LOCUS       NM_024374               1338 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus myotrophin (Mtpn), mRNA.
ACCESSION   NM_024374
VERSION     NM_024374.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1338)
  AUTHORS   Das,B., Gupta,S., Vasanji,A., Xu,Z., Misra,S. and Sen,S.
  TITLE     Nuclear co-translocation of myotrophin and p65 stimulates myocyte
            growth. Regulation by myotrophin hairpin loops
  JOURNAL   J Biol Chem 283 (41), 27947-27956 (2008)
   PUBMED   18693253
  REMARK    GeneRIF: after internalization into myocytes, myotrophin
            cotranslocates into the nucleus with p65 to stimulate myocyte
            growth.
REFERENCE   2  (bases 1 to 1338)
  AUTHORS   Lowe,A.R. and Itzhaki,L.S.
  TITLE     Biophysical characterisation of the small ankyrin repeat protein
            myotrophin
  JOURNAL   J Mol Biol 365 (4), 1245-1255 (2007)
   PUBMED   17113103
  REMARK    GeneRIF: characterisation of the small ankyrin repeat protein
            myotrophin
REFERENCE   3  (bases 1 to 1338)
  AUTHORS   Bhattacharya,N., Ghosh,S., Sept,D. and Cooper,J.A.
  TITLE     Binding of myotrophin/V-1 to actin-capping protein: implications
            for how capping protein binds to the filament barbed end
  JOURNAL   J Biol Chem 281 (41), 31021-31030 (2006)
   PUBMED   16895918
REFERENCE   4  (bases 1 to 1338)
  AUTHORS   Knuefermann,P., Shi,S.P., Chen,P., Sakata,Y., Baumgarten,G. and
            Sivasubramanian,N.
  TITLE     Myotrophin/V-1 does not act as an extracellular signal to induce
            myocyte hypertrophy
  JOURNAL   Tex Heart Inst J 33 (3), 281-289 (2006)
   PUBMED   17041682
  REMARK    GeneRIF: Results suggest that myotrophin V1 is a predominantly
            cytosolic protein that could regulate the NFkappa-beta mediated
            transcription process.
REFERENCE   5  (bases 1 to 1338)
  AUTHORS   Adhikary,G., Gupta,S., Sil,P., Saad,Y. and Sen,S.
  TITLE     Characterization and functional significance of myotrophin: a gene
            with multiple transcripts
  JOURNAL   Gene 353 (1), 31-40 (2005)
   PUBMED   15946807
  REMARK    GeneRIF: Data strongly suggest that myotrophin appears to be a
            candidate gene for cardiac hypertrophy and heart failure.
REFERENCE   6  (bases 1 to 1338)
  AUTHORS   Yang,Y., Rao,N.S., Walker,E., Sen,S. and Qin,J.
  TITLE     Nuclear magnetic resonance assignment and secondary structure of an
            ankyrin-like repeat-bearing protein: myotrophin
  JOURNAL   Protein Sci 6 (6), 1347-1351 (1997)
   PUBMED   9194197
REFERENCE   7  (bases 1 to 1338)
  AUTHORS   Sivasubramanian,N., Adhikary,G., Sil,P.C. and Sen,S.
  TITLE     Cardiac myotrophin exhibits rel/NF-kappa B interacting activity in
            vitro
  JOURNAL   J Biol Chem 271 (5), 2812-2816 (1996)
   PUBMED   8576259
REFERENCE   8  (bases 1 to 1338)
  AUTHORS   Taoka,M., Isobe,T., Okuyama,T., Watanabe,M., Kondo,H., Yamakawa,Y.,
            Ozawa,F., Hishinuma,F., Kubota,M., Minegishi,A. et al.
  TITLE     Murine cerebellar neurons express a novel gene encoding a protein
            related to cell cycle control and cell fate determination proteins
  JOURNAL   J Biol Chem 269 (13), 9946-9951 (1994)
   PUBMED   8144589
REFERENCE   9  (bases 1 to 1338)
  AUTHORS   Sil,P., Misono,K. and Sen,S.
  TITLE     Myotrophin in human cardiomyopathic heart
  JOURNAL   Circ Res 73 (1), 98-108 (1993)
   PUBMED   8508536
REFERENCE   10 (bases 1 to 1338)
  AUTHORS   Taoka,M., Yamakuni,T., Song,S.Y., Yamakawa,Y., Seta,K., Okuyama,T.
            and Isobe,T.
  TITLE     A rat cerebellar protein containing the cdc10/SWI6 motif
  JOURNAL   Eur J Biochem 207 (2), 615-620 (1992)
   PUBMED   1633812
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088136.1.
            
            On Jun 10, 2007 this sequence version replaced NM_024374.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088136.1, AY951952.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1338
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..1338
                     /gene="Mtpn"
                     /gene_synonym="Gcdp"
                     /note="myotrophin"
                     /db_xref="GeneID:79215"
                     /db_xref="RGD:619806"
     exon            1..191
                     /gene="Mtpn"
                     /gene_synonym="Gcdp"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..476
                     /gene="Mtpn"
                     /gene_synonym="Gcdp"
                     /note="growth factor; stimulates myocyte growth; protein
                     V-1; granule cell differentiation protein; V-1 protein"
                     /codon_start=1
                     /product="myotrophin"
                     /protein_id="NP_077350.1"
                     /db_xref="GeneID:79215"
                     /db_xref="RGD:619806"
                     /translation="MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAAD
                     CGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGL
                     TALEATDNQAIKALLQ"
     exon            192..305
                     /gene="Mtpn"
                     /gene_synonym="Gcdp"
                     /inference="alignment:Splign:2.1.0"
     exon            306..389
                     /gene="Mtpn"
                     /gene_synonym="Gcdp"
                     /inference="alignment:Splign:2.1.0"
     exon            390..1314
                     /gene="Mtpn"
                     /gene_synonym="Gcdp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctagccgc ggcccacagt ctcgcccgct cggctgcctg aggcacgtcg tttcctcgtg
       61 tccttcgtcg ggcgtaatcg ccgcttctgc ccgacccgcc ggcccatccc gctgcagtga
      121 tgtgcgacaa ggagttcatg tgggccctga aaaacggaga cttggatgag gtgaaggact
      181 atgtggctaa gggagaagat gtcaaccgga cactagaggg tgggaggaag cctcttcact
      241 atgctgcaga ttgtggacag cttgaaatcc tggaatttct gctgctgaaa ggagcagata
      301 ttaatgctcc agataaacat catatcaccc ctcttctgtc tgctgtctat gagggtcatg
      361 tttcctgtgt gaaattgctt ctgtcaaagg gtgctgataa gactgtgaaa ggcccagatg
      421 gactgaccgc ccttgaagcc actgacaacc aggcaatcaa agctcttctc cagtgatgga
      481 tggatggact gataacttgg gaagaatgac tctcctgtgg cctcacactg ctgcctgtct
      541 gtctgtcact ttctatctgc cagcttcttc agctaaatac tttaagaggg tgaagggaga
      601 gagaaattca taacaaatca gactgccagg ggggaattaa acatgttttg gaggagcagt
      661 ggggaatgtg atgagacttt tactgggatt cctgaacaaa ccagcctgtt tttcatttcc
      721 agtaaaatat acagcttata cccaagggag agcagaaata ccgtctgctg gaatccttgg
      781 accttctcag ctccctagtg atttcttaat tagtgtactg aaggtctggc cacacaaggc
      841 caactcttcc tatttggtgg ccctagctgt gagcagtagt ggctgctgtt ctgtcaactt
      901 agggtgctga gataagcaat tagctccagc cttccttctg ccttaagaat gcactctcct
      961 gggggctcct ggctggttaa gagcgctgcc tgcagttagt gaccaaaacc tctctcgaat
     1021 gactttagtc tttatgtaag agcttagata aggttaggag cagcgcactc ctcaattgct
     1081 ggatgactaa actttggatt ttctctcccc tttcacatca atttcatgtc tcttttagat
     1141 aaaactgact agttttattt ataaaatgtt aaattctagg agcctaaagg aggaaccatt
     1201 ccagtaggct gatttctttt ttctccttta gactcagaca tttatataac attgaaacac
     1261 tttgagactc cttctggtag taaaggagat ttaaaaataa aatcatagcc ataaaaaaaa
     1321 aaaaaaaaaa aaaaaaaa
//
