LOCUS       NM_001394711            3809 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Rattus norvegicus myotubularin related protein 6 (Mtmr6),
            transcript variant 1, mRNA.
ACCESSION   NM_001394711 XM_006252111
VERSION     NM_001394711.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3809)
  AUTHORS   Zou,J., Zhang,C., Marjanovic,J., Kisseleva,M.V., Majerus,P.W. and
            Wilson,M.P.
  TITLE     Myotubularin-related protein (MTMR) 9 determines the enzymatic
            activity, substrate specificity, and role in autophagy of MTMR8
  JOURNAL   Proc Natl Acad Sci U S A 109 (24), 9539-9544 (2012)
   PUBMED   22647598
REFERENCE   2  (bases 1 to 3809)
  AUTHORS   Lorenzo,O., Urbe,S. and Clague,M.J.
  TITLE     Systematic analysis of myotubularins: heteromeric interactions,
            subcellular localisation and endosome related functions
  JOURNAL   J Cell Sci 119 (Pt 14), 2953-2959 (2006)
   PUBMED   16787938
REFERENCE   3  (bases 1 to 3809)
  AUTHORS   Srivastava,S., Li,Z., Lin,L., Liu,G., Ko,K., Coetzee,W.A. and
            Skolnik,E.Y.
  TITLE     The phosphatidylinositol 3-phosphate phosphatase myotubularin-
            related protein 6 (MTMR6) is a negative regulator of the
            Ca2+-activated K+ channel KCa3.1
  JOURNAL   Mol Cell Biol 25 (9), 3630-3638 (2005)
   PUBMED   15831468
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On May 3, 2021 this sequence version replaced XM_006252111.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.59890.1,
                                           SRR26643290.46282.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               JAXUCZ010000015.1  38596091-38596198
            109-225             JAXUCZ010000015.1  38609385-38609501
            226-388             JAXUCZ010000015.1  38612409-38612571
            389-546             JAXUCZ010000015.1  38614278-38614435
            547-675             JAXUCZ010000015.1  38616985-38617113
            676-810             JAXUCZ010000015.1  38621244-38621378
            811-924             JAXUCZ010000015.1  38622380-38622493
            925-1057            JAXUCZ010000015.1  38623661-38623793
            1058-1167           JAXUCZ010000015.1  38624533-38624642
            1168-1293           JAXUCZ010000015.1  38625103-38625228
            1294-1343           JAXUCZ010000015.1  38627784-38627833
            1344-1544           JAXUCZ010000015.1  38628236-38628436
            1545-1676           JAXUCZ010000015.1  38629704-38629835
            1677-1803           JAXUCZ010000015.1  38630709-38630835
            1804-3809           JAXUCZ010000015.1  38632018-38634023
FEATURES             Location/Qualifiers
     source          1..3809
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..3809
                     /gene="Mtmr6"
                     /note="myotubularin related protein 6"
                     /db_xref="GeneID:305935"
                     /db_xref="RGD:1305378"
     exon            1..108
                     /gene="Mtmr6"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..2052
                     /gene="Mtmr6"
                     /EC_number="3.1.3.95"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphatidylinositol-3-phosphate phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6"
                     /codon_start=1
                     /product="phosphatidylinositol-3,5-bisphosphate
                     3-phosphatase MTMR6 isoform 1"
                     /protein_id="NP_001381640.1"
                     /db_xref="GeneID:305935"
                     /db_xref="RGD:1305378"
                     /translation="MEHIRTTKVEQVKLLDRFSTNNKSLTGTLYLTATHLLFIDAHQK
                     ETWILHHHIASVEKLALTTSGCPLVIQCKNFRIVHFIVPRERDCHDIYNSLLQLSKQA
                     KYEDLYAFSYNPKQNDTERLNGWQLIDLAAEYERMGVPNANWQLSDANREYKVCETYP
                     RELYVPRTASRPVIVGSSNFRSKGRLPVLSYCQQGTEAAICRCSQPLSGFSARCLEDE
                     HLLQAISKANPGNRYMYVVDTRPKLRMQSWWDTQKDIGRIIVRISSKIWNDEKIRESD
                     EKKRLNAMANRAAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEVNGSKGLSVN
                     DFYSGLESSGWLRHIKAVLDAAIFLAKAIVVENASVLVHCSDGWDRTSQVCSLGSLLL
                     DSYYRTMKGFMVLIEKDWISFGHKFSERCGHLDGDPKEVSPVFTQFLECVWHLTEQFP
                     QAFEFNEAFLLQIHEHIHSCQFGNFLGNCQKEREELRLKEKTYSLWPFLLADKKKYLN
                     PLYSSKSQRLTVLEPNTASFNFKFWRNMYHQFDRTLHPRQSVLNIIMNMNEQNKQLEE
                     DVKDLEAKIKQCKSGILTKDLLHAVHPESPSLKTSLCLKEQSLLPVKDTLRAVEGSSP
                     ADNRYCDYTEEFSKSEPAVVSLEYGVARMTC"
     exon            109..225
                     /gene="Mtmr6"
                     /inference="alignment:Splign:2.1.0"
     exon            226..388
                     /gene="Mtmr6"
                     /inference="alignment:Splign:2.1.0"
     exon            389..546
                     /gene="Mtmr6"
                     /inference="alignment:Splign:2.1.0"
     exon            547..675
                     /gene="Mtmr6"
                     /inference="alignment:Splign:2.1.0"
     exon            676..810
                     /gene="Mtmr6"
                     /inference="alignment:Splign:2.1.0"
     exon            811..924
                     /gene="Mtmr6"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1057
                     /gene="Mtmr6"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1167
                     /gene="Mtmr6"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1293
                     /gene="Mtmr6"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1343
                     /gene="Mtmr6"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1544
                     /gene="Mtmr6"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1676
                     /gene="Mtmr6"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1803
                     /gene="Mtmr6"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..3809
                     /gene="Mtmr6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttcctgcg ggtggctgtc accgccccgt tcctctccca atggtgttct cctgaggcta
       61 gctgcctgcg ggcgtcgccc cgggatggag cacatccgga caaccaaggt tgaacaagta
      121 aagttacttg accggtttag taccaacaac aagtcactga caggaacact gtatcttacg
      181 gccacacacc tattatttat tgatgctcat caaaaagaaa cctggatact acatcaccat
      241 attgcctccg tggagaaact tgctctgacc acttctggat gcccactcgt gattcagtgc
      301 aagaacttca ggattgtgca tttcattgtt cccagggaaa gagattgcca tgatatttat
      361 aactctctac tgcaactatc aaaacaagca aaatatgaag atctgtatgc attctcttac
      421 aaccccaagc aaaatgacac tgagcggctg aacgggtggc agctcattga ccttgctgca
      481 gagtacgaga ggatgggagt gcccaacgca aactggcaac tgtccgatgc caaccgagag
      541 tacaaggtct gtgagactta tcccagagag ctgtatgttc ctcggacagc tagccggcca
      601 gtgatcgtcg gcagttccaa cttccggagc aagggcagac ttccggtcct gtcctactgc
      661 cagcagggca ctgaggctgc catttgtcga tgcagtcagc cattgtcagg cttcagtgcc
      721 aggtgcctag aggatgagca tttgcttcaa gccattagta aagccaaccc aggaaaccgc
      781 tacatgtatg ttgtggatac caggcccaag cttcgcatgc agagctggtg ggatacacaa
      841 aaggacattg gcagaattat agtgaggatt tcttcaaaaa tctggaatga tgagaaaata
      901 agagaaagcg atgagaaaaa gcgactcaat gcaatggcta acagagcagc tggaaaaggt
      961 tatgaaaatg aagacaacta ttctaatatt agatttcagt ttgttggaat agaaaatatt
     1021 catgtcatga gatccagcct tcagaaatta ctggaagtga atggcagcaa ggggctttct
     1081 gtcaacgatt tctactctgg tttggagagt tcaggatggc ttcgtcatat caaggctgtt
     1141 ttggatgctg caatcttctt agccaaagca atagtggttg aaaatgcaag tgtgctggta
     1201 cactgttcgg atgggtggga caggacctcc caagtgtgtt cccttggttc gctcttgttg
     1261 gattcctact acaggacaat gaaaggattc atggttttaa tagaaaaaga ttggatatca
     1321 tttgggcata aattttcaga gaggtgtggc catttggatg gtgacccaaa ggaagtctca
     1381 ccagtgttta ctcagttctt ggagtgtgta tggcatctga ctgagcagtt cccacaagcc
     1441 tttgagttca acgaagcgtt tcttcttcag atccatgagc acattcactc atgccaattt
     1501 gggaacttcc ttggcaactg tcagaaggaa agagaggaac tcaggttgaa ggagaagact
     1561 tactccctgt ggccttttct tttggctgac aaaaagaagt acttaaatcc tctctacagt
     1621 tccaaatctc agagattgac agtcttggag ccaaatacag cctctttcaa ttttaaattt
     1681 tggagaaaca tgtaccacca atttgatcgg acgctccatc cccggcagtc tgtactgaac
     1741 ataattatga atatgaatga gcaaaacaag cagttagagg aagacgttaa agacctagag
     1801 gctaaaatta agcaatgcaa aagtggcatc ctgacgaagg acttgctgca tgccgttcac
     1861 cctgagtcgc ccagtctgaa aacctcactg tgtctgaaag agcagagtct gctcccggtg
     1921 aaggacacac tccgagctgt agagggcagc agcccagcag ataatcgcta ctgtgactac
     1981 accgaggagt tttccaagtc ggagcctgct gtggtcagct tggagtacgg cgtggcccga
     2041 atgacttgtt agcctccttc agtggtccct ggatggctgt agtgtgagaa gggtctgtac
     2101 acacgggcag gaggtctgag tgacttaggg gcttagcagc aggtgaatag ctgagaaaag
     2161 gtagcagctc ttgggaggag taagtcagcc aagtgccact ggcagcgagc gagtgctgtt
     2221 gtgtgtgctt cctggaaatg atttacacag tgctagtgag ctggcagtct gttgattcag
     2281 atgttaatta cagccaaact caatagcttt ccttgagtgt aatgtaactc tgagagaaca
     2341 gacctgacaa cctgaaccct caatgactga catggcatgt gctttcagtt ctggagctgt
     2401 ggccgtttgc gtattctgcc acttagtgac attttattga agtgccatgt gaagtacttc
     2461 tgagacagcc ttaaagtaga ctctcggttg gttctgtggc ctttatagcc gaggacagga
     2521 tgtctgatct ctcctttaat cagccttatt tcttatgaag agctgcactc tcattacctg
     2581 ggggccgcac actgcagcgc tctacatgga gagctgtgag tactccgcta gctagttcgt
     2641 gattagccag ctccacccgt attgaaatta gtgctacgga aggctttgtt ctggttgtca
     2701 gttgtctcga tctgcagctg acagttcatt attcacagct tagaggactc atttcttagg
     2761 ccactataag cacatttggc atttactttc ggcttactgc agtctattaa ttcctcctct
     2821 ggttggcttt aatcctttga taactgtaca tttaaagtgg caaagctcca aagtgttctg
     2881 agtactacat acatttttac cttgagagca gctgcctaca gactttcagg taaaggaaag
     2941 ggggagtgct ggtggtggag atttgcgtgg ttatgatttt aaagcgacca tttttatgta
     3001 gagcatattt cttttctctt aatatagacg ggacagagaa gggagcactg agggaggcag
     3061 ttaatgtcca acaaacggca gctttgacgc tggaaaaggg tttattttgc tttgttggac
     3121 tcattgttta tcccatgcac tgagacatac gtatctgttt tttaaaaatc acttgcaatt
     3181 ggcagtatta ccagctggct ttcaaacaaa gtttaatacc attgatggta taaagtacag
     3241 ttcaggggca ctatgaaatc tgtgtatgtt atcatatata tctcctgatt atatctatat
     3301 ctgtaatatt tcttgtatta gttttgaaca taagtatctt tttttggaaa aaaaagcttt
     3361 attgtatgtg attttatcta gtccttattt ttccagttta cttgtgtaag cccttatgta
     3421 ataaaacact gcattttaaa gcataacaga aatatactaa aaaatacaat gtataattaa
     3481 cagtgtttag acattgggaa gggaaactta atctctgagg ccacacatga agttccgtgc
     3541 cttggttccc gtcaggctgt gggtttaaac ttctatggca gacttcttag tcatcttttc
     3601 ggttcattat gctaatcatc aatttcacat gtatatatgt gtttacatgc tcacacacag
     3661 ataagatcct gagtgacgca cagggcatat gttggcaaaa gtctgtaaat gtcttataaa
     3721 attaggttta cattcattgt gttttgggat ctatagcatg taaattattt cgtgtattat
     3781 ttaaaggcaa ttaaatgttc gtgttttac
//
