LOCUS       NM_019906               8543 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Rattus norvegicus mechanistic target of rapamycin kinase (Mtor),
            mRNA.
ACCESSION   NM_019906
VERSION     NM_019906.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8543)
  AUTHORS   Huang,Y., Yue,S., Yan,Z., Liu,Y., Qiao,J., Zhang,M., Dong,Y. and
            Zheng,J.
  TITLE     Lactate-upregulated ARG2 expression induces cellular senescence in
            fibroblast-like synoviocytes of osteoarthritis via activating the
            mTOR/S6K1 signaling pathway
  JOURNAL   Int Immunopharmacol 142 (Pt A), 113071 (2024)
   PUBMED   39236462
  REMARK    GeneRIF: Lactate-upregulated ARG2 expression induces cellular
            senescence in fibroblast-like synoviocytes of osteoarthritis via
            activating the mTOR/S6K1 signaling pathway.
REFERENCE   2  (bases 1 to 8543)
  AUTHORS   Liu,N., Li,C., Yan,C., Yan,H.C., Jin,B.X., Yang,H.R., Jiang,G.Y.,
            Gong,H.D., Li,J.Y., Ma,S.J., Liu,H.L. and Gao,C.
  TITLE     BCAT1 alleviates early brain injury by inhibiting ferroptosis
            through PI3K/AKT/mTOR/GPX4 pathway after subarachnoid hemorrhage
  JOURNAL   Free Radic Biol Med 222, 173-186 (2024)
   PUBMED   38871197
  REMARK    GeneRIF: BCAT1 alleviates early brain injury by inhibiting
            ferroptosis through PI3K/AKT/mTOR/GPX4 pathway after subarachnoid
            hemorrhage.
REFERENCE   3  (bases 1 to 8543)
  AUTHORS   Wei,X.H., Liao,L.Y., Yin,Y.X., Xu,Q., Xie,S.S., Liu,M., Gao,L.B.,
            Chen,H.Q. and Zhou,R.
  TITLE     Overexpression of long noncoding RNA DUXAP8 inhibits ER-phagy
            through activating AKT/mTOR signaling and contributes to
            preeclampsia
  JOURNAL   Cell Mol Life Sci 81 (1), 336 (2024)
   PUBMED   39120751
  REMARK    GeneRIF: Overexpression of long noncoding RNA DUXAP8 inhibits
            ER-phagy through activating AKT/mTOR signaling and contributes to
            preeclampsia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8543)
  AUTHORS   Wang,X., Liu,H., Wang,Y., Wang,P., Yi,Y., Lin,Y. and Li,X.
  TITLE     Novel protein C6ORF120 promotes liver fibrosis by activating
            hepatic stellate cells through the PI3K/Akt/mTOR pathway
  JOURNAL   J Gastroenterol Hepatol 39 (7), 1422-1430 (2024)
   PUBMED   38523410
  REMARK    GeneRIF: Novel protein C6ORF120 promotes liver fibrosis by
            activating hepatic stellate cells through the PI3K/Akt/mTOR
            pathway.
REFERENCE   5  (bases 1 to 8543)
  AUTHORS   Banjac,K., Obradovic,M., Zafirovic,S., Essack,M., Gluvic,Z.,
            Sunderic,M., Nedic,O. and Isenovic,E.R.
  TITLE     The involvement of Akt, mTOR, and S6K in the in vivo effect of
            IGF-1 on the regulation of rat cardiac Na+/K+-ATPase
  JOURNAL   Mol Biol Rep 51 (1), 517 (2024)
   PUBMED   38622478
  REMARK    GeneRIF: The involvement of Akt, mTOR, and S6K in the in vivo
            effect of IGF-1 on the regulation of rat cardiac Na[+]/K[+]-ATPase.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8543)
  AUTHORS   Gingras,A.C., Gygi,S.P., Raught,B., Polakiewicz,R.D., Abraham,R.T.,
            Hoekstra,M.F., Aebersold,R. and Sonenberg,N.
  TITLE     Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism
  JOURNAL   Genes Dev 13 (11), 1422-1437 (1999)
   PUBMED   10364159
REFERENCE   7  (bases 1 to 8543)
  AUTHORS   Sabatini,D.M., Barrow,R.K., Blackshaw,S., Burnett,P.E., Lai,M.M.,
            Field,M.E., Bahr,B.A., Kirsch,J., Betz,H. and Snyder,S.H.
  TITLE     Interaction of RAFT1 with gephyrin required for rapamycin-sensitive
            signaling
  JOURNAL   Science 284 (5417), 1161-1164 (1999)
   PUBMED   10325225
REFERENCE   8  (bases 1 to 8543)
  AUTHORS   Brunn,G.J., Hudson,C.C., Sekulic,A., Williams,J.M., Hosoi,H.,
            Houghton,P.J., Lawrence,J.C. Jr. and Abraham,R.T.
  TITLE     Phosphorylation of the translational repressor PHAS-I by the
            mammalian target of rapamycin
  JOURNAL   Science 277 (5322), 99-101 (1997)
   PUBMED   9204908
REFERENCE   9  (bases 1 to 8543)
  AUTHORS   Sabers,C.J., Martin,M.M., Brunn,G.J., Williams,J.M., Dumont,F.J.,
            Wiederrecht,G. and Abraham,R.T.
  TITLE     Isolation of a protein target of the FKBP12-rapamycin complex in
            mammalian cells
  JOURNAL   J Biol Chem 270 (2), 815-822 (1995)
   PUBMED   7822316
REFERENCE   10 (bases 1 to 8543)
  AUTHORS   Sabatini,D.M., Erdjument-Bromage,H., Lui,M., Tempst,P. and
            Snyder,S.H.
  TITLE     RAFT1: a mammalian protein that binds to FKBP12 in a
            rapamycin-dependent fashion and is homologous to yeast TORs
  JOURNAL   Cell 78 (1), 35-43 (1994)
   PUBMED   7518356
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1 and U11681.1.
            
            On Nov 22, 2020 this sequence version replaced NM_019906.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U11681.1, L37085.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 JAXUCZ010000005.1  164167985-164167989
            6-8004              U11681.1           17-8015
            8005-172198309      JAXUCZ010000005.1  1-172190305
            172198310-172198847 U11681.1           8017-8554
FEATURES             Location/Qualifiers
     source          1..8543
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..8543
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /note="mechanistic target of rapamycin kinase"
                     /db_xref="GeneID:56718"
                     /db_xref="RGD:68371"
     exon            1..38
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            39..214
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..7702
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.10.2"
                     /note="FK506 binding protein 12-rapamycin associated
                     protein 1; RAPT1; mammalian target of rapamycin;
                     FKBP12-rapamycin complex-associated protein; FK506-binding
                     protein 12-rapamycin complex-associated protein 1;
                     rapamycin target protein 1; mechanistic target of
                     rapamycin (serine/threonine kinase); rapamycin and FKBP12
                     target-1 protein; tyrosine-protein kinase mTOR"
                     /codon_start=1
                     /product="serine/threonine-protein kinase mTOR"
                     /protein_id="NP_063971.1"
                     /db_xref="GeneID:56718"
                     /db_xref="RGD:68371"
                     /translation="MLGTGPATATAGAATSSNVSVLQQFASGLKSRNEETRAKAAKEL
                     QHYVTMELREMSQEESTRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNST
                     RIGRFANYLRNLLPSSDPVVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADR
                     NEGRRHAAVLVLRELAISVPTFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLI
                     LTTQREPKEMQKPQWYRHTFEEAEKGFDETLAKEKGMNRDDRIHGALLILNELVRISS
                     MEGERLREEMEEITQQQLVHDKYCKDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLL
                     GYSSHQGLMGFGASPSPTKSTLVESRCCRDLMEEKFDQVCQWVLKCRSSKNSLIQMTI
                     LNLLPRLAAFRPSAFTDTQYLQDTMNHVLSCVKKEKERTAAFQALGLLSVAVRSEFKV
                     YLPRVLDIIRAALPPKDFAHKRQKTVQVDATVFTCISMLARAMGPGIQQDIKELLEPM
                     LAVGLSPALTAVLYDLSRQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGMPKGLAHQLA
                     SPGLTTLPEASDVASITLALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIRMEAAR
                     TCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASLDER
                     FDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTE
                     LEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDPNPGVINNV
                     LATIGELAQVSGLEMRKWVDELFVIIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVE
                     PYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASA
                     VSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFRDQSLSHHHTMVV
                     QAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLVSFVKSHIRPY
                     MDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLRVFMHDNSQ
                     GRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEVPLPSRKAALETVDRLTESL
                     DFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLVRHRI
                     NHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSSQGDALASGPVETGPMKKLHVST
                     INLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
                     AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDN
                     GIVLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAASGVLEYA
                     MKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLH
                     QQCCEKWTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLAL
                     HQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPE
                     RREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLAL
                     AHKTLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQ
                     QAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDR
                     SWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKLRHASGANITNATTTATTAASAAAAT
                     STEGSNSESEAESNESSPTPSPLQKKVTEDLSKTLLLYTVPAVQGFFRSISLSRGNNL
                     QDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIH
                     QLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEEL
                     IRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAY
                     GRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPKLLM
                     CRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHE
                     DLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHA
                     LIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLK
                     SPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEV
                     AMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRTTCHTVMEVLREHKDSVMAVLEAFV
                     YDPLLNWRLMDTNAKGNKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIH
                     SFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENL
                     CQCYIGWCPFW"
     exon            215..323
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            324..556
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            557..757
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            758..892
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1168
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1277
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1464
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1593
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1838
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..2054
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2260
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2383
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2473
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..2566
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2701
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..2831
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..3082
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3083..3169
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3170..3337
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3338..3450
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3451..3613
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3614..3706
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3707..3853
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3854..3996
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3997..4159
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            4160..4305
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            4306..4381
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            4382..4521
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            4522..4622
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            4623..4738
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            4739..4816
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            4817..4924
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            4925..5050
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            5051..5182
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            5183..5298
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            5299..5416
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            5417..5665
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            5666..5766
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            5767..5863
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            5864..5962
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            5963..6085
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            6086..6268
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            6269..6403
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            6404..6578
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            6579..6714
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            6715..6862
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            6863..6985
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            6986..7068
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            7069..7141
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            7142..7216
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            7217..7352
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            7353..7418
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            7419..7499
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            7500..7580
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            7581..7686
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
     exon            7687..8543
                     /gene="Mtor"
                     /gene_synonym="Frap1; RAFT1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggcggcgg tagctgaggc ggtggccgaa gccgcgcgaa cctcagggca agatgcttgg
       61 gacaggccct gccacggcca ccgccggtgc cgccacatct agcaacgtga gcgttctgca
      121 gcagttcgcc agtgggctga agagccggaa tgaggagacc agggccaaag cagccaagga
      181 gctccagcac tatgtcacca tggaacttcg agagatgagt caggaggagt ctactcgctt
      241 ctatgaccag ctgaaccatc acatttttga actggtttcc agctcagacg ccaatgagag
      301 gaagggtggc atcttggcca ttgccagcct cattggagtg gaaggtggga attccaccag
      361 gattggcaga tttgccaact accttcggaa cctcctcccc tcaagtgatc cagttgtcat
      421 ggagatggca tccaaggcca ttggccgcct tgcaatggca ggggacactt tcactgctga
      481 gtatgtggag tttgaagtga agcgagcctt ggagtggctg ggtgctgacc gaaatgaggg
      541 ccggagacat gcagctgtcc tcgttctccg tgagctggcc atcagcgtcc ccaccttctt
      601 cttccagcaa gttcagccct tctttgacaa catttttgtg gctgtgtggg accccaagca
      661 ggccatccgt gaaggagctg tggctgccct tcgtgcctgt ctgattctta ccacgcagcg
      721 ggagccgaag gagatgcaga agcctcagtg gtacaggcac acatttgaag aagcagagaa
      781 aggttttgat gagaccctgg ccaaagagaa gggtatgaac cgagatgatc gaatccacgg
      841 ggccttgctg atcctcaacg agctcgtccg aatcagcagc atggagggag agcgtctgag
      901 agaggagatg gaggaaatca cccagcagca gctggtacat gacaagtact gcaaagacct
      961 aatgggcttt gggacaaagc ctcggcacat cactcccttc accagcttcc aggctgtgca
     1021 gccccagcag tcaaacgcct tggtgggact gctggggtac agctcccacc aaggcctaat
     1081 ggggtttggg gcttccccca gccctacaaa gtccactctg gtggaaagcc gttgttgcag
     1141 agacttgatg gaagagaaat ttgatcaggt gtgccagtgg gtgctgaaat gtaggagcag
     1201 caagaactca ctgatccaaa tgacaatcct taatctgttg ccccgcttgg ctgcattccg
     1261 accgtctgcc ttcacagata cccagtacct gcaagacacc atgaaccatg tcctgagctg
     1321 tgtcaagaag gaaaaggaac ggaccgcagc gttccaggcc ctagggctgc tttctgtggc
     1381 ggtgaggtcc gagtttaagg tctacctgcc ccgagtactt gacatcatcc gagcagccct
     1441 gcctccaaag gactttgccc acaagaggca gaaaactgtg caggtggatg ccacagtgtt
     1501 cacgtgcatc agcatgctgg cgcgggccat ggggccaggc atccagcagg acatcaagga
     1561 gctgctggag cccatgttgg cagtgggcct gagccctgcg ctcactgctg tgctctatga
     1621 cctgagccgg cagattccgc agctgaagaa agatattcag gacgggcttc tgaagatgct
     1681 gtccctggtc cttatgcaca aacccctgcg gcacccgggc atgcccaaag gcctggccca
     1741 ccagctggcc tccccaggtc ttaccaccct ccctgaggcc agcgacgtgg ccagcatcac
     1801 tcttgccctt cgaactctcg gcagctttga atttgaaggc cactctctga cccagttcgt
     1861 ccgacactgc gcagatcatt tcctgaacag tgagcacaag gagatccgca tggaagcagc
     1921 ccgcacctgc tcccgcctgc tcacaccctc catccacctc atcagcggcc atgcccatgt
     1981 ggttagccag accgcagtgc aagtggtagc agatgtgctc agcaagctgc ttgtggtcgg
     2041 cataacagat cctgatcctg atatccgcta ctgtgtcttg gcctccctgg atgagcgctt
     2101 cgatgcccac ttggcccagg cagaaaactt acaagctctg tttgtggctc tgaatgacca
     2161 ggtctttgag atccgagagc tggccatctg cactgtgggc cgactcagta gcatgaaccc
     2221 agcctttgtc atgcctttcc tgcgcaagat gctcatccag attttgacag agctggagca
     2281 cagtggcatt gggagaatca aggagcagag tgcccgcatg ctggggcacc tggtctccaa
     2341 tgccccccgc ctcatccgcc cctatatgga gcctattctg aaggctttaa ttttgaaact
     2401 caaagatcca gaccctgacc caaacccggg cgtgatcaat aacgtgttgg ccactatagg
     2461 agaactggct caggttagcg gcctggagat gaggaagtgg gtggacgagc tctttgtcat
     2521 catcatggac atgctgcagg actcctctct tctggccaaa agacaggtgg ctttgtggac
     2581 cctgggacag ttggtggcca gtactggcta cgtggtggag ccctacagga agtaccccac
     2641 tctgcttgaa gtgctgctga attttctgaa gacggagcag aaccagggca ctcggagaga
     2701 ggccatccga gtgttagggc tcctcggggc tttggacccc tacaagcaca aagtgaacat
     2761 cggcatgatt gaccagtccc gagatgcttc tgctgtcagc ctgtcagaat ccaagtcaag
     2821 tcaagattcc tctgactaca gcaccagtga aatgctggtc aacatgggaa acctgccact
     2881 ggacgagttc taccccgccg tgtccatggt ggccttgatg cggatcttcc gagaccagtc
     2941 cctctctcac caccacacca tggtggttca ggccatcacc ttcatcttca agtccctggg
     3001 gctcaagtgt gtgcagttcc tgccccaggt catgcccacg ttccttaacg tcatccgagt
     3061 ctgtgatggg gccatccggg aatttctgtt ccagcagctg ggaatgctgg tgtcctttgt
     3121 gaagagccac atccgtccct acatggatga aatagtcacc ctcatgagag aattttgggt
     3181 catgaacacc tcaatccaga gcacaatcat tcttctcatt gagcaaatcg tggtggctct
     3241 tggaggtgaa tttaagctct acctgcccca gctgatccca cacatgctgc gtgtcttcat
     3301 gcatgacaac agccagggcc gcatagtctc catcaagctg ttagcagcga tccagctgtt
     3361 tggcgccaac ctggatgact atctgcactt gttgttgcct ccgatcgtga aattgtttga
     3421 tgcccctgaa gttccactgc cgtcgagaaa ggcagcgttg gagacagtgg accgcctgac
     3481 agagtccctg gatttcactg actatgcctc ccgcatcatt cacccgattg ttcgcacgct
     3541 agaccagagc ccagagctgc gctccacagc catggacacc ctgtcttcac ttgtgtttca
     3601 actagggaag aagtaccaga tcttcattcc aatggtgaat aaagtccttg tgcgacaccg
     3661 gatcaatcac cagcgctacg acgtgctgat ctgcagaatc gtcaaggggt acacgcttgc
     3721 tgatgaagaa gaagaccctt tgatttacca gcatcgaatg ctaaggagca gccagggaga
     3781 tgccctggcc agtggaccag ttgaaacagg acccatgaag aaactgcatg tcagcaccat
     3841 caacctccaa aaggcctggg gagctgccag aagggtctcc aaggacgact ggctggagtg
     3901 gctgcgacgc ttgagtctgg agctgctgaa ggattcctca tcaccttccc tgcgctcatg
     3961 ctgggccctg gcccaggcct acaaccccat ggccagggat ctcttcaacg ctgcgtttgt
     4021 gtcctgctgg tctgaactga atgaagacca acaagatgag ctcatcagga gcattgagtt
     4081 ggctctcact tctcaagaca ttgctgaagt cacacaaacc ctcttgaact tggctgagtt
     4141 catggagcac agtgacaagg gccccctacc actgagagat gacaatggca tcgtgctgtt
     4201 gggtgagaga gctgccaagt gccgggcata tgccaaagca ctacactaca aagagctgga
     4261 gttccagaag gggcccacgc ctgccatact tgagtccctc atcagcatta ataataaact
     4321 gcagcagcct gaggcagcgt ccggggtgtt agagtacgcc atgaaacact tcggagagct
     4381 ggagatccag gccacctggt atgagaagtt gcatgagtgg gaggacgccc ttgtggccta
     4441 cgacaagaag atggacacga acaaggatga cccagagctg atgctgggcc gcatgcgctg
     4501 tctcgaggcc ttgggagaat ggggccagct tcatcagcag tgctgtgaaa agtggactct
     4561 ggttaatgac gagacccagg ctaagatggc ccggatggct gctgcagcag catggggttt
     4621 aggtcagtgg gacagcatgg aggagtacac ctgtatgatt cctcgggata ctcacgatgg
     4681 agcattctac agagcagtgt tggcactgca tcaggatctc ttctccttgg ctcaacagtg
     4741 cattgacaag gccagggacc tgctggacgc cgagctgact gccatggcag gggagagcta
     4801 cagccgagcc tatggggcca tggtttcttg ccacatgctg tccgagctgg aggaggttat
     4861 ccagtacaaa ctcgtcccgg agcgacggga gatcatccgc cagatctggt gggagagact
     4921 gcagggctgc cagcgtattg tagaggactg gcagaaaatc ctcatggtcc ggtcccttgt
     4981 ggtcagccct cacgaggaca tgagaacctg gctcaagtac gcaagcctgt gtggcaagag
     5041 cggcagactg gctcttgctc ataaaacctt agtgttgctc ttgggagttg atccatctcg
     5101 gcaacttgac catcctctgc caacagttca ccctcaagtg acctatgcct acatgaaaaa
     5161 catgtggaaa agcgctcgga agattgatgc cttccagcac atgcagcact ttgtgcagac
     5221 catgcagcag caggcccagc acgccattgc cacagaggac cagcagcaca agcaggagct
     5281 gcataagctc atggccaggt gttttctgaa acttggggag tggcagctga acctccaggg
     5341 catcaacgag agcaccatcc ccaaggtgct acagtactac agtgctgcca cagagcatga
     5401 ccgcagctgg tataaggctt ggcacgcatg ggcagtgatg aactttgaag ccgtgctaca
     5461 ctacaaacat cagaaccaag cccgcgatga gaagaagaaa ctgcgccatg ccagcggggc
     5521 caacatcacc aatgccacca ccactgccac caccgctgcc tccgctgccg ctgccaccag
     5581 cacagagggc agcaacagtg aaagtgaagc cgagagcaat gagagcagcc ccaccccgtc
     5641 ccctctgcag aagaaggtca ctgaggattt gtccaaaacc ctcttgttgt acactgtccc
     5701 tgctgtccaa ggcttcttcc gttctatctc cttgtcgaga ggcaacaacc tccaggatac
     5761 actcagagtc ctcaccttgt ggtttgatta tggtcactgg ccagatgtca atgaagccct
     5821 ggtggaaggg gtgaaggcca tacagattga cacttggtta caggttatac ctcagctcat
     5881 tgcaagaatt gacacgccca gacccttggt gggccggctc attcaccagc tcctcacaga
     5941 tattggtcgg taccacccac aggccctcat ctaccccctg acggtggctt ctaagtctac
     6001 caccacagcc cgtcacaatg cagccaacaa gatcctgaag aacatgtgcg agcacagcaa
     6061 cacgctagtc cagcaggcca tgatggtgag tgaagagctg attcgagtag ccatcctctg
     6121 gcatgagatg tggcatgaag gcctagaaga ggcctctcgc ttgtactttg gggagaggaa
     6181 cgtcaaaggc atgtttgagg tgctggagcc cctgcatgct atgatggaac gcggtcccca
     6241 gaccctgaag gaaacgtcct ttaatcaggc atatggtcga gatttaatgg aggcacaaga
     6301 atggtgccga aagtacatga aatcagggaa cgtcaaggac ctcacccaag cctgggacct
     6361 ctactatcac gtgttcagac ggatctccaa gcagctacca cagctcacat ccctggagct
     6421 gcagtatgtg tcccccaaac ttttgatgtg cagagacctt gaattggctg tgccaggaac
     6481 atatgacccc aaccagccaa tcattcgcat tcagtccata gccccgtctt tgcaagtcat
     6541 cacatccaag cagaggcctc ggaagctgac cctgatgggc agcaatgggc acgagtttgt
     6601 tttcctcctg aaaggccatg aagatctgcg gcaggacgag cgagtgatgc agctctttgg
     6661 cctggtgaac acactcctag ccaatgaccc aacttctctt cgaaagaacc tcagcatcca
     6721 gagatacgcc gtcattcctc tgtccaccaa ctcgggcctg attggctggg tgccccactg
     6781 tgacacgctg catgccctca tccgggacta cagagagaag aagaagatcc tgctgaacat
     6841 cgagcaccgc atcatgctgc ggatggctcc tgactatgac cacctgactc tgatgcagaa
     6901 ggtggaggtg tttgagcatg ctgtcaacaa cacagccggg gatgacctgg ccaagctgct
     6961 gtggctgaaa agccccagct cagaggtgtg gtttgaccga agaaccaatt atactcgctc
     7021 cctggctgtc atgtccatgg ttggatacat tttaggcctt ggagacaggc acccatccaa
     7081 cctgatgctg gaccggctga gtggaaagat cctgcacatt gactttgggg actgctttga
     7141 ggttgctatg accagagaga aatttccaga aaagattcca tttagactaa caagaatgtt
     7201 gaccaatgct atggaggtta ccggtctcga tggcaactat agaaccacat gccacacagt
     7261 gatggaggtg cttcgggagc acaaggacag tgtcatggct gtgctagaag cctttgtcta
     7321 tgaccctctg ctgaattgga ggctgatgga cacaaatgcc aaaggcaaca agcggtcccg
     7381 aaccaggaca gactcctatt ctgcaggcca gtcagtagaa attttggacg gtgtagaact
     7441 tggagaacca gcccataaga aaacagggac cactgtgcca gaatccatcc attctttcat
     7501 tggagatggt ttggtgaaac cagaagcctt aaacaagaaa gctattcaga ttattaacag
     7561 ggttcgagat aagctcactg gtcgggattt ctctcatgat gacactttgg atgttccaac
     7621 ccaagtggaa ctgcttatca agcaagcgac atctcatgag aacctctgcc agtgctacat
     7681 tggctggtgt cctttctggt aaccaaggcc tggcaaagaa aatcatctcc tccgatgctt
     7741 ttgtaccttg gtctgtgctt ccagtggact gaaaccatgg tcataaagtt ggactttgtt
     7801 aatattttga aatgtatatg aaaagaacta ctgtatattc aaagttggct tatgccaacc
     7861 tcctagctgc tgttgaaaag acactgtcag aaacacaagg cttgattcag ttcccaggac
     7921 agtgaaacac agtaatccta cagaaaccaa gcctttgatt ttgggagaac agaagatgag
     7981 taactgacta agaaatacgg gttttgactt aacttacaga agaactcatc atacgcattt
     8041 gctgaccgaa taatctagtt gatcctctca accaggggct tcaacagcaa ggacacagat
     8101 gtcagcactc caccatcctg ttacctcacc cgtccctgga tgcagtggca acatctgcag
     8161 gatgggccac cgtgtgtgta agaagatctg tcttccacct gatcccatga tgctgaacct
     8221 cacagagccg gccttccagg aaggacgttt gctcagacgc ctggccaccg aggatgagca
     8281 ggtgtgccag gatctcagtg cagggtccac gctggccctg ctgctgtgtt cagtgaggga
     8341 tggatatgtt gtgtttgcag cagggactca gaacacaaat gcttttgtgg aagtgctgat
     8401 ctcagaggga cactagcgca ggttgtgaat taagagcaaa gtaaatatcc aactaaacac
     8461 aaagtataag tgaagccaca tctagacacc attgtatctg agtaattttt gtgccaataa
     8521 atgacatcag aattttaaaa gta
//
