LOCUS       XM_039096108            4998 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus 5-methyltetrahydrofolate-homocysteine
            methyltransferase (Mtr), transcript variant X4, mRNA.
ACCESSION   XM_039096108
VERSION     XM_039096108.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051352.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_039096108.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4998
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..4998
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /note="5-methyltetrahydrofolate-homocysteine
                     methyltransferase; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 1 Protein, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 16 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:81522"
                     /db_xref="RGD:621283"
     CDS             337..2946
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /codon_start=1
                     /product="methionine synthase isoform X3"
                     /protein_id="XP_038952036.1"
                     /db_xref="GeneID:81522"
                     /db_xref="RGD:621283"
                     /translation="MKKTLQDEIEAILRKRIMVLDGGMGTMIQRYKLSEENFQGQEFK
                     DHSRPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAY
                     RMNKCSADVARKAAEEITLQTGVKRFVAGSLGPTNKTLSVSPSVERPDYRNITFDELV
                     EAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQKLFEENYASPRPIFISGTIVD
                     KSGRTLSGQTGEAFVTSVSHSDPLCIGLNCALGAAEMRPFIETIGKCTTAYVLCYPNA
                     GLPNTFGDYDETPAMMAMHLKDFAVDGLVNVVGGCCGSTPDHIREIAEAVKNCKPRVP
                     PDSVFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSKKFAKLIMAGNYEEALSVAKV
                     QVEMGAQVLDINMDDGMLDGPSAMTKFCNFIASEPDIAKVPLCIDSSNFAVIEAGLKC
                     CQGKCIVNSISLKEGEEDFLEKARKIKKFGAAVVVMAFDEEGQATETDVKVSVCTRAY
                     HLLVEKVGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATRVIKETLPGVRISGGLS
                     NLSFAFRGMDAIREAMHGVFLYHAIKFGMDMGIVNAGSLPVYDDIHKDLLQLCEDLIW
                     NRDAEATEKLLRYAQTHGKGGKKVIQTDEWRNGSIEERLEYALVKGIEKHIVEDTEEA
                     RLNREKYPRPLNIIEGPLMNGMKVVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFME
                     KEREEARVLNGSVEEEDPYQGTIVLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMT
                     PCDKILQAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIKIPLLIGGATTSRKLG
                     LALLHALSRSLAK"
ORIGIN      
        1 gccctcctgc gggaggctag attgagcgga gagctaaggg ccctgcgggg gcctgtggcc
       61 gtgtctacgt agtctactcc tttagtctta cgttgaggcc ttggcagtaa cgcggacctc
      121 tgcgcttggg agttaggtaa gaagcgcgtg cccgaggtgc agtacccgga ggcccggtgt
      181 gtctgctctg gagcttcagg gatctcgtga gccagttcgt caggccacta aacgctggct
      241 ggagtcgcct gcggtaggat tctttggaga tcaagctttc tttgcttgaa gaggacgttt
      301 ggcggcgtgt cgcctgcgct ggtgcagccg ggagagatga agaaaaccct gcaggatgag
      361 attgaagcca ttcttcggaa gaggattatg gtgctagatg gcgggatggg gaccatgatc
      421 cagcggtaca aactaagcga agaaaatttc caaggtcaag agtttaaaga ccacagcagg
      481 ccactgaaag gcaacaatga catcttgagt ataactcagc ctgatgttat ttaccagatt
      541 cataaggaat acttgctggc cggagcagac atcattgaaa caaacacttt cagcagcact
      601 agtatcgccc aggctgacta tggcctcgaa cacttggcct accggatgaa caaatgctcc
      661 gcagacgtgg ccagaaaagc cgccgaggag ataactctgc agacaggagt caagaggttt
      721 gtggctggat ctctgggtcc gactaacaag acactttcag tttccccatc tgtggaaagg
      781 ccagattaca ggaacatcac atttgatgag cttgttgaag cataccagga gcaggccaag
      841 ggactgctgg atggtggggt tgacatctta ctcattgaga cgatttttga tacagccaat
      901 gccaaagcag ccttgtttgc gctccagaaa ctctttgaag agaattatgc ttctcccagg
      961 cctatcttta tttctgggac cattgttgat aaaagtggac ggactctttc tggccagaca
     1021 ggagaggctt ttgtcaccag cgtgtctcat tcagaccccc tgtgcattgg attaaattgt
     1081 gctctgggtg cagctgaaat gaggcctttc attgaaacaa ttggaaaatg tacaacagct
     1141 tatgtcctct gttacccaaa tgcaggtctt cccaatacct ttggtgatta tgatgaaaca
     1201 ccagccatga tggccatgca cctgaaggac tttgccgtgg acggcttggt gaatgtagtt
     1261 ggtggatgct gtggttcaac gcctgatcac atcagggaaa ttgcagaagc tgtgaaaaat
     1321 tgtaagccaa gagttccccc tgatagtgtt tttgaaggac atatgttact gtctggtcta
     1381 gagcccttca ggattggacc atacactaac tttgttaaca ttggagagcg ctgtaacgtg
     1441 gcaggatcca agaaatttgc taagctcatc atggcaggaa actatgagga agccctgagc
     1501 gttgccaaag tgcaggtgga aatgggagct caggtgctgg atatcaacat ggatgacggc
     1561 atgctggatg gtcccagtgc gatgaccaaa ttttgcaact tcattgcttc ggagcctgac
     1621 attgccaagg tgcccctgtg cattgactct tccaattttg ctgtgatcga ggcggggttg
     1681 aagtgctgcc aagggaagtg catagtcaac agcatcagcc tgaaggaggg ggaggaggac
     1741 ttcctggaga aggccaggaa gattaagaag tttggagctg ctgtggtggt tatggctttt
     1801 gatgaggaag gacaggcaac agaaacagat gttaaagtca gtgtgtgcac tagagcctac
     1861 catctacttg tggaaaaagt gggcttcaat ccaaatgata tcatctttga ccccaacatc
     1921 cttaccattg gaactggaat ggaagaacat aacttgtatg ctatcaattt tattcatgca
     1981 acgagagtca ttaaggaaac attaccagga gtcagaataa gtggaggtct ctccaaccta
     2041 tccttcgcct tccgagggat ggacgccatt cgagaagcaa tgcacggtgt tttcctttat
     2101 catgcaatca agttcggtat ggacatgggg atagtcaatg ccggcagtct ccccgtgtac
     2161 gatgatatcc ataaggacct tcttcagctc tgtgaagacc tcatctggaa cagagacgct
     2221 gaggctactg agaaactctt acgatatgcc cagactcatg gcaaaggagg gaagaaagtc
     2281 atccagacag atgagtggag gaatggctcg attgaagagc gcctggagta tgctcttgtg
     2341 aagggcattg aaaagcacat tgttgaagac actgaagaag ccaggttaaa ccgggaaaaa
     2401 tacccccggc ctctgaatat aattgaaggg cccctgatga atggcatgaa agtggttggt
     2461 gatctttttg gagctggaaa aatgtttcta cctcaggtta taaagtcagc ccgtgtcatg
     2521 aagaaggctg ttggccacct tatccctttc atggaaaaag aaagagaaga agccagggtg
     2581 cttaatggtt cggttgaaga agaggaccct taccaaggca ccattgtgct ggccactgtt
     2641 aaaggtgatg tgcatgacat tggcaagaac attgttggtg tggtgctggg ctgtaataat
     2701 ttcagagtta ttgatttagg agtcatgact ccctgtgata agatacttca agctgctctg
     2761 gaccacaaag cagatataat tggcttgtca ggactcatca cgccatcctt ggatgaaatg
     2821 atttttgttg ccaaggaaat ggagaggttg gctataaaga ttccattgtt gataggagga
     2881 gcaaccactt caagaaagct gggacttgca cttctgcatg ctctgagcag gagtctggct
     2941 aagtaattgt aagttccctt gaagatgctc aaaccttgta agaatttgga gacagactag
     3001 tgaaaatgaa gaagtcgggt ggaggacttg ggggaaacta ggataaaaga cataaagagg
     3061 agaatgttca cattgactca cataggcagt gtttaactca agttcttcct gggatcgtgg
     3121 tcatagtgag aatgccgggc ttctgtagca tttcttacat cacagatact tggtttgcag
     3181 ggtggtcccg gttgaactgg gtagtcccac agtgtgaagt ttgtttgttt gtttagtgca
     3241 aaaatgaaat tctagtctgg tcgtaagatt ctagaactcc tcacagagtg acagatttat
     3301 ttttaggaat tggcttgtgt ggttgtaggg ctggaaggtc tggaatctgt aggctgcagt
     3361 atcagacaag ggctgctatt gcagtcttca ggcagaagtt ctttgtacaa gaggcagggt
     3421 taatgagact gcttgatatt tctctgaagt tttttagctt attgcagagg ttaatccatt
     3481 acagagggta atctactgtg tctacagatt taagtgtcta ttacatctaa aaaacatgtg
     3541 gactgcatgc agtaccaaac tgcatagtgt ggcatacccc agctcgcaca cagaattcgc
     3601 catcatgtta tttgtagtgt gaatggagag ttcccacaag tagcagaata tttatgtctt
     3661 tacctgttga ttacttttca taccgcggtg acttgacagc tctgccattg ttgctgatgt
     3721 taacaaaact ggagttctta ctagcagagt ggctgaatta ttcttacagg atctggtcga
     3781 acattgataa agaggatttg agtttgtttt cttttggttc tggaatctat acctaggacc
     3841 ttgtacttgc tactcaagat ctctctcaca ggctatgcta tgtccccagc ccacacttta
     3901 cttaaaatct tgtcgttttt actttgagac agggtctcac tgaattgcct agtcttgaac
     3961 tcactctagc ccaggctggc cttgaatttg cagtcctctg tctcagcttc caagtagttg
     4021 gacagtcggt ctatctggac ctccaggcct ggcccataac ttgagcttta tgaaattaac
     4081 ctggtctttt gcttaggtgg aaagtggcaa gaggacctgt ggattattgt cagagtgaag
     4141 actttaagaa gttgtggtta tgtaatataa caaatctgtt gtctacctgg gaccctggtt
     4201 catgctaata atatatcaca gtttgcttca ttaagatcag aaatttgcta tgtggtcctt
     4261 tttattacaa gagccatcag acaaaagaaa aaagccctcc tgagaccctg gttgcttctc
     4321 ctcaggtaat tgagggttca gtgactcgtc ttttgccaga tgacagctca ggatttgtat
     4381 ggtttcagga gacagatttc tgagggtgat aagacttttt cagtagtagc atgaaccaga
     4441 cagacctgtg cttctgagac attcaaggtc aaggtataac cctccagtga aggttagggg
     4501 tcagagatgg gtgggaatat acttggagtg tcccttttaa acctgcattt atagacaaga
     4561 aaaccaatta ttattccgtt cgcagtatgg gtcatgcagt atcacaaaag gaaatctggc
     4621 ctttttatgg gcagaacttc acaaggatat atattctgaa agtcagctgt taaatttaac
     4681 taatgtatag ccaattactg caaagtaggt tttgcaatta ctttttcttt gaaaatttaa
     4741 ccaagtcaca ttgctctact gtagagaaaa ttttctgagt gagtgtgagt gtgtgtgtgt
     4801 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgcttagtt gctcagaagt aagataagta
     4861 attttatctt cccgtttgca ctaaccataa gctttccata gagaagctta gaattttagg
     4921 gctgttctta cttccgattt aatcttgatt tctctatctt tatttttttc ctcctttcta
     4981 aaaaattcta tgtgtgtg
//
