LOCUS       NM_001107880            2656 bp    mRNA    linear   ROD 13-OCT-2024
DEFINITION  Rattus norvegicus myotubularin related protein 14 (Mtmr14), mRNA.
ACCESSION   NM_001107880 XM_001076560 XM_232266
VERSION     NM_001107880.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2656)
  AUTHORS   Pan,Q., Liu,Y., Wang,G., Wen,Z. and Wang,Y.
  TITLE     MTMR14 protects against cerebral stroke through suppressing
            PTEN-regulated autophagy
  JOURNAL   Biochem Biophys Res Commun 529 (4), 1045-1052 (2020)
   PUBMED   32819563
  REMARK    GeneRIF: MTMR14 protects against cerebral stroke through
            suppressing PTEN-regulated autophagy.
REFERENCE   2  (bases 1 to 2656)
  AUTHORS   Tosch,V., Rohde,H.M., Tronchere,H., Zanoteli,E., Monroy,N.,
            Kretz,C., Dondaine,N., Payrastre,B., Mandel,J.L. and Laporte,J.
  TITLE     A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating
            variant in centronuclear myopathy
  JOURNAL   Hum Mol Genet 15 (21), 3098-3106 (2006)
   PUBMED   17008356
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473957.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001076560.1, XM_232266.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132291,
                              SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2656
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2656
                     /gene="Mtmr14"
                     /gene_synonym="RGD1304842"
                     /note="myotubularin related protein 14"
                     /db_xref="GeneID:312634"
                     /db_xref="RGD:1304842"
     exon            1..272
                     /gene="Mtmr14"
                     /gene_synonym="RGD1304842"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..2063
                     /gene="Mtmr14"
                     /gene_synonym="RGD1304842"
                     /EC_number="3.1.3.95"
                     /codon_start=1
                     /product="myotubularin-related protein 14"
                     /protein_id="NP_001101350.1"
                     /db_xref="GeneID:312634"
                     /db_xref="RGD:1304842"
                     /translation="MAGARAAAAASAGSTASSGSPPPQEPGLWELLEEFSRTQYRAKD
                     SGGKSGSKVELIEKRCLELFGRDYCFSVIPNVNGDICGHYPRHIVFLEYESSEKEKDT
                     FQSTVQVNKLQDLIHRSKMARCRGRFVCPVILFKGKHICRSATLAGWGELYGRSGYNY
                     FFSGGADDTWANTEDVTEEDFVLRSGDTHLFDKVRGYDIKLLQYLSVKYICDLMVENK
                     KVKFGMNVTSSEKVDKAQRYANFTLLSIPYPGCEFFKEYKDRDYMAEGLIFNWKQDYV
                     DAPLNIPDFLTQSLNIDWSQYQSWDLVQQTQNYLKLLLFIMNRDDDHGLLVHCISGWD
                     RTPLFISLLRLSLWADGLIHTSLKPAEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFC
                     FNFLKHITSEEFCLKTQRRKSLPTRDAGFTVEDICMLRHRDRGSTTSLGSDFSLVLEH
                     SPGAVGSFSYEAVELVPAGAPTQAAWRKSHSSSPQSMLWSRPQPSDDRLPSHHGFTEA
                     KSSSSSSSNHSDNFFRMGSSPLEVPKPRSVDHPLPGSSLSTDFGSWQMVSGCGSIQER
                     PVLHTDSSLPFSFQDELPNSCLLTALSDRETRLQEVRSAFLAAYSSTVRLRAAAPSPS
                     GAIGGLLEQFARGVGLRGTSTSAL"
     exon            273..421
                     /gene="Mtmr14"
                     /gene_synonym="RGD1304842"
                     /inference="alignment:Splign:2.1.0"
     exon            422..530
                     /gene="Mtmr14"
                     /gene_synonym="RGD1304842"
                     /inference="alignment:Splign:2.1.0"
     exon            531..606
                     /gene="Mtmr14"
                     /gene_synonym="RGD1304842"
                     /inference="alignment:Splign:2.1.0"
     exon            607..667
                     /gene="Mtmr14"
                     /gene_synonym="RGD1304842"
                     /inference="alignment:Splign:2.1.0"
     exon            668..790
                     /gene="Mtmr14"
                     /gene_synonym="RGD1304842"
                     /inference="alignment:Splign:2.1.0"
     exon            791..864
                     /gene="Mtmr14"
                     /gene_synonym="RGD1304842"
                     /inference="alignment:Splign:2.1.0"
     exon            865..935
                     /gene="Mtmr14"
                     /gene_synonym="RGD1304842"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1010
                     /gene="Mtmr14"
                     /gene_synonym="RGD1304842"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1077
                     /gene="Mtmr14"
                     /gene_synonym="RGD1304842"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1163
                     /gene="Mtmr14"
                     /gene_synonym="RGD1304842"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1240
                     /gene="Mtmr14"
                     /gene_synonym="RGD1304842"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1277
                     /gene="Mtmr14"
                     /gene_synonym="RGD1304842"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1345
                     /gene="Mtmr14"
                     /gene_synonym="RGD1304842"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1404
                     /gene="Mtmr14"
                     /gene_synonym="RGD1304842"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1543
                     /gene="Mtmr14"
                     /gene_synonym="RGD1304842"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1723
                     /gene="Mtmr14"
                     /gene_synonym="RGD1304842"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1879
                     /gene="Mtmr14"
                     /gene_synonym="RGD1304842"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2656
                     /gene="Mtmr14"
                     /gene_synonym="RGD1304842"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggaagtgga agaagaaggc ggcggctgag tcggttcagg aggttttaga gcccgagtcc
       61 gagcttcagg tgccatgggt tgggtgaagg cgccctgagg ggacttgagg ctgtgcatgg
      121 cgggtgctcg ggccgccgcc gccgcctcgg cgggttccac tgcctcttca ggcagcccgc
      181 cgcctcagga gccggggctc tgggagctgc tggaggagtt ctcccggact cagtaccgtg
      241 ccaaggacag cggcgggaag agcggctcta aggttgaact cattgagaag agatgtctgg
      301 agctatttgg ccgtgactac tgtttcagcg tgattccaaa tgtgaatggt gatatctgcg
      361 gccactaccc ccgccacatc gtattcctgg agtatgagag ttctgagaaa gagaaagaca
      421 cgtttcagag cacggtgcag gtgaacaagc tgcaagacct cattcaccga agcaagatgg
      481 ccaggtgcag aggccggttt gtctgcccag tgatcctgtt taaaggcaag catatttgca
      541 ggtcggccac actggctgga tggggagagc tgtatggacg ctctggatac aactattttt
      601 tctcaggggg agcagatgat acctgggcaa atacagaaga tgtcacagaa gaggactttg
      661 ttctccgaag tggtgacacg caccttttcg ataaggtgag aggctatgat atcaagctgc
      721 ttcagtacct gtcagtcaag tacatctgtg acctgatggt ggagaacaag aaggtgaagt
      781 ttggcatgaa tgtaacctcc tctgagaagg tggacaaagc ccagcgctat gcaaacttca
      841 ctctcctttc tattccatat ccaggctgtg aattcttcaa ggaatataaa gatcgggatt
      901 acatggcaga agggctcata tttaactgga agcaggacta cgtcgatgcc ccattgaaca
      961 tccccgactt cctgactcaa tctctgaata ttgactggag ccagtatcag agttgggacc
     1021 tggtgcaaca aacacagaac tacctgaaac tgctgctttt catcatgaac agagacgatg
     1081 accacgggct gctggtacac tgtatctcag gctgggatcg gacccccctc ttcatctctc
     1141 ttctacgcct ttccttgtgg gctgatgggc taattcacac atccctgaag cctgctgaga
     1201 tcctctacct gactgtggcc tatgactggt tcctctttgg acacatgttg gtagatcggc
     1261 tcagcaaagg agaggagatt ttcttctttt gcttcaattt tttgaagcat atcacctccg
     1321 aagagttctg cctgaagacc cagaggagga agagtttgcc aactcgggat gcaggcttca
     1381 ctgtggaaga tatctgcatg ttgagacaca gagatcgagg cagcacaacc agcctaggca
     1441 gcgacttctc cctggtcttg gagcactcac caggagctgt gggcagcttc agctatgagg
     1501 ctgtggaact tgtcccggca ggagcaccaa ctcaggcagc ttggaggaag agtcactcat
     1561 cctccccaca gagtatgctc tggagccggc cacagccctc tgacgaccgc ctaccttcac
     1621 accatgggtt cactgaagcc aagtcttcta gctcttcatc ctcaaaccat tctgacaact
     1681 ttttcaggat gggcagcagt cctcttgagg tccccaaacc cagatcagtg gaccatcccc
     1741 tgcccggatc ctctctctcc acagactttg gcagctggca gatggtatcg ggctgtggca
     1801 gtattcagga acggcctgtc ctgcacacag actcctctct ccctttcagc ttccaggatg
     1861 agctccctaa cagttgtcta cttacagctc tgagtgacag ggagacacgg ctgcaggagg
     1921 tgcggtctgc cttcttggct gcatacagca gtacagtgag acttcgagct gcagccccca
     1981 gtccctctgg tgccattggg ggcctgctag aacaatttgc ccgtggtgtt gggctccggg
     2041 gcacaagcac cagtgccttg tgaagctgac agcccatggt tgtttcctgc ccatctcagc
     2101 tgagccctcg gtggaatcaa gccatgcctg gcaaaagggg cattgtggag caggggaaat
     2161 gtcacatcca tcccctcact gttgcacaca tgacaacccc aaacctgagc aggcctgagg
     2221 atgggacttt ctacctccca acctcctgac tggtgaccac tcttgtcact gcctcccacc
     2281 aaccctgcct ggtctttgga ttactgtcaa ctctcagaac tgtgttggag ggtacagggg
     2341 gttcccaggg cctcgtgaag gctataatgt cagaaaagac cccagtctgc actttttgtt
     2401 tcctgggaag gagagtcacc tgcactgaaa atgaggcaat ttcacactaa tcacaaaata
     2461 aaatcaagtt ttttgaacag cttctctctg gcgtttctgg ttgtgactgt cctagggcta
     2521 ctcggaacct tactgcctgt ccttgtgccg gatgaagggt taagctttga ggatggaagc
     2581 aatggagggt ttatctggtc tttctctgct ggggaaagaa acccaggcct tgtgtctgag
     2641 cagataaatg ctctac
//
