LOCUS       NM_001393841            1247 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus melatonin receptor 1B (Mtnr1b), transcript
            variant 1, mRNA.
ACCESSION   NM_001393841
VERSION     NM_001393841.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1247)
  AUTHORS   Osier,N.D., Pham,L., Pugh,B.J., Puccio,A., Ren,D., Conley,Y.P.,
            Alexander,S. and Dixon,C.E.
  TITLE     Brain injury results in lower levels of melatonin receptors
            subtypes MT1 and MT2
  JOURNAL   Neurosci Lett 650, 18-24 (2017)
   PUBMED   28377323
  REMARK    GeneRIF: TBI in rats resulted in lower levels of MT1 and MT2;
            replication of these findings is necessary as is evaluation of the
            consequences of lower receptor levels.
REFERENCE   2  (bases 1 to 1247)
  AUTHORS   Juszczak,M., Wolak,M., Bojanowska,E., Piera,L. and Roszczyk,M.
  TITLE     The role of melatonin membrane receptors in melatonin-dependent
            oxytocin secretion from the rat hypothalamo-neurohypophysial system
            - an in vitro and in vivo approach
  JOURNAL   Endokrynol Pol 67 (5), 507-514 (2016)
   PUBMED   26884304
  REMARK    GeneRIF: An inhibitory effect of melatonin on oxytocin secretion
            from the rat hypothalamo-neurohypophysial system is mediated
            through a subtype MT1 membrane receptor and its action is
            independent of subtype MT2 receptor. However, for the stimulatory
            effect of pharmacological concentration of the pineal hormone on
            oxytocin release, probably mechanisms other than membrane MT1/MT2
            receptor(s)-dependent are involved.
REFERENCE   3  (bases 1 to 1247)
  AUTHORS   Lopez-Canul,M., Comai,S., Dominguez-Lopez,S., Granados-Soto,V. and
            Gobbi,G.
  TITLE     Antinociceptive properties of selective MT(2) melatonin receptor
            partial agonists
  JOURNAL   Eur J Pharmacol 764, 424-432 (2015)
   PUBMED   26162699
  REMARK    GeneRIF: Suggest MT2 melatonin receptor may be a novel target for
            analgesic drug development.
REFERENCE   4  (bases 1 to 1247)
  AUTHORS   Sheng,W.L., Chen,W.Y., Yang,X.L., Zhong,Y.M. and Weng,S.J.
  TITLE     Co-expression of two subtypes of melatonin receptor on rat M1-type
            intrinsically photosensitive retinal ganglion cells
  JOURNAL   PLoS One 10 (2), e0117967 (2015)
   PUBMED   25714375
  REMARK    GeneRIF: We demonstrated the co-existence of MT1 and MT2 receptors
            in all melanopsin-positive M1 ipRGCs, and the expression of MT1 and
            MT2 receptors in these cells could be seen as early as the day of
            birth (P0).
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1247)
  AUTHORS   Ochoa-Sanchez,R., Comai,S., Lacoste,B., Bambico,F.R.,
            Dominguez-Lopez,S., Spadoni,G., Rivara,S., Bedini,A., Angeloni,D.,
            Fraschini,F., Mor,M., Tarzia,G., Descarries,L. and Gobbi,G.
  TITLE     Promotion of non-rapid eye movement sleep and activation of
            reticular thalamic neurons by a novel MT2 melatonin receptor ligand
  JOURNAL   J Neurosci 31 (50), 18439-18452 (2011)
   PUBMED   22171046
REFERENCE   6  (bases 1 to 1247)
  AUTHORS   Poirel,V.J., Masson-Pevet,M., Pevet,P. and Gauer,F.
  TITLE     MT1 melatonin receptor mRNA expression exhibits a circadian
            variation in the rat suprachiasmatic nuclei
  JOURNAL   Brain Res 946 (1), 64-71 (2002)
   PUBMED   12133595
REFERENCE   7  (bases 1 to 1247)
  AUTHORS   Armstrong,K.J. and Niles,L.P.
  TITLE     Induction of GDNF mRNA expression by melatonin in rat C6 glioma
            cells
  JOURNAL   Neuroreport 13 (4), 473-475 (2002)
   PUBMED   11930164
REFERENCE   8  (bases 1 to 1247)
  AUTHORS   Musshoff,U., Riewenherm,D., Berger,E., Fauteck,J.D. and
            Speckmann,E.J.
  TITLE     Melatonin receptors in rat hippocampus: molecular and functional
            investigations
  JOURNAL   Hippocampus 12 (2), 165-173 (2002)
   PUBMED   12000116
  REMARK    GeneRIF: Since binding sites for melatonin have been found in the
            hippocampus of several mammals, it has been suggested that the
            pineal hormone melatonin is able to modulate neuronal functions of
            hippocampal cells
REFERENCE   9  (bases 1 to 1247)
  AUTHORS   Doolen,S., Krause,D.N. and Duckles,S.P.
  TITLE     Estradiol modulates vascular response to melatonin in rat caudal
            artery
  JOURNAL   Am J Physiol 276 (4 Pt 2), H1281-H1288 (1999)
   PUBMED   10199853
REFERENCE   10 (bases 1 to 1247)
  AUTHORS   Reppert,S.M., Godson,C., Mahle,C.D., Weaver,D.R., Slaugenhaupt,S.A.
            and Gusella,J.F.
  TITLE     Molecular characterization of a second melatonin receptor expressed
            in human retina and brain: the Mel1b melatonin receptor
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8734-8738 (1995)
   PUBMED   7568007
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB377275.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN17050745 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-323               JAXUCZ010000008.1  20933772-20934094   c
            324-1247            JAXUCZ010000008.1  20922517-20923440   c
FEATURES             Location/Qualifiers
     source          1..1247
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q12"
     gene            1..1247
                     /gene="Mtnr1b"
                     /gene_synonym="Mel1b-r; Mt2"
                     /note="melatonin receptor 1B"
                     /db_xref="GeneID:192646"
                     /db_xref="RGD:620798"
     exon            1..323
                     /gene="Mtnr1b"
                     /gene_synonym="Mel1b-r; Mt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1195
                     /gene="Mtnr1b"
                     /gene_synonym="Mel1b-r; Mt2"
                     /note="melatonin receptor type 1B; mel-1B-R; mel1b
                     melatonin receptor; mel1b receptor"
                     /codon_start=1
                     /product="melatonin receptor type 1B precursor"
                     /protein_id="NP_001380770.1"
                     /db_xref="GeneID:192646"
                     /db_xref="RGD:620798"
                     /translation="MPDNSSIANCCAASGLAARPSWPGSAEAEPPETPRAPWVAPMLS
                     TVVIVTTAVDFVGNLLVILSVLRNRKLRNAGNLFVVNLALADLVVALYPYPLILVAIL
                     HDGWVLGEIHCKASAFVMGLSVIGSVFNITAIAINRYWCICHSATYHRACSQWHAPLY
                     ISLIWLLTLVALVPNFFVGSLEYDPRIYSCTFIQTASTQYTMAVVAIHFLLPIAVVSF
                     CYLRIWILVLQARRKAKAERKLRLRPSDLRSFLTMFAVFVVFAICWAPLNCIGLAVAI
                     NPEAMALQIPEGLFVTSYFLAYFNSCLNAIVYGLLNQNFRREYKRILSALWSTGRCFH
                     DASKCHLTEDLQGPVPPAAMATIPVQEGAL"
     exon            324..1247
                     /gene="Mtnr1b"
                     /gene_synonym="Mel1b-r; Mt2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccacagcctc ttcttagcac ttgctgggcg gggaggggac agcgggagcg cccccaagca
       61 gtgcacacct tgcgcatcta tcccgggctg cagcgtcacc atgcctgaca acagctccat
      121 cgccaactgc tgtgcggcca gcgggctggc agcgcgccct agttggcccg ggtcagcgga
      181 ggcggagccc cctgagactc cccgggcacc ctgggtggct cccatgctat ctacagtagt
      241 cattgtcacc acagctgtgg acttcgtggg gaacctgctt gtgatcctct cggtgctcag
      301 gaaccgcaag ctgcggaacg caggtaattt atttgtggtg aatctggcct tggctgacct
      361 ggtggtagcc ctgtaccctt acccactcat ccttgtggcc attctccatg acggttgggt
      421 acttggggag atccactgta aggccagtgc ctttgtgatg ggcctgagtg tcattggctc
      481 tgtcttcaac atcacagcca ttgccatcaa ccgctactgg tgcatctgtc acagtgcgac
      541 ctaccaccga gcctgcagtc agtggcatgc tcccctctac atcagcctca tctggcttct
      601 cactctggtg gccttggtgc ccaatttctt tgtggggtct ctagaatatg acccgcgaat
      661 ctattcctgc accttcatcc agacagccag cacccaatac actatggctg tggtggccat
      721 ccacttcctc cttccaattg ctgtggtgtc cttttgctac ctgcgaatat ggatactggt
      781 gctccaggcc cgaaggaagg caaaggctga gagaaagcta cgcctgagac ccagtgacct
      841 gcgcagtttc ctaaccatgt tcgcagtgtt tgtggttttc gccatatgct gggcccccct
      901 caactgtatt ggccttgcag tggccatcaa tccagaggca atggctcttc agatcccaga
      961 agggcttttt gtcaccagtt acttcctagc ttacttcaac agctgcctta atgctattgt
     1021 ttatgggctt ctgaaccaga acttccgcag ggagtacaag aggatcctct cggccctctg
     1081 gagcactggg cgctgcttcc atgatgcttc caaatgccac ctgactgagg atttgcaggg
     1141 cccagtgcca cctgctgcca tggccaccat acctgtccag gaaggtgctc tctagcctgc
     1201 atcagctcgt ggacctagca gcaaacctgt gaaatgagca gaacgga
//
