LOCUS       NM_001039003            2387 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus 5-methyltetrahydrofolate-homocysteine
            methyltransferase reductase (Mtrr), mRNA.
ACCESSION   NM_001039003 XM_225078
VERSION     NM_001039003.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2387)
  AUTHORS   Cheng,H., Li,H., Bu,Z., Zhang,Q., Bai,B., Zhao,H., Li,R.K.,
            Zhang,T. and Xie,J.
  TITLE     Functional variant in methionine synthase reductase intron-1 is
            associated with pleiotropic congenital malformations
  JOURNAL   Mol Cell Biochem 407 (1-2), 51-56 (2015)
   PUBMED   26045171
REFERENCE   2  (bases 1 to 2387)
  AUTHORS   Gherasim,C., Yadav,P.K., Kabil,O., Niu,W.N. and Banerjee,R.
  TITLE     Nitrite reductase activity and inhibition of HS biogenesis by human
            cystathionine ss-synthase
  JOURNAL   PLoS One 9 (1), e85544 (2014)
   PUBMED   24416422
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2387)
  AUTHORS   Padmanabhan,N., Jia,D., Geary-Joo,C., Wu,X., Ferguson-Smith,A.C.,
            Fung,E., Bieda,M.C., Snyder,F.F., Gravel,R.A., Cross,J.C. and
            Watson,E.D.
  TITLE     Mutation in folate metabolism causes epigenetic instability and
            transgenerational effects on development
  JOURNAL   Cell 155 (1), 81-93 (2013)
   PUBMED   24074862
REFERENCE   4  (bases 1 to 2387)
  AUTHORS   Lautner-Csorba,O., Gezsi,A., Erdelyi,D.J., Hullam,G., Antal,P.,
            Semsei,A.F., Kutszegi,N., Kovacs,G., Falus,A. and Szalai,C.
  TITLE     Roles of genetic polymorphisms in the folate pathway in childhood
            acute lymphoblastic leukemia evaluated by Bayesian relevance and
            effect size analysis
  JOURNAL   PLoS One 8 (8), e69843 (2013)
   PUBMED   23940529
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2387)
  AUTHORS   Zhao,J.Y., Yang,X.Y., Gong,X.H., Gu,Z.Y., Duan,W.Y., Wang,J.,
            Ye,Z.Z., Shen,H.B., Shi,K.H., Hou,J., Huang,G.Y., Jin,L., Qiao,B.
            and Wang,H.Y.
  TITLE     Functional variant in methionine synthase reductase intron-1
            significantly increases the risk of congenital heart disease in the
            Han Chinese population
  JOURNAL   Circulation 125 (3), 482-490 (2012)
   PUBMED   22179537
REFERENCE   6  (bases 1 to 2387)
  AUTHORS   Gemmati,D., Ongaro,A., Scapoli,G.L., Della Porta,M., Tognazzo,S.,
            Serino,M.L., Di Bona,E., Rodeghiero,F., Gilli,G., Reverberi,R.,
            Caruso,A., Pasello,M., Pellati,A. and De Mattei,M.
  TITLE     Common gene polymorphisms in the metabolic folate and methylation
            pathway and the risk of acute lymphoblastic leukemia and
            non-Hodgkin's lymphoma in adults
  JOURNAL   Cancer Epidemiol Biomarkers Prev 13 (5), 787-794 (2004)
   PUBMED   15159311
REFERENCE   7  (bases 1 to 2387)
  AUTHORS   Gueant-Rodriguez,R.M., Rendeli,C., Namour,B., Venuti,L., Romano,A.,
            Anello,G., Bosco,P., Debard,R., Gerard,P., Viola,M., Salvaggio,E.
            and Gueant,J.L.
  TITLE     Transcobalamin and methionine synthase reductase mutated
            polymorphisms aggravate the risk of neural tube defects in humans
  JOURNAL   Neurosci Lett 344 (3), 189-192 (2003)
   PUBMED   12812837
REFERENCE   8  (bases 1 to 2387)
  AUTHORS   Pietrzyk,J.J., Bik-Multanowski,M., Sanak,M. and Twardowska,M.
  TITLE     Polymorphisms of the 5,10-methylenetetrahydrofolate and the
            methionine synthase reductase genes as independent risk factors for
            spina bifida
  JOURNAL   J Appl Genet 44 (1), 111-113 (2003)
   PUBMED   12590188
REFERENCE   9  (bases 1 to 2387)
  AUTHORS   Doolin,M.T., Barbaux,S., McDonnell,M., Hoess,K., Whitehead,A.S. and
            Mitchell,L.E.
  TITLE     Maternal genetic effects, exerted by genes involved in homocysteine
            remethylation, influence the risk of spina bifida
  JOURNAL   Am J Hum Genet 71 (5), 1222-1226 (2002)
   PUBMED   12375236
REFERENCE   10 (bases 1 to 2387)
  AUTHORS   Olteanu,H. and Banerjee,R.
  TITLE     Human methionine synthase reductase, a soluble P-450 reductase-like
            dual flavoprotein, is sufficient for NADPH-dependent methionine
            synthase activation
  JOURNAL   J Biol Chem 276 (38), 35558-35563 (2001)
   PUBMED   11466310
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC100107.1.
            
            On Jan 12, 2006 this sequence version replaced XM_225078.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100107.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00155337, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2387
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..2387
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /note="5-methyltetrahydrofolate-homocysteine
                     methyltransferase reductase"
                     /db_xref="GeneID:290947"
                     /db_xref="RGD:1308671"
     exon            1..40
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            41..205
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1597
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /EC_number="1.16.1.8"
                     /note="aqCbl reductase; aquacobalamin reductase"
                     /codon_start=1
                     /product="methionine synthase reductase"
                     /protein_id="NP_001034092.1"
                     /db_xref="GeneID:290947"
                     /db_xref="RGD:1308671"
                     /translation="MRRFLLLYATQRGQAKAIAEEISEQALSHGFSADLHCVSESEKS
                     SLSIPAVSPEYLEVYLQESLGQDENQASVPPSVDPIFQVPISKAVELTTNDAIKTTLL
                     LELDISKVEFSHQPGDSFNVICPNSGSEVEDLLQRLQLADKQAHRVILKIKMDTKKKG
                     ASLPQHVPEGSSLQFIFTWCLEIRAVPKKAFLRALSDYTSDATEKRRLQELCSKQGAA
                     DYNRFIRDASVCLLDLLLTFPSCQPPLNLLLEHLPKLQPRPYSCASSSLLHPDKLHFV
                     FNIVELPSNTTAASLRKGVCTGWLATLVAPFLQPNTEVLTADHSDALAPEILISPRAT
                     NSFHLPDDLSAPIIMVGPGTGVAPFVGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDR
                     DYLFREELRHFLKTGVLTHLKVSFSRDAAPEEEEEAPAKYVQDNLQHHSQQVARTLLQ
                     ENGYIYVCGDAKNMAKDVHDALVEIISKEAGVDKLEAMKTLATLKQEKRYLQDIWS"
     exon            206..274
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            275..400
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            401..554
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            555..643
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            644..824
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            825..867
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1054
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1173
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1266
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1452
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..2363
                     /gene="Mtrr"
                     /gene_synonym="MSR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgagaaaaa cggggacccg cgcggaattc gcaccaggag tctcactgtt ggagttacag
       61 ctgatgacct gaggtgatga gaaggttttt gttactgtat gctacacagc gagggcaggc
      121 aaaggccata gctgaagaaa taagtgagca ggctctgtca cacgggtttt ccgcagatct
      181 tcactgcgtc agtgagtcag aaaagagctc tctaagtatt cctgctgtgt ccccagaata
      241 tttggaggtc tatcttcagg agtctcttgg ccaggatgaa aaccaagcat ctgtgccacc
      301 atcagtcgat ccaatttttc aagttccaat ttcaaaagct gttgagctga ctacaaacga
      361 tgccataaag accactctgc tgttggaatt ggacatctca aaagtagagt tttcccatca
      421 acctggagat tccttcaatg tgatctgtcc aaacagtggt tctgaagtag aagacttgct
      481 gcaaaggctg cagctggctg acaaacaagc acaccgggtc atcctgaaaa ttaagatgga
      541 caccaagaag aaaggagctt ctctgcccca gcatgtgcct gaggggagtt ctctccagtt
      601 catcttcacc tggtgtcttg aaatacgagc agttcctaaa aaggcttttt tgagggccct
      661 ttcggattac accagcgatg ccactgaaaa gcggaggctt caggagctct gcagtaagca
      721 gggagcagct gattacaacc gcttcatccg agatgccagt gtctgcctgc tagacctcct
      781 gcttaccttc ccatcctgcc agcctccgct caacctcctg ctggagcacc ttcctaaact
      841 ccagcctcga ccatactcgt gcgcaagctc cagcttactc catccagaca agcttcactt
      901 tgtgtttaac atcgtagagc ttccgtcgaa caccactgca gcctcactgc ggaagggagt
      961 gtgcacaggc tggctagcca cattggttgc tccatttctt cagccaaaca cagaagtttt
     1021 gactgcagac catagtgatg ctctggctcc tgagatactt atctctcctc gggcaacaaa
     1081 ttccttccac ttaccagatg acctgtcggc ccccatcata atggtgggtc caggaactgg
     1141 tgtagccccc tttgttggct tcctgcagca cagagaaaaa ctccaagaac aacacccaga
     1201 cggaaacttt ggagcaatgt ggctgttttt tggctgcaga cataaggaca gagactattt
     1261 gttcagggag gagctcaggc atttcctcaa gactggggtc ttgactcacc tgaaggtctc
     1321 attctcaaga gatgctgcgc ctgaggaaga ggaggaggcc ccagcaaagt atgtgcaaga
     1381 caacctccag catcacagcc agcaggtggc caggaccctc cttcaggaga atggctacat
     1441 ttacgtgtgt ggagacgcca agaatatggc taaggatgta cacgacgccc ttgtagaaat
     1501 cataagcaaa gaagctggag ttgacaaact agaagcaatg aagacactgg caaccttaaa
     1561 gcaagaaaag cggtatctgc aggatatctg gtcgtgaaac tagaagggag gtttcagtgt
     1621 gcttgcttgc ttgtttgttt tttgaaatgc caaaggacag ttgtacagaa gataggtttt
     1681 gggtatttct tggcagaggc tttgtgggga acagctcact tacaggtacc accgcctgat
     1741 acaatctcag gtttgtctcc cactctgtgt cccacccagc accccactgt gtggagcgga
     1801 gaggcagctc tcagctggct cccaaggagg acagatagtc gtcaatggct ctgggcacat
     1861 cgtggagagt ttgtggacat gttctctttc aatgaagtac attcagagga tattcattct
     1921 gatgatattt aaattaatac agacatacag agcatacttt tgcatgtttg cacttaattg
     1981 tggtttatta tcaaaattat atttctgata aaatatttta attttgaggt aatccttaca
     2041 aaataagggt ttttatgcta ctagaaatat attttgaaat acaattgaaa ttgtgctctg
     2101 ccattttcat catgttaact tttagtgtca cagtcctaca gcttaggggc atttgcattc
     2161 ccctgacaaa ggcatgtgtg tacatctcag taacatcatg ccctgttctc ctggactcta
     2221 ttcatcaatg ctcctcacta acagacttgg tattccccaa tacctgactg tacttctgtg
     2281 attcagctca gagtaaagag ctccagttag acttctaata ccaaattctc ttgcaagttt
     2341 cgaaaataaa gcatataaaa ggaaaaaaaa aaaaaaaaaa aaaaaaa
//
