LOCUS       NM_053676               1774 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Rattus norvegicus melatonin receptor 1A (Mtnr1a), mRNA.
ACCESSION   NM_053676 XM_001061841 XM_341441
VERSION     NM_053676.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1774)
  AUTHORS   Sheng,W.L., Chen,W.Y., Yang,X.L., Zhong,Y.M. and Weng,S.J.
  TITLE     Co-expression of two subtypes of melatonin receptor on rat M1-type
            intrinsically photosensitive retinal ganglion cells
  JOURNAL   PLoS One 10 (2), e0117967 (2015)
   PUBMED   25714375
  REMARK    GeneRIF: We demonstrated the co-existence of MT1 and MT2 receptors
            in all melanopsin-positive M1 ipRGCs, and the expression of MT1 and
            MT2 receptors in these cells could be seen as early as the day of
            birth (P0).
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1774)
  AUTHORS   Zhang,Y., Cook,A., Kim,J., Baranov,S.V., Jiang,J., Smith,K.,
            Cormier,K., Bennett,E., Browser,R.P., Day,A.L., Carlisle,D.L.,
            Ferrante,R.J., Wang,X. and Friedlander,R.M.
  TITLE     Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death
            pathway, inhibits MT1 receptor loss and delays disease progression
            in a mouse model of amyotrophic lateral sclerosis
  JOURNAL   Neurobiol Dis 55, 26-35 (2013)
   PUBMED   23537713
REFERENCE   3  (bases 1 to 1774)
  AUTHORS   Hill,S.M., Cheng,C., Yuan,L., Mao,L., Jockers,R., Dauchy,B. and
            Blask,D.E.
  TITLE     Age-related decline in melatonin and its MT1 receptor are
            associated with decreased sensitivity to melatonin and enhanced
            mammary tumor growth
  JOURNAL   Curr Aging Sci 6 (1), 125-133 (2013)
   PUBMED   23895529
  REMARK    Review article
REFERENCE   4  (bases 1 to 1774)
  AUTHORS   Ahn,S.K., Khalmuratova,R., Hah,Y.S., Jeon,S.Y., Hur,D.G., Kang,H.S.
            and Balaban,C.D.
  TITLE     Immunohistochemical and biomolecular identification of melatonin 1a
            and 1b receptors in rat vestibular nuclei
  JOURNAL   Auris Nasus Larynx 39 (5), 479-483 (2012)
   PUBMED   22055508
  REMARK    GeneRIF: The present study demonstrates, for the first time, that
            MT1a receptors are localized and expressed in rat vestibular
            nuclei. This study provides additional insight into the role of
            melatonin receptors during vestibular signal processing.
REFERENCE   5  (bases 1 to 1774)
  AUTHORS   Muhlbauer,E., Albrecht,E., Bazwinsky-Wutschke,I. and Peschke,E.
  TITLE     Melatonin influences insulin secretion primarily via MT(1)
            receptors in rat insulinoma cells (INS-1) and mouse pancreatic
            islets
  JOURNAL   J Pineal Res 52 (4), 446-459 (2012)
   PUBMED   22288848
REFERENCE   6  (bases 1 to 1774)
  AUTHORS   Armstrong,K.J. and Niles,L.P.
  TITLE     Induction of GDNF mRNA expression by melatonin in rat C6 glioma
            cells
  JOURNAL   Neuroreport 13 (4), 473-475 (2002)
   PUBMED   11930164
REFERENCE   7  (bases 1 to 1774)
  AUTHORS   Musshoff,U., Riewenherm,D., Berger,E., Fauteck,J.D. and
            Speckmann,E.J.
  TITLE     Melatonin receptors in rat hippocampus: molecular and functional
            investigations
  JOURNAL   Hippocampus 12 (2), 165-173 (2002)
   PUBMED   12000116
  REMARK    GeneRIF: Since binding sites for melatonin have been found in the
            hippocampus of several mammals, it has been suggested that the
            pineal hormone melatonin is able to modulate neuronal functions of
            hippocampal cells
REFERENCE   8  (bases 1 to 1774)
  AUTHORS   Roka,F., Brydon,L., Waldhoer,M., Strosberg,A.D., Freissmuth,M.,
            Jockers,R. and Nanoff,C.
  TITLE     Tight association of the human Mel(1a)-melatonin receptor and G(i):
            precoupling and constitutive activity
  JOURNAL   Mol Pharmacol 56 (5), 1014-1024 (1999)
   PUBMED   10531408
REFERENCE   9  (bases 1 to 1774)
  AUTHORS   Fujieda,H., Hamadanizadeh,S.A., Wankiewicz,E., Pang,S.F. and
            Brown,G.M.
  TITLE     Expression of mt1 melatonin receptor in rat retina: evidence for
            multiple cell targets for melatonin
  JOURNAL   Neuroscience 93 (2), 793-799 (1999)
   PUBMED   10465462
REFERENCE   10 (bases 1 to 1774)
  AUTHORS   Reppert,S.M., Weaver,D.R. and Ebisawa,T.
  TITLE     Cloning and characterization of a mammalian melatonin receptor that
            mediates reproductive and circadian responses
  JOURNAL   Neuron 13 (5), 1177-1185 (1994)
   PUBMED   7946354
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB377274.1.
            
            On Aug 30, 2012 this sequence version replaced NM_053676.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB377274.1, AF130341.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680414, SAMN06680433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1774              AB377274.1         2-1775
FEATURES             Location/Qualifiers
     source          1..1774
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..1774
                     /gene="Mtnr1a"
                     /note="melatonin receptor 1A"
                     /db_xref="GeneID:114211"
                     /db_xref="RGD:620797"
     exon            1..398
                     /gene="Mtnr1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1267
                     /gene="Mtnr1a"
                     /note="mel-1A-R; mel1a melatonin receptor; mel1a receptor"
                     /codon_start=1
                     /product="melatonin receptor type 1A"
                     /protein_id="NP_446128.1"
                     /db_xref="GeneID:114211"
                     /db_xref="RGD:620797"
                     /translation="MKGNVSELLNASQQAPGGGEEIRSRPSWLASTLAFILIFTIVVD
                     ILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPFPLALTSILNNGWNLGYLH
                     CQVSAFLMGLSVIGSVFNITGIAMNRYCYICHSLKYDRIYSNKNSLCYVFLIWTLTLI
                     AIMPNLQTGTLQYDPRIYSCTFTQSVSSAYTIALVVFHFVVPMIIVTFCYLRIWILVL
                     QVRRRVKPDSKPKLKPQDFRNFVTMFVVFVLFALCWAPLNFIGLIVASDPAAMAPRIP
                     EWLFVASYYLAYFNSCLNAIIYGLLNQNFRKEYKRIIISLCTAKMFFVDSSNDAADKI
                     KCKPSPLITNNNLIKVDSV"
     exon            399..1774
                     /gene="Mtnr1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaagggtgt cctgccaccg ggaggggctg gagcggggta aggggcagga ccgcgaagca
       61 gccataagga tgcaaagtag gcgcgggagg gctctcccca gccataaaaa gtggcggaga
      121 gggcgcaagc agagctgggc acttgagggc gcggggctac aggatgatgg ccctggctgt
      181 gctgcggtaa gtcacccagg ggaccatgaa gggcaatgtc agcgagcttc tcaacgcctc
      241 tcagcaggct ccaggcggcg gggaggaaat aagatcgcgg ccgtcgtggc tggcctctac
      301 actggccttc atcctcatct ttactatcgt ggtggacatc ctgggcaacc tgctggtcat
      361 cctgtctgtg tatcgcaaca agaagctcag gaacgcaggg aatatatttg tggtgagttt
      421 agctgtggca gacctcgtgg tggctattta cccatttccc ttggcgctga cgtctatact
      481 taacaatgga tggaacctgg gatatctgca ttgtcaagtt agtgccttcc taatgggcct
      541 gagtgtcatt ggctcggtat tcaacatcac cgggatcgct atgaaccgct actgctacat
      601 ttgccacagt ctcaagtatg ataggatata cagtaacaag aattccctgt gctacgtgtt
      661 cctgatatgg acactgacac tcatagccat catgcccaac ctgcaaaccg gaactctcca
      721 gtacgacccc cggatctact cctgtacctt cacccagtcc gtcagctcgg cgtacacgat
      781 tgccctggtg gttttccatt tcgtagttcc aatgattatt gtcactttct gctacttaag
      841 gatatggatc ctggttcttc aggtcagacg gagggtgaaa ccggacagca aacccaaact
      901 gaagccgcag gacttcagga actttgtcac catgtttgta gtttttgtac tttttgccct
      961 gtgctgggcc ccactcaact tcataggtct tattgtggcc tcagatccgg ccgccatggc
     1021 ccccaggatc ccggagtggc tcttcgtggc tagttactac ctggcgtatt tcaacagctg
     1081 cctcaacgca atcatatacg gactactgaa ccaaaatttc agaaaggagt acaagaggat
     1141 tatcatctca ctgtgcacag ctaagatgtt ctttgtggac agttcaaatg atgcagcaga
     1201 taagattaaa tgtaagccct ctccactaat aaccaataat aatttaataa aggtggactc
     1261 tgtttaaaaa agccagtggt gccagcaggt tacgctcgct ggttggggtc ttactgcttt
     1321 ctcttgtcta gaaatcaatc tatccatctt gaagctctca agagttgcca gcatagtgtt
     1381 ggagcggacc tcctgtctgc cctttaatca gatcttcagt atcaagggga atactgaaca
     1441 cgcacaaagg tatatgtgca gactctcatc tctgggtgac caggtcttag gggcccacac
     1501 ttagcattac aataacatag caacacacca aagctgaaca aaatgtgaga tgaattcaag
     1561 agaggccgtg ggcacctttc ttttgttgca aacaagtgat acagggtgtt tattcttacc
     1621 tgtggctgaa ttaaaatagt cagaaaaact cacatggaca tatatttctt tttattggcc
     1681 cccttaacaa tgcagtgtaa tgtactagac attatatgta acccagcaat ggtttaaaga
     1741 actgtattgt gaagttatat gtttgttata tacg
//
