LOCUS       NM_001415695            3534 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus myotubularin related protein 1 (Mtmr1),
            transcript variant 2, mRNA.
ACCESSION   NM_001415695 XM_039096936
VERSION     NM_001415695.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3534)
  AUTHORS   Bong,S.M., Son,K.B., Yang,S.W., Park,J.W., Cho,J.W., Kim,K.T.,
            Kim,H., Kim,S.J., Kim,Y.J. and Lee,B.I.
  TITLE     Crystal Structure of Human Myotubularin-Related Protein 1 Provides
            Insight into the Structural Basis of Substrate Specificity
  JOURNAL   PLoS One 11 (3), e0152611 (2016)
   PUBMED   27018598
  REMARK    Erratum:[PLoS One. 2018 Jan 2;13(1):e0190844. PMID: 29293653]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3534)
  AUTHORS   Lorenzo,O., Urbe,S. and Clague,M.J.
  TITLE     Systematic analysis of myotubularins: heteromeric interactions,
            subcellular localisation and endosome related functions
  JOURNAL   J Cell Sci 119 (Pt 14), 2953-2959 (2006)
   PUBMED   16787938
REFERENCE   3  (bases 1 to 3534)
  AUTHORS   Buj-Bello,A., Furling,D., Tronchere,H., Laporte,J., Lerouge,T.,
            Butler-Browne,G.S. and Mandel,J.L.
  TITLE     Muscle-specific alternative splicing of myotubularin-related 1 gene
            is impaired in DM1 muscle cells
  JOURNAL   Hum Mol Genet 11 (19), 2297-2307 (2002)
   PUBMED   12217958
REFERENCE   4  (bases 1 to 3534)
  AUTHORS   Kim,S.A., Taylor,G.S., Torgersen,K.M. and Dixon,J.E.
  TITLE     Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated
            in myotubular myopathy and type 4B Charcot-Marie-Tooth disease
  JOURNAL   J Biol Chem 277 (6), 4526-4531 (2002)
   PUBMED   11733541
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Dec 23, 2022 this sequence version replaced XM_039096936.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.40711.1,
                                           SRR26643296.37218.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               JAXUCZ010000018.1  229417-229680
            265-370             JAXUCZ010000018.1  231574-231679
            371-394             JAXUCZ010000018.1  235889-235912
            395-470             JAXUCZ010000018.1  241971-242046
            471-565             JAXUCZ010000018.1  244892-244986
            566-673             JAXUCZ010000018.1  245274-245381
            674-775             JAXUCZ010000018.1  246567-246668
            776-859             JAXUCZ010000018.1  247107-247190
            860-1009            JAXUCZ010000018.1  247477-247626
            1010-1198           JAXUCZ010000018.1  248302-248490
            1199-1384           JAXUCZ010000018.1  252635-252820
            1385-1591           JAXUCZ010000018.1  253865-254071
            1592-1684           JAXUCZ010000018.1  255021-255113
            1685-1798           JAXUCZ010000018.1  259118-259231
            1799-1975           JAXUCZ010000018.1  260046-260222
            1976-3534           JAXUCZ010000018.1  261335-262893
FEATURES             Location/Qualifiers
     source          1..3534
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p13"
     gene            1..3534
                     /gene="Mtmr1"
                     /note="myotubularin related protein 1"
                     /db_xref="GeneID:317296"
                     /db_xref="RGD:1306569"
     exon            1..264
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..2140
                     /gene="Mtmr1"
                     /EC_number="3.1.3.64"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="myotubularin-related protein 1 isoform 2"
                     /protein_id="NP_001402624.1"
                     /db_xref="GeneID:317296"
                     /db_xref="RGD:1306569"
                     /translation="MDRPGAAASGCESAAGPGPGPGASWRPARVAGGASGSSRHPSME
                     TLDSPAGSHVEWCKQLIAATISTQMSGSVTSENVSRDYKVFRRPDTRALRDGNKLAQM
                     EEAPLFPGESIKAIVKDVIYICPFAGAVSGTLTVTDFKMFFKNVERDPHFILDVPLGV
                     ISRVEKIGAQSHGDNSCGIEIVCKDMRNLRLAYKQEEQRKLGIFENLNKHAFPLSNGQ
                     ALFAFNYKEKFPVNGWKVYDPVSEYKRQGLPNESWKISKINSNYEFCDTYPAVIVVPT
                     SVKDDDLLKVSAFRAKGRVPVLSWIHPESQATITRCGQPLVGPNDKRCKEDEKYLQTI
                     MDANAQSHKLTIFDARQNSVADTNKAKGGGYECESAYPNAELIFLEIPNIHVMRESLR
                     KLKEVVYPAIDESHWLSNVDGTHWLEYIRVLLAGAVRIADKIESGKTSVVVHCSDGWD
                     RTPQLTSLAMLMLDSYYRTIPGFEALIEKEWISFGHRFALRVGHGDDNHADADRSPIF
                     LQFIDCVWQMTRQFPSAFEFNELFLIAILDHLYSCLFGTFLCNCEQQRVREDVCAKTL
                     SLWSYINSQLDEFSNPFFVSYDHHVLYPVASVSRLELWVNYYVRWNPRMRPQMPIHQN
                     LKELLAVKAELRKRVEDLQREAAARTVPSSSERGPSPTHSAPPVHTSV"
     exon            265..370
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..394
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            395..470
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            471..565
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            566..673
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            674..775
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            776..859
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1009
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1198
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1384
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1591
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1684
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1798
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1975
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..3534
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgccaggt gacggctcac ggcggcggcc gcctgacgcg ggtggtcgat cgtcggagcg
       61 gggcggaagg ggcgcagtcg gggagatcgg gggtcacggg agccgccgga cctgacgcgt
      121 gatggacagg ccgggagcgg cggcgtcggg ctgcgaaagc gctgcgggcc ccgggccggg
      181 accgggcgcc agctggagac ccgctcgtgt tgcggggggc gcttccggca gttcccgaca
      241 ccccagcatg gagaccctgg acagccccgc agggtcgcac gtggagtggt gcaagcagct
      301 catcgcggcc acgatctcca cacagatgtc aggctcggtg acgtcagaaa acgtgtccag
      361 ggattacaag gttttcagga gaccagatac cagggctctg agggatggaa ataaactggc
      421 gcagatggag gaagctccgc ttttcccggg ggagtccatt aaggccattg tgaaggacgt
      481 catctacatc tgcccgttcg cgggagccgt gagtgggact ctgacagtga cggacttcaa
      541 aatgttcttc aaaaacgtgg aaagggaccc gcatttcatc ctcgacgtcc cgcttggagt
      601 catcagcaga gtggagaaga tcggtgccca gagccacggg gacaattcct gtggtataga
      661 gattgtgtgc aaggacatga ggaacctgag actcgcgtat aagcaggaag aacagagaaa
      721 acttgggata tttgagaacc tcaacaagca cgcttttcct ctttccaatg gacaggcgct
      781 gtttgcgttc aactataaag agaagtttcc agttaacggc tggaaagtct acgacccagt
      841 gtctgaatac aagagacagg gcctgccaaa tgagagctgg aaaatatcca aaatcaacag
      901 taattatgag ttctgcgata cctaccctgc cgtcatcgtt gtgccaacga gcgtgaaaga
      961 tgatgacctt ctgaaagtgt cagcctttcg agcaaagggc agagtccctg tgttgtcgtg
     1021 gattcatccg gagagtcagg ccacaattac acgttgcggc cagccattgg tgggtcccaa
     1081 cgataaacgc tgcaaagaag atgagaaata cctgcagacc atcatggatg ccaatgcgca
     1141 gtcacataaa ctcactatct tcgatgcccg gcagaacagc gttgccgata ctaacaaggc
     1201 gaagggcggc ggatatgaat gtgaaagcgc ttaccctaac gcggagctca tcttcctgga
     1261 gatacccaac attcacgtga tgagggagtc actccgtaag ttgaaggagg tcgtgtaccc
     1321 tgccatcgac gagtcgcact ggctgtccaa tgtggacggg acgcactggc tggaatacat
     1381 acgggtcctt ctggctgggg cagtgagaat tgcggataaa atagagtctg ggaaaacgtc
     1441 tgtggtcgtc cactgcagtg acggctggga ccgcacgccc cagctcacat ctctggcaat
     1501 gctcatgttg gacagttact accgaaccat cccagggttc gaggccctca tagaaaagga
     1561 gtggataagc tttggacaca ggtttgcact gagagtgggc cacggtgacg acaaccacgc
     1621 tgacgctgac cggtcgccta tatttctcca gttcattgat tgcgtttggc agatgacaag
     1681 gcagttccct tcggcattcg agtttaacga gttgttcctg atcgcaattt tggatcacct
     1741 gtacagctgc ctcttcggga ccttcctgtg caactgcgag cagcagcgtg tcagagagga
     1801 cgtctgtgca aagaccctgt cgctgtggtc ctacatcaac agccaactcg acgaattctc
     1861 caaccccttc ttcgtgagct acgaccacca cgtgctgtat ccggtcgcga gtgttagccg
     1921 cttggaattg tgggtaaatt actacgtacg gtggaaccca cggatgaggc cgcagatgcc
     1981 gatccaccag aacctgaagg agttgctggc cgtcaaggcc gaactgcgga agcgggtgga
     2041 ggacttgcag cgggaggcgg ccgcgcggac cgtcccgtcg tcctctgaga ggggcccctc
     2101 gccgacccac tcagctcctc ctgtgcacac ctcagtctga tgaacggagc cagcgtcctg
     2161 ggccatcttg ctgctctcct gtcttctggt ggctcaggga cccggccatg gacaccatgg
     2221 ttccagcacc gtcttagctc ttaggccgga gaccgcagca cagcccattg tgcagcctgt
     2281 tccggcactg gaggtcgcag caggttccca aagacgcact gaatgcttgg tcttccagcc
     2341 tgcaggtgaa ctgagtactc tgcatttggc ggcctcccgc catgacactt ctctaaaggg
     2401 ggaagcctcg aagatggtgc tgacctctca gcgcctgtgg aggtggctgg cgctgacatc
     2461 aaatcgcgtc taaccttgcc tgctggacgc ccggaagtct cgtttccgtc tgtcgcggtc
     2521 tcttctcggt gggattacgt cacttccagt ccatccttta aggcagtgca gcctgggtgg
     2581 aaagcgagcg tagcgtgctc ttcctccgtt tcccctcgga cccagcctgg gctaacgcag
     2641 gcttttctcc agtgagctct gctacttcat ccatctgctt caccgccgcc atttccattt
     2701 ctgggcgtcg tcaggtccgt ccgagctgga ggtgtgtttg aggctgaccg cgtggctgaa
     2761 cttcaattcc cagacgcctc tgcgccccgg actcggccaa cggtttccca gcggcctcac
     2821 gggtgaacgg ctgtgagagg tggcttcggt caccgtgtgg ctgaactaca attcccagag
     2881 gccactcagt cgtgcacatc gaccgccatc ttcaaaacgt attcttaaag gttttttttt
     2941 ttttgttttt tgtttttttt ttaaatacag ccacgtacat gggaaataga tgtttcagcc
     3001 cggaaccttc cgggcaggac aggaaactgc cagaccggaa gttactgtag acattcgttc
     3061 cggggaattt ggtgagctgc gcccgggtct ccatttttgt caggataaac cgccgtatcc
     3121 gaggtcggag aagctgagag ttcggggtcg gctttggctg acttccggta cactggaacc
     3181 cgggctcaaa atcaatgctg gatagcaaag aaaacgtgaa ccccgatatt ttttcttcgt
     3241 atgcttttta aggctggggg cgttgcccat ctcttttccc ggagacgtcg ggtaatttcc
     3301 tggcaacccc atgtgttgca catagagcgg accgatgggg ttgggacaga agcggagaag
     3361 ccatggcagc ggcggctgcg cggtgaggtc gggtagcctg atgggtggct gtgaacgggg
     3421 gaacccaggt cccggtccag ccacgtcccc caagccgcac cccgaaaaat gtctcgtctg
     3481 aggcacggtc ccaacccgcg aataaagcga tgatatttgc cccgccccca ccca
//
