LOCUS       NM_001012038            5733 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Rattus norvegicus myotubularin related protein 3 (Mtmr3), mRNA.
ACCESSION   NM_001012038 XM_223569
VERSION     NM_001012038.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5733)
  AUTHORS   Vicinanza,M., Korolchuk,V.I., Ashkenazi,A., Puri,C., Menzies,F.M.,
            Clarke,J.H. and Rubinsztein,D.C.
  TITLE     PI(5)P regulates autophagosome biogenesis
  JOURNAL   Mol Cell 57 (2), 219-234 (2015)
   PUBMED   25578879
REFERENCE   2  (bases 1 to 5733)
  AUTHORS   Lorenzo,O., Urbe,S. and Clague,M.J.
  TITLE     Systematic analysis of myotubularins: heteromeric interactions,
            subcellular localisation and endosome related functions
  JOURNAL   J Cell Sci 119 (Pt 14), 2953-2959 (2006)
   PUBMED   16787938
REFERENCE   3  (bases 1 to 5733)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   4  (bases 1 to 5733)
  AUTHORS   Walker,D.M., Urbe,S., Dove,S.K., Tenza,D., Raposo,G. and
            Clague,M.J.
  TITLE     Characterization of MTMR3. an inositol lipid 3-phosphatase with
            novel substrate specificity
  JOURNAL   Curr Biol 11 (20), 1600-1605 (2001)
   PUBMED   11676921
REFERENCE   5  (bases 1 to 5733)
  AUTHORS   Taylor,G.S., Maehama,T. and Dixon,J.E.
  TITLE     Myotubularin, a protein tyrosine phosphatase mutated in myotubular
            myopathy, dephosphorylates the lipid second messenger,
            phosphatidylinositol 3-phosphate
  JOURNAL   Proc Natl Acad Sci U S A 97 (16), 8910-8915 (2000)
   PUBMED   10900271
REFERENCE   6  (bases 1 to 5733)
  AUTHORS   Zhao,R., Qi,Y. and Zhao,Z.J.
  TITLE     FYVE-DSP1, a dual-specificity protein phosphatase containing an
            FYVE domain
  JOURNAL   Biochem Biophys Res Commun 270 (1), 222-229 (2000)
   PUBMED   10733931
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087045.1.
            
            On Feb 11, 2005 this sequence version replaced XM_223569.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087045.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..5733
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..5733
                     /gene="Mtmr3"
                     /note="myotubularin related protein 3"
                     /db_xref="GeneID:305482"
                     /db_xref="RGD:1310972"
     exon            1..162
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            163..211
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            212..301
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..3805
                     /gene="Mtmr3"
                     /EC_number="3.1.3.95"
                     /note="phosphatidylinositol-3-phosphate phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase"
                     /codon_start=1
                     /product="phosphatidylinositol-3,5-bisphosphate
                     3-phosphatase MTMR3"
                     /protein_id="NP_001012038.1"
                     /db_xref="GeneID:305482"
                     /db_xref="RGD:1310972"
                     /translation="MRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEYVGRA
                     EDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFPTFEQ
                     CQDWLKRLNNAIRPPGKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNE
                     VERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVAGFRSWKRIPAVI
                     YRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSQSSVGKVSTRNSCRG
                     FPNAGDLSDVEFDASLSNASGTESLALQPQKLLILDARSYAAAVANRAKGGGCECPEY
                     YPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSAL
                     LVVHAVDRDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTVEGFQVLVEMEWLDFGH
                     KFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCL
                     FGTFLCNNAKERGEKQTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLM
                     LWSAVYLPCPSPSTPTDDSCAPYPAPGTSPDEPPLSRLPKTRSFDNLTTTCDNMVPLA
                     SRRSSDPSLNEKWQEHGRSLELSSFAGSGEEVPAIDSLRRPSRLLGGAELSVAAGVAE
                     GQMENILQEATKEESGVEEPTHREHTEVPEVKEEAPLAKESRTAAQGSGVLYQEPQLD
                     DATLRSHLGPSLSSFSQGIPEHREVGHSVLSSSLPASLRGEDSQEVPVEQPQVENIAE
                     DRENVVPAVPVDVKIGLGTSESSPLLPSQVPFETRGPHMNNSVHMLLEDKVKSESGPQ
                     LHHRPCLASSGRFSGKDMLPIAPEPRSAERPQWDSVLHRTSSPGNTLSLMMQAPCALP
                     LDKCRQRIVCNGALETENKASEQPAGFDTLQKYPTPNGHCANGETGRSKDSLSHQLSA
                     TSYSSAHSCSRNLHHKWLNSHSGRPSTTNSPEQPSRSHLDDDGMPVYTDTIQQRLRQI
                     ESGHQQEVETLKKQVQELKSRLESQYLTSSLRFNGDFGDEVTSIPDSESNLDQNCLSR
                     CSTEIFSEASWEQVDKQDTEMTRWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCS
                     SCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN"
     exon            302..418
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            419..501
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            502..668
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            669..765
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            766..879
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1085
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1217
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1329
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1525
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1711
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1882
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2028
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..3433
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3434..3544
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3545..3633
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
     exon            3634..5708
                     /gene="Mtmr3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgtggttg tgagaaggcg gcggcggcag cggtggcggc ggagcagccg gtggagacgc
       61 tccagcggcc caggcgctgc cccccgccga ccctggctgg cagcctcctg gggtggcgga
      121 ggaggccgtg cggtggcggg cctcgccatg tcctgcctcc cgatttcctt gtaaaacctt
      181 gtagaagaaa aagttctcag gaagatactt ggatgaagag atgcggcata gccttgagtg
      241 catccaggcc aatcagatct ttcccaggaa gcagctgatt cgggaggatg aaaatcttca
      301 ggttcctttc cttgaactcc atggagagag cacagagtat gtgggccgtg ctgaggatgc
      361 catcattgcc ctctctaatt acagacttca catcaagttt aaggagtctc ttgtgaatgt
      421 tccattacag cttatagaaa gcgttgaatg ccgtgatata tttcagcttc acttgacatg
      481 caaagactgc aaagttatca ggtgtcagtt cccaaccttt gagcagtgtc aagattggct
      541 taagagatta aacaatgcaa tccgaccacc tggaaaaata gaagatctct tctcatttgc
      601 ataccatgct tggtgcatgg aggtctatgc cagtgaaaaa gagcagcatg gagacctgtg
      661 cagaccaggg gaacatgtaa cgtcaaggtt taagaatgaa gtggagcgga tgggttttga
      721 tatgaacaat gcctggagga tttccaacat caatgagaaa tacaaattat gtggtagtta
      781 tccacaagag ctcatagtac ctgcctggat cactgacaaa gaactagaaa gcgtggcagg
      841 cttcagatcc tggaagcgca tccccgccgt catctacagg caccagagca atggagccgt
      901 cattgcccgc tgcggacagc ccgaggttag ctggtggggc tggcggaatg ctgatgatga
      961 acatctggtg cagtcagtgg ccaaggcttg tgcttctgac tctcagtcaa gtgttggcaa
     1021 ggtttccact cggaacagtt gtcggggctt tcccaatgca ggggatcttt ctgatgtgga
     1081 gttcgatgcc tctctgtcaa atgcttcagg aacagaaagt ttagctctcc agccacagaa
     1141 gcttttgatc ttggacgcac gctcctatgc agcagctgtg gcaaatcgag ccaaaggagg
     1201 gggctgtgag tgtccagagt attatccaaa ctgtgaagtt gtgtttatgg gaatggcaaa
     1261 catacattct atccggagga gtttccagtc tctgcgactg ctgtgcacac agatgccaga
     1321 tcctggaaat tggctttctg ctcttgaaag tacgaagtgg ctccaccacc tgtctgtgct
     1381 tctgaagtcg gcacttctcg tggtgcatgc tgtggaccga gatcagcgac cagtgctggt
     1441 gcactgctca gatggctggg atcgcactcc ccaaatcgtg gccctggcta agcttctgct
     1501 ggacccttat taccgaaccg tagagggttt ccaagtcctt gtggagatgg aatggctgga
     1561 ttttggccat aagtttgctg atcggtgtgg tcatggggag aactcagatg acctgaatga
     1621 gcgttgccca gtgtttctcc aatggcttga ctgtgttcat caactccaga ggcaatttcc
     1681 ttgctctttt gagttcaacg aagcattcct tgtgaagctg gttcagcaca cctattcctg
     1741 tctctttggg acattcctgt gcaacaacgc caaggagagg ggggagaagc agactcagga
     1801 acggacatgc tcggtgtggt cgcttctgcg ggccggcaac aaggccttca aaaacctgct
     1861 atattcatcc cagtcagaag ccgtgctgta ccctgtgtgc catgtgcgga atctgatgct
     1921 gtggagtgca gtgtaccttc cctgcccgtc cccatccacc cccacagacg acagctgtgc
     1981 accataccca gccccaggca ccagccctga tgagcctcca ctgagccggc tacccaagac
     2041 tagatcattt gacaatctga ccacaacctg tgacaacatg gtgccgctgg ccagccggcg
     2101 cagcagtgac cccagcctga atgagaagtg gcaggagcac gggcgctcgc tggagttgag
     2161 cagctttgct ggctctgggg aagaggtgcc tgccatagac agcctgcgca ggcccagcag
     2221 gctgctcgga ggagccgagc tatctgtggc agctggtgtg gctgaagggc agatggagaa
     2281 tattttgcaa gaggccacca aagaggagag tggggtagaa gagcccaccc acagggagca
     2341 cactgaggtg ccagaggtca aagaggaggc acccctagca aaagagagta ggacggcagc
     2401 tcagggctca ggtgtacttt accaagaacc acagctggat gatgctactc taaggagcca
     2461 tttaggcccc agcctgtctt cgttctccca gggtattcct gagcatcggg aggtggggca
     2521 cagtgttctc tctagttcac tcccagcttc tctcagggga gaggactccc aggaggtccc
     2581 tgtagaacag cctcaagtag agaacattgc agaggacagg gagaatgtag tccctgctgt
     2641 cccagtagat gtaaaaattg gccttggtac ctcagagtct agtcctctgc tgccttccca
     2701 agtcccattc gagacaagag gaccacacat gaacaactcc gtgcacatgt tattagaaga
     2761 taaggtgaag tccgagagtg ggccccagct ccatcacaga ccctgcctgg caagcagtgg
     2821 tagattcagt ggcaaggaca tgcttcctat agcaccagag cccaggtctg ctgagaggcc
     2881 ccagtgggac tctgtgctac acaggacttc ttcccctggc aacaccctca gcctgatgat
     2941 gcaggctcct tgtgccttgc cattagacaa atgtagacag agaattgtgt gcaacggtgc
     3001 cctagagact gaaaacaagg cctcagaaca gcctgcaggg tttgacaccc ttcagaagta
     3061 ccccacaccc aatgggcatt gtgccaatgg ggagactggg aggagtaagg actcactgag
     3121 ccaccagctg tctgccacaa gctatagctc tgctcactcg tgctcaagga acttgcacca
     3181 caagtggctg aatagccact cggggaggcc atccactacc aacagccctg agcagccttc
     3241 ccgcagccac ctggatgatg acggcatgcc tgtgtacaca gacacgatcc aacagcgcct
     3301 gcgacagata gagtctggtc accagcagga agtggagacc ttgaagaaac aagtccagga
     3361 actgaagagt cgcctggaga gccagtacct gaccagctct ctgcgcttca atggggactt
     3421 tggagatgaa gtgacttcaa tccccgactc ggaaagcaat ctggatcaga actgtttgtc
     3481 tcgctgcagc acagagattt tctctgaagc cagctgggag caggtggata aacaggacac
     3541 agagatgacc cgttggctac ctgaccactt ggctgcccac tgctatgcct gtgacagtgc
     3601 cttctggctt gccagtagga agcaccactg caggaattgt gggaacgtat tctgctccag
     3661 ttgttgtaac cagaaggttc cagttcccag ccagcagctc tttgaaccca gtcgagtgtg
     3721 caagtcttgc tatagcagcc tccatcccac aagctccagc attgaccttg aactggataa
     3781 gcctattgct gccacttcaa actgaagctc agtgacctgg ggtgacagag gccatgctgc
     3841 tgtccctgta acaggctcac acacagcctg ggcagtccga gaagcccata cattttggat
     3901 gggggcatgg aacaacctgt acagagattg gggtgtacca ctggatcgta gatcgatttt
     3961 cctttccttc cccttccctt tccatcctcc tctttgcctt ctaaaaagaa aaatgtccca
     4021 gttgtcttaa ttttttttaa tggaagccca gaggttacca ggctcttaga actgctgagt
     4081 ggcttgctgt cgggcactct gtgacatcac tcagtgcttc cctatggaag gaggcacaat
     4141 gaaggcctga gacagcagga cagaaagcca gcctaccatt aatgaccgtt ctccacatga
     4201 agctgtgcca cagttgactg gtgcaccttt gcagctgggg aggctggaag cccttttctt
     4261 gagtactgtt cctcagaggg atagataggg ccatcctacc tcacagacaa aaagcaggat
     4321 ggtgttgaga ggaagcacac agtgaagtgc tccacaggcc tcactttgaa aagagaggta
     4381 tgtgcttctt ttgagttact gagggcctag atggctgaca tgttggccca ggtggatcca
     4441 tctttaacaa gattgggtag ggctttcttt gcttctttag gcttccagac caaaaggtac
     4501 agactggcca gaaagcagta tcctgctgca gtggtcaagg cctgcactga gctgggcacc
     4561 tgaggtcccc ctctgggtcc tagtcccata agcaatctct tcctcagcca acacagggaa
     4621 atccagactc agggttccac agtctcctgt tcccaaagca aaccaatcat gcatctcccc
     4681 ttgagggaca gatccccaca gttccgaagc tctccacaca atcagccttc ctctcttact
     4741 tctgggcagc aggaaggacc caggagtccc ttgtcctgct tttggctgcc tgagtgggca
     4801 catgtctggc tcttgctatc agtgaagagc ccttggtgat tgtagggttc ttagaagatg
     4861 acatggctga ggagattcgg ggtaccttcc cgtagtgagc tttgatgtgg tccaaaaaga
     4921 gccttaagtc tgtagttatc tgtgctggag gtgggtatga agggtagaga gcagttttgg
     4981 tttgtacttt gaattgttgg catctgtctg tgcccacccc atcccccaag ggtgatgctt
     5041 ggctctgcca aaagctgcaa tctggtaaca gagcagatta tagtgttggg gctgggtgag
     5101 gctgggtgag gctgggggac acctaatttt agcctggcct atgtccttgc tcctctcctc
     5161 tggaagctgt tacctggcca tgggccttcc gtgtctcagg aaggtggctt ctgcatgttc
     5221 ctcagtatga ctggagaagc cagagccttc ccagcagttg tgtgctgaag ggaaggctgc
     5281 agtctccgag tattgctggt ccttcaggag caggccgggc agaggccgag tttagtgaaa
     5341 cagggtgaag ttctccaagc tcgctgtggt ctggagttgc gggtggggaa ggtcggcata
     5401 actgaagact gcagttccta gtgagaggtg ccaagaggtt atgatacggg tgtcttgggt
     5461 ctgttgtaca gtgtgaataa gtgcttgcag ctcttagccc tttttgatca atgaagcact
     5521 tttttattaa tattttcttt gtatgtaaag gaggaaccgt aactctccat agctgtacat
     5581 ataacccctt tctcctaaag aggagtccgt gctcctatat ttttcatttt ttgtcaaagc
     5641 aagaagtaaa tactttagaa ttgttaaata catagataaa gtgaataaag ttgagtgtca
     5701 gcaaggtgaa aaaaaaaaaa aaaaaaaaaa aaa
//
