LOCUS       NM_001108123            3818 bp    mRNA    linear   ROD 13-OCT-2024
DEFINITION  Rattus norvegicus myotubularin related protein 2 (Mtmr2), mRNA.
ACCESSION   NM_001108123 XM_001068538 XM_235822
VERSION     NM_001108123.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3818)
  AUTHORS   Vaccari,I., Dina,G., Tronchere,H., Kaufman,E., Chicanne,G.,
            Cerri,F., Wrabetz,L., Payrastre,B., Quattrini,A., Weisman,L.S.,
            Meisler,M.H. and Bolino,A.
  TITLE     Genetic interaction between MTMR2 and FIG4 phospholipid
            phosphatases involved in Charcot-Marie-Tooth neuropathies
  JOURNAL   PLoS Genet 7 (10), e1002319 (2011)
   PUBMED   22028665
REFERENCE   2  (bases 1 to 3818)
  AUTHORS   Xhabija,B., Taylor,G.S., Fujibayashi,A., Sekiguchi,K. and
            Vacratsis,P.O.
  TITLE     Receptor mediated endocytosis 8 is a novel PI(3)P binding protein
            regulated by myotubularin-related 2
  JOURNAL   FEBS Lett 585 (12), 1722-1728 (2011)
   PUBMED   21510942
  REMARK    GeneRIF: suggest a model in which the localization of RME-8 to
            endosomal compartments is spatially mediated by PI(3)P binding and
            temporally regulated by MTMR2 activity
REFERENCE   3  (bases 1 to 3818)
  AUTHORS   Lee,H.W., Kim,Y., Han,K., Kim,H. and Kim,E.
  TITLE     The phosphoinositide 3-phosphatase MTMR2 interacts with PSD-95 and
            maintains excitatory synapses by modulating endosomal traffic
  JOURNAL   J Neurosci 30 (16), 5508-5518 (2010)
   PUBMED   20410104
  REMARK    GeneRIF: MTMR2 is targeted to excitatory synapses via direct
            interaction with PSD-95 and is important for excitatory synapse
            maintenance by regulating endosomal trafficking.
REFERENCE   4  (bases 1 to 3818)
  AUTHORS   Bolis,A., Coviello,S., Visigalli,I., Taveggia,C., Bachi,A.,
            Chishti,A.H., Hanada,T., Quattrini,A., Previtali,S.C., Biffi,A. and
            Bolino,A.
  TITLE     Dlg1, Sec8, and Mtmr2 regulate membrane homeostasis in Schwann cell
            myelination
  JOURNAL   J Neurosci 29 (27), 8858-8870 (2009)
   PUBMED   19587293
REFERENCE   5  (bases 1 to 3818)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   6  (bases 1 to 3818)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   7  (bases 1 to 3818)
  AUTHORS   Lorenzo,O., Urbe,S. and Clague,M.J.
  TITLE     Systematic analysis of myotubularins: heteromeric interactions,
            subcellular localisation and endosome related functions
  JOURNAL   J Cell Sci 119 (Pt 14), 2953-2959 (2006)
   PUBMED   16787938
REFERENCE   8  (bases 1 to 3818)
  AUTHORS   Berger,P., Berger,I., Schaffitzel,C., Tersar,K., Volkmer,B. and
            Suter,U.
  TITLE     Multi-level regulation of myotubularin-related protein-2
            phosphatase activity by myotubularin-related protein-13/set-binding
            factor-2
  JOURNAL   Hum Mol Genet 15 (4), 569-579 (2006)
   PUBMED   16399794
REFERENCE   9  (bases 1 to 3818)
  AUTHORS   Previtali,S.C., Zerega,B., Sherman,D.L., Brophy,P.J., Dina,G.,
            King,R.H., Salih,M.M., Feltri,L., Quattrini,A., Ravazzolo,R.,
            Wrabetz,L., Monaco,A.P. and Bolino,A.
  TITLE     Myotubularin-related 2 protein phosphatase and neurofilament light
            chain protein, both mutated in CMT neuropathies, interact in
            peripheral nerve
  JOURNAL   Hum Mol Genet 12 (14), 1713-1723 (2003)
   PUBMED   12837694
REFERENCE   10 (bases 1 to 3818)
  AUTHORS   Kim,S.A., Vacratsis,P.O., Firestein,R., Cleary,M.L. and Dixon,J.E.
  TITLE     Regulation of myotubularin-related (MTMR)2 phosphatidylinositol
            phosphatase by MTMR5, a catalytically inactive phosphatase
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4492-4497 (2003)
   PUBMED   12668758
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473993.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_235822.4, XM_001068538.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3818
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q12"
     gene            1..3818
                     /gene="Mtmr2"
                     /note="myotubularin related protein 2"
                     /db_xref="GeneID:315422"
                     /db_xref="RGD:1311865"
     exon            1..1073
                     /gene="Mtmr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             994..2925
                     /gene="Mtmr2"
                     /EC_number="3.1.3.95"
                     /codon_start=1
                     /product="myotubularin-related protein 2"
                     /protein_id="NP_001101593.1"
                     /db_xref="GeneID:315422"
                     /db_xref="RGD:1311865"
                     /translation="MEKSSSCESLGAQLPAARLPSEDSLSSASTSHSENSVHTKSVSA
                     ISSDSISTSADNFSPDLRVLREANKLAEMEEPALLPGENIKDMAKDVTYICPFTGAVR
                     GTLTVTNYRLYFKSMERDPPFVLDASLGVISRVEKIGGASSRGENSYGLETVCKDIRN
                     LRFAHKPEGRTRRSIFENLMKYAFPVSNGLPLFAFEYKEVFPENGWKLYDPLLEYRRQ
                     GIPNESWRITKVNERYELCDTYPALLAVPANIPDEELKRVASFRSRGRIPVLSWIHPE
                     SQATVTRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKG
                     GGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHI
                     KLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVE
                     KEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITI
                     LDHLYSCLFGTFLCNSEQQRGKENLPKKTVSLWSYINSQLEDFTNPLFGSYSNHVLYP
                     VASMRHLELWVGYYIRWNPRMKPQEPIHSRYKELLAKRTELQRKVEELQREISNRSTS
                     SSERASSPAQCVTPVQTVV"
     exon            1074..1179
                     /gene="Mtmr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1255
                     /gene="Mtmr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1350
                     /gene="Mtmr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1461
                     /gene="Mtmr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1563
                     /gene="Mtmr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1647
                     /gene="Mtmr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1797
                     /gene="Mtmr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1986
                     /gene="Mtmr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2172
                     /gene="Mtmr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2379
                     /gene="Mtmr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2472
                     /gene="Mtmr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2586
                     /gene="Mtmr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2763
                     /gene="Mtmr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..3818
                     /gene="Mtmr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcttttatga gtttaacaga ttcttcctct ttctcacttc aatacttagt acgccttaca
       61 gggtggtgtc aaagtgctta tcagttacag acacacttcc cggccacttt aacccatact
      121 cttgtcacag gaggcctgaa aacttcaact ccattctcac tttcctttgt ataacgctgt
      181 ttagaggtgt aaacattaga aatgtaattt tcagcgtttt ccctcccctc ccccggtggg
      241 tgttattacc tttctcctac caactacttg ttaatggtct gccatccttt agttttcttt
      301 ctttaacagt aaccatttat taaatttgtt aggttgttta tatatgcgca cccattgact
      361 acagcctgag cgcttcttaa gcaggcattg ctttaggcat tttacattta tcaacacatt
      421 ctgtgatgct aacacacgta cacagaagga agcaaatgta aacgcaaggt aactggaggc
      481 cgtggaatct gaatctgctt atcttcactg tgacctctac aaaataggtt ctcacatcac
      541 gtatgacata cgtttcacta tttctaacct catccttaaa tacttttact ccttaatctc
      601 ccacctcacc ccctcatccc ataggccgcc cacattcctc tcatttccct cgagtcagcc
      661 gcttccaagc cttcacatct tgtctctttt ctttgacgta ctggtgtcct cttccttatg
      721 aaggctttcc ttgtagctga aagtatccac cagactctta ggctgcctct cactgggtgg
      781 ccagggcgcg tgcgcaccgc accgctttgt agagccaagg gggcccgact cccaacagcc
      841 cccgcgcgca gtgcaggctg ggggaacatg gccgcttccg gtctcgcagt cttcctggcg
      901 aggggttgac agcggctgcg gccctgcgcg ctcctccctc tgcatctcgc gccggcggcc
      961 gcggagggcg cagcggcctc ctgttctcgc gccatggaga agagctcgag ctgcgagagt
     1021 cttggcgcgc agctcccggc ggcaaggctt cccagcgagg actcactgtc cagtgcttcc
     1081 acttctcatt cagagaactc ggttcatacc aaatcagttt ctgctatatc atcagattct
     1141 atttcaacct ctgcagacaa cttctctcct gatctgaggg tcctgaggga ggcaaacaaa
     1201 ttagcagaaa tggaggaacc agccctgctt ccaggagaga acatcaaaga tatggccaaa
     1261 gatgtgactt acatatgtcc gttcactggt gctgtacgag ggacgctgac tgtcacaaat
     1321 tacagattat atttcaagag catggaacgg gaccctccgt ttgttctaga tgcttctctt
     1381 ggggtgataa gtagagtaga aaaaatcggt ggtgcatcta gccgtggtga aaattcttat
     1441 ggcctggaaa cggtgtgcaa ggatatcagg aatttacgat ttgctcataa accagagggg
     1501 cgaacaagaa gatcaatatt tgagaatcta atgaaatatg catttcctgt gtctaacggc
     1561 ttgcctcttt ttgcttttga gtataaagaa gtattccctg aaaatgggtg gaaactgtat
     1621 gacccccttc tagagtacag aagacagggg attccaaatg aaagctggag aataacaaag
     1681 gtcaatgaac gctatgaact ctgtgacaca tatcctgccc tcttggccgt gccagcaaac
     1741 attcctgatg aggaactcaa gagagtggca tccttcaggt cccggggccg gatcccagtt
     1801 ttatcatgga ttcatcctga aagtcaggcc acagtcaccc gctgcagcca gcccatggtt
     1861 ggagtgagtg ggaagcgcag caaagaggat gagaagtatc ttcaggccat catggactcc
     1921 aatgcccagt ctcacaaaat atttatattt gatgctcggc caagtgtcaa tgctgttgcc
     1981 aataaggcaa agggcggagg ttatgaaagt gaagacgctt atcaaaatgc agaactcgtt
     2041 ttcctggaca ttcataatat ccatgttatg agagaatcat tacggaagct taaggagatt
     2101 gtgtacccca acattgagga aactcactgg ttgtctaact tagaatctac acactggctg
     2161 gaacacatca agctcattct tgcgggggct cttcggattg ctgacaaggt ggagtctggg
     2221 aagacgtctg tggtggtgca ctgcagtgat gggtgggatc gcacagctca gctcacgtcc
     2281 ctggccatgc ttatgctgga tggatactat cgaaccatac gaggatttga agtccttgtg
     2341 gagaaagagt ggctaagctt tggacatcga ttccaactaa gagttggcca tggcgataag
     2401 aaccatgctg atgcagaccg atcacctgtt ttccttcagt tcattgactg tgtctggcag
     2461 atgacaagac agttccctac cgcatttgaa ttcaatgagt attttctcat taccatcctg
     2521 gaccacttgt acagctgtct atttgggaca ttcctctgta acagtgaaca gcagagggga
     2581 aaagagaatc ttcctaagaa gacagtgtca ctgtggtcct atataaacag ccagctggaa
     2641 gacttcacta atcctctttt tgggagctac tccaatcatg tcctttaccc agtagccagc
     2701 atgcgccacc tagagctctg ggtgggctat tatataaggt ggaacccccg gatgaaacca
     2761 caggaaccta tccacagcag atacaaagaa cttcttgcca aaagaacaga gcttcaaaga
     2821 aaagtagagg aacttcagag agaaatttcc aaccgctcaa cctcctcttc agagagagcc
     2881 agctctcccg cacagtgtgt gactcctgtc caaactgttg tatgaaagaa ctaggcatgt
     2941 tgccaggaac ttgacattac agcaccttat gcgtagaaag ccttctgtgt tttaaaccca
     3001 tctgtgggag aatccttcag atgctgtatt tatttcaaat ctctcttaga tgagtttaga
     3061 aacatagcgg tgcaagtgac aatgaagatg atctcatttg taattaaaga tgacactaat
     3121 ctgaagtccc ccaaagaata ctaaagtact gcagtcctgt gctcaccctg ggagccagct
     3181 tttcatttaa agctgtctta aaagcactgc taagagctct aggtggggag aaaagcaagg
     3241 ctgttcttgc acctgagagc atacatacca agccttgatc tcaactgtcc cattttttgt
     3301 ggtatttaat atagtaaaaa gcattgtctt aaaattgtta cagcatagta gtagttggaa
     3361 attgctgctg acattgtaat tagcgtattt tcaacagcag ttaggaaacg atgccttata
     3421 tatttgcttt gggggtgaag ggacaaagta actgtcatcc aggaattcaa aaatattctt
     3481 tcccgtcagc caatttccat ttgtatgttg atcacaaata ccacagacac tttaaaacct
     3541 taccattact ccacttatct taatgctgat tggcaagttt taaaaactta agtgctatat
     3601 ttaaatttca catgaacatt ttatcaaaga ccactctgca tgtgagttag tctcggtgcc
     3661 agcaagtaaa gcctcgcttc tctgctcgcc tgagttgggt gctggtgtga acagttgact
     3721 cctggtgtct gtttcactct gtataagagc catatgtaat gtactgtaac aaacgagctt
     3781 cttaccactt ggtcttttaa ttaaatgact tcaaactt
//
