LOCUS       NM_001100977            2890 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus mitochondrial fission regulator 1 (Mtfr1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001100977 XM_001055144 XM_006232178 XM_230569
VERSION     NM_001100977.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2890)
  AUTHORS   Huang,L., Guo,B., Liu,S., Miao,C. and Li,Y.
  TITLE     Inhibition of the LncRNA Gpr19 attenuates ischemia-reperfusion
            injury after acute myocardial infarction by inhibiting apoptosis
            and oxidative stress via the miR-324-5p/Mtfr1 axis
  JOURNAL   IUBMB Life 72 (3), 373-383 (2020)
   PUBMED   31622017
  REMARK    GeneRIF: Inhibition of the LncRNA Gpr19 attenuates
            ischemia-reperfusion injury after acute myocardial infarction by
            inhibiting apoptosis and oxidative stress via the miR-324-5p/Mtfr1
            axis.
REFERENCE   2  (bases 1 to 2890)
  AUTHORS   Monticone,M., Panfoli,I., Ravera,S., Puglisi,R., Jiang,M.M.,
            Morello,R., Candiani,S., Tonachini,L., Biticchi,R., Fabiano,A.,
            Cancedda,R., Boitani,C. and Castagnola,P.
  TITLE     The nuclear genes Mtfr1 and Dufd1 regulate mitochondrial dynamic
            and cellular respiration
  JOURNAL   J Cell Physiol 225 (3), 767-776 (2010)
   PUBMED   20568109
REFERENCE   3  (bases 1 to 2890)
  AUTHORS   Hoja,M.R., Wahlestedt,C. and Hoog,C.
  TITLE     A visual intracellular classification strategy for uncharacterized
            human proteins
  JOURNAL   Exp Cell Res 259 (1), 239-246 (2000)
   PUBMED   10942595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Dec 3, 2020 this sequence version replaced
            XM_006232178.2, NM_001100977.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ217237.1, SRR26643290.7839.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                JAXUCZ010000002.1  103595420-103595469
            51-192              JAXUCZ010000002.1  103609681-103609822
            193-291             JAXUCZ010000002.1  103616353-103616451
            292-407             JAXUCZ010000002.1  103619669-103619784
            408-640             JAXUCZ010000002.1  103624190-103624422
            641-896             JAXUCZ010000002.1  103625906-103626161
            897-1065            JAXUCZ010000002.1  103626982-103627150
            1066-2890           JAXUCZ010000002.1  103627873-103629697
FEATURES             Location/Qualifiers
     source          1..2890
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..2890
                     /gene="Mtfr1"
                     /gene_synonym="RGD1304936"
                     /note="mitochondrial fission regulator 1"
                     /db_xref="GeneID:311403"
                     /db_xref="RGD:1304936"
     exon            1..50
                     /gene="Mtfr1"
                     /gene_synonym="RGD1304936"
                     /inference="alignment:Splign:2.1.0"
     exon            51..192
                     /gene="Mtfr1"
                     /gene_synonym="RGD1304936"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1134
                     /gene="Mtfr1"
                     /gene_synonym="RGD1304936"
                     /codon_start=1
                     /product="mitochondrial fission regulator 1"
                     /protein_id="NP_001094447.2"
                     /db_xref="GeneID:311403"
                     /db_xref="RGD:1304936"
                     /translation="MLGWIKCLMRMWFQRVGVSMQSVLWSGKPYGSSRSIVRKIGTNL
                     SLIQCPRVQFQLTSHATEWSPTHPGEDVVATFADVGWVATDEGECSTRLRTEVRSKPP
                     LENNPPCFEKPPSRHISLPNSSQDKPSPKTTLASEEALQKISALENELAALRAQIAKI
                     VTLQEQQSPSAGCLDSSTPVIVVPPPPPPPPPPPPLPPPPLVLHPSTSALDLIKERRE
                     QRLSAGKTLAKGHPKKLDMPNMLEILKDMNSVKLRPVKRSEKDEKPRPVDITDPAALI
                     AEALKKKFAYRHRHNSQGEAERGIPKPESDATSEPALFGPHTLKSTGKMKALIENVSD
                     S"
     exon            193..291
                     /gene="Mtfr1"
                     /gene_synonym="RGD1304936"
                     /inference="alignment:Splign:2.1.0"
     exon            292..407
                     /gene="Mtfr1"
                     /gene_synonym="RGD1304936"
                     /inference="alignment:Splign:2.1.0"
     exon            408..640
                     /gene="Mtfr1"
                     /gene_synonym="RGD1304936"
                     /inference="alignment:Splign:2.1.0"
     exon            641..896
                     /gene="Mtfr1"
                     /gene_synonym="RGD1304936"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1065
                     /gene="Mtfr1"
                     /gene_synonym="RGD1304936"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..2890
                     /gene="Mtfr1"
                     /gene_synonym="RGD1304936"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatctggaag gctgagtagc tgggaaggtg agggctgctt cgcggctgag tgtgctctat
       61 ggaccatgtg ctgctatgga tgcctgaagt acttgacctg caggttggga agactcagcc
      121 atctccatgc tgggctggat taagtgcctg atgaggatgt ggtttcagcg agttggggtc
      181 agcatgcagt cggttctgtg gtctggaaaa ccatatggtt catctcgaag tattgtaagg
      241 aaaattggta ccaacttatc tctgattcag tgtccaagag ttcaatttca gcttaccagc
      301 catgcaacag aatggagtcc cacgcaccca ggagaggatg tggtggcaac ttttgctgat
      361 gttggatggg tagccaccga tgaaggagaa tgctcaacaa gactcaggac agaagtcagg
      421 tccaagcctc ctcttgagaa caaccctcct tgctttgaga agcccccaag caggcacatt
      481 tccttaccaa actcgtctca agacaagcct tctccaaaga cgacactagc cagcgaggag
      541 gccttgcaga agatctctgc acttgagaat gagcttgctg cccttagagc tcagattgcc
      601 aagattgtga ccctgcagga gcaacagagt ccaagtgcag gttgcttaga ttcttccaca
      661 cctgttattg tagtaccacc accaccgccg ccgccgccgc ctcctcctcc cctccctccc
      721 ccaccattgg tgctccaccc aagtacatct gctcttgatc tgattaaaga acgaagagag
      781 caaagactca gtgctggaaa gactctggct aagggccacc caaagaagct tgacatgcca
      841 aatatgctag agatccttaa agacatgaac agtgtgaagc tacggccagt caagaggtca
      901 gagaaagatg aaaaacctag gccagtggat attactgatc ctgctgccct catagcagag
      961 gctctgaaaa agaagtttgc atatcggcat cgacacaata gccaaggaga agctgaaaga
     1021 ggaattccaa agccagagtc agacgcaacc tcagagccag ccctgtttgg cccacataca
     1081 ttgaagtcta cagggaaaat gaaggcttta attgaaaatg tttcagactc ctaaatggac
     1141 aatgaattca gaaagactcc tggtttacct gttggcttgc agagctgagt ttggctagta
     1201 gaaatcacca gtatttagta aattcctgac tgtagtgctc attggtctcc ttcttagcct
     1261 aattagagga gtaagaagtg gtgaaagcac cagaagttgg tttggctcct agaagatggt
     1321 cagttctgga gctctcctta tcacacatgt attatgtgca ttttcagtta acactaaagt
     1381 ctgtgcaaga gttttatatg catacgtttg gatacaaaga tgtaaaagct cccagtgact
     1441 ggcatcagcg aggacaccct tcctctgcat tgagaggtca ctagtcagcg atggaacact
     1501 gatgccgtta gcatagcaca ctattggagc tgggaatgct gcggacagga cttgagtata
     1561 ttctcacttt ctgctttctg gagctgagtt tacataaaca gcagaagatg cttcctgccg
     1621 agtctctgta ttgctttctg ttagagggaa gtgaggacca ggaaggctgt gtaaacctca
     1681 ttaccactca atactgagaa gcaaatgtac ttctcaagta gtgacaagtc aaattactga
     1741 attaaatcat ttcttaaata aaagccagaa tgtatcatct ttcttatcaa tttaataagt
     1801 tccctcataa agatgattta ttgctaagtt aacaattgtc ttagttaagg ttactatcac
     1861 tgtgatgaaa caccatggcc aaaagcaact tgggggagga aatggtttat ttcactcaca
     1921 gtaccatata gcagttcatc atcacaagca gtgagggcag gaagtaagca gggcaggatc
     1981 ctggagtcag gagctgatgc agaagccatg cagggtgctc cttactgcct tgcttcccat
     2041 ggcttgctca gcctgttttc ttatagaacc caggaccacc agcccagggt gagcaccacc
     2101 ccacagtagg ctgggccctc ccccatcaat cactaattaa gagaatgcct tatagccaga
     2161 tcttatggag gcattttctc aattgaggtt cacttccttt tacatgactc tagctatgtc
     2221 aagctgacag actagccagc atagtacttc tagaaatgtc agcataattg aatttatagt
     2281 tttgacatat tggtcaagat attctttata atgaaatatt actgaatagg tgaataaatt
     2341 ccctttaagc tatttattat tggtcagcca atggattata ttatgcagat aaaccttagg
     2401 tgttattaga aagtagaaaa ctgcctttac tatctaaggc ttggaaggac ttgttataat
     2461 ctaaagttct tagtactttt catgattttt ttgtttctga taaactcttc aatgccagaa
     2521 tctctcttac catgagtaaa tatttggatt atttaaatct agactagtgg ttcttcccag
     2581 gagaatttag agatgggaag tatagataat attttaagtt attgaaaata gatgttctaa
     2641 atcataacaa agattgggct atttttcata gcttatttag tttaaattgt ggtatgtttt
     2701 tgctgtatat tgtttctaaa tattttgtat ggtttgaaaa ctgtctttta tgagattcag
     2761 aaaattcacc tgaccatatt ttgacctaag aagtttatat ttatatcagt attgaatttg
     2821 gctagtattc tcctatatga aagttattat tttaaaataa accaagctgt tgaattttct
     2881 ttcaatgata
//
