LOCUS       NM_030864               4483 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus 5-methyltetrahydrofolate-homocysteine
            methyltransferase (Mtr), mRNA.
ACCESSION   NM_030864
VERSION     NM_030864.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4483)
  AUTHORS   Ngai,Y.F., Sulistyoningrum,D.C., O'Neill,R., Innis,S.M.,
            Weinberg,J. and Devlin,A.M.
  TITLE     Prenatal alcohol exposure alters methyl metabolism and programs
            serotonin transporter and glucocorticoid receptor expression in
            brain
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 309 (5), R613-R622 (2015)
   PUBMED   26180184
REFERENCE   2  (bases 1 to 4483)
  AUTHORS   Vujkovic,M., Kershenbaum,A., Wray,L., McWilliams,T., Cannon,S.,
            Devidas,M., Stork,L. and Aplenc,R.
  TITLE     Associations between genetic variants in folate and drug
            metabolizing pathways and relapse risk in pediatric acute lymphoid
            leukemia on CCG-1952
  JOURNAL   Leuk Res Rep 4 (2), 47-50 (2015)
   PUBMED   26605150
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4483)
  AUTHORS   Jing,M., Rech,L., Wu,Y., Goltz,D., Taylor,C.G. and House,J.D.
  TITLE     Effects of zinc deficiency and zinc supplementation on homocysteine
            levels and related enzyme expression in rats
  JOURNAL   J Trace Elem Med Biol 30, 77-82 (2015)
   PUBMED   25467853
  REMARK    GeneRIF: The objective of this study was to investigate the effects
            of dietary Zn supply on homocysteine levels and expression of
            Methionine synthase and betaine-homocysteine methyltransferase in
            growing rats.
REFERENCE   4  (bases 1 to 4483)
  AUTHORS   Fofou-Caillierez,M.B., Mrabet,N.T., Chery,C., Dreumont,N.,
            Flayac,J., Pupavac,M., Paoli,J., Alberto,J.M., Coelho,D.,
            Camadro,J.M., Feillet,F., Watkins,D., Fowler,B., Rosenblatt,D.S.
            and Gueant,J.L.
  TITLE     Interaction between methionine synthase isoforms and MMACHC:
            characterization in cblG-variant, cblG and cblC inherited causes of
            megaloblastic anaemia
  JOURNAL   Hum Mol Genet 22 (22), 4591-4601 (2013)
   PUBMED   23825108
REFERENCE   5  (bases 1 to 4483)
  AUTHORS   Lu,S.C. and Mato,J.M.
  TITLE     S-adenosylmethionine in liver health, injury, and cancer
  JOURNAL   Physiol Rev 92 (4), 1515-1542 (2012)
   PUBMED   23073625
  REMARK    Review article
REFERENCE   6  (bases 1 to 4483)
  AUTHORS   Watkins,D., Ru,M., Hwang,H.Y., Kim,C.D., Murray,A., Philip,N.S.,
            Kim,W., Legakis,H., Wai,T., Hilton,J.F., Ge,B., Dore,C., Hosack,A.,
            Wilson,A., Gravel,R.A., Shane,B., Hudson,T.J. and Rosenblatt,D.S.
  TITLE     Hyperhomocysteinemia due to methionine synthase deficiency, cblG:
            structure of the MTR gene, genotype diversity, and recognition of a
            common mutation, P1173L
  JOURNAL   Am J Hum Genet 71 (1), 143-153 (2002)
   PUBMED   12068375
REFERENCE   7  (bases 1 to 4483)
  AUTHORS   Huang,L., Zhang,J., Hayakawa,T. and Tsuge,H.
  TITLE     Assays of methylenetetrahydrofolate reductase and methionine
            synthase activities by monitoring 5-methyltetrahydrofolate and
            tetrahydrofolate using high-performance liquid chromatography with
            fluorescence detection
  JOURNAL   Anal Biochem 299 (2), 253-259 (2001)
   PUBMED   11730351
REFERENCE   8  (bases 1 to 4483)
  AUTHORS   Swanson,D.A., Liu,M.L., Baker,P.J., Garrett,L., Stitzel,M., Wu,J.,
            Harris,M., Banerjee,R., Shane,B. and Brody,L.C.
  TITLE     Targeted disruption of the methionine synthase gene in mice
  JOURNAL   Mol Cell Biol 21 (4), 1058-1065 (2001)
   PUBMED   11158293
REFERENCE   9  (bases 1 to 4483)
  AUTHORS   Yamada,K., Tobimatsu,T. and Toraya,T.
  TITLE     Cloning, sequencing, and heterologous expression of rat methionine
            synthase cDNA
  JOURNAL   Biosci Biotechnol Biochem 62 (11), 2155-2160 (1998)
   PUBMED   9972236
REFERENCE   10 (bases 1 to 4483)
  AUTHORS   Cheng,F.W., Shane,B. and Stokstad,E.L.
  TITLE     The anti-folate effect of methionine on bone marrow of normal and
            vitamin B12 deficient rats
  JOURNAL   Br J Haematol 31 (3), 323-336 (1975)
   PUBMED   1201245
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Nov 26, 2020 this sequence version replaced NM_030864.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF034214.1, SRR26643287.33970.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-278               JAXUCZ010000017.1  62911778-62912055
            279-493             JAXUCZ010000017.1  62918585-62918799
            494-583             JAXUCZ010000017.1  62923014-62923103
            584-653             JAXUCZ010000017.1  62924408-62924477
            654-746             JAXUCZ010000017.1  62926469-62926561
            747-853             JAXUCZ010000017.1  62928076-62928182
            854-916             JAXUCZ010000017.1  62930747-62930809
            917-1011            JAXUCZ010000017.1  62939554-62939648
            1012-1112           JAXUCZ010000017.1  62940996-62941096
            1113-1174           JAXUCZ010000017.1  62942724-62942785
            1175-1242           JAXUCZ010000017.1  62944602-62944669
            1243-1322           JAXUCZ010000017.1  62947031-62947110
            1323-1435           JAXUCZ010000017.1  62948674-62948786
            1436-1576           JAXUCZ010000017.1  62950556-62950696
            1577-1762           JAXUCZ010000017.1  62954152-62954337
            1763-1942           JAXUCZ010000017.1  62958935-62959114
            1943-2059           JAXUCZ010000017.1  62961959-62962075
            2060-2200           JAXUCZ010000017.1  62962660-62962800
            2201-2290           JAXUCZ010000017.1  62964643-62964732
            2291-2443           JAXUCZ010000017.1  62965815-62965967
            2444-2551           JAXUCZ010000017.1  62970877-62970984
            2552-2652           JAXUCZ010000017.1  62971860-62971960
            2653-2720           JAXUCZ010000017.1  62979294-62979361
            2721-2841           JAXUCZ010000017.1  62979806-62979926
            2842-2923           JAXUCZ010000017.1  62983847-62983928
            2924-3022           JAXUCZ010000017.1  62985055-62985153
            3023-3098           JAXUCZ010000017.1  62986206-62986281
            3099-3254           JAXUCZ010000017.1  62988746-62988901
            3255-3451           JAXUCZ010000017.1  62990308-62990504
            3452-3652           JAXUCZ010000017.1  62993064-62993264
            3653-3845           JAXUCZ010000017.1  62993937-62994129
            3846-3958           JAXUCZ010000017.1  62995336-62995448
            3959-4483           JAXUCZ010000017.1  62996017-62996541
FEATURES             Location/Qualifiers
     source          1..4483
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.1"
     gene            1..4483
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /note="5-methyltetrahydrofolate-homocysteine
                     methyltransferase"
                     /db_xref="GeneID:81522"
                     /db_xref="RGD:621283"
     exon            1..278
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            279..493
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..4045
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /EC_number="2.1.1.13"
                     /note="MS; vitamin-B12 dependent methionine synthase;
                     cobalamin-dependent methionine synthase"
                     /codon_start=1
                     /product="methionine synthase"
                     /protein_id="NP_110491.2"
                     /db_xref="GeneID:81522"
                     /db_xref="RGD:621283"
                     /translation="MKKTLQDEIEAILRKRIMVLDGGMGTMIQRYKLSEENFQGQEFK
                     DHSRPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAY
                     RMNKCSADVARKAAEEITLQTGVKRFVAGSLGPTNKTLSVSPSVERPDYRNITFDELV
                     EAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQKLFEENYASPRPIFISGTIVD
                     KSGRTLSGQTGEAFVTSVSHSDPLCIGLNCALGAAEMRPFIETIGKCTTAYVLCYPNA
                     GLPNTFGDYDETPAMMAMHLKDFAVDGLVNVVGGCCGSTPDHIREIAEAVKNCKPRVP
                     PDSVFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSKKFAKLIMAGNYEEALSVAKV
                     QVEMGAQVLDINMDDGMLDGPSAMTKFCNFIASEPDIAKVPLCIDSSNFAVIEAGLKC
                     CQGKCIVNSISLKEGEEDFLEKARKIKKFGAAVVVMAFDEEGQATETDVKVSVCTRAY
                     HLLVEKVGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATRVIKETLPGVRISGGLS
                     NLSFAFRGMDAIREAMHGVFLYHAIKFGMDMGIVNAGSLPVYDDIHKDLLQLCEDLIW
                     NRDAEATEKLLRYAQTHGKGGKKVIQTDEWRNGSIEERLEYALVKGIEKHIVEDTEEA
                     RLNREKYPRPLNIIEGPLMNGMKVVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFME
                     KEREEARVLNGSVEEEDPYQGTIVLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMT
                     PCDKILQAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIKIPLLIGGATTSRTHT
                     AVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLKDDYFEEILEEYEDIRQDHYESLKE
                     RKYLPLSQARKHSFHIDWLSEPHPVKPTFIGTQVFEDYNLQKLVDYIDWKPFFDVWQL
                     RGKYPNRGFPKIFNDKAVGEEARKVYEDAQNMLNILISRKKLRARGVVGFWPAQSVQD
                     DIHLYAEGAVPQAAEPIATFYGLRQQAEKDSSSTDPYHCLSDFVAPLHSGVRDYLGLF
                     AVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELWAYCGSEQL
                     GVTDLRKLRYEGIRPAPGYPSQPDHTEKLTMWRLANIEQATGIRLTESLAMAPASAVS
                     GLYFSNVKSKYFAVGKISKDQIEDYALRKNMSVAEVEKWLGPILGYDTD"
     exon            494..583
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            584..653
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            654..746
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            747..853
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            854..916
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1011
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1112
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1174
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1242
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1322
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1435
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1576
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1762
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1942
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2059
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2200
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2290
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2443
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2551
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2652
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2720
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..2841
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..2923
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            2924..3022
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            3023..3098
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            3099..3254
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..3451
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            3452..3652
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            3653..3845
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            3846..3958
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
     exon            3959..4483
                     /gene="Mtr"
                     /gene_synonym="methioninesynthase"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtggccgtg tctacgtagt ctactccttt agtcttacgt tgaggccttg gcagtaacgc
       61 ggacctctgc gcttgggagt taggtaagaa gcgcgtgccc gaggtgcagt acccggaggc
      121 ccggtgtgtc tgctctggag cttcagggat ctcgtgagcc agttcgtcag gccactaaac
      181 gctggctgga gtcgcctgcg gtaggattct ttggagatca agctttcttt gcttgaagag
      241 gacgtttggc ggcgtgtcgc ctgcgctggt gcagccggga gagatgaaga aaaccctgca
      301 ggatgagatt gaagccattc ttcggaagag gattatggtg ctagatggcg ggatggggac
      361 catgatccag cggtacaaac taagcgaaga aaatttccaa ggtcaagagt ttaaagacca
      421 cagcaggcca ctgaaaggca acaatgacat cttgagtata actcagcctg atgttattta
      481 ccagattcat aaggaatact tgctggccgg agcagacatc attgaaacaa acactttcag
      541 cagcactagt atcgcccagg ctgactatgg cctcgaacac ttggcctacc ggatgaacaa
      601 atgctccgca gacgtggcca gaaaagccgc cgaggagata actctgcaga caggagtcaa
      661 gaggtttgtg gctggatctc tgggtccgac taacaagaca ctttcagttt ccccatctgt
      721 ggaaaggcca gattacagga acatcacatt tgatgagctt gttgaagcat accaggagca
      781 ggccaaggga ctgctggatg gtggggttga catcttactc attgagacga tttttgatac
      841 agccaatgcc aaagcagcct tgtttgcgct ccagaaactc tttgaagaga attatgcttc
      901 tcccaggcct atctttattt ctgggaccat tgttgataaa agtggacgga ctctttctgg
      961 ccagacagga gaggcttttg tcaccagcgt gtctcattca gaccccctgt gcattggatt
     1021 aaattgtgct ctgggtgcag ctgaaatgag gcctttcatt gaaacaattg gaaaatgtac
     1081 aacagcttat gtcctctgtt acccaaatgc aggtcttccc aatacctttg gtgattatga
     1141 tgaaacacca gccatgatgg ccatgcacct gaaggacttt gccgtggacg gcttggtgaa
     1201 tgtagttggt ggatgctgtg gttcaacgcc tgatcacatc agggaaattg cagaagctgt
     1261 gaaaaattgt aagccaagag ttccccctga tagtgttttt gaaggacata tgttactgtc
     1321 tggtctagag cccttcagga ttggaccata cactaacttt gttaacattg gagagcgctg
     1381 taacgtggca ggatccaaga aatttgctaa gctcatcatg gcaggaaact atgaggaagc
     1441 cctgagcgtt gccaaagtgc aggtggaaat gggagctcag gtgctggata tcaacatgga
     1501 tgacggcatg ctggatggtc ccagtgcgat gaccaaattt tgcaacttca ttgcttcgga
     1561 gcctgacatt gccaaggtgc ccctgtgcat tgactcttcc aattttgctg tgatcgaggc
     1621 ggggttgaag tgctgccaag ggaagtgcat agtcaacagc atcagcctga aggaggggga
     1681 ggaggacttc ctggagaagg ccaggaagat taagaagttt ggagctgctg tggtggttat
     1741 ggcttttgat gaggaaggac aggcaacaga aacagatgtt aaagtcagtg tgtgcactag
     1801 agcctaccat ctacttgtgg aaaaagtggg cttcaatcca aatgatatca tctttgaccc
     1861 caacatcctt accattggaa ctggaatgga agaacataac ttgtatgcta tcaattttat
     1921 tcatgcaacg agagtcatta aggaaacatt accaggagtc agaataagtg gaggtctctc
     1981 caacctatcc ttcgccttcc gagggatgga cgccattcga gaagcaatgc acggtgtttt
     2041 cctttatcat gcaatcaagt tcggtatgga catggggata gtcaatgccg gcagtctccc
     2101 cgtgtacgat gatatccata aggaccttct tcagctctgt gaagacctca tctggaacag
     2161 agacgctgag gctactgaga aactcttacg atatgcccag actcatggca aaggagggaa
     2221 gaaagtcatc cagacagatg agtggaggaa tggctcgatt gaagagcgcc tggagtatgc
     2281 tcttgtgaag ggcattgaaa agcacattgt tgaagacact gaagaagcca ggttaaaccg
     2341 ggaaaaatac ccccggcctc tgaatataat tgaagggccc ctgatgaatg gcatgaaagt
     2401 ggttggtgat ctttttggag ctggaaaaat gtttctacct caggttataa agtcagcccg
     2461 tgtcatgaag aaggctgttg gccaccttat ccctttcatg gaaaaagaaa gagaagaagc
     2521 cagggtgctt aatggttcgg ttgaagaaga ggacccttac caaggcacca ttgtgctggc
     2581 cactgttaaa ggtgatgtgc atgacattgg caagaacatt gttggtgtgg tgctgggctg
     2641 taataatttc agagttattg atttaggagt catgactccc tgtgataaga tacttcaagc
     2701 tgctctggac cacaaagcag atataattgg cttgtcagga ctcatcacgc catccttgga
     2761 tgaaatgatt tttgttgcca aggaaatgga gaggttggct ataaagattc cattgttgat
     2821 aggaggagca accacttcaa gaacccacac agcagttaaa atagcaccac ggtacagtgc
     2881 gcctgtaatc catgttctag atgcatccaa gagtgtggtg gtgtgttctc agctgttaga
     2941 tgaaaatctg aaagatgact actttgaaga aatactggaa gagtatgaag atattagaca
     3001 ggaccactac gagtctctca aagagagaaa atacttaccc ctaagtcaag ccagaaaaca
     3061 cagtttccac attgattggc tgtctgaacc tcacccagtg aagcccacgt ttattgggac
     3121 ccaggtcttt gaagactaca acctgcaaaa gctggtggac tacattgact ggaagccttt
     3181 ctttgatgtc tggcagctcc gcggcaagta cccgaaccga ggatttccca agatattcaa
     3241 tgacaaagca gtaggtgaag aagccagaaa ggtatatgag gatgctcaga acatgctgaa
     3301 catactgatc agtcgaaaga aactccgggc caggggtgtg gttggattct ggccagcaca
     3361 gagcgtccaa gatgacatcc acctgtatgc agagggggcg gtgccccagg ccgccgagcc
     3421 catagccacc ttctatggac tgaggcagca ggctgagaag gactcctcca gtacagaccc
     3481 ctaccactgc ctctcagact tcgttgctcc tctgcattct ggtgtccgtg actacttggg
     3541 tctgtttgct gtggcctgct ttggggttga agagctgagt aaggcctatg aggatgatgg
     3601 cgatgactac agcagcatca tggtgaaggc cctgggggac aggctggcgg aggcctttgc
     3661 agaggagctc cacgagagag tgcgcagaga actctgggct tactgtggga gtgagcagtt
     3721 gggtgtcaca gacttgcgca aactccgcta tgagggcatc cggccagctc ctggttaccc
     3781 cagccagcct gaccataccg agaagctcac catgtggagg ctggccaaca tcgagcaggc
     3841 cacaggcatc aggttgacag aatccttggc aatggcacct gcttcagcag tgtcgggtct
     3901 ctacttctcc aatgtaaagt ccaaatattt tgctgtgggg aaaatttcca aagatcagat
     3961 tgaggattat gccttgagga agaacatgtc agtggccgag gtggaaaaat ggcttggccc
     4021 cattctggga tatgatacag actgacttct ctctctcctt tactcttttc tgtttctttt
     4081 tgaaactttt atgtttgccg acctcaaggg gctatagtcc agtgtgcctt agaaataaca
     4141 acagaaaagc gcctttgtgt ctgcctgccc tgccctgctg tgagaaggct ggttgatggc
     4201 atgtgatgta gagcgtcttc tagggtctgg gaaaataagc acttttccag ggaccttaaa
     4261 ggaggagcaa caaggtgcca aagctcatgg tgtccctgag ccctcaggat tgggacaagc
     4321 agaagacatc ttttggattt caaagcaggg cacccagctt tttaccattt ttgcctttga
     4381 cccaggaagg cacttgttcc tgggtttgtc tgtttggttc tttgtcttgg tttgttttgt
     4441 ttgttttatt gactgcctag tatattaaaa aagattctga aaa
//
