LOCUS       NM_001009349            2782 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus methenyltetrahydrofolate synthetase (Mthfs),
            mRNA.
ACCESSION   NM_001009349 XM_217214
VERSION     NM_001009349.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2782)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2782)
  AUTHORS   Wu,D., Li,Y., Song,G., Cheng,C., Zhang,R., Joachimiak,A., Shaw,N.
            and Liu,Z.J.
  TITLE     Structural basis for the inhibition of human
            5,10-methenyltetrahydrofolate synthetase by N10-substituted folate
            analogues
  JOURNAL   Cancer Res 69 (18), 7294-7301 (2009)
   PUBMED   19738041
REFERENCE   3  (bases 1 to 2782)
  AUTHORS   Anguera,M.C., Suh,J.R., Ghandour,H., Nasrallah,I.M., Selhub,J. and
            Stover,P.J.
  TITLE     Methenyltetrahydrofolate synthetase regulates folate turnover and
            accumulation
  JOURNAL   J Biol Chem 278 (32), 29856-29862 (2003)
   PUBMED   12764149
REFERENCE   4  (bases 1 to 2782)
  AUTHORS   Bertrand,R., Beauchemin,M., Dayan,A., Ouimet,M. and Jolivet,J.
  TITLE     Identification and characterization of human mitochondrial
            methenyltetrahydrofolate synthetase activity
  JOURNAL   Biochim Biophys Acta 1266 (3), 245-249 (1995)
   PUBMED   7766710
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087144.1.
            
            On Jan 7, 2005 this sequence version replaced XM_217214.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087144.1, CV107207.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2782
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..2782
                     /gene="Mthfs"
                     /note="methenyltetrahydrofolate synthetase"
                     /db_xref="GeneID:300886"
                     /db_xref="RGD:1306876"
     exon            1..123
                     /gene="Mthfs"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..618
                     /gene="Mthfs"
                     /EC_number="6.3.3.2"
                     /note="5, 10-methenyltetrahydrofolate synthetase;
                     5,10-methenyltetrahydrofolate synthetase
                     (5-formyltetrahydrofolate cyclo-ligase)"
                     /codon_start=1
                     /product="5-formyltetrahydrofolate cyclo-ligase"
                     /protein_id="NP_001009349.1"
                     /db_xref="GeneID:300886"
                     /db_xref="RGD:1306876"
                     /translation="MAAVTVNSAKRGLRAELKQRLRALGAEERLRQSHLLTQKVIAHS
                     QYQNSKRISIFLSMQDEIETEEIIKDIFKQGKICFIPRYQFHSNHMDMVRLTAPEEVA
                     LLPKTSWNIHQPGEGDVREEALSTGGLDLIFLPGLGFDKDGNRLGRGKGYYDTYLKRC
                     VQHQKVKPYTLALAFREQICPQIPVDEHDMKVDEVLYEDSPTS"
     exon            124..385
                     /gene="Mthfs"
                     /inference="alignment:Splign:2.1.0"
     exon            386..2755
                     /gene="Mthfs"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggaaatgg cggcggtcac cgtaaacagc gccaagcggg gcctgcgggc cgagctgaag
       61 cagcgcttgc gagctttggg cgccgaggaa cggctgcgcc agtctcacct cctcacacag
      121 aaggtgattg cccacagtca gtatcaaaat tccaaaagaa tttccatctt tctgagcatg
      181 caagatgaaa ttgagacgga agaaatcatc aaggacattt tcaaacaagg caaaatctgc
      241 ttcatccctc ggtaccagtt tcacagcaat cacatggaca tggtgaggct aacagcacct
      301 gaagaagttg ctttacttcc caagacatct tggaatattc atcagcctgg tgagggagat
      361 gttcgggagg aggccttatc cactggtgga cttgacctca tcttccttcc tggcctcggg
      421 tttgacaaag atggcaaccg gctgggtcgg ggcaaggggt actatgacac ctacctgaag
      481 cgctgtgtac agcatcagaa agtgaagccc tacaccttgg ctttggcctt tagagagcag
      541 atctgtccac agatcccagt ggatgagcac gacatgaagg tagatgaagt cctttacgaa
      601 gactccccaa catcttaaat tacaccacga cgaccacact tactgctttg tactggcgta
      661 aagaaaatat gtatattttt ctcttgtcac aaatgaatca aaatgacaca ttaaagtgaa
      721 tatggattgt catttttagt gtaaatataa aataatataa aatctttttt tagaaatcaa
      781 tagaaatgtt actattagaa tattaatgca aatggagtgg aaactgcatg gttttcagct
      841 tagctttctg gtgttaagat gttacattga cctttctgtc tctagtttaa attaagtatt
      901 tatgagtatt agagaaagat agaaattgga tgtgagtgaa gacactgttt tttaatatcc
      961 agtcataggc ctgattgctc tggcatatgg agactcagct gttattaatt ggtttggcag
     1021 tacttggtat ggataaaata ttccccaaga ctattattat accacttgat atatcatggc
     1081 ttcatttact caccttgaag ttttgtgtgt gacattttat agcttcatgt ggtgagtaga
     1141 tgggaatctt ttgtggttta catactttga ttcagttgat tggtctctgg ccttaggact
     1201 tacataagga atcatttctg ttaagtcgtg ggttccactt ggaatggaag ctgccctgga
     1261 ttggacattg ccagatggcc tcacagttgg gagaggtact tttgttgagg ggaaagattt
     1321 ggttatcaca agacactcag gggtcttcct ggacatgact gcttgcttgg ttccacctgc
     1381 agcctgtcac tagctcctgc tggcattgcc tctgggatgc cgtctacatc tgctctctcc
     1441 ttcctgtctt cctgctccca ttttcttcag ctctcagcat ttctcagctc aagtaggcag
     1501 tctccatgct cagcttcttt tgcctccaat ttatttcagg gatgatctgg taagatataa
     1561 atctagtgtg gacactctgc atcaaagtat tttggagaca tacatcttaa caagtagatg
     1621 ccttcccctg tagaagaaat cccttgtaag cccctccctc ttctgtcgtc tcttccctct
     1681 cccccgtatg tctttctgtg catgctgtaa gcgccacagg ctctctgtcc agtgcacgct
     1741 gctttcctgc atctcagtgc tggctcctgt atcttcagga cgctgccctt gctttgtttc
     1801 tccaggacgt gttccatggc tcccctcctg ccagttctag atcctccttc ccttgctgtg
     1861 gccattgccc atttatcaca tcatcctgca gagcagttac tagtgtccat gtctgtccct
     1921 tcatgaggct gtacgtttga aagaacttct tgtctttggt agttgactga tggagagtat
     1981 tcgataacat tttttaaaat cataaacaga atatatgtat aattatttca ttgtaaacac
     2041 agatctacta tttttttgca taataatatg cagtttggta tttcgtgtgc aaaaagtaaa
     2101 tgtatatata ttctttaaaa atgccaattc aggtaagagt ggatctgtac aatttagaat
     2161 atgcaatgag aaatgagaga gaaatggaat tactatgagc tgtgatggca ttatatactg
     2221 attaatctta ttcagtgtta cttcagtggc aaggataagg taaatgttat tataactgac
     2281 atgactgttg gggtgaaata gttaaatcat agaattactg agctgttgca ggtcgagaaa
     2341 gctttgcttt cttacctatg ttgttcttgt attacagaga gcatgcaaga gcaggtatag
     2401 ttagaacaga caaatgactt ccagaacctg ctggccgctt aggattcaga acaatcaaaa
     2461 gccacatgat ctctttctat aatggctaat cttgtaaact tgatggggtt tagaattacc
     2521 atagaaacac gtccctgggt atgtttatga gggtgtttcc tgaaaggttt aatcaaacag
     2581 tgaagactta atatgtcata actgtgtctc atggggtggg gctgaatgag aaggggaaaa
     2641 tgagttgagc actaatgatc attgatctct gcttcctgac tgtggatgcc tctggatgct
     2701 ataatggatt atatattgcc aaaataaata acttccttaa gttgtttctt ataaaaaaaa
     2761 aaaaaaaaaa aaaaaaaaaa aa
//
