LOCUS       NM_001415035            4622 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus myotubularin related protein 12 (Mtmr12),
            transcript variant 1, mRNA.
ACCESSION   NM_001415035 XM_006232046
VERSION     NM_001415035.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4622)
  AUTHORS   Slater,L.H., Hett,E.C., Clatworthy,A.E., Mark,K.G. and Hung,D.T.
  TITLE     CCT chaperonin complex is required for efficient delivery of
            anthrax toxin into the cytosol of host cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9932-9937 (2013)
   PUBMED   23716698
REFERENCE   2  (bases 1 to 4622)
  AUTHORS   Lorenzo,O., Urbe,S. and Clague,M.J.
  TITLE     Systematic analysis of myotubularins: heteromeric interactions,
            subcellular localisation and endosome related functions
  JOURNAL   J Cell Sci 119 (Pt 14), 2953-2959 (2006)
   PUBMED   16787938
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Dec 20, 2022 this sequence version replaced XM_006232046.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.5823.1,
                                           SRR26643289.5683.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               JAXUCZ010000002.1  62950889-62951070
            183-246             JAXUCZ010000002.1  62975536-62975599
            247-392             JAXUCZ010000002.1  62978405-62978550
            393-465             JAXUCZ010000002.1  62979472-62979544
            466-596             JAXUCZ010000002.1  62981432-62981562
            597-687             JAXUCZ010000002.1  62982954-62983044
            688-817             JAXUCZ010000002.1  62991454-62991583
            818-893             JAXUCZ010000002.1  62998012-62998087
            894-1000            JAXUCZ010000002.1  63003611-63003717
            1001-1125           JAXUCZ010000002.1  63004525-63004649
            1126-1204           JAXUCZ010000002.1  63005933-63006011
            1205-1275           JAXUCZ010000002.1  63007927-63007997
            1276-1448           JAXUCZ010000002.1  63010673-63010845
            1449-1616           JAXUCZ010000002.1  63013599-63013766
            1617-1778           JAXUCZ010000002.1  63014640-63014801
            1779-4622           JAXUCZ010000002.1  63017476-63020319
FEATURES             Location/Qualifiers
     source          1..4622
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..4622
                     /gene="Mtmr12"
                     /gene_synonym="Pip3ap"
                     /note="myotubularin related protein 12"
                     /db_xref="GeneID:310155"
                     /db_xref="RGD:1307902"
     exon            1..182
                     /gene="Mtmr12"
                     /gene_synonym="Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..2348
                     /gene="Mtmr12"
                     /gene_synonym="Pip3ap"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphatidylinositol 3-phosphatase-associated protein;
                     inactive phosphatidylinositol 3-phosphatase 12"
                     /codon_start=1
                     /product="myotubularin-related protein 12 isoform 1"
                     /protein_id="NP_001401964.1"
                     /db_xref="GeneID:310155"
                     /db_xref="RGD:1307902"
                     /translation="MLGKGGVGGGGGTKAPKPSFVSYVRPEEIHTNEKEVTEKEEVTL
                     HLLPGEQLLCEASTVLKYVQEDSCQLGICGRLVCTDFRISFLGDEGSAVDNGAETHFK
                     NKIIGVNDIPLHCVDQIYGVFDEKKKPLFGQLKKYPEKLVIHCKDLRVLHFCLRYTKE
                     EEVKRIVSGIIHHTQSPKLLKRLFLFSYAAAVHGTAADPRNCTVMFDTPKDWCWELER
                     TKGSVKYKTVSVNEGYRVCDRLPAYFVVPTPLLEDDVKRFQGRGIPIWCWSCHNGSAL
                     LKMSALPKEQDDSALQIQKSFLDGIYKTIHRPPYEMVKTEDLSSNFLSLQEIQSSYCK
                     FKQLFLIDSSSEFWDTDVKWFSLLESSGWLDIIRRCLKRAIEIIECLEAQNMNVLLLE
                     ENASDLCCLLSSLVQVMMDAHCRTWTGFQSLIQKEWVMGGHSFLDRCNHLHQSDKEEV
                     PVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNMGRE
                     SLDAQSKPLTLLTVWDWSVQFEPKAQTLLRNPLYVEKPKLDKGQRKGSRFKHQRQLSL
                     PLTQSKSSPKRGFFREETDHLIKNLLGKRISKLINSSDDLQDNSREFYDNWHSKPTDY
                     HGLLLPHIEGPEIKVWAQRYLRWIPEAQILGGGRVATMGKLLEMMEEVQSLQEKIEAR
                     HHRQEAIHVQAPGLLRNSARLSSLFPFAMHQRHSAKPVLPTSGWKALGGEDDLAKRED
                     EFVDLGDV"
     exon            183..246
                     /gene="Mtmr12"
                     /gene_synonym="Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            247..392
                     /gene="Mtmr12"
                     /gene_synonym="Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            393..465
                     /gene="Mtmr12"
                     /gene_synonym="Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            466..596
                     /gene="Mtmr12"
                     /gene_synonym="Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            597..687
                     /gene="Mtmr12"
                     /gene_synonym="Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            688..817
                     /gene="Mtmr12"
                     /gene_synonym="Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            818..893
                     /gene="Mtmr12"
                     /gene_synonym="Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1000
                     /gene="Mtmr12"
                     /gene_synonym="Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1125
                     /gene="Mtmr12"
                     /gene_synonym="Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1204
                     /gene="Mtmr12"
                     /gene_synonym="Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1275
                     /gene="Mtmr12"
                     /gene_synonym="Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1448
                     /gene="Mtmr12"
                     /gene_synonym="Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1616
                     /gene="Mtmr12"
                     /gene_synonym="Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1778
                     /gene="Mtmr12"
                     /gene_synonym="Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..4622
                     /gene="Mtmr12"
                     /gene_synonym="Pip3ap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagccccgg ccgctggtgc tggtggccgc cgccactgcc ggaacctgag ccggagccgc
       61 cgcctctgcc gccgcgcgtc gttgcttcgc aaggcggcgg aatgctgggg aaagggggag
      121 tcggcggtgg cggcggcacc aaggcgccca agccctcctt cgtgtcgtac gtgcgccctg
      181 aggaaattca cacaaatgag aaggaagtaa cagagaagga ggaagtcact cttcacttgt
      241 tgccaggtga acaactgctc tgtgaagcca gcacggtcct gaagtatgtg caggaggact
      301 cttgtcagct tggtatctgt gggaggctcg tctgcaccga cttcagaatc tccttcctgg
      361 gggatgaagg ctcggctgtg gataatgggg cggaaactca ttttaagaat aagatcatag
      421 gagtaaatga cattccactc cactgtgtgg atcagattta tggagtgttt gatgagaaaa
      481 aaaaacctct gtttggacaa ctgaagaaat accctgagaa gcttgttatc cattgcaaag
      541 acctgcgggt gctccacttc tgtctgaggt acacaaagga ggaggaagtc aaaaggattg
      601 tcagtggcat aatccatcat acccagagtc ccaaactgct gaaaagactg tttctgtttt
      661 cctacgcagc tgctgtgcat ggcacagctg ctgaccccag gaactgtacc gtaatgtttg
      721 acacacccaa agactggtgc tgggagctgg agcggaccaa ggggagtgtg aagtacaaaa
      781 cagtgagtgt gaatgaaggc tacagagtct gtgacaggtt gccggcatac tttgttgtcc
      841 ccactcccct tctcgaagac gatgtgaagc gttttcaggg ccgtggcata ccaatctggt
      901 gttggtcctg tcacaatgga agtgcccttc tgaaaatgtc agcactgccc aaagaacagg
      961 atgacagtgc tttgcaaatt cagaagagct tcttggatgg aatttacaag actatccaca
     1021 ggccacccta cgaaatggtt aaaacggaag acttgtcaag caacttcctt tccctacagg
     1081 agatccagag ttcatactgt aaatttaagc agctgtttct gatagatagc agttcagaat
     1141 tttgggacac agatgtaaag tggttttctc tcttagaaag cagcggctgg ctggatataa
     1201 tcagacgctg cctgaagaga gcaatagaga ttatagaatg cctggaagcg cagaacatga
     1261 acgtcctcct cttggaagag aacgcttctg atctctgctg cctcctatca tctctggtgc
     1321 aagtgatgat ggatgcccac tgtcgaacct ggactgggtt tcagagcctc atccaaaagg
     1381 agtgggtcat gggtggccac tcttttttgg accgctgtaa ccatctccac cagagcgaca
     1441 aagaggaggt ccctgtgttc ctgcttttct tggactgtgt ctggcaactg gtgcaccagc
     1501 atcccccggc atttgagttc acagagacat acctgactgt tctgtcagat agcctgtata
     1561 tacctatttt tagcaccttc ttcttcaatt cacctcatca aaaagatact aacatgggca
     1621 gggagagcct ggatgcacaa agcaagcctt tgacgctgct caccgtgtgg gattggtcag
     1681 tacagtttga acccaaagca cagactttgc tcagaaaccc tctttatgtg gaaaagccaa
     1741 aactggacaa aggccagcgg aaaggatcac gtttcaaaca tcaacgacaa ctttctttgc
     1801 cacttaccca gtctaagtca tctcccaaaa gaggattttt cagagaagaa acggatcatt
     1861 taatcaaaaa ccttctaggc aagagaatta gtaaacttat taactcttcc gatgatctcc
     1921 aggacaactc tcgagagttc tatgacaact ggcatagtaa gcccacagac taccatggct
     1981 tgttgttgcc tcacattgag gggcctgaaa tcaaggtgtg ggctcagcgc tatttacgtt
     2041 ggattccaga agcccaaatc ctgggtggtg gcagagtggc cactatgggc aaactcttgg
     2101 aaatgatgga ggaagtgcag agcttacagg agaaaataga ggcaaggcat cacagacagg
     2161 aggctatcca cgtacaggcg cctggcctgc tcaggaactc tgcccgcctg tcttccctgt
     2221 tcccctttgc aatgcaccag cgacattcag ccaagcctgt cttacccacc agtggctgga
     2281 aagctttggg aggtgaagat gacctggcca aacgagaaga tgagtttgtg gacctagggg
     2341 acgtgtgact ctcttctcag ggactgtgaa agaggcacac tgtacggtgg gacaattgtt
     2401 cctggactgg tgtcacgatg ttagctcagt gctgtgaagg agagagcagg gctttcagga
     2461 agagagctgg ttctcctttt cttccacagt tctggaagac agcgcaacaa agccatgcct
     2521 ctaggatgca taggagggag ttcctacttg acctgtcata ggattggggt catttcctga
     2581 catctgtatt atatgtacac acaatggctc gtggccaggc tgctgtgaga gcctcctgat
     2641 ttctctgtgc caagataatt acatagccat ttcgaacaag agtaagggca gctttatgcg
     2701 gcatctaagt ggagagacag aggattaaga gatgtgcttt gtcttaaacc atattccagc
     2761 gtgcacacac acacatgcac gcaccacaga aaagttgaca gttcttctgg tgtcatccat
     2821 cctaatgttc agtccctcct tcctgaactg taacaaggca cagggtgggt ggggcagccg
     2881 ccttcccttt tcctttgctg tcattcccat cttacctttt cctgttctgt gccattctgg
     2941 gggtccactc ggtgcacatc atcccagggt cttgttgctg acctggggaa ggtcctctgg
     3001 cttccacggg ggagctcttg gagccctgtt ttgttctttt cttttttttt tttttttttg
     3061 gttctttttt ttccggagct ggggaccgaa cccagggcct tgcgcttcct aggtaagcgc
     3121 tctaccactg agctaaatcc ccagcccctg gagccctgtt ttgactgcac acttggctct
     3181 ctgctcgaat accaaggctc ggggcaccta gagactctca gcagcccctc agctcccttt
     3241 gcctccccac taccctcatg atgctggggc aagcaggaca attcgaatgt ggctctcaca
     3301 ggaaagcagc catgtcagca gcaattatca caggatgcct cagtgattga aaaagccata
     3361 gaagggaact cagccctgcc tagtcaccgt gggtctgctg tgttaaagat acatattttc
     3421 ttactgtttg aaagcatact ttgtaaggct tcatgctgtc attctcaaca aagctctgtc
     3481 cagtcccaca gaagtgtaga gaagagggag tgggcaaggg acctcactga gactgcctca
     3541 catgtttgcc ttttttctct atttgctggt agggagaggt cctgttagga aatctctgtt
     3601 gctcatgggc aataaggcat tttggaactt aacaaaaagt cctttctgat tgcactgaat
     3661 tatctttcat atgtagtgat catttttcct cggctccctc cacagtagcg cacagtctgg
     3721 gttggcgtgt tgactcagca tgttgggggg tgggggtcaa gatctgtgtt tctgggacca
     3781 aatgcactca gtctcggttg ccttaagaat ctttcaggcc aggcctgcgc taggagtgcg
     3841 ctagggatct agaacacgcc cgttcctagc tgcctacctt gtgttccttg ggctctctta
     3901 agctagcgct aactgccacg ccctcagcct ctgcttcaca agtcctcagt ggagagaact
     3961 atttttgtta ccgtattata gcatgaatat ttatatggta gcctctgcag tcttagtgat
     4021 ttctctcccc cccccccaaa aaaaaattgc ctcatgtgat gttttatact tcacaaagta
     4081 tggtttaaag gcacaaggtc atcatccttg ttatatcagt tgaatgtgca ttgaaatatt
     4141 tttctatgct ttttttaaat cacaatagaa aaggtaaaca agctgttgca acctgtgtgg
     4201 ttacgacaat ttatgttatg tatttatatt tgaaaccaga tttctataac ttgcatttct
     4261 gtacagaact ttccataggt ttatatattg tgtattttta ttcaagattg agatgtggtt
     4321 tatgtttaac attaaaagat aaaataagac cctttgttta aaacacactg tgcaagtttg
     4381 gaagtgtctg ttaataattt actgtatata atacttgcct ttgtttatac ctccaagttt
     4441 ttacactgaa gataaactag ctttaattaa attttaaaaa tttaagggaa taagctgttc
     4501 ggctgagtca gtttaaatgt gcagtttatt ttcggggtgt tggtggaagt ttatacatgc
     4561 ctcactgcat tgtaactgac tgcagagatt aaagaacaac tttcaatcag cgccataact
     4621 ga
//
