
     4141 cttttctttg aaaaacaagc tccttttaca gactataagc aaacagtagt gcctgtggtt
     4201 tagcccacca accttgatga ctcaaagtag ctgatgcatt gtgcatatga tgcttgagat
     4261 ggtttttgca gatgcagaaa tcgctgcgag gtcattctaa tagagacaag tggtatttta
     4321 aacctttgaa aggaatggat gtaactgtac cttggtacag cttctcactt gtttagtttt
     4381 taaacgttag tataatctga ataaagttaa tataaactgt tgccaaattc aatgtagaaa
     4441 gaatgtgaca aacaccttgg gtagttctgt ttgtgttttt gcacattgta aaagcagtgt
     4501 cacagctgaa aacaaaccct ttctaaaggt aaattattgt ggtttagttg ctagtttgta
     4561 ttgagagttg acctctccct gtgcagtttt tgtttgaaac ttgtatagat aacagcgtgt
     4621 aatgtgtctc ccttctacat tgtaacagtt gcttctgcct accttataaa taaagaatca
     4681 ctaagaaaaa a
//
