LOCUS       NP_001386242             584 aa            linear   ROD 31-MAR-2024
DEFINITION  poly(A) RNA polymerase, mitochondrial isoform 1 [Rattus
            norvegicus].
ACCESSION   NP_001386242 XP_038951672
VERSION     NP_001386242.1
DBSOURCE    REFSEQ: accession NM_001399313.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 584)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (residues 1 to 584)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (residues 1 to 584)
  AUTHORS   Bai,Y., Srivastava,S.K., Chang,J.H., Manley,J.L. and Tong,L.
  TITLE     Structural basis for dimerization and activity of human PAPD1, a
            noncanonical poly(A) polymerase
  JOURNAL   Mol Cell 41 (3), 311-320 (2011)
   PUBMED   21292163
REFERENCE   4  (residues 1 to 584)
  AUTHORS   Crosby,A.H., Patel,H., Chioza,B.A., Proukakis,C., Gurtz,K.,
            Patton,M.A., Sharifi,R., Harlalka,G., Simpson,M.A., Dick,K.,
            Reed,J.A., Al-Memar,A., Chrzanowska-Lightowlers,Z.M., Cross,H.E.
            and Lightowlers,R.N.
  TITLE     Defective mitochondrial mRNA maturation is associated with spastic
            ataxia
  JOURNAL   Am J Hum Genet 87 (5), 655-660 (2010)
   PUBMED   20970105
  REMARK    GeneRIF: Our molecular investigation of an autosomal-recessive
            spastic ataxia with optic atrophy, present among the Old Order
            Amish, identified a mutation of MTPAP associated with the disease
            phenotype.
REFERENCE   5  (residues 1 to 584)
  AUTHORS   Mullen,T.E. and Marzluff,W.F.
  TITLE     Degradation of histone mRNA requires oligouridylation followed by
            decapping and simultaneous degradation of the mRNA both 5' to 3'
            and 3' to 5'
  JOURNAL   Genes Dev 22 (1), 50-65 (2008)
   PUBMED   18172165
REFERENCE   6  (residues 1 to 584)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Jan 6, 2022 this sequence version replaced XP_038951672.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.61123.1,
                                           SRR26643298.69503.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760434 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..584
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.1"
     Protein         1..584
                     /product="poly(A) RNA polymerase, mitochondrial isoform 1"
                     /EC_number="2.7.7.19"
                     /note="poly(A) RNA polymerase, mitochondrial; PAP
                     associated domain containing 1"
                     /calculated_mol_wt=64637
     Region          63..131
                     /region_name="RL"
                     /note="RL domain; pfam17797"
                     /db_xref="CDD:465510"
     Region          184..>496
                     /region_name="TRF4"
                     /note="DNA polymerase sigma [Replication, recombination
                     and repair]; COG5260"
                     /db_xref="CDD:227585"
     Region          209..347
                     /region_name="NT_PAP_TUTase"
                     /note="Nucleotidyltransferase (NT) domain of poly(A)
                     polymerases and terminal uridylyl transferases; cd05402"
                     /db_xref="CDD:143392"
     Site            order(233..235,245..246,248,312..313,315,317,328,335..336,
                     339..340)
                     /site_type="active"
                     /db_xref="CDD:143392"
     Site            order(233,312,315,317,328,335..336)
                     /site_type="active"
                     /note="putative primer-binding pocket [active]"
                     /db_xref="CDD:143392"
     Site            order(246,248,328)
                     /site_type="metal-binding"
                     /note="metal binding triad [ion binding]"
                     /db_xref="CDD:143392"
     CDS             1..584
                     /gene="Mtpap"
                     /gene_synonym="Papd1"
                     /coded_by="NM_001399313.1:20..1774"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:307050"
                     /db_xref="RGD:1310900"
ORIGIN      
        1 maargvgllt rlplcsqrrs rvphsisrhl scpgtrvasv gseeqpsgga etgtedktlq
       61 kkfsevqker reqaqrtvli hcpnninekk flkylsqhgs isnhffyesf glyavvefcq
      121 kdsinslqng thtptqstea aipfksrfln lklknpsnqv sgqsfvqads qsppsskklf
      181 ellsyaesid aqltallkaf qlteenvrlr hltcsliedi aaayfpscvv wpfgssvntf
      241 gklgcdldmf ldldetgnls dhkntgnflm efqvknvpse rvatqkilsv igecldnfgp
      301 gcvgvqkiln arcplvrfsh qgsgfqcdlt annsialkss ellyiygsld srvralvfgv
      361 rcwarahslt ssipgawitn fsltmmviff lqrrsppilp tldslksmad aedrcilegn
      421 nctfiqdink ikpsgntetl elllkeffey fgnfafnkns inirqgreqn kpdssplyiq
      481 npfetslnis knvsqnqlqk fvelardsaw ileqekkdqp sssshpwgla alllppgagq
      541 tslsrkkkkk pmsekvkgll asiksnspdr stdasgkrav stqa
//
