LOCUS       NM_001034093            3582 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus Mtr4 exosome RNA helicase (Mtrex), mRNA.
ACCESSION   NM_001034093 XM_342196 XM_345153
VERSION     NM_001034093.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3582)
  AUTHORS   Lingaraju M, Johnsen D, Schlundt A, Langer LM, Basquin J, Sattler
            M, Heick Jensen T, Falk S and Conti E.
  TITLE     The MTR4 helicase recruits nuclear adaptors of the human RNA
            exosome using distinct arch-interacting motifs
  JOURNAL   Nat Commun 10 (1), 3393 (2019)
   PUBMED   31358741
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3582)
  AUTHORS   Weick EM, Puno MR, Januszyk K, Zinder JC, DiMattia MA and Lima CD.
  TITLE     Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of
            a Human Nuclear RNA Exosome-MTR4 Complex
  JOURNAL   Cell 173 (7), 1663-1677 (2018)
   PUBMED   29906447
REFERENCE   3  (bases 1 to 3582)
  AUTHORS   Puno MR and Lima CD.
  TITLE     Structural basis for MTR4-ZCCHC8 interactions that stimulate the
            MTR4 helicase in the nuclear exosome-targeting complex
  JOURNAL   Proc Natl Acad Sci U S A 115 (24), E5506-E5515 (2018)
   PUBMED   29844170
REFERENCE   4  (bases 1 to 3582)
  AUTHORS   Hiraishi N, Ishida YI, Sudo H and Nagahama M.
  TITLE     WDR74 participates in an early cleavage of the pre-rRNA processing
            pathway in cooperation with the nucleolar AAA-ATPase NVL2
  JOURNAL   Biochem Biophys Res Commun 495 (1), 116-123 (2018)
   PUBMED   29107693
REFERENCE   5  (bases 1 to 3582)
  AUTHORS   Yoshikatsu Y, Ishida Y, Sudo H, Yuasa K, Tsuji A and Nagahama M.
  TITLE     NVL2, a nucleolar AAA-ATPase, is associated with the nuclear
            exosome and is involved in pre-rRNA processing
  JOURNAL   Biochem Biophys Res Commun 464 (3), 780-786 (2015)
   PUBMED   26166824
REFERENCE   6  (bases 1 to 3582)
  AUTHORS   Gustafson MP, Welcker M, Hwang HC and Clurman BE.
  TITLE     Zcchc8 is a glycogen synthase kinase-3 substrate that interacts
            with RNA-binding proteins
  JOURNAL   Biochem Biophys Res Commun 338 (3), 1359-1367 (2005)
   PUBMED   16263084
REFERENCE   7  (bases 1 to 3582)
  AUTHORS   Farkas RH, Qian J, Goldberg JL, Quigley HA and Zack DJ.
  TITLE     Gene expression profiling of purified rat retinal ganglion cells
  JOURNAL   Invest Ophthalmol Vis Sci 45 (8), 2503-2513 (2004)
   PUBMED   15277470
REFERENCE   8  (bases 1 to 3582)
  AUTHORS   Hong SJ, Li H, Becker KG, Dawson VL and Dawson TM.
  TITLE     Identification and analysis of plasticity-induced late-response
            genes
  JOURNAL   Proc Natl Acad Sci U S A 101 (7), 2145-2150 (2004)
   PUBMED   14766980
REFERENCE   9  (bases 1 to 3582)
  AUTHORS   Jurica MS, Licklider LJ, Gygi SR, Grigorieff N and Moore MJ.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   10 (bases 1 to 3582)
  AUTHORS   Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ,
            Stoecklin G, Moroni C, Mann M and Karin M.
  TITLE     AU binding proteins recruit the exosome to degrade ARE-containing
            mRNAs
  JOURNAL   Cell 107 (4), 451-464 (2001)
   PUBMED   11719186
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CB576727.1,
            CB724841.1, CV106248.1, CA510648.1, CO384799.1, CF977889.1,
            CO571909.1, CO401332.1 and CB327646.1.
            
            On or before Oct 13, 2005 this sequence version replaced
            XM_342196.1, XM_345153.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-586               CB576727.1         1-586
            587-820             CB724841.1         342-575
            821-1026            CV106248.1         329-534
            1027-1353           CA510648.1         163-489
            1354-1951           CO384799.1         43-640
            1952-2330           CF977889.1         67-445
            2331-2525           CO571909.1         308-502
            2526-2996           CO401332.1         166-636
            2997-3582           CB327646.1         1-586               c
FEATURES             Location/Qualifiers
     source          1..3582
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q14"
     gene            1..3582
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /note="Mtr4 exosome RNA helicase"
                     /db_xref="GeneID:365668"
                     /db_xref="RGD:1305984"
     exon            1..379
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..3374
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /EC_number="3.6.4.13"
                     /note="Ski2 like RNA helicase 2"
                     /codon_start=1
                     /product="exosome RNA helicase MTR4"
                     /protein_id="NP_001029265.1"
                     /db_xref="GeneID:365668"
                     /db_xref="RGD:1305984"
                     /translation="MADAFGDELFSVFEDDSTTAAGTKKDKEKEKDKWKGPPGPADKA
                     GKRLDTRLQSEPASSGKNKRDLDVEGTDEPIFGKKPRIEDSINEDLSLADLMPRVKVQ
                     SVETVEGCTHEVALPADEDYIPLKPRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVS
                     AHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTI
                     NPTASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDN
                     VHYVFLSATIPNARQFAEWICHLHKQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDE
                     NGDFREDNFNTAMQVLRDAGDLAKGDQKGRKGGTKGPSNVFKIVKMIMERNFQPVIIF
                     SFSKKDCEAYALQMTKLDFNTDEEKKMVEEVFNNAIDCLSDEDKKLPQVEHVLPLLKR
                     GIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKYDGKD
                     FRWISSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSAFHLT
                     YNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPGVVEKVKNSEEQYNKIVIPNEENVV
                     IYYKIRQQLAKLGKEIEEYIHKPKYCLPFLQPGRLVKVKNEGDDFGWGVVVNFSKKSN
                     VKPNSGELDPLYVVEVLLRCSKESLKNSATEAAKPAKPDEKGEMQVVPVLVHLLSAIS
                     TVRLYIPKDLRPVDNRQSVLKSIQEVQKRFPDGVPLLDPIDDMGIQDQGLKKVIQKVE
                     AFEHRMYSHPLHNDPNLETVYTLCEKKAQIAIDIKSAKRELKKARTVLQMDELKCRKR
                     VLRRLGFATSSDVIEMKGRVACEISSADELLLTEMMFNGLFNDLSSEQATALLSCFVF
                     QENSSEMPKLTEQLAGPLRQMQECAKRIAKVSAEAKLEIDEETYLSSFKPHLMDVVYT
                     WATGATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELENKFAEGITKI
                     KRDIVFAASLYL"
     exon            380..517
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            518..584
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            585..647
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            648..760
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            761..935
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1026
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1151
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1250
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1353
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1485
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1565
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1676
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1778
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1904
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2055
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2228
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2297
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2426
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2537
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2538..2726
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..2890
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2891..2996
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3053
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            3054..3216
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            3217..3321
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            3322..3564
                     /gene="Mtrex"
                     /gene_synonym="RGD1305984; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggcatgt ctgccgtcgt gcgccacttg tcgctaagtt tttagtcatt gaactgccgg
       61 actcgcagtg gtctaaaaag aaaaggaaca agacgcagac gagaaggaga aaagttactc
      121 aggccttaag gcttgctcac ttttgattcc tgcgggccac cgtagagtcc ctatttggcg
      181 tcactgtagg tgcgatcccg gggcctcttg ggtaggaggg agattcagtc ttagagttcc
      241 gaaagatggc ggacgctttc ggggatgagc ttttcagcgt tttcgaggat gattcgacca
      301 ctgcagcggg aaccaagaaa gacaaagaaa aggagaaaga taaatggaag gggccaccgg
      361 ggcctgcaga caaggccggg aaacgactgg ataccagatt acagtcagaa ccagccagta
      421 gtgggaaaaa caagagagat ctagatgttg aaggcacaga tgaacctatt tttggcaaga
      481 agcccaggat agaagactca attaatgaag atttaagctt ggcggacctg atgcccagag
      541 tcaaggtaca gtcggttgaa acagttgaag gctgtacaca cgaggtcgct cttcctgcag
      601 atgaggatta tataccactt aagcctcgag ttgggaaggc agcaaaggaa tacccgttca
      661 ttcttgatgc tttccaaaga gaagccattc agtgtgttga taacaatcag tctgtgttag
      721 tatctgctca tacatcagcg gggaaaaccg tgtgcgctga gtatgctatt gcactggctt
      781 taagggaaaa acagcgtgta atatttacca gcccaataaa ggctctaagt aatcagaaat
      841 accgtgaaat gtatgaagaa tttcaagatg ttggtctgat gactggagat gttactatta
      901 atcccacagc atcttgtctg gttatgacta cagagatttt gagaagtatg ctgtacagag
      961 gctctgaagt tatgcgagaa gttgcgtggg tcatatttga tgaaattcat tacatgagag
     1021 attcagagcg tggtgtagta tgggaagaaa ctattatttt gcttccagac aatgttcact
     1081 atgtctttct ttcggctact attcccaatg ctcgacagtt tgctgagtgg atctgccacc
     1141 tacataaaca gccctgtcat gtaatttata ctgattatcg acctactcca ttgcaacact
     1201 acatatttcc agcaggggga gatggccttc accttgtggt tgatgaaaat ggtgacttca
     1261 gagaagataa ttttaacact gcaatgcaag tacttcggga tgcaggtgat ttggccaaag
     1321 gagaccagaa gggacggaaa ggaggaacaa aaggtccatc aaatgtgttc aagattgtga
     1381 agatgattat ggaaagaaat tttcaacctg tgattatctt cagttttagt aagaaggatt
     1441 gtgaagcata cgcccttcaa atgactaaac tagacttcaa cacagatgaa gaaaagaaga
     1501 tggttgaaga agttttcaat aatgcaattg actgtttgtc tgatgaagat aaaaagctcc
     1561 ctcaggttga acatgtactt ccacttttga aacgggggat tggtattcac catggtggtt
     1621 tgcttcctat tttaaaggaa actatagaga ttctcttttc tgaaggattg ataaaggcct
     1681 tatttgccac agagactttt gctatgggaa ttaacatgcc agctagaact gttttattta
     1741 caaatgcccg taaatatgat gggaaggatt ttagatggat ttcctcaggt gagtacatcc
     1801 agatgtctgg tcgtgcagga aggaggggga tggatgacag agggattgtg attcttatgg
     1861 tcgatgaaaa gatgagccca acaattggaa aacaactgct taagggctca gctgatcctc
     1921 tgaatagtgc tttccatcta acgtacaaca tggttttgaa cttactaaga gtagaagaaa
     1981 ttaatcccga gtacatgctt gaaaaatcct tctaccagtt tcagcattat agagcaattc
     2041 caggagttgt agaaaaggta aagaactcgg aagaacagta taataaaata gtaattccca
     2101 atgaagaaaa tgtggtcatc tattacaaga ttagacagca acttgccaag ctgggaaaag
     2161 agattgaaga atatattcat aagccaaaat actgcttacc ctttctacaa ccaggccgtt
     2221 tagtaaaggt gaagaatgaa ggtgatgatt tcggctgggg agtagtggtg aacttctcaa
     2281 aaaagtcaaa cgtcaagccc aattctggcg aactggatcc cttgtatgtg gtggaagtgc
     2341 tcctgcgctg tagcaaggaa agcctgaaaa actccgccac agaggcagca aagccagcaa
     2401 agccggatga gaagggggag atgcaggttg ttccggtttt ggtgcatctc ctgtctgcca
     2461 tcagcactgt tagactctac attccaaaag acctccgccc cgtggacaac agacagagtg
     2521 tcctaaaatc catacaggaa gttcaaaagc ggtttcccga tggtgttccg ttgttagatc
     2581 ctatcgatga tatgggcatt caagatcaag gactgaaaaa agtcattcag aaagtagagg
     2641 cttttgagca tcgaatgtac tcgcacccac ttcacaatga tcctaatctg gaaactgtgt
     2701 ataccctttg tgaaaaaaag gcacagattg caatagatat taagtctgca aagagagaac
     2761 tgaagaaagc aagaactgtt ctgcaaatgg atgaactcaa atgtcgtaag cgtgttctaa
     2821 gaaggctggg ttttgctaca tcttctgatg tcatagagat gaaaggacgg gtggcttgtg
     2881 agataagcag tgctgacgag ctccttctaa cagagatgat gtttaatggg ctcttcaatg
     2941 acctttcttc agaacaggcg accgcactgc taagctgttt tgtgtttcaa gagaattcta
     3001 gtgagatgcc caaattaaca gagcagttag ctggaccact ccgacaaatg caggaatgtg
     3061 ctaaaaggat tgcaaaggtt tctgcagagg caaaactgga gattgatgaa gaaacttact
     3121 taagctcatt caagcctcac ctgatggatg tggtgtacac ctgggcaact ggggccacat
     3181 ttgcccacat ctgcaaaatg acagatgtct ttgaaggcag tataatccgt tgtatgaggc
     3241 gcctggaaga actgcttcga cagatgtgtc aagcagcgaa agccattgga aacacagagc
     3301 tggagaacaa gtttgctgaa ggaatcacca aaatcaagag ggatattgta tttgctgcca
     3361 gcctctactt atagagttca atgttagtca ccacctgtct gattgcagtt gactacaaat
     3421 gctttttcaa gtgttcaagt ggttctccca attcaagagt tgttcgcaag catttttatt
     3481 atatttaaat caaatatcat tctgagaagg catgtaacat acacatttgt acatagcatc
     3541 tttcaataaa aaaatgtaca ggtgaaaaaa aaaaaaaaaa aa
//
