LOCUS       NM_001105827            5684 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus myotubularin related protein 4 (Mtmr4), mRNA.
ACCESSION   NM_001105827 XM_001081167 XM_213426
VERSION     NM_001105827.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5684)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   2  (bases 1 to 5684)
  AUTHORS   Plant,P.J., Correa,J., Goldenberg,N., Bain,J. and Batt,J.
  TITLE     The inositol phosphatase MTMR4 is a novel target of the ubiquitin
            ligase Nedd4
  JOURNAL   Biochem J 419 (1), 57-63 (2009)
   PUBMED   19125695
  REMARK    GeneRIF: Data show that MTMR4 expression was decreased in
            atrophying muscle.
REFERENCE   3  (bases 1 to 5684)
  AUTHORS   Lorenzo,O., Urbe,S. and Clague,M.J.
  TITLE     Systematic analysis of myotubularins: heteromeric interactions,
            subcellular localisation and endosome related functions
  JOURNAL   J Cell Sci 119 (Pt 14), 2953-2959 (2006)
   PUBMED   16787938
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Sep 23, 2014 this sequence version replaced NM_001105827.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.35399.1,
                                           SRR26643288.42483.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                JAXUCZ010000010.1  72890665-72890700
            37-75               JAXUCZ010000010.1  72891049-72891087
            76-165              JAXUCZ010000010.1  72895169-72895258
            166-282             JAXUCZ010000010.1  72895587-72895703
            283-365             JAXUCZ010000010.1  72896472-72896554
            366-526             JAXUCZ010000010.1  72898230-72898390
            527-623             JAXUCZ010000010.1  72898505-72898601
            624-737             JAXUCZ010000010.1  72898780-72898893
            738-934             JAXUCZ010000010.1  72900186-72900382
            935-1063            JAXUCZ010000010.1  72900592-72900720
            1064-1175           JAXUCZ010000010.1  72901195-72901306
            1176-1371           JAXUCZ010000010.1  72901795-72901990
            1372-1557           JAXUCZ010000010.1  72902220-72902405
            1558-1728           JAXUCZ010000010.1  72902485-72902655
            1729-1883           JAXUCZ010000010.1  72902796-72902950
            1884-3270           JAXUCZ010000010.1  72908264-72909650
            3271-3381           JAXUCZ010000010.1  72910736-72910846
            3382-3470           JAXUCZ010000010.1  72911087-72911175
            3471-5684           JAXUCZ010000010.1  72911385-72913598
FEATURES             Location/Qualifiers
     source          1..5684
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..5684
                     /gene="Mtmr4"
                     /note="myotubularin related protein 4"
                     /db_xref="GeneID:287607"
                     /db_xref="RGD:1310306"
     exon            1..36
                     /gene="Mtmr4"
                     /inference="alignment:Splign:2.1.0"
     exon            37..75
                     /gene="Mtmr4"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..3648
                     /gene="Mtmr4"
                     /EC_number="3.1.3.48"
                     /codon_start=1
                     /product="myotubularin-related protein 4"
                     /protein_id="NP_001099297.4"
                     /db_xref="GeneID:287607"
                     /db_xref="RGD:1310306"
                     /translation="MGEEGPPSLEYIQAKDLFPPKELVKEEENLQVPFTVLQGEGVEF
                     LGRAADALIAISNYRLHIKFKDSVINVPLRMIDSVESRDMFQLHIACKDSKVVRCHFS
                     TFKQCQEWLSRLSRATARPAKPEDLFAFAYHAWCLGLTEEDQHTHLCQPGEHIRCRQE
                     AELARMGFDLQNVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPV
                     VVYRHLRNGAAIARCSQPEISWWGWRNADDEYLVTSIAKACALDPGTRASGGSLSAGT
                     NDASEACDTDFDSSLTACSGVESTAAPQKLLILDARSYTAAVANRAKGGGCECEEYYP
                     NCEVVFMGMANIHAIRNSFQYLRAVCSQMPDPSNWLSALESTKWLQHLSVMLKAAVLV
                     ANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKF
                     GDRCGHQENAEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYG
                     TFLANNPCEREKRNIYKRTCSVWALLRAGNKNFHNFLYTPGSDMVLHPVCHVRALHLW
                     TAVYLPASSPCTLGEENMDLYLSPVAQSQEFSGRSLDRLPKTRSMDDLLSACDTSSPL
                     TRTSSDPNLNNHCQEVRVSLEPWHSNPEGAEAVIESGVGSPQLTVGDVGLPPPLPSSQ
                     KDYLSNKPFKGHKSCSLSYKLLNTSVSWEMKNTSEIKVLEETEALAPGPPAREEQSRT
                     SDGLGKPPEQCPEKEATSSLSNVSSKCGGACDFPGEPPQDSFTGTPQQPHLDSMQAVP
                     IRCTPDHGQGSLCNPPSAASQTLQEPNTDLISQDPPGSMAGISYQEQPSSVSDLIYKK
                     EDAGKRGSKNGQLVENPRFGKMPLELARKPISQSQISEFSFLGSNWDSFQGMMTSFPS
                     GETTPRRLLAYGCCSKRPSNKHIRAAAPCFGGQWAQREGMKSPVCSSHSNGHCTGPGG
                     KNNRMWFSSHPKQVSSTKPSLLSCPSPVPPLYLDDDGLPFPTDVIQHRLRQIEAGYKQ
                     EVEQLRRQVRELQMRLDIRHCCAPPAEPPMDYEDDFTCLKESDGSDTEDFGSDHSEDC
                     LSEASWEPVDKKETEVTRWVPDHMASHCYNCDCEFWLAKRRHHCRNCGNVFCAGCCHL
                     KLPIPDQQLYDPVLVCNSCYEHIQVSRARELMSQHLKKPIATASS"
     exon            76..165
                     /gene="Mtmr4"
                     /inference="alignment:Splign:2.1.0"
     exon            166..282
                     /gene="Mtmr4"
                     /inference="alignment:Splign:2.1.0"
     exon            283..365
                     /gene="Mtmr4"
                     /inference="alignment:Splign:2.1.0"
     exon            366..526
                     /gene="Mtmr4"
                     /inference="alignment:Splign:2.1.0"
     exon            527..623
                     /gene="Mtmr4"
                     /inference="alignment:Splign:2.1.0"
     exon            624..737
                     /gene="Mtmr4"
                     /inference="alignment:Splign:2.1.0"
     exon            738..934
                     /gene="Mtmr4"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1063
                     /gene="Mtmr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1175
                     /gene="Mtmr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1371
                     /gene="Mtmr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1557
                     /gene="Mtmr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1728
                     /gene="Mtmr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1883
                     /gene="Mtmr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..3270
                     /gene="Mtmr4"
                     /inference="alignment:Splign:2.1.0"
     exon            3271..3381
                     /gene="Mtmr4"
                     /inference="alignment:Splign:2.1.0"
     exon            3382..3470
                     /gene="Mtmr4"
                     /inference="alignment:Splign:2.1.0"
     exon            3471..5684
                     /gene="Mtmr4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagccctgtg gattcatgcc cctaccaggg ccaaaatgac gagcaggcag ccaggaccct
       61 cgccaaggta gaatgggtga ggagggcccc cccagcctgg agtacatcca agccaaggat
      121 ctgttccccc ccaaggaact ggtgaaggag gaggaaaatc ttcaggtacc cttcacagtg
      181 ctacagggtg agggagtgga attcctgggc cgggcagctg atgccctcat tgcaatctcc
      241 aactaccggc tgcatatcaa gttcaaagac tctgtcatca acgtgcccct ccgtatgatt
      301 gacagtgtgg aaagccgtga tatgtttcag ttgcacattg cctgcaagga ctctaaagtg
      361 gtgaggtgcc acttctccac tttcaagcag tgccaagagt ggctctcaag gctaagccgg
      421 gccacagcaa gacctgccaa gcccgaggat ctctttgcct ttgcctacca tgcctggtgc
      481 ctggggctga ctgaggagga tcagcatacc cacctgtgtc agccaggaga gcacatccga
      541 tgtcgacagg aggccgagct cgcaaggatg ggttttgacc tgcagaatgt ctggagagtc
      601 tcgcatatca acagcaatta caagctgtgc cctagctacc cccagaagct gctggttcct
      661 gtgtggatca cagataaaga gctggagaat gtggcttctt tccgctcttg gaagcgcatc
      721 cctgttgtgg tgtacagaca cctgcgcaac ggggctgcca ttgcccgctg cagccagcct
      781 gagatcagct ggtggggctg gcgcaatgct gatgatgaat acctcgtcac gtccattgcc
      841 aaagcctgcg ccttagaccc agggaccagg gccagtgggg gctccctcag tgctgggact
      901 aatgatgcca gcgaggcatg tgacacggat ttcgattctt ctctgactgc atgctctggg
      961 gtagagagca cagcagcccc ccaaaaactg ctgatcctgg atgcacggtc ctacacagca
     1021 gcagtggcca accgggccaa gggtggaggc tgtgaatgtg aagaatacta tccgaactgt
     1081 gaggtcgtgt ttatgggaat ggccaacatc catgccatcc ggaacagctt ccagtacctc
     1141 cgggctgtgt gtagccagat gccagatccc agcaactggt tgtcggctct ggagagtacc
     1201 aaatggctac agcacttgtc agtgatgcta aaagcggctg tgttggtagc caatacagta
     1261 gatcgggaag gccggcctgt gctggtgcac tgctctgatg gctgggatcg tacgccacag
     1321 attgtagccc tggccaaaat actactggat ccgtattaca ggactctgga gggcttccaa
     1381 gtgttagtgg agtctgattg gctggatttt gggcacaagt ttggagatcg ctgtggccat
     1441 caggaaaatg cagaggacca aaatgaacag tgtccggtgt tcctccagtg gcttgattct
     1501 gtacatcagc tgcttaagca gttcccctgc ctgtttgaat tcaatgaagc atttctggta
     1561 aaactggtgc agcacacgta ctcctgcctc tacggcacat tcctggccaa caacccctgc
     1621 gagcgagaga agcgcaacat ctataaacgg acatgctcgg tgtgggcact cctgcgagct
     1681 ggcaacaaga acttccataa cttcctctac acacctgggt cagacatggt cctacatccc
     1741 gtgtgtcacg tccgggccct gcacctctgg acagctgttt acctgcctgc gtcatcgccg
     1801 tgcacccttg gagaggagaa tatggatctt tacctttccc cagtggctca gagccaggaa
     1861 ttttctggtc gttctctgga caggttacct aaaaccagat ccatggatga tcttctttct
     1921 gcctgtgata caagcagccc cctcactcgt acttccagtg acccgaacct gaataaccac
     1981 tgtcaggagg tcagagtcag cctggagccc tggcacagca atcctgaagg agcagaggca
     2041 gtcatagaat ctggagtcgg aagcccacag ctgactgtgg gagacgtggg ccttcctcct
     2101 cctctgccca gtagccagaa agactacttg agcaataaac ctttcaaggg tcacaaaagt
     2161 tgttctctta gttataagtt gcttaatact tctgtgtcct gggaaatgaa gaacacctct
     2221 gagatcaaag tcctggaaga aactgaagca ctggccccgg gccctccagc ccgagaggag
     2281 cagagtagga cttctgatgg cttagggaag ccacctgaac agtgtccaga gaaggaagct
     2341 accagctcac tctccaatgt ttccagcaag tgtggaggag cctgtgattt tcctggggag
     2401 cctccccagg attcctttac aggtactccc caacagcccc atctagactc catgcaggct
     2461 gtgcccatca ggtgtactcc agatcacggt cagggcagcc tttgcaaccc accaagtgct
     2521 gccagccaaa ctcttcaaga gccaaatact gacctcatca gccaagatcc ccctgggtct
     2581 atggcaggta tctcctacca ggaacagcct agttctgtgt cggatctgat ctataagaag
     2641 gaagatgctg gcaagagagg aagtaaaaat gggcagttgg tggaaaatcc tcgctttggg
     2701 aaaatgccat tagagttggc ccgaaagcca atttctcaga gccagatcag tgagttctca
     2761 tttttagggt caaactggga cagcttccaa gggatgatga cgtcattccc cagtggagag
     2821 accactcctc ggcggctgct tgcttatggc tgttgtagca agaggccgag caataagcat
     2881 atccgagctg cagcgccctg ctttgggggc cagtgggctc agagagaagg gatgaagtcg
     2941 cccgtctgct ctagtcattc caatggacac tgtacaggcc caggaggaaa gaacaaccgg
     3001 atgtggtttt ccagtcatcc aaagcaagtc tccagcacaa agccttctct tctgagctgc
     3061 ccttctccag tgcctcctct ctacctggat gatgatggac tcccctttcc cacggatgtg
     3121 atccaacata ggttacggca gatcgaagca gggtacaagc aagaggtaga acagctacgt
     3181 cgacaggttc gagagcttca gatgaggcta gacattcgtc actgctgtgc ccctccagca
     3241 gagcccccca tggactatga ggatgacttt acgtgtttaa aggagtcaga tggcagtgac
     3301 actgaagact ttggctctga tcacagtgag gactgccttt cagaagcaag ctgggaacct
     3361 gttgataaga aggagacgga ggtgactcgc tgggttccag accatatggc atcacactgc
     3421 tataactgtg actgtgaatt ctggttggcc aaacgaaggc atcattgcag aaattgtggg
     3481 aacgtatttt gtgctggatg ctgccacctt aagctgccca ttcccgatca gcaactctat
     3541 gacccagttc tcgtctgtaa ctcatgttac gagcacattc aagtgtctcg tgccagggag
     3601 ctcatgagcc aacatctgaa gaaacccatt gctacagctt ccagttgaat gccagaggag
     3661 atgatctgtc catttttagc aggtttgaag ggaggatctg cttcaggtgt agtctggaag
     3721 gttccttggt atggctcatg aacacagagc tcaaagatac cgtcttgaga aatcctcctt
     3781 ggtaccatgt gaccggagca gaggaatttg aatttggcag gagatttttc taccacagag
     3841 accctcactt tggggtaatg gtcctgatcc agacccagag tctggaagct tcacactgag
     3901 ttggtgactc cagcttctct ctcctggagg tcccgagatg atgattcaga aattctgcct
     3961 ggtgcacagt gctcaaacag caataggaag gcaaactggt aaccagactc ccaagtcaca
     4021 gtgggaccca tctctgcctg caaagagcag atcatagtag acgagatagg aattcccatc
     4081 ctatttgagt tgaactctct tctgtacctc tgtgctctgt gtctgtgcat gaaggctcag
     4141 tctttagagg cactccctct agttgattag cactatcttc tgtggagttt ggttcaaaga
     4201 ctggtttggc aaatagaggt ttggatgcat ttttcatctg gctcgttggc tagcatcagt
     4261 gaatattcag tttcagaggg acagttctga ggattaagac acttttggaa tcagaaaaac
     4321 tctggcgatg cttagtcttg tgagaatcag ttttctgagc tgtgagggca gttgtcacta
     4381 ttatgtagtg gctgctcttg aggtacgcac tgtgaagaat gagaagggaa aagcaagatt
     4441 acccttgtga attctgctga ttgtgcccta ccctttgcac ctgacttttc ctagttgtcc
     4501 tggtgctaac atgggagcta caccttgatc ctctcctggc atgaaaataa aggattttat
     4561 tgttccactg cccacttccc ccatgttgtc tttcccttgg ccgctgcctc ctctgggtca
     4621 cactgcttct tatcctgaac acttgacacc tcgagggtag aatatagcat ttggttttta
     4681 cctcctagca tatgctactt ggtatgtgag ggtttcagta caaatgctgc tgtctatttc
     4741 tgtgcactta acaatggaac ccaaacagaa ggaagaaagc cttgatacca aaattgggag
     4801 tgaggatgtg tccatttgga ccaaacactt tattctgttt tatttagatt ttgtttttca
     4861 tcttactatg taccagtggc acttaaccaa aagatacagt aatacagcca tgttctgtgg
     4921 ttgggacaga tacagtctcc ttggctcata ggacttccta gctacattct ccttactgca
     4981 ctaatgtaga gaagatacgc tgcccactct gttaaagccg cagctgctgt ctttctcacc
     5041 tgctactgtc atgttgcttt ctagaaaaca ctttttcatt ccagactaac cagaacctgc
     5101 atttagaata ggaattgttt ctcctgacct tttcttcagt tctacagcaa agcctctgtg
     5161 ctccttttat acttgccatg gatgtaacct aaaaagtttt ggcatattta ggtcaaccta
     5221 gcacattttt tcttctcatt ttaatggagc tggataatgg agatttttgt gtctgggaaa
     5281 ttcctaagat caatgaaaga gtgacaagca gtttgtctct gatacataaa attattttaa
     5341 gcattttctc aatcattaaa tgttactgcc agtcccaagt ggctttttaa ttaccagttt
     5401 tcattgcact tcactctgtt ttcaggggga tcgggaacat tcggggagac tgtatctgtc
     5461 tactttgtgt ggctgttttg agggactgtc ccatcagtga acagattgca tggcctggag
     5521 agactgggct tctggctcag atgcgttcac cctttcagag ctgatgtggg tgtaagtgac
     5581 atgatgcggc caaatatcca aactgtgcag ttgcgttgtg atacacatgc aatgtgctgt
     5641 aagaactcaa tacagttcaa ataaaatctc tatattagtg ctgc
//
